JP2010534237A5 - - Google Patents
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- JP2010534237A5 JP2010534237A5 JP2010517507A JP2010517507A JP2010534237A5 JP 2010534237 A5 JP2010534237 A5 JP 2010534237A5 JP 2010517507 A JP2010517507 A JP 2010517507A JP 2010517507 A JP2010517507 A JP 2010517507A JP 2010534237 A5 JP2010534237 A5 JP 2010534237A5
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- JP
- Japan
- Prior art keywords
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- amino acid
- acid sequence
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- Prior art date
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95176507P | 2007-07-25 | 2007-07-25 | |
| US60/951,765 | 2007-07-25 | ||
| PCT/IB2008/002536 WO2009013619A2 (en) | 2007-07-25 | 2008-07-24 | The ed-a antigen of fibrinogen is associated with the neovas culature of tumor metastases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013026422A Division JP5705893B2 (ja) | 2007-07-25 | 2013-02-14 | 腫瘍転移の新生血管と関連するフィブリノーゲンのｅｄ−ａ抗原 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010534237A JP2010534237A (ja) | 2010-11-04 |
| JP2010534237A5 true JP2010534237A5 (https=) | 2012-10-04 |
| JP5204228B2 JP5204228B2 (ja) | 2013-06-05 |
Family
ID=40085445
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010517507A Expired - Fee Related JP5204228B2 (ja) | 2007-07-25 | 2008-07-24 | 腫瘍転移の新生血管と関連するフィブリノーゲンのｅｄ−ａ抗原 |
| JP2013026422A Expired - Fee Related JP5705893B2 (ja) | 2007-07-25 | 2013-02-14 | 腫瘍転移の新生血管と関連するフィブリノーゲンのｅｄ−ａ抗原 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013026422A Expired - Fee Related JP5705893B2 (ja) | 2007-07-25 | 2013-02-14 | 腫瘍転移の新生血管と関連するフィブリノーゲンのｅｄ−ａ抗原 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20100183506A1 (https=) |
| EP (2) | EP2167541B1 (https=) |
| JP (2) | JP5204228B2 (https=) |
| KR (1) | KR101781638B1 (https=) |
| CN (2) | CN101754978B (https=) |
| AU (2) | AU2008278702B2 (https=) |
| BR (1) | BRPI0812765B8 (https=) |
| CA (1) | CA2691218C (https=) |
| EA (1) | EA017995B1 (https=) |
| ES (2) | ES2398536T3 (https=) |
| WO (1) | WO2009013619A2 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008120101A2 (en) | 2007-04-02 | 2008-10-09 | Philogen S.P.A. | The ed-a antigen of fibrinogen is associated with the neovasculature of tumour metastases |
| DK3281952T3 (da) | 2007-10-30 | 2020-08-03 | Philogen Spa | Antigen, der er forbundet med reumatoid artritis |
| CA2748401C (en) | 2009-01-07 | 2017-09-12 | Philogen S.P.A. | Antigens associated with endometriosis |
| EP2461832B1 (en) | 2009-08-05 | 2017-06-28 | Philogen S.p.A. | Targeting of bone marrow neovasculature |
| EP2632950B1 (en) * | 2010-10-26 | 2018-08-22 | UMC Utrecht Holding B.V. | Antibody binding to fibronectin-eda for preventing myocardial infarction-related complications |
| ES2872964T3 (es) * | 2011-07-27 | 2021-11-03 | Philogen Spa | Inmunoconjugado de IL-12 |
| ES2743423T3 (es) | 2012-10-03 | 2020-02-19 | Philogen Spa | Conjugado de anticuerpos para su uso en el tratamiento de una enfermedad inflamatoria intestinal |
| CN106170496B (zh) | 2013-12-12 | 2019-10-08 | Umc乌得勒支控股有限公司 | 针对纤连蛋白-eda的免疫球蛋白样分子 |
| KR20170103792A (ko) * | 2014-12-12 | 2017-09-13 | 엔케어 바이오텍 비.브이. | 피브로넥틴-eda에 대해 유도된 면역글로불린-유사 분자 |
| CR20180087A (es) | 2015-07-16 | 2018-05-14 | Philogen Spa | Inmunoconjugados de il22 |
| ES3007557T3 (en) | 2016-10-17 | 2025-03-20 | Pfizer | Anti-edb antibodies and antibody-drug conjugates |
| GB201621806D0 (en) | 2016-12-21 | 2017-02-01 | Philogen Spa | Immunocytokines with progressive activation mechanism |
| CN110997718B (zh) | 2017-06-07 | 2023-11-10 | 菲洛根股份公司 | 血管内皮生长因子/抗纤连蛋白抗体融合蛋白 |
| PL237087B1 (pl) | 2017-10-25 | 2021-03-08 | Univ Medyczny Im Piastow Slaskich We Wroclawiu | Sposób diagnozowania nowotworów układu chłonnego |
| WO2019185792A1 (en) | 2018-03-29 | 2019-10-03 | Philogen S.P.A | Cancer treatment using immunoconjugates and immune check-point inhibitors |
| WO2020249757A1 (en) | 2019-06-14 | 2020-12-17 | Philogen S.P.A | Immunoconjugates comprising a single chain diabody and interleukin-15 or interleukin-15 and a sushi domain of interleukin-15 receptor alpha |
| EP4185615A1 (en) | 2020-07-22 | 2023-05-31 | Philogen S.p.A. | Treatment of pulmonary hypertension |
| WO2023175077A1 (en) | 2022-03-17 | 2023-09-21 | Philogen S.P.A | Anti-ed-a antibodies for the treatment of pulmonary hypertension |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US5420012A (en) * | 1989-05-08 | 1995-05-30 | Locus Genex Oy | Method for the detection of reactive conditions |
| US5859205A (en) * | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| GB9206318D0 (en) | 1992-03-24 | 1992-05-06 | Cambridge Antibody Tech | Binding substances |
