JP2010534637A - ポリオールのマイクロナイゼーション - Google Patents
ポリオールのマイクロナイゼーション Download PDFInfo
- Publication number
- JP2010534637A JP2010534637A JP2010517418A JP2010517418A JP2010534637A JP 2010534637 A JP2010534637 A JP 2010534637A JP 2010517418 A JP2010517418 A JP 2010517418A JP 2010517418 A JP2010517418 A JP 2010517418A JP 2010534637 A JP2010534637 A JP 2010534637A
- Authority
- JP
- Japan
- Prior art keywords
- polyol
- micronized
- mannitol
- particle size
- polyols
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920005862 polyol Polymers 0.000 title claims abstract description 76
- 150000003077 polyols Chemical class 0.000 title claims abstract description 76
- 239000002245 particle Substances 0.000 claims abstract description 46
- 239000000203 mixture Substances 0.000 claims abstract description 32
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims abstract description 27
- 229930195725 Mannitol Natural products 0.000 claims abstract description 27
- 239000000594 mannitol Substances 0.000 claims abstract description 27
- 235000010355 mannitol Nutrition 0.000 claims abstract description 27
- 238000000034 method Methods 0.000 claims abstract description 27
- 229940112822 chewing gum Drugs 0.000 claims abstract description 19
- 235000015218 chewing gum Nutrition 0.000 claims abstract description 19
- 238000009826 distribution Methods 0.000 claims abstract description 17
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract description 13
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000004386 Erythritol Substances 0.000 claims abstract description 11
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims abstract description 11
- 235000019414 erythritol Nutrition 0.000 claims abstract description 11
- 229940009714 erythritol Drugs 0.000 claims abstract description 11
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000007787 solid Substances 0.000 claims abstract description 10
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 claims abstract description 8
- 239000000845 maltitol Substances 0.000 claims abstract description 8
- 235000010449 maltitol Nutrition 0.000 claims abstract description 8
- 229940035436 maltitol Drugs 0.000 claims abstract description 8
- 235000013305 food Nutrition 0.000 claims abstract description 7
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims abstract description 6
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims abstract description 6
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims abstract description 6
- 239000000905 isomalt Substances 0.000 claims abstract description 6
- 235000010439 isomalt Nutrition 0.000 claims abstract description 6
- HPIGCVXMBGOWTF-UHFFFAOYSA-N isomaltol Natural products CC(=O)C=1OC=CC=1O HPIGCVXMBGOWTF-UHFFFAOYSA-N 0.000 claims abstract description 6
- 239000000600 sorbitol Substances 0.000 claims abstract description 6
- 235000010356 sorbitol Nutrition 0.000 claims abstract description 6
- 239000000811 xylitol Substances 0.000 claims abstract description 6
- 235000010447 xylitol Nutrition 0.000 claims abstract description 6
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims abstract description 6
- 229960002675 xylitol Drugs 0.000 claims abstract description 6
- 239000002537 cosmetic Substances 0.000 claims abstract description 5
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 5
- 229960001855 mannitol Drugs 0.000 claims abstract description 4
- 238000003825 pressing Methods 0.000 claims abstract description 4
- 229960002920 sorbitol Drugs 0.000 claims abstract description 4
