JP2010535220A - 抗精神病用の併用療法剤を使用する統合失調症の治療のための方法および組成物 - Google Patents

抗精神病用の併用療法剤を使用する統合失調症の治療のための方法および組成物 Download PDF

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JP2010535220A
JP2010535220A JP2010519954A JP2010519954A JP2010535220A JP 2010535220 A JP2010535220 A JP 2010535220A JP 2010519954 A JP2010519954 A JP 2010519954A JP 2010519954 A JP2010519954 A JP 2010519954A JP 2010535220 A JP2010535220 A JP 2010535220A
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antipsychotic
schizophrenia
dimebon
various examples
combination therapy
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JP2010535220A5 (enExample
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セルゲイ オレゴビッチ バシュリン,
ブラディミール ビクトロビッチ グリゴリエフ,
マルガリータ エー. モロツォバ,
アラン ジー. ベニアシュビリ,
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メディベイション ニューロロジー, インコーポレイテッド
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Priority claimed from RU2007129567/15A external-priority patent/RU2508106C2/ru
Priority claimed from RU2007129568/15A external-priority patent/RU2508096C2/ru
Application filed by メディベイション ニューロロジー, インコーポレイテッド filed Critical メディベイション ニューロロジー, インコーポレイテッド
Publication of JP2010535220A publication Critical patent/JP2010535220A/ja
Publication of JP2010535220A5 publication Critical patent/JP2010535220A5/ja
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2010519954A 2007-08-01 2008-08-01 抗精神病用の併用療法剤を使用する統合失調症の治療のための方法および組成物 Pending JP2010535220A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
RU2007129567/15A RU2508106C2 (ru) 2007-08-01 2007-08-01 Способы и композиции для лечения шизофрении с использованием атипичной нейролептической комбинированной терапии
RU2007129568/15A RU2508096C2 (ru) 2007-08-01 2007-08-01 Способы и композиции для лечения шизофрении с использованием нейролептической комбинированной терапии
PCT/US2008/009357 WO2009017836A1 (en) 2007-08-01 2008-08-01 Methods and compositions for treating schizophrenia using antipsychotic combination therapy

Publications (2)

Publication Number Publication Date
JP2010535220A true JP2010535220A (ja) 2010-11-18
JP2010535220A5 JP2010535220A5 (enExample) 2011-09-15

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JP2010519954A Pending JP2010535220A (ja) 2007-08-01 2008-08-01 抗精神病用の併用療法剤を使用する統合失調症の治療のための方法および組成物

Country Status (10)

Country Link
US (1) US20110269777A1 (enExample)
EP (1) EP2175724A4 (enExample)
JP (1) JP2010535220A (enExample)
KR (1) KR20100054812A (enExample)
CN (1) CN101842010A (enExample)
AU (1) AU2008282742A1 (enExample)
BR (1) BRPI0815850A2 (enExample)
CA (1) CA2719824A1 (enExample)
MX (1) MX2010001218A (enExample)
WO (1) WO2009017836A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014128882A1 (ja) * 2013-02-21 2014-08-28 医療法人 和楽会 不安うつ病の治療薬