| US6172197B1 (en) | 1991-07-10 | 2001-01-09 | Medical Research Council | Methods for producing members of specific binding pairs |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US6492160B1 (en) | 1991-05-15 | 2002-12-10 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| DE69230142T2 (de) | 1991-05-15 | 2000-03-09 | Cambridge Antibody Technology Ltd. | Verfahren zur herstellung von spezifischen bindungspaargliedern |
| US6225447B1 (en) | 1991-05-15 | 2001-05-01 | Cambridge Antibody Technology Ltd. | Methods for producing members of specific binding pairs |
| US5962255A (en) | 1992-03-24 | 1999-10-05 | Cambridge Antibody Technology Limited | Methods for producing recombinant vectors |
| US5858657A (en) | 1992-05-15 | 1999-01-12 | Medical Research Council | Methods for producing members of specific binding pairs |
| US5565332A (en) | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
| PT1024191E (pt) | 1991-12-02 | 2008-12-22 | Medical Res Council | Produção de auto-anticorpos a partir de reportórios de segmentos de anticorpo e exibidos em fagos |
| US5872215A (en) | 1991-12-02 | 1999-02-16 | Medical Research Council | Specific binding members, materials and methods |
| US5733743A (en) | 1992-03-24 | 1998-03-31 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| ES2156149T3 (es) | 1992-12-04 | 2001-06-16 | Medical Res Council | Proteinas de union multivalente y multiespecificas, su fabricacion y su uso. |
| US5644033A (en) * | 1992-12-22 | 1997-07-01 | Health Research, Inc. | Monoclonal antibodies that define a unique antigen of human B cell antigen receptor complex and methods of using same for diagnosis and treatment |
| DK1137941T4 (da) | 1998-12-10 | 2014-01-06 | Brystol Myers Squibb Company | Protein-scaffolds til antistof-mimetika og andre bindingsproteiner |
| AU2001239470A1 (en) | 2000-02-24 | 2001-09-03 | Philogen S.R.L. | Compositions and methods for treatment of angiogenesis in pathological lesions |
| WO2001076630A1 (en) * | 2000-04-06 | 2001-10-18 | Kyowa Hakko Kogyo Co., Ltd. | Diagnostics and remedies for rheumatoid arthritis |
| IT1317108B1 (it) | 2000-12-06 | 2003-05-26 | Philogen Srl | Processo per la selezione di frammenti anticorporali anti-angiogenesi,frammenti anticorpali anti-angiogenesi cosi' ottenuti e loro uso. |
| EP1224943A1 (en) * | 2001-01-19 | 2002-07-24 | Crucell Holland B.V. | Fibronectin as a tumor marker detected by phage antibodies |
| US7560095B2 (en) | 2003-04-22 | 2009-07-14 | A & G Pharmaceutical, Inc. | Cancer specific monoclonal antibodies |
| JP2008514900A (ja) * | 2004-07-30 | 2008-05-08 | アデザ・バイオメデイカル・コーポレイシヨン | 疾病および他の状態のマーカーとしての癌胎児性フィブロネクチンならびに癌胎児性フィブロネクチンの検出のための方法 |
| US7785591B2 (en) * | 2004-10-14 | 2010-08-31 | Morphosys Ag | Identification and characterization of function-blocking anti-ED-B-fibronectin antibodies |
| WO2008120101A2 (en) * | 2007-04-02 | 2008-10-09 | Philogen S.P.A. | The ed-a antigen of fibrinogen is associated with the neovasculature of tumour metastases |
| EP2461832B1 (en) * | 2009-08-05 | 2017-06-28 | Philogen S.p.A. | Targeting of bone marrow neovasculature |
| US9209965B2 (en) | 2014-01-14 | 2015-12-08 | Microsemi Semiconductor Ulc | Network interface with clock recovery module on line card |
-
2008
- 2008-07-24 EP EP08807180A patent/EP2167541B1/en active Active
- 2008-07-24 BR BRPI0812765A patent/BRPI0812765B8/pt not_active IP Right Cessation
- 2008-07-24 CN CN2008800252537A patent/CN101754978B/zh not_active Expired - Fee Related
- 2008-07-24 KR KR1020107004009A patent/KR101781638B1/ko not_active Expired - Fee Related
- 2008-07-24 EP EP12195313.7A patent/EP2612869B1/en active Active
- 2008-07-24 CN CN201310127909.9A patent/CN103212072B/zh not_active Expired - Fee Related
- 2008-07-24 AU AU2008278702A patent/AU2008278702B2/en not_active Ceased
- 2008-07-24 ES ES08807180T patent/ES2398536T3/es active Active
- 2008-07-24 ES ES12195313.7T patent/ES2534726T3/es active Active
- 2008-07-24 JP JP2010517507A patent/JP5204228B2/ja not_active Expired - Fee Related
- 2008-07-24 CA CA2691218A patent/CA2691218C/en active Active
- 2008-07-24 US US12/665,930 patent/US20100183506A1/en not_active Abandoned
- 2008-07-24 EA EA201070179A patent/EA017995B1/ru not_active IP Right Cessation
- 2008-07-24 WO PCT/IB2008/002536 patent/WO2009013619A2/en not_active Ceased
-
2013
- 2013-02-14 JP JP2013026422A patent/JP5705893B2/ja not_active Expired - Fee Related
-
2014
- 2014-07-02 AU AU2014203612A patent/AU2014203612B2/en not_active Ceased
- 2014-08-11 US US14/456,966 patent/US20150030536A1/en not_active Abandoned
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