- 239000000126 substance Substances 0.000 claims abstract description 3
- SERLAGPUMNYUCK-YJOKQAJESA-N 6-O-alpha-D-glucopyranosyl-D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-YJOKQAJESA-N 0.000 claims description 7
- 238000004519 manufacturing process Methods 0.000 claims description 7
- 229910001873 dinitrogen Inorganic materials 0.000 claims description 5
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 4
- -1 altitol Chemical compound 0.000 claims description 3
- 239000011343 solid material Substances 0.000 claims description 3
- FBPFZTCFMRRESA-FBXFSONDSA-N Allitol Chemical compound OC[C@H](O)[C@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-FBXFSONDSA-N 0.000 claims description 2
- HEBKCHPVOIAQTA-QWWZWVQMSA-N D-arabinitol Chemical compound OC[C@@H](O)C(O)[C@H](O)CO HEBKCHPVOIAQTA-QWWZWVQMSA-N 0.000 claims description 2
- UNXHWFMMPAWVPI-QWWZWVQMSA-N D-threitol Chemical compound OC[C@@H](O)[C@H](O)CO UNXHWFMMPAWVPI-QWWZWVQMSA-N 0.000 claims description 2
- JVWLUVNSQYXYBE-UHFFFAOYSA-N Ribitol Natural products OCC(C)C(O)C(O)CO JVWLUVNSQYXYBE-UHFFFAOYSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-GUCUJZIJSA-N galactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-GUCUJZIJSA-N 0.000 claims description 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims description 2
- 239000000832 lactitol Substances 0.000 claims description 2
- 235000010448 lactitol Nutrition 0.000 claims description 2
- VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 claims description 2
- 229960003451 lactitol Drugs 0.000 claims description 2
- HEBKCHPVOIAQTA-ZXFHETKHSA-N ribitol Chemical compound OC[C@H](O)[C@H](O)[C@H](O)CO HEBKCHPVOIAQTA-ZXFHETKHSA-N 0.000 claims description 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract description 4
- SERLAGPUMNYUCK-DCUALPFSSA-N 1-O-alpha-D-glucopyranosyl-D-mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-DCUALPFSSA-N 0.000 abstract 1
- 239000000843 powder Substances 0.000 description 18
- 239000000523 sample Substances 0.000 description 14
- 239000007789 gas Substances 0.000 description 11
- 238000002360 preparation method Methods 0.000 description 5
- 238000003860 storage Methods 0.000 description 5
- 238000000227 grinding Methods 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 239000011236 particulate material Substances 0.000 description 4
- 238000010998 test method Methods 0.000 description 4
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 235000014633 carbohydrates Nutrition 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 238000003801 milling Methods 0.000 description 2
- 238000010079 rubber tapping Methods 0.000 description 2
- FBPFZTCFMRRESA-KAZBKCHUSA-N D-altritol Chemical compound OC[C@@H](O)[C@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KAZBKCHUSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 239000005913 Maltodextrin Substances 0.000 description 1
- 229920002774 Maltodextrin Polymers 0.000 description 1
- 239000004614 Process Aid Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000004568 cement Substances 0.000 description 1
- 238000001311 chemical methods and process Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-NGQZWQHPSA-N d-xylitol Chemical compound OC[C@H](O)C(O)[C@H](O)CO HEBKCHPVOIAQTA-NGQZWQHPSA-N 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 150000002016 disaccharides Chemical class 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- FBPFZTCFMRRESA-UHFFFAOYSA-N hexane-1,2,3,4,5,6-hexol Chemical compound OCC(O)C(O)C(O)C(O)CO FBPFZTCFMRRESA-UHFFFAOYSA-N 0.000 description 1
