JP2010534236A5 - - Google Patents
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- Publication number
- JP2010534236A5 JP2010534236A5 JP2010517503A JP2010517503A JP2010534236A5 JP 2010534236 A5 JP2010534236 A5 JP 2010534236A5 JP 2010517503 A JP2010517503 A JP 2010517503A JP 2010517503 A JP2010517503 A JP 2010517503A JP 2010534236 A5 JP2010534236 A5 JP 2010534236A5
- Authority
- JP
- Japan
- Prior art keywords
- medicament
- corm
- medicament according
- nsaid
- pharmaceutical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 claims 12
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 4
- 229940021182 non-steroidal anti-inflammatory drugs Drugs 0.000 claims 4
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 206010001897 Alzheimer's disease Diseases 0.000 claims 1
- 210000001198 Duodenum Anatomy 0.000 claims 1
- 208000005189 Embolism Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- 208000003278 Patent Ductus Arteriosus Diseases 0.000 claims 1
- 206010037660 Pyrexia Diseases 0.000 claims 1
- 210000002784 Stomach Anatomy 0.000 claims 1
- 208000007107 Stomach Ulcer Diseases 0.000 claims 1
- 208000001435 Thromboembolism Diseases 0.000 claims 1
- 229940072056 alginate Drugs 0.000 claims 1
- 235000010443 alginic acid Nutrition 0.000 claims 1
- 229920000615 alginic acid Polymers 0.000 claims 1
- 230000033115 angiogenesis Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229940079593 drugs Drugs 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 201000005917 gastric ulcer Diseases 0.000 claims 1
- 230000004968 inflammatory condition Effects 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 150000002894 organic compounds Chemical class 0.000 claims 1
- 125000002524 organometallic group Chemical group 0.000 claims 1
- 230000001575 pathological Effects 0.000 claims 1
- 201000004681 psoriasis Diseases 0.000 claims 1
- 230000035939 shock Effects 0.000 claims 1
- 230000001629 suppression Effects 0.000 claims 1
- 201000010874 syndrome Diseases 0.000 claims 1
Claims (12)
- 対象におけるNSAIDまたはアルコール誘発性の胃潰瘍を抑制するための、有効量のCOを含む、医薬。
- 医薬が、炎症状態以外の状態に対してNSAID療法を受けている対象を処置するためのものである、請求項1に記載の医薬。
- 医薬が、炎症、疼痛、発熱、血栓塞栓症、動脈管開存症、バーター症候群、癌、病的血管新生に関連する状態、乾癬、アルツハイマー病、および/またはショックに対してNSAID療法を受けている対象を処置するためのものである、請求項1に記載の医薬。
- COが、ガスである、請求項1に記載の医薬。
- COが、CORMである、請求項1に記載の医薬。
- CORMが、CO含有有機金属錯体である、請求項5に記載の医薬。
- CORMが、有機化合物である、請求項5に記載の医薬。
- CORMが、アルギン酸塩溶液である薬学的に許容し得る担体中に製剤化されている、請求項5に記載の医薬。
- 医薬が、NSAIDをさらに含む、請求項5に記載の医薬。
- NSAIDが、可消化リンカーを介してCORMに共有結合的に複合化されている、請求項9に記載の医薬。
- CORMが、胃および/または十二指腸の粘膜表面に結合する担体と共に製剤化されている、請求項5に記載の医薬。
- COが経口投与用である、請求項1〜11のいずれかに記載の医薬。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US95165007P | 2007-07-24 | 2007-07-24 | |
US60/951,650 | 2007-07-24 | ||
PCT/IB2008/001945 WO2009013612A1 (en) | 2007-07-24 | 2008-07-24 | Prevention of gastric ulcery by carbon monoxide |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2010534236A JP2010534236A (ja) | 2010-11-04 |
JP2010534236A5 true JP2010534236A5 (ja) | 2012-11-22 |
JP5563452B2 JP5563452B2 (ja) | 2014-07-30 |
Family
ID=40010478
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010517503A Expired - Fee Related JP5563452B2 (ja) | 2007-07-24 | 2008-07-24 | 一酸化炭素による胃潰瘍の予防 |
Country Status (5)
Country | Link |
---|---|
US (3) | US20110038955A1 (ja) |
EP (1) | EP2182961B1 (ja) |
JP (1) | JP5563452B2 (ja) |
AT (1) | ATE555795T1 (ja) |
WO (1) | WO2009013612A1 (ja) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0111872D0 (en) | 2001-05-15 | 2001-07-04 | Northwick Park Inst For Medica | Therapeutic agents and methods |