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7837812B2 (en) 2004-05-21 2010-11-23 Ati Properties, Inc. Metastable beta-titanium alloys and methods of processing the same by direct aging
CN101868234A (zh) 2007-09-20 2010-10-20 D2E有限公司 具有神经保护和认知增强特性的氢化吡啶并[4,3-b]吲哚的含氟衍生物,其制备方法及应用
RU2007139634A (ru) 2007-10-25 2009-04-27 Сергей Олегович Бачурин (RU) Новые тиазол-, триазол- или оксадиазол-содержащие тетрациклические соединения
RU2544856C2 (ru) * 2008-01-25 2015-03-20 Сергей Олегович Бачурин НОВЫЕ ПРОИЗВОДНЫЕ 2,3,4,5-ТЕТРАГИДРО-1-ПИРИДО[4,3-b]ИНДОЛА И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
BRPI0906245A2 (pt) 2008-03-24 2015-06-30 Medivation Technologies Inc Composto, método para tratar um distúrbio cognitivo, psicótico, mediado por neurotransmissor ou um distúrbio neuronal em indivíduo, uso de um composto, composição farmacêutica e kit
WO2009120717A2 (en) 2008-03-24 2009-10-01 Medivation Technologies, Inc. Pyrido [3, 4-b] indoles and methods of use
CN105168219B (zh) 2008-05-27 2018-11-20 细胞内治疗公司 用于睡眠障碍和其他疾病的方法和组合物
CN102271508B (zh) 2008-10-31 2015-04-29 梅迪维新技术公司 含有刚性部分的吡啶并[4,3-b]吲哚类化合物
EP2348847A4 (en) 2008-10-31 2012-05-23 Medivation Technologies Inc AZEPINO [4, 5-B] INDOLE AND USE PROCESS
SG173639A1 (en) 2009-02-11 2011-09-29 Sunovion Pharmaceuticals Inc Histamine h3 inverse agonists and antagonists and methods of use thereof
CN103145707B (zh) * 2009-04-10 2016-05-25 中国人民解放军军事医学科学院毒物药物研究所 氢化吡啶[4,3-b]吲哚类化合物的制备方法
CN102480956B (zh) 2009-04-29 2015-04-08 梅迪维新技术公司 吡啶并[4,3-b]吲哚类和使用方法
WO2010127177A1 (en) 2009-04-29 2010-11-04 Medivation Technologies, Inc. Pyrido [4,3-b] indoles and methods of use
CN102711466A (zh) 2009-09-23 2012-10-03 梅迪维新技术公司 桥连杂环化合物及其使用方法
BR112012006646A2 (pt) 2009-09-23 2019-09-24 Medivation Technologies Inc composto, composição farmacêutica, método de tratamento de um distùrbio cognitivo, distúrbio psicótico, distúrbio mediado por neurotransmissor ou um distúrbio neuronal e kit
CA2775328A1 (en) 2009-09-23 2011-03-31 Medivation Technologies, Inc. Pyrido[4,3-b]indoles and methods of use
WO2011103485A1 (en) * 2010-02-18 2011-08-25 Medivation Technologies, Inc. Fused tetracyclic pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use
US9034865B2 (en) 2010-02-18 2015-05-19 Medivation Technologies, Inc. Pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use
US9193728B2 (en) 2010-02-18 2015-11-24 Medivation Technologies, Inc. Fused tetracyclic pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use
US9187471B2 (en) 2010-02-19 2015-11-17 Medivation Technologies, Inc. Pyrido [4,3-b] indole and pyrido [3,4-b] indole derivatives and methods of use
WO2011103448A1 (en) * 2010-02-19 2011-08-25 Medivation Technologies, Inc. Methods and compositions for treating psychotic disorders using antipsychotic combination therapy
MX345230B (es) 2010-02-24 2017-01-20 The Broad Inst Inc * Metodos para diagnosticar patogenos de enfermedad infecciosa y su sensibilidad a farmacos.
US20140303144A1 (en) 2011-02-18 2014-10-09 Medivation Technologies, Inc. Compounds and methods of treating hypertension
WO2012112963A1 (en) 2011-02-18 2012-08-23 Medivation Technologies, Inc. Compounds and methods for treatment of hypertension
WO2012112964A2 (en) 2011-02-18 2012-08-23 Medivation Technologies, Inc. PYRIDO[4,3-b]INDOLE AND PYRIDO[3,4-b]INDOLE DERIVATIVES AND METHODS OF USE
CN103476416B (zh) 2011-02-18 2016-09-21 梅迪维新技术公司 治疗高血压的化合物和方法
US20150224120A1 (en) * 2011-09-14 2015-08-13 Catherine Clelland Compositions and methods for treating hyperprolinemia-associated mental disorders
US10039813B2 (en) 2012-02-07 2018-08-07 Massachusetts Institute Of Technology Use of antagonists of ghrelin or ghrelin receptor to prevent or treat stress-sensitive psychiatric illness
MX2014012374A (es) 2012-04-14 2015-04-17 Intra Cellular Therapies Inc Compuestos organicos.
US9724396B2 (en) 2013-03-15 2017-08-08 Massachusetts Institute Of Technology Use of antagonists of growth hormone or growth hormone receptor to prevent or treat stress-sensitive psychiatric illness
WO2014145192A1 (en) 2013-03-15 2014-09-18 Intra-Cellular Therapies, Inc. Organic compounds
EP3076967B1 (en) 2013-12-03 2021-07-28 Intra-Cellular Therapies, Inc. Methods for treating residual symptoms of schizophrenia
US10077267B2 (en) 2014-04-04 2018-09-18 Intra-Cellular Therapies, Inc. Organic compounds
KR101646962B1 (ko) 2014-09-29 2016-08-10 한국과학기술연구원 CaM 저해활성을 가지는 페노싸이아진 유도체
US20160184290A1 (en) * 2014-12-31 2016-06-30 Paul J. Markovitz Method of treating schizophrenia
WO2016138099A1 (en) 2015-02-24 2016-09-01 Massachusetts Institute Of Technology Use of ghrelin or functional ghrelin receptor agonists to prevent and treat stress-sensitive psychiatric illness
WO2016205631A1 (en) * 2015-06-17 2016-12-22 Massachusetts Institute Of Technology Serotonin 2c receptor antagonists to prevent and treat stress-related trauma disorders
RU2743513C2 (ru) 2016-01-26 2021-02-19 Интра-Селлулар Терапиз, Инк. Органические соединения
JP6686168B2 (ja) 2016-03-25 2020-04-22 イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. 有機化合物
EP3436016B1 (en) 2016-03-28 2022-04-27 Intra-Cellular Therapies, Inc. Novel co-crystals
WO2017172784A1 (en) 2016-03-28 2017-10-05 Intra-Cellular Therapies, Inc. Novel salts and crystals
JP2019510039A (ja) 2016-03-28 2019-04-11 イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. 新規組成物および方法
WO2018071233A1 (en) 2016-10-12 2018-04-19 Intra-Cellular Therapies, Inc. Amorphous solid dispersions
CN110087641B (zh) 2016-12-20 2024-03-12 罗曼治疗系统股份公司 含有阿塞那平和聚硅氧烷或聚异丁烯的透皮治疗系统
KR102506333B1 (ko) 2016-12-20 2023-03-06 에르테에스 로만 테라피-시스테메 아게 아세나핀을 함유하는 경피흡수 치료 시스템
WO2018126140A1 (en) 2016-12-29 2018-07-05 Intra-Cellular Therapies, Inc. Organic compounds
EP3562484B1 (en) 2016-12-29 2021-08-25 Intra-Cellular Therapies, Inc. Pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline derivatives useful in the treatment of cns disorders
CA3045043A1 (en) 2016-12-31 2018-07-05 Bioxcel Therapeutics, Inc. Use of sublingual dexmedetomidine for the treatment of agitation
MX387784B (es) 2017-03-24 2025-03-18 Intra Celular Therapies Inc Composiciones novedosas y metodos.
US10035795B1 (en) 2017-04-06 2018-07-31 Korea Institute Of Science And Technology Phenothiazine derivatives having CaM inhibitory activity
EP3644973B1 (en) 2017-06-26 2021-03-24 LTS LOHMANN Therapie-Systeme AG Transdermal therapeutic system containing asenapine and silicone acrylic hybrid polymer
CA3071137A1 (en) 2017-07-26 2019-01-31 Intra-Cellular Therapies, Inc. Prodrugs of substituted heterocycle fused gamma-carbolines
IL272249B2 (en) 2017-07-26 2023-11-01 Intra Cellular Therapies Inc Organic compounds
JP2020535231A (ja) 2017-09-26 2020-12-03 イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. 新規な塩および結晶
US11980617B2 (en) 2018-03-16 2024-05-14 Intra-Cellular Therapies, Inc. Methods of treating acute depression and/or acute anxiety
CN112040940A (zh) 2018-03-23 2020-12-04 细胞内治疗公司 有机化合物
EP3628007B1 (en) 2018-06-06 2023-05-03 Intra-Cellular Therapies, Inc. Novel salts and crystals
CA3102948A1 (en) 2018-06-08 2019-12-12 Intra-Cellular Therapies, Inc. Novel methods
CN112704672A (zh) 2018-06-20 2021-04-27 罗曼治疗系统股份公司 含有阿塞那平的透皮治疗系统
CN112533593A (zh) 2018-06-20 2021-03-19 罗曼治疗系统股份公司 含有阿塞那平的透皮治疗系统
CN115154440A (zh) 2018-06-27 2022-10-11 比奥克斯塞尔医疗股份有限公司 含右美托咪定的膜制剂及其制造方法
WO2020047241A1 (en) 2018-08-29 2020-03-05 Intra-Cellular Therapies, Inc. Novel compositions and methods
EP3843738A4 (en) 2018-08-31 2022-06-01 Intra-Cellular Therapies, Inc. NEW METHODS
CA3108558A1 (en) 2018-08-31 2020-03-05 Intra-Cellular Therapies, Inc. Novel methods
JP7377871B2 (ja) 2018-12-21 2023-11-10 イントラ-セルラー・セラピーズ・インコーポレイテッド 有機化合物
CN114072150A (zh) 2019-07-07 2022-02-18 细胞内治疗公司 新方法
WO2021016112A2 (en) 2019-07-19 2021-01-28 Bioxcel Therapeutics, Inc. Non-sedating dexmedetomidine treatment regimens
EP4072554A4 (en) 2019-12-11 2023-12-20 Intra-Cellular Therapies, Inc. ORGANIC COMPOUND
US20240139169A1 (en) * 2021-02-26 2024-05-02 Bioxcel Therapeutics, Inc. Methods and compositions for treating agitation
US12414948B2 (en) 2022-05-18 2025-09-16 Intra-Cellular Therapies, Inc. Methods
CN115290775A (zh) * 2022-07-25 2022-11-04 上海市徐汇区中心医院 一种精神类药物质控品、其试剂盒、制备方法及应用
US11806334B1 (en) 2023-01-12 2023-11-07 Bioxcel Therapeutics, Inc. Non-sedating dexmedetomidine treatment regimens