- 238000005984 hydrogenation reaction Methods 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 229940035034 maltodextrin Drugs 0.000 description 1
- 238000010297 mechanical methods and process Methods 0.000 description 1
- 230000007483 microbial process Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 238000010951 particle size reduction Methods 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 150000004044 tetrasaccharides Chemical class 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- 150000004043 trisaccharides Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/04—Disaccharides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/346—Finished or semi-finished products in the form of powders, paste or liquids
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/38—Sucrose-free products
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/42—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds characterised by the carbohydrates used, e.g. polysaccharides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
- A23G4/10—Chewing gum characterised by the composition containing organic or inorganic compounds characterised by the carbohydrates used, e.g. polysaccharides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/30—Artificial sweetening agents
- A23L27/33—Artificial sweetening agents containing sugars or derivatives
- A23L27/34—Sugar alcohols
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
- A23L29/37—Sugar alcohols
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/02—Monosaccharides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G2200/00—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF containing organic compounds, e.g. synthetic flavouring agents
- A23G2200/06—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF containing organic compounds, e.g. synthetic flavouring agents containing beet sugar or cane sugar if specifically mentioned or containing other carbohydrates, e.g. starches, gums, alcohol sugar, polysaccharides, dextrin or containing high or low amount of carbohydrate
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G2220/00—Products with special structure
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Nutrition Science (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Preparation (AREA)
- Confectionery (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
Abstract
ポリオールをマイクロナイズするための方法は、a)化学式CnH2n+2Onを有しかつ20〜25℃で固体であるポリオールを取り込む工程と、b)ポリオールをジェットミル内に供給しかつ窒素を用いて圧力を加える工程と、c)マイクロナイズドポリオールを捕集する工程と、を含む。
マイクロナイズドポリオールは、食品組成物、飼料組成物、化粧組成物、および医薬組成物、特定的にはチューインガム組成物に有用である。
Description
a)固体ポリオールを取り込む工程と、
b)ポリオールをジェットミル内に供給しかつ窒素ガスを用いて圧力を加える工程と、
マイクロナイズドポリオールを捕集する工程と、
を含む。
a)化学式CnH2n+2Onを有しかつ20〜25℃の温度で固体材料であるポリオールを取り込む工程と、
b)ポリオールをジェットミル内に供給しかつ窒素ガスを用いて圧力を加える工程と、
c)マイクロナイズドポリオールを捕集する工程と、
を含む。
乾燥窒素のフローを用いて、67μmの平均粒径を有する結晶性マンニトールを、直径10cmの粉砕チャンバーを有するマイクロナイザー内に供給した。マイクロナイザー内への結晶性マンニトールの供給速度は、毎時3.1kgであった。ノズルを介して乾燥窒素をチャンバー内に注入することによりチャンバー内のガス圧力(P2)を2bar(2×105Pa)に保持した。33μmの平均粒径を一貫して有する乾燥自由流動性マイクロナイズドマンニトールを得た。
マイクロナイザーに供給した結晶性マンニトールが82μmの平均粒径を有していたこと、供給速度が毎時1.1kgであったこと、およびミルのチャンバー内のN2の圧力(P2)が1.5barであったこと以外は、実施例1に記載の手順を反復した。この場合も、マイクロナイズド生成物は、33μmの平均粒径を有していた。
以上の実施例1に記載したのと類似した手順を用いて、以下の表2に示されるように他のポリオールをマイクロナイズして好結果を得た。
圧縮性指数(%)=100×(Vo−Vf)/Vo
3回の測定の平均値を使用する。
使用した装置は、Pharma Test Apperatebau(Hainburg)製のPharma Test PTG−1であった。装置は、ノズル(オリフィス)を底部に有しかつ撹拌機を内部に備えたフロー漏斗を含んでいた。フロー漏斗は、秤上に配設された容器の上に鉛直に垂下される。装置は、異なる直径、たとえば、10mm、15mm、および25mmのオリフィスの選択肢を提供する。ノズル中を粉末が通過するのを支援するために撹拌機を使用可能でありかつ5〜25rpmの速度で使用可能である。
