JP2004533246A5 - - Google Patents
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- Publication number
- JP2004533246A5 JP2004533246A5 JP2002587611A JP2002587611A JP2004533246A5 JP 2004533246 A5 JP2004533246 A5 JP 2004533246A5 JP 2002587611 A JP2002587611 A JP 2002587611A JP 2002587611 A JP2002587611 A JP 2002587611A JP 2004533246 A5 JP2004533246 A5 JP 2004533246A5
- Authority
- JP
- Japan
- Prior art keywords
- lactococcus
- strain
- gene
- transformed strain
- transformed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000178948 Lactococcus sp. Species 0.000 claims 11
- 102000005497 Thymidylate Synthase Human genes 0.000 claims 3
- 108010067449 Thymidylate Synthase Proteins 0.000 claims 3
- 230000003449 preventive Effects 0.000 claims 3
- 230000001225 therapeutic Effects 0.000 claims 3
- 230000001131 transforming Effects 0.000 claims 3
- 206010021972 Inflammatory bowel disease Diseases 0.000 claims 1
- 229940076144 Interleukin-10 Drugs 