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5865217A (ja) * 1981-08-20 1983-04-18 チエスコスロベンスカ・アカデミ−・ベド 治療製剤及びその製法
JPS6270374A (ja) * 1985-09-16 1987-03-31 アメリカン・ホ−ム・プロダクツ・コ−ポレイシヨン 抗精神病γ−カルボリン
JPH08509221A (ja) * 1993-04-14 1996-10-01 イーライ・リリー・アンド・カンパニー テトラヒドロ−ピリド−インドール
JPH09216882A (ja) * 1995-10-17 1997-08-19 Isukura Sangyo Kk 水素化ピリド〔4,3−b〕インドール誘導体、その製造法、医薬組成物及び治療方法
JPH09510215A (ja) * 1994-03-11 1997-10-14 イーライ・リリー・アンド・カンパニー 8−置換テトラヒドロ−β−カルボリン
JP2000510860A (ja) * 1996-05-23 2000-08-22 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 抗精神病薬としてのヘキサヒドロ―ピリド(4,3―b)インドール誘導体
JP2005526691A (ja) * 2001-08-08 2005-09-08 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー 治療剤1H−ピリド[4,3−b]インドール
US20070117834A1 (en) * 2005-10-04 2007-05-24 David Hung Methods and compositions for treating Huntington's disease
JP2009513672A (ja) * 2005-10-31 2009-04-02 ブレインセルス,インコーポレイティド 神経発生のgaba受容体媒介調節
JP2009524676A (ja) * 2006-01-25 2009-07-02 メディベイション ニューロロジー, インコーポレイテッド 精神分裂病を治療するための方法および組成物
JP2010528016A (ja) * 2007-05-25 2010-08-19 メディベーション ニューロロジー, インコーポレイテッド 細胞を刺激するための方法および組成物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005120463A1 (en) * 2004-06-09 2005-12-22 Ranbaxy Laboratories Limited Rapidly disintegrating tablets of risperidone