チューインガムの調製
以下の処方をチューインガムの調製に適用した。
装置:Texture Analyser Profile TA_XTPlus
Ta−XTPlusの設定値:
モード:圧縮時の力の測定
オプション:開始に戻る
試験前速度:0.8mm/s
試験速度:0.8mm/s
試験後速度:3.0mm/s
距離:2mm
トリガー力タイプ:270g
データ取得速度:250pps
Claims (14)
- 20〜60μmの粒径分布(d50)と、5s/100g以下、好ましくは5s/100g未満の流動度と、を有するマイクロナイズドポリオール。
- 40以上の圧縮性指数を有することを特徴とする、請求項1に記載のマイクロナイズドポリオール。
- 前記ポリオールが、マルチトール、イソマルト、マンニトール、ソルビトール、キシリトール、エリトリトール、およびそれらの2種以上の混合物から選択されることを特徴とする、請求項1または2に記載のマイクロナイズドポリオール。
- 前記ポリオールがマンニトールである、請求項3に記載のマイクロナイズドポリオール。
- 前記ポリオールがエリトリトールである、請求項3に記載のマイクロナイズドポリオール。
- 固体ポリオールをマイクロナイズする方法であって、以下の工程、すなわち、
a)固体ポリオールを取り込む工程と、
b)前記ポリオールをジェットミル内に供給しかつ窒素ガスを用いて圧力を加える工程と、
c)マイクロナイズドポリオールを捕集する工程と、
を含む方法。 - 前記固体ポリオールが化学式CnH2n+2Onを有しかつ20〜25℃の範囲内の温度で固体材料である、請求項6に記載の方法。
- 前記固体ポリオールが、エリトリトール、トレイトール、アラビニトール、キシリトール、リビトール、アリトール、アルトリトール、グリトール、ガラクチトール、マンニトール、ソルビトール、タリトール、マルチトール、イソマルチトール、イソマルト、ラクチトール、およびそれらの2種以上の混合物から選択される、請求項6または7に記載の方法。
- 前記固体ポリオールが、マルチトール、イソマルト、マンニトール、ソルビトール、キシリトール、エリトリトール、およびそれらの2種以上の混合物から選択される、請求項8に記載の方法。
- 前記ジェットミル内に加えられる圧力が2〜6barの範囲内である、請求項6〜9のいずれか1つに記載の方法。
- 前記マイクロナイズドポリオールが、20〜60μmの範囲内の平均粒径と、5s/100g以下、好ましくは5s/100g未満の流動度と、を有する、請求項6〜10のいずれか1つに記載の方法。
- 請求項1〜5のいずれか1つに記載のマイクロナイズドポリオールを含有する、食品組成物、飼料組成物、化粧組成物、または医薬組成物。
- 前記食品組成物がチューインガム組成物である、請求項12に記載の食品組成物および/または医薬組成物。
- マイクロナイズドマンニトールを含みかつ製造の24時間後に3500g以上、好ましくは4000gより大きい硬さを有する、請求項13に記載のチューインガム組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07113374.8 | 2007-07-27 | ||
EP07113374 | 2007-07-27 | ||
PCT/EP2008/059834 WO2009016133A1 (en) | 2007-07-27 | 2008-07-25 | Micronization of polyols |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2010534637A true JP2010534637A (ja) | 2010-11-11 |
JP2010534637A5 JP2010534637A5 (ja) | 2011-07-21 |
JP5547068B2 JP5547068B2 (ja) | 2014-07-09 |
Family
ID=38823526
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010517418A Expired - Fee Related JP5547068B2 (ja) | 2007-07-27 | 2008-07-25 | ポリオールのマイクロナイゼーション |
Country Status (12)
Country | Link |
---|---|
US (1) | US20100255307A1 (ja) |
EP (2) | EP2264042B1 (ja) |
JP (1) | JP5547068B2 (ja) |
CN (2) | CN101765606A (ja) |
AU (1) | AU2008281850B2 (ja) |
BR (1) | BRPI0814175A2 (ja) |
CA (1) | CA2694280A1 (ja) |
DK (1) | DK2264042T3 (ja) |
ES (1) | ES2388494T3 (ja) |
PL (1) | PL2264042T3 (ja) |
RU (1) | RU2479587C2 (ja) |
WO (1) | WO2009016133A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2016534726A (ja) * | 2013-10-31 | 2016-11-10 | ズートツッカー アクチェンゲゼルシャフト マンハイム/オクセンフルト | 改良されたチューインガム及びその調製方法 |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AUPQ899700A0 (en) | 2000-07-25 | 2000-08-17 | Borody, Thomas Julius | Probiotic recolonisation therapy |
AUPS088702A0 (en) * | 2002-03-04 | 2002-03-28 | Borody, Thomas Julius | Electrolyte purgative |
PT2334202E (pt) * | 2008-09-04 | 2012-02-28 | Cargill Inc | Fabrico de comprimidos de eritritol |
EP2228175B1 (de) * | 2009-03-12 | 2013-06-19 | Ferton Holding SA | Verwendung eines Pulvers oder Pulvergemisches zur Herstellung eines Mittels zur Pulverstrahlreinigung von Zahnoberflächen |
JP5751677B2 (ja) | 2009-08-18 | 2015-07-22 | カーギル インコーポレイテッド | エリトリトールおよびイソマルトのタブレット化 |
JP5691219B2 (ja) * | 2010-03-30 | 2015-04-01 | 住友ベークライト株式会社 | 半導体封止用樹脂組成物の製造方法および粉砕装置 |
CA2796541A1 (en) | 2010-04-19 | 2011-10-27 | Catherine Patricia L. Boghmans | Lozenges of erythritol and isomalt |
US20130059030A1 (en) * | 2010-05-12 | 2013-03-07 | Cargil, Inc | Sweetner compositions with reduced bitter off taste and methods of preparing |
