JP2010535220A - 抗精神病用の併用療法剤を使用する統合失調症の治療のための方法および組成物 - Google Patents
抗精神病用の併用療法剤を使用する統合失調症の治療のための方法および組成物 Download PDFInfo
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- JP2010535220A JP2010535220A JP2010519954A JP2010519954A JP2010535220A JP 2010535220 A JP2010535220 A JP 2010535220A JP 2010519954 A JP2010519954 A JP 2010519954A JP 2010519954 A JP2010519954 A JP 2010519954A JP 2010535220 A JP2010535220 A JP 2010535220A
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- antipsychotic
- schizophrenia
- dimebon
- various examples
- combination therapy
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
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Landscapes
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| RU2007129567/15A RU2508106C2 (ru) | 2007-08-01 | 2007-08-01 | Способы и композиции для лечения шизофрении с использованием атипичной нейролептической комбинированной терапии |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014128882A1 (ja) * | 2013-02-21 | 2014-08-28 | 医療法人 和楽会 | 不安うつ病の治療薬 |
| JP2024507991A (ja) * | 2021-02-26 | 2024-02-21 | バイオエクセル セラピューティクス，インコーポレイテッド | 激越を処置するための方法及び組成物 |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| RU2007139634A (ru) | 2007-10-25 | 2009-04-27 | Сергей Олегович Бачурин (RU) | Новые тиазол-, триазол- или оксадиазол-содержащие тетрациклические соединения |
| RU2544856C2 (ru) | 2008-01-25 | 2015-03-20 | Сергей Олегович Бачурин | НОВЫЕ ПРОИЗВОДНЫЕ 2,3,4,5-ТЕТРАГИДРО-1-ПИРИДО[4,3-b]ИНДОЛА И СПОСОБЫ ИХ ПРИМЕНЕНИЯ |
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| WO2011103448A1 (en) * | 2010-02-19 | 2011-08-25 | Medivation Technologies, Inc. | Methods and compositions for treating psychotic disorders using antipsychotic combination therapy |
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| WO2012112961A1 (en) | 2011-02-18 | 2012-08-23 | Medivation Technologies, Inc. | Compounds and methods of treating hypertension |
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| US20140155384A1 (en) | 2011-02-18 | 2014-06-05 | Medivation Technologies, Inc. | Compounds and methods of treating diabetes |
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| US10039813B2 (en) | 2012-02-07 | 2018-08-07 | Massachusetts Institute Of Technology | Use of antagonists of ghrelin or ghrelin receptor to prevent or treat stress-sensitive psychiatric illness |
| JP2015514135A (ja) | 2012-04-14 | 2015-05-18 | イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． | 新規組成物および方法 |
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| US20160184290A1 (en) * | 2014-12-31 | 2016-06-30 | Paul J. Markovitz | Method of treating schizophrenia |
| US10317418B2 (en) | 2015-02-24 | 2019-06-11 | Massachusetts Institute Of Technology | Use of ghrelin or functional ghrelin receptor agonists to prevent and treat stress-sensitive psychiatric illness |
| WO2016205631A1 (en) * | 2015-06-17 | 2016-12-22 | Massachusetts Institute Of Technology | Serotonin 2c receptor antagonists to prevent and treat stress-related trauma disorders |
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| JP7013454B2 (ja) | 2016-10-12 | 2022-02-15 | イントラ－セルラー・セラピーズ・インコーポレイテッド | アモルファス固体分散体 |
| PL3338768T3 (pl) | 2016-12-20 | 2020-05-18 | Lts Lohmann Therapie-Systeme Ag | Transdermalny system terapeutyczny zawierający asenapinę |
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Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5865217A (ja) * | 1981-08-20 | 1983-04-18 | チエスコスロベンスカ・アカデミ−・ベド | 治療製剤及びその製法 |
| JPS6270374A (ja) * | 1985-09-16 | 1987-03-31 | アメリカン・ホ−ム・プロダクツ・コ−ポレイシヨン | 抗精神病γ−カルボリン |
| JPH08509221A (ja) * | 1993-04-14 | 1996-10-01 | イーライ・リリー・アンド・カンパニー | テトラヒドロ−ピリド−インドール |
| JPH09216882A (ja) * | 1995-10-17 | 1997-08-19 | Isukura Sangyo Kk | 水素化ピリド〔４，３−ｂ〕インドール誘導体、その製造法、医薬組成物及び治療方法 |