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5865217A (ja) * 1981-08-20 1983-04-18 チエスコスロベンスカ・アカデミ−・ベド 治療製剤及びその製法
JPS6270374A (ja) * 1985-09-16 1987-03-31 アメリカン・ホ−ム・プロダクツ・コ−ポレイシヨン 抗精神病γ−カルボリン
JPH08509221A (ja) * 1993-04-14 1996-10-01 イーライ・リリー・アンド・カンパニー テトラヒドロ−ピリド−インドール
JPH09510215A (ja) * 1994-03-11 1997-10-14 イーライ・リリー・アンド・カンパニー 8−置換テトラヒドロ−β−カルボリン
JPH09216882A (ja) * 1995-10-17 1997-08-19 Isukura Sangyo Kk 水素化ピリド〔4,3−b〕インドール誘導体、その製造法、医薬組成物及び治療方法
JP2000510860A (ja) * 1996-05-23 2000-08-22 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 抗精神病薬としてのヘキサヒドロ―ピリド(4,3―b)インドール誘導体
JP2005526691A (ja) * 2001-08-08 2005-09-08 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー 治療剤1H−ピリド[4,3−b]インドール
US20070117834A1 (en) * 2005-10-04 2007-05-24 David Hung Methods and compositions for treating Huntington's disease
JP2009513672A (ja) * 2005-10-31 2009-04-02 ブレインセルス,インコーポレイティド 神経発生のgaba受容体媒介調節
JP2009524676A (ja) * 2006-01-25 2009-07-02 メディベイション ニューロロジー, インコーポレイテッド 精神分裂病を治療するための方法および組成物
JP2010528016A (ja) * 2007-05-25 2010-08-19 メディベーション ニューロロジー, インコーポレイテッド 細胞を刺激するための方法および組成物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JPN6013018003; ABOU-GHARBIA,M.: 'BIOLOGICAL ACTIVITY OF SUBSTITUTED GAMMA CARBOLINES' Drugs of the Future Vol.14, No.5, 1989, p.453-459 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014128882A1 (ja) * 2013-02-21 2014-08-28 医療法人 和楽会 不安うつ病の治療薬

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