US20130072578A1 (en) | 2010-06-01 | 2013-03-21 | Catherine Patricia L. BOGHMANS | Orodispersible tablets of erythritol and isomalt |
US20130129806A1 (en) | 2010-07-27 | 2013-05-23 | Carglil Incorporated | Hard coating with erythritol |
EP2600877A4 (en) | 2010-08-04 | 2014-05-07 | Borody Thomas J | COMPOSITIONS FOR FLORAL TRANSPLANTATION OF FECAL MATERIALS AND METHODS OF MAKING AND USING SAME, AND DEVICES FOR THEIR ADMINISTRATION |
JP2013536694A (ja) | 2010-09-07 | 2013-09-26 | カーギル インコーポレイテッド | 凝固糖アルコール混合物 |
WO2012069073A1 (de) * | 2010-11-12 | 2012-05-31 | La Prairie Group Ag | Kosmetische und/oder dermatologische zubereitungen enthaltend schneealgenextrakt |
CN103338768B (zh) | 2010-12-13 | 2019-04-19 | 萨利克斯药品有限公司 | 胃和结肠的配制剂及其制备和使用方法 |
JP2014507481A (ja) | 2011-03-09 | 2014-03-27 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | 結腸微生物相移植のための組成物及び方法 |
WO2013176774A1 (en) | 2012-05-25 | 2013-11-28 | Arizona Board Of Regents | Microbiome markers and therapies for autism spectrum disorders |
EP3659598A1 (en) | 2012-06-04 | 2020-06-03 | Gaurav Agrawal | Compositions and methods for treating crohn's disease and related conditions and infections |
TR201904884T4 (tr) | 2012-07-27 | 2019-05-21 | Redhill Biopharma Ltd | Koloni̇k boşaltmada kullanima yöneli̇k formülasyonlar ve formülasyonlarin üreti̇m yöntemleri̇ |
EP2742806A1 (en) * | 2012-12-13 | 2014-06-18 | Südzucker Aktiengesellschaft | Process for reducing the stickiness of a chewing gum core composition to a surface of a processing machinery using isomalt |
RU2015132902A (ru) * | 2013-01-07 | 2017-02-09 | Сам-А Фарм. Ко., Лтд. | Новый быстрорастворимый состав гранул с улучшенной растворимостью |
AU2014262125B2 (en) | 2013-04-30 | 2020-02-13 | Thomas Julius Borody | Compositions and methods for treating microbiota-related psychotropic conditions and diseases |
FR3023128B1 (fr) | 2014-07-01 | 2017-11-10 | Roquette Freres | Nouvelle composition edulcorante |
CN104311610B (zh) * | 2014-11-06 | 2017-03-08 | 山东绿健生物技术有限公司 | 一种快速制备粒状乳糖醇的方法 |
KR102561989B1 (ko) | 2015-05-14 | 2023-07-31 | 핀치 테라퓨틱스 홀딩스 엘엘씨 | 대변 균무리 이식용 조성물, 및 이의 제조 및 사용 방법, 및 이의 전달을 위한 장치 |
AU2016268158B2 (en) | 2015-05-22 | 2022-03-17 | Arizona Board Of Regents On Behalf Of Arizona State University | Methods for treating autism spectrum disorder and associated symptoms |
US11214773B2 (en) | 2015-09-24 | 2022-01-04 | San Diego State University (Sdsu) Foundation | Antibacterial and protective bacteriophage formulations and methods for making and using them |
CN105901339A (zh) * | 2016-04-26 | 2016-08-31 | 彭险峰 | 液体木糖醇及含有木糖醇的组合物在制备猪用饲料中的应用 |
US20170360848A1 (en) | 2016-06-15 | 2017-12-21 | Arizona Board Of Regents On Behalf Of Arizona State University | Methods for treating autism spectrum disorder and associated symptoms |
US10849936B2 (en) | 2016-07-01 | 2020-12-01 | Regents Of The University Of Minnesota | Compositions and methods for C. difficile treatment |
US20180036352A1 (en) | 2016-08-03 | 2018-02-08 | Crestovo Holdings Llc | Methods for treating ulcerative colitis |
WO2018071536A1 (en) | 2016-10-11 | 2018-04-19 | Crestovo Holdings Llc | Compositions and methods for treating primary sclerosing cholangitis and related disorders |
US10092601B2 (en) | 2016-10-11 | 2018-10-09 | Crestovo Holdings Llc | Compositions and methods for treating multiple sclerosis and related disorders |
US11026978B2 (en) | 2016-10-11 | 2021-06-08 | Finch Therapeutics Holdings Llc | Compositions and methods for treating multiple sclerosis and related disorders |
JP6908717B2 (ja) * | 2016-11-18 | 2021-07-28 | フェルティン ファルマ アー/エス | 経口送達ビヒクル |