| JPH09510215A (ja) * | 1994-03-11 | 1997-10-14 | イーライ・リリー・アンド・カンパニー | ８−置換テトラヒドロ−β−カルボリン |
| JP2000510860A (ja) * | 1996-05-23 | 2000-08-22 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 抗精神病薬としてのヘキサヒドロ―ピリド（４，３―ｂ）インドール誘導体 |
| JP2005526691A (ja) * | 2001-08-08 | 2005-09-08 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | 治療剤１Ｈ−ピリド［４，３−ｂ］インドール |
| US20070117834A1 (en) * | 2005-10-04 | 2007-05-24 | David Hung | Methods and compositions for treating Huntington's disease |
| JP2009513672A (ja) * | 2005-10-31 | 2009-04-02 | ブレインセルス，インコーポレイティド | 神経発生のｇａｂａ受容体媒介調節 |
| JP2009524676A (ja) * | 2006-01-25 | 2009-07-02 | メディベイション ニューロロジー， インコーポレイテッド | 精神分裂病を治療するための方法および組成物 |
| JP2010528016A (ja) * | 2007-05-25 | 2010-08-19 | メディベーション ニューロロジー， インコーポレイテッド | 細胞を刺激するための方法および組成物 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005120463A1 (en) * | 2004-06-09 | 2005-12-22 | Ranbaxy Laboratories Limited | Rapidly disintegrating tablets of risperidone |
-
2008
- 2008-08-01 CA CA2719824A patent/CA2719824A1/en not_active Abandoned
- 2008-08-01 US US12/671,679 patent/US20110269777A1/en not_active Abandoned
- 2008-08-01 CN CN200880107277A patent/CN101842010A/zh active Pending
- 2008-08-01 JP JP2010519954A patent/JP2010535220A/ja active Pending
- 2008-08-01 EP EP08826868A patent/EP2175724A4/en not_active Withdrawn
- 2008-08-01 WO PCT/US2008/009357 patent/WO2009017836A1/en not_active Ceased
- 2008-08-01 BR BRPI0815850-9A2A patent/BRPI0815850A2/pt not_active IP Right Cessation
- 2008-08-01 MX MX2010001218A patent/MX2010001218A/es not_active Application Discontinuation
- 2008-08-01 AU AU2008282742A patent/AU2008282742A1/en not_active Abandoned
- 2008-08-01 KR KR1020107004429A patent/KR20100054812A/ko not_active Withdrawn
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5865217A (ja) * | 1981-08-20 | 1983-04-18 | チエスコスロベンスカ・アカデミ−・ベド | 治療製剤及びその製法 |
| JPS6270374A (ja) * | 1985-09-16 | 1987-03-31 | アメリカン・ホ−ム・プロダクツ・コ−ポレイシヨン | 抗精神病γ−カルボリン |
| JPH08509221A (ja) * | 1993-04-14 | 1996-10-01 | イーライ・リリー・アンド・カンパニー | テトラヒドロ−ピリド−インドール |
| JPH09510215A (ja) * | 1994-03-11 | 1997-10-14 | イーライ・リリー・アンド・カンパニー | ８−置換テトラヒドロ−β−カルボリン |
| JPH09216882A (ja) * | 1995-10-17 | 1997-08-19 | Isukura Sangyo Kk | 水素化ピリド〔４，３−ｂ〕インドール誘導体、その製造法、医薬組成物及び治療方法 |
| JP2000510860A (ja) * | 1996-05-23 | 2000-08-22 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 抗精神病薬としてのヘキサヒドロ―ピリド（４，３―ｂ）インドール誘導体 |
| JP2005526691A (ja) * | 2001-08-08 | 2005-09-08 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | 治療剤１Ｈ−ピリド［４，３−ｂ］インドール |
| US20070117834A1 (en) * | 2005-10-04 | 2007-05-24 | David Hung | Methods and compositions for treating Huntington's disease |
| JP2009513672A (ja) * | 2005-10-31 | 2009-04-02 | ブレインセルス，インコーポレイティド | 神経発生のｇａｂａ受容体媒介調節 |
| JP2009524676A (ja) * | 2006-01-25 | 2009-07-02 | メディベイション ニューロロジー， インコーポレイテッド | 精神分裂病を治療するための方法および組成物 |
| JP2010528016A (ja) * | 2007-05-25 | 2010-08-19 | メディベーション ニューロロジー， インコーポレイテッド | 細胞を刺激するための方法および組成物 |
Non-Patent Citations (1)
| Title |
|---|
| JPN6013018003; ＡＢＯＵ-ＧＨＡＲＢＩＡ，Ｍ．: 'ＢＩＯＬＯＧＩＣＡＬ ＡＣＴＩＶＩＴＹ ＯＦ ＳＵＢＳＴＩＴＵＴＥＤ ＧＡＭＭＡ ＣＡＲＢＯＬＩＮＥＳ' Ｄｒｕｇｓ ｏｆ ｔｈｅ Ｆｕｔｕｒｅ Ｖｏｌ．１４， Ｎｏ．５, 1989, ｐ．４５３-４５９ * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014128882A1 (ja) * | 2013-02-21 | 2014-08-28 | 医療法人 和楽会 | 不安うつ病の治療薬 |
| JP2024507991A (ja) * | 2021-02-26 | 2024-02-21 | バイオエクセル セラピューティクス，インコーポレイテッド | 激越を処置するための方法及び組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009017836A1 (en) | 2009-02-05 |
| BRPI0815850A2 (pt) | 2014-10-07 |
| KR20100054812A (ko) | 2010-05-25 |
| CA2719824A1 (en) | 2009-02-05 |
| MX2010001218A (es) | 2010-04-07 |
| CN101842010A (zh) | 2010-09-22 |
| EP2175724A4 (en) | 2010-09-15 |
| EP2175724A1 (en) | 2010-04-21 |
| AU2008282742A1 (en) | 2009-02-05 |
| US20110269777A1 (en) | 2011-11-03 |
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