US7968605B2 (en) | 2002-02-04 | 2011-06-28 | ALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda. | Methods for treating inflammatory disease by administering aldehydes and derivatives thereof |
WO2003066067A2 (en) | 2002-02-04 | 2003-08-14 | Alfama - Investigaçao E Desenvolvimento De Produtos Farmaceuticos Lda. | Use of co-releasing compounds for the manufacture of a medicament for the treatment of inflammatory diseases |
GB2395432B (en) | 2002-11-20 | 2005-09-14 | Northwick Park Inst For Medica | Therapeutic delivery of carbon monoxide to extracorporeal and isolated organs |
WO2005013691A1 (en) * | 2003-08-04 | 2005-02-17 | Hemocorm Limited | Use of boranocarbonates for the therapeutic delivery of carbon monoxide |
GB0601394D0 (en) | 2006-01-24 | 2006-03-01 | Hemocorm Ltd | Therapeutic delivery of carbon monoxide |
EP2545064B1 (en) | 2010-03-08 | 2020-05-06 | University of Zürich | Carbon monoxide releasing rhenium compounds for medical use |
WO2012075244A2 (en) * | 2010-12-01 | 2012-06-07 | Virginia Commonwealth University | Use of hemoglobin effectors to increase the bioavailability of therapeutic gases |
ES2656237T3 (es) * | 2011-04-19 | 2018-02-26 | Alfama, Inc. | Moléculas liberadoras de monóxido de carbono y usos de las mismas |
ES2628634T3 (es) | 2011-07-21 | 2017-08-03 | Alfama, Inc. | Moléculas liberadoras de monóxido de carbono-rutenio y usos de las mismas |
JP6564785B2 (ja) * | 2014-03-21 | 2019-08-21 | ユニベルシテ パリ−エスト クレテイユ ヴァル ド マルヌUniversite Paris−Est Creteil Val De Marne | フマレート−co−放出分子ハイブリッド、炎症性疾患又は心血管疾患の治療におけるそれらの使用及びそれらの調製方法 |
JP2018145248A (ja) * | 2017-03-02 | 2018-09-20 | 国立大学法人京都大学 | 無限配位高分子(ICPs)を用いた一酸化炭素放出材料 |
EP3866773A4 (en) * | 2018-10-16 | 2022-10-26 | Georgia State University Research Foundation, Inc. | CARBON MONOXIDE PRODRUGS FOR THE TREATMENT OF MEDICAL CONDITIONS |
US20230398141A1 (en) * | 2020-09-08 | 2023-12-14 | The Brigham And Women's Hospital, Inc. | Therapeutic carbon monoxide formulations |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3065250A (en) * | 1960-05-13 | 1962-11-20 | Hercules Powder Co Ltd | Nitrile-metal carbonyl complexes |
US4569214A (en) * | 1983-09-14 | 1986-02-11 | Yang Yaw Kuen | Push button security lock |
US4792452A (en) * | 1987-07-28 | 1988-12-20 | E. R. Squibb & Sons, Inc. | Controlled release formulation |
WO2003066067A2 (en) * | 2002-02-04 | 2003-08-14 | Alfama - Investigaçao E Desenvolvimento De Produtos Farmaceuticos Lda. | Use of co-releasing compounds for the manufacture of a medicament for the treatment of inflammatory diseases |
WO2004000368A1 (en) * | 2002-06-21 | 2003-12-31 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Pharmaceutical use of nitric oxide, heme oxygenase-1 and products of heme degradation |
US8148356B2 (en) * | 2005-08-24 | 2012-04-03 | Cumberland Pharmaceuticals, Inc. | Acetylcysteine composition and uses therefor |
GB0601394D0 (en) * | 2006-01-24 | 2006-03-01 | Hemocorm Ltd | Therapeutic delivery of carbon monoxide |
JP2010525055A (ja) * | 2007-04-24 | 2010-07-22 | アルファーマ−インベスティガシオ エ デセンボルビメント デ プロデュトス ファルマセウティコス エレデア. | 一酸化炭素による感染症の処置 |
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2008
- 2008-07-24 US US12/670,466 patent/US20110038955A1/en not_active Abandoned
- 2008-07-24 AT AT08788928T patent/ATE555795T1/de active
- 2008-07-24 JP JP2010517503A patent/JP5563452B2/ja not_active Expired - Fee Related
- 2008-07-24 WO PCT/IB2008/001945 patent/WO2009013612A1/en active Application Filing
- 2008-07-24 EP EP08788928A patent/EP2182961B1/en not_active Not-in-force
-
2013
- 2013-10-11 US US14/052,551 patent/US20140212514A1/en not_active Abandoned
-
2016
- 2016-07-25 US US15/218,564 patent/US20170157168A1/en not_active Abandoned