JP6840849B2 (ja) * | 2016-11-18 | 2021-03-10 | フェルティン ファルマ アー/エス | 別個の結合剤及びエリスリトールを含む錠剤 |
US11040073B2 (en) | 2017-04-05 | 2021-06-22 | Finch Therapeutics Holdings Llc | Compositions and methods for treating diverticulitis and related disorders |
CN110831606A (zh) | 2017-04-05 | 2020-02-21 | 克雷斯顿沃控股公司 | 治疗帕金森氏病(pd)和相关疾病的组合物和方法 |
EP3630190B1 (en) | 2017-05-26 | 2024-02-21 | Finch Therapeutics Holdings LLC | Lyophilized compositions comprising fecal microbe-based therapeutic agents and methods for making and using same |
US11865145B2 (en) | 2017-08-07 | 2024-01-09 | Finch Therapeutics Holdings Llc | Compositions and methods for maintaining and restoring a healthy gut barrier |
US11090263B2 (en) | 2018-05-22 | 2021-08-17 | Fertin Pharma A/S | Tableted chewing gum suitable for active pharmaceutical ingredients |
US20190350858A1 (en) | 2018-05-17 | 2019-11-21 | Fertin Pharma A/S | Oral tablet for delivery of active ingredients to the gastrointestinal tract |
US11096896B2 (en) | 2018-05-17 | 2021-08-24 | Fertin Pharma A/S | Tablet dosage form for buccal absorption of active ingredients |
US11135157B2 (en) | 2018-05-17 | 2021-10-05 | Fertin Pharma A/S | Oral tablet for delivery of active ingredients to the throat |
US11052047B2 (en) | 2018-05-17 | 2021-07-06 | Fertin Pharma A/S | Oral tablet suitable for fast release of active pharmaceutical ingredients |
US11096895B2 (en) | 2018-05-17 | 2021-08-24 | Fertin Pharma A/S | Oral tablet suitable for active pharmaceutical ingredients |
US11096894B2 (en) | 2018-05-17 | 2021-08-24 | Fertin Pharma A/S | Oral tablet for induced saliva generation |
US11166990B2 (en) | 2018-07-13 | 2021-11-09 | Finch Therapeutics Holdings Llc | Methods and compositions for treating ulcerative colitis |
US11911419B2 (en) | 2018-09-27 | 2024-02-27 | Finch Therapeutics Holdings Llc | Compositions and methods for treating epilepsy and related disorders |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH04335870A (ja) * | 1991-01-02 | 1992-11-24 | Cerestar Holding Bv | エリスリト−ル組成物 |
JPH08511415A (ja) * | 1993-03-19 | 1996-12-03 | キシロフィン オイ | 甘味料、その製造方法、及びその用途 |
JPH10306048A (ja) * | 1997-05-08 | 1998-11-17 | Mitsubishi Chem Corp | エリスリトール結晶及びその製造方法 |
WO2003037907A1 (fr) * | 2001-10-31 | 2003-05-08 | Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyusho | Cristaux de maltitol contenant des cristaux d'un saccharide autre que le maltitol et procede de production de ces cristaux |
JP2004510805A (ja) * | 2000-10-12 | 2004-04-08 | ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | チオトロピウムを含む新規吸入性粉剤 |
JP2004510806A (ja) * | 2000-10-12 | 2004-04-08 | ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | 粉末製剤の調製方法 |
WO2004067595A2 (en) * | 2003-01-29 | 2004-08-12 | Spi Polyols, Inc. | Compositions of polyol granules and processes of manufacture |
JP2005513151A (ja) * | 2001-12-13 | 2005-05-12 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | 直接圧縮可能なα−マンニトールの製造方法 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57134498A (en) * | 1981-02-12 | 1982-08-19 | Hayashibara Biochem Lab Inc | Anhydrous crystalline maltitol and its preparation and use |
FR2571046B1 (fr) | 1984-10-03 | 1987-10-16 | Roquette Freres | Procede de preparation de mannitol granulaire directement compressible |
IT1191945B (it) * | 1986-06-04 | 1988-03-31 | Avantgarde Spa | N-alchilammidi della d(+)-carnitina dotate di attivita' antibatterica,procedimento per la loro preparazione e composizioni farmaceutiche e cosmetiche che le contengono |
