JP2010534236A5 - - Google Patents

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Publication number
JP2010534236A5
JP2010534236A5 JP2010517503A JP2010517503A JP2010534236A5 JP 2010534236 A5 JP2010534236 A5 JP 2010534236A5 JP 2010517503 A JP2010517503 A JP 2010517503A JP 2010517503 A JP2010517503 A JP 2010517503A JP 2010534236 A5 JP2010534236 A5 JP 2010534236A5
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JP
Japan
Prior art keywords
medicament
corm
medicament according
nsaid
pharmaceutical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2010517503A
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English (en)
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JP5563452B2 (ja
JP2010534236A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/IB2008/001945 external-priority patent/WO2009013612A1/en
Publication of JP2010534236A publication Critical patent/JP2010534236A/ja
Publication of JP2010534236A5 publication Critical patent/JP2010534236A5/ja
Application granted granted Critical
Publication of JP5563452B2 publication Critical patent/JP5563452B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Claims (12)

  1. 対象におけるNSAIDまたはアルコール誘発性の胃潰瘍を抑制するための、有効量のCOを含む、医薬
  2. 医薬が、炎症状態以外の状態に対してNSAID療法を受けている対象を処置するためのものである、請求項1に記載の医薬
  3. 医薬が、炎症、疼痛、発熱、血栓塞栓症、動脈管開存症、バーター症候群、癌、病的血管新生に関連する状態、乾癬、アルツハイマー病、および/またはショックに対してNSAID療法を受けている対象を処置するためのものである、請求項1に記載の医薬
  4. COが、ガスである、請求項1に記載の医薬
  5. COが、CORMである、請求項1に記載の医薬
  6. CORMが、CO含有有機金属錯体である、請求項5に記載の医薬
  7. CORMが、有機化合物である、請求項5に記載の医薬
  8. CORMが、アルギン酸塩溶液である薬学的に許容し得る担体中に製剤化されている、請求項5に記載の医薬
  9. 医薬が、NSAIDをさらに含む、請求項5に記載の医薬
  10. NSAIDが、可消化リンカーを介してCORMに共有結合的に複合化されている、請求項9に記載の医薬
  11. CORMが、胃および/または十二指腸の粘膜表面に結合する担体と共に製剤化されている、請求項5に記載の医薬
  12. COが経口投与用である、請求項1〜1のいずれかに記載の医薬
JP2010517503A 2007-07-24 2008-07-24 一酸化炭素による胃潰瘍の予防 Expired - Fee Related JP5563452B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US95165007P 2007-07-24 2007-07-24
US60/951,650 2007-07-24
PCT/IB2008/001945 WO2009013612A1 (en) 2007-07-24 2008-07-24 Prevention of gastric ulcery by carbon monoxide

Publications (3)

Publication Number Publication Date
JP2010534236A JP2010534236A (ja) 2010-11-04
JP2010534236A5 true JP2010534236A5 (ja) 2012-11-22
JP5563452B2 JP5563452B2 (ja) 2014-07-30

Family

ID=40010478

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010517503A Expired - Fee Related JP5563452B2 (ja) 2007-07-24 2008-07-24 一酸化炭素による胃潰瘍の予防

Country Status (5)

Country Link
US (3) US20110038955A1 (ja)
EP (1) EP2182961B1 (ja)
JP (1) JP5563452B2 (ja)
AT (1) ATE555795T1 (ja)
WO (1) WO2009013612A1 (ja)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0111872D0 (en) 2001-05-15 2001-07-04 Northwick Park Inst For Medica Therapeutic agents and methods
US7968605B2 (en) 2002-02-04 2011-06-28 ALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda. Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
WO2003066067A2 (en) 2002-02-04 2003-08-14 Alfama - Investigaçao E Desenvolvimento De Produtos Farmaceuticos Lda. Use of co-releasing compounds for the manufacture of a medicament for the treatment of inflammatory diseases
GB2395432B (en) 2002-11-20 2005-09-14 Northwick Park Inst For Medica Therapeutic delivery of carbon monoxide to extracorporeal and isolated organs
WO2005013691A1 (en) * 2003-08-04 2005-02-17 Hemocorm Limited Use of boranocarbonates for the therapeutic delivery of carbon monoxide
GB0601394D0 (en) 2006-01-24 2006-03-01 Hemocorm Ltd Therapeutic delivery of carbon monoxide
EP2545064B1 (en) 2010-03-08 2020-05-06 University of Zürich Carbon monoxide releasing rhenium compounds for medical use
WO2012075244A2 (en) * 2010-12-01 2012-06-07 Virginia Commonwealth University Use of hemoglobin effectors to increase the bioavailability of therapeutic gases
ES2656237T3 (es) * 2011-04-19 2018-02-26 Alfama, Inc. Moléculas liberadoras de monóxido de carbono y usos de las mismas
ES2628634T3 (es) 2011-07-21 2017-08-03 Alfama, Inc. Moléculas liberadoras de monóxido de carbono-rutenio y usos de las mismas
JP6564785B2 (ja) * 2014-03-21 2019-08-21 ユニベルシテ パリ−エスト クレテイユ ヴァル ド マルヌUniversite Paris−Est Creteil Val De Marne フマレート−co−放出分子ハイブリッド、炎症性疾患又は心血管疾患の治療におけるそれらの使用及びそれらの調製方法
JP2018145248A (ja) * 2017-03-02 2018-09-20 国立大学法人京都大学 無限配位高分子(ICPs)を用いた一酸化炭素放出材料
EP3866773A4 (en) * 2018-10-16 2022-10-26 Georgia State University Research Foundation, Inc. CARBON MONOXIDE PRODRUGS FOR THE TREATMENT OF MEDICAL CONDITIONS
US20230398141A1 (en) * 2020-09-08 2023-12-14 The Brigham And Women's Hospital, Inc. Therapeutic carbon monoxide formulations

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3065250A (en) * 1960-05-13 1962-11-20 Hercules Powder Co Ltd Nitrile-metal carbonyl complexes
US4569214A (en) * 1983-09-14 1986-02-11 Yang Yaw Kuen Push button security lock
US4792452A (en) * 1987-07-28 1988-12-20 E. R. Squibb & Sons, Inc. Controlled release formulation
WO2003066067A2 (en) * 2002-02-04 2003-08-14 Alfama - Investigaçao E Desenvolvimento De Produtos Farmaceuticos Lda. Use of co-releasing compounds for the manufacture of a medicament for the treatment of inflammatory diseases
WO2004000368A1 (en) * 2002-06-21 2003-12-31 University Of Pittsburgh Of The Commonwealth System Of Higher Education Pharmaceutical use of nitric oxide, heme oxygenase-1 and products of heme degradation
US8148356B2 (en) * 2005-08-24 2012-04-03 Cumberland Pharmaceuticals, Inc. Acetylcysteine composition and uses therefor
GB0601394D0 (en) * 2006-01-24 2006-03-01 Hemocorm Ltd Therapeutic delivery of carbon monoxide
JP2010525055A (ja) * 2007-04-24 2010-07-22 アルファーマ−インベスティガシオ エ デセンボルビメント デ プロデュトス ファルマセウティコス エレデア. 一酸化炭素による感染症の処置

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