IT1235494B (it) * | 1987-12-02 | 1992-09-04 | Avantgarde Spa | N-alchilammidi della dl e l(-)carnitina dotate di attivita' antibatterica, procedimento per la loro preparazione e composizioni farmaceutiche e cosmetiche che le contengono |
US5536526A (en) * | 1988-01-11 | 1996-07-16 | Cultor Ltd. | Xylitol-based binding and diluting agent and a process for the production thereof |
US5204115A (en) * | 1990-12-12 | 1993-04-20 | Suomen Xyrofin Oy | Directly compressible xylitol and method |
FR2670398B1 (fr) * | 1990-12-14 | 1995-02-17 | Roquette Freres | Composition pulverulente directement compressible et procede d'obtention. |
JP4711471B2 (ja) | 1996-07-05 | 2011-06-29 | 三菱商事フードテック株式会社 | 結晶マルチトール及びそれを含有する含蜜結晶の製造方法 |
JP3624672B2 (ja) * | 1998-01-27 | 2005-03-02 | 株式会社林原生物化学研究所 | 無水結晶マルチトールの連続的製造方法及び製造装置 |
GB9826284D0 (en) * | 1998-12-01 | 1999-01-20 | Rhone Poulence Rorer Limited | Process |
EP1269995A1 (en) * | 2000-03-27 | 2003-01-02 | Kyowa Hakko Kogyo Co., Ltd. | Easy-to-take granule |
FR2832311B1 (fr) * | 2001-11-21 | 2004-04-16 | Besins Int Belgique | Poudre filmogene, compositions la comprenant, leurs procedes de preparation et leurs utilisations |
US7445769B2 (en) * | 2002-10-31 | 2008-11-04 | Cadbury Adams Usa Llc | Compositions for removing stains from dental surfaces and methods of making and using the same |
FR2855375B1 (fr) * | 2003-05-27 | 2006-08-11 | Roquette Freres | Comprime de chewing-gum sans sucre et son procede de fabrication |
DE102004027874A1 (de) * | 2004-06-08 | 2006-01-05 | Bayer Chemicals Ag | Verfahren zur Herstellung von feinteiligen Treibmittelpulvern |
US7641892B2 (en) * | 2004-07-29 | 2010-01-05 | Cadburry Adams USA, LLC | Tooth whitening compositions and delivery systems therefor |
US7641926B2 (en) * | 2004-08-25 | 2010-01-05 | Cadbury Adams Usa, Llc | Liquid-filled chewing gum composition |
WO2007136375A2 (en) | 2005-05-23 | 2007-11-29 | Cadbury Adams Usa Llc | Package assembly for multi-modality taste chewing gum compositions |
JP2006106226A (ja) * | 2004-10-01 | 2006-04-20 | Kao Corp | トナーの製造方法 |
CN100469452C (zh) * | 2005-06-20 | 2009-03-18 | 张爱华 | 制备超细材料的高速流体电喷射的方法及系统 |
-
2008
- 2008-07-25 EP EP10175145A patent/EP2264042B1/en not_active Not-in-force
- 2008-07-25 CA CA2694280A patent/CA2694280A1/en not_active Abandoned
- 2008-07-25 RU RU2010107188/04A patent/RU2479587C2/ru not_active IP Right Cessation
- 2008-07-25 DK DK10175145.1T patent/DK2264042T3/da active
- 2008-07-25 US US12/668,384 patent/US20100255307A1/en not_active Abandoned
- 2008-07-25 JP JP2010517418A patent/JP5547068B2/ja not_active Expired - Fee Related
- 2008-07-25 AU AU2008281850A patent/AU2008281850B2/en not_active Ceased
- 2008-07-25 BR BRPI0814175-4A2A patent/BRPI0814175A2/pt not_active Application Discontinuation
- 2008-07-25 EP EP08775360A patent/EP2183262A1/en not_active Withdrawn
- 2008-07-25 PL PL10175145T patent/PL2264042T3/pl unknown
- 2008-07-25 CN CN200880100640A patent/CN101765606A/zh active Pending
- 2008-07-25 WO PCT/EP2008/059834 patent/WO2009016133A1/en active Application Filing
- 2008-07-25 CN CN201310650226.1A patent/CN103691530A/zh active Pending
- 2008-07-25 ES ES10175145T patent/ES2388494T3/es active Active
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH04335870A (ja) * | 1991-01-02 | 1992-11-24 | Cerestar Holding Bv | エリスリト−ル組成物 |
JPH08511415A (ja) * | 1993-03-19 | 1996-12-03 | キシロフィン オイ | 甘味料、その製造方法、及びその用途 |
JPH10306048A (ja) * | 1997-05-08 | 1998-11-17 | Mitsubishi Chem Corp | エリスリトール結晶及びその製造方法 |
JP2004510805A (ja) * | 2000-10-12 | 2004-04-08 | ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | チオトロピウムを含む新規吸入性粉剤 |
JP2004510806A (ja) * | 2000-10-12 | 2004-04-08 | ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | 粉末製剤の調製方法 |
WO2003037907A1 (fr) * | 2001-10-31 | 2003-05-08 | Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyusho | Cristaux de maltitol contenant des cristaux d'un saccharide autre que le maltitol et procede de production de ces cristaux |
JP2005513151A (ja) * | 2001-12-13 | 2005-05-12 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | 直接圧縮可能なα−マンニトールの製造方法 |
WO2004067595A2 (en) * | 2003-01-29 | 2004-08-12 | Spi Polyols, Inc. | Compositions of polyol granules and processes of manufacture |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2016534726A (ja) * | 2013-10-31 | 2016-11-10 | ズートツッカー アクチェンゲゼルシャフト マンハイム/オクセンフルト | 改良されたチューインガム及びその調製方法 |
US11445736B2 (en) | 2013-10-31 | 2022-09-20 | Sudzucker Aktiengesellschaft Mannheim/Ochsenfurt | Chewing gums and methods for their preparation |
Also Published As
Publication number | Publication date |
---|---|
CN101765606A (zh) | 2010-06-30 |
DK2264042T3 (da) | 2012-08-20 |
EP2264042B1 (en) | 2012-07-18 |
EP2264042A1 (en) | 2010-12-22 |
AU2008281850B2 (en) | 2013-10-10 |
CA2694280A1 (en) | 2009-02-05 |
RU2479587C2 (ru) | 2013-04-20 |
EP2183262A1 (en) | 2010-05-12 |
AU2008281850A1 (en) | 2009-02-05 |
ES2388494T3 (es) | 2012-10-15 |
BRPI0814175A2 (pt) | 2015-01-20 |
WO2009016133A1 (en) | 2009-02-05 |
PL2264042T3 (pl) | 2012-10-31 |
CN103691530A (zh) | 2014-04-02 |
US20100255307A1 (en) | 2010-10-07 |
RU2010107188A (ru) | 2011-09-10 |
JP5547068B2 (ja) | 2014-07-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP5547068B2 (ja) | ポリオールのマイクロナイゼーション | |
US20070184117A1 (en) | Tocopheryl polyethylene glycol succinate powder and process for preparing same | |
EP2836204B1 (en) | Aggregate particles | |
HU217770B (hu) | Eljárás anyagok vagy anyagkeverékek kondicionálására és az így előállított gyógyszerkészítmények | |
EP1487832B1 (de) | Kristallines mikronisat des tiotropiumbromids | |
US20060002864A1 (en) | Milling process for the production of finely milled medicinal substances | |
EP2344197B1 (de) | Tablettierhilfsstoff auf laktose- und cellulosebasis | |
EP2299982B1 (de) | Direkt verpressbare und schnell zerfallende tablettenmatirx | |
EP2209739B1 (de) | Fällungskieselsäuren für lagerstabile rtv-1 siliconkautschukformulierungen ohne stabilisator | |
EP1860067B1 (de) | Fällungskieselsäuren mit speziellen Oberflächeneigenschaften | |
KR20080031944A (ko) | 자일리톨 결정 입자 및 다른 폴리올을 함유하는 분말의제조 방법 | |
KR101279762B1 (ko) | 폴리올의 스팀 응집화 | |
EP1567135B1 (de) | Tiotropiumhaltige pulverformulierung für die inhalation | |
EP2293774A1 (de) | Direkt verpressbare polyolkombination | |
CN106883283B (zh) | 环索奈德一水合物及其晶型与制备方法 | |
EP1720517A1 (de) | Phasenumwandlung in molekularen festkörpern | |
EP4201228A1 (de) | Rieselfähige kohlenhydrate und verfahren zu ihrer herstellung | |
Pan | Pharmaceutical powder dispensing by ultrasonic vibration dosing system |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20110405 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20110606 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20130716 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20131009 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20140507 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20140514 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 5547068 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
LAPS | Cancellation because of no payment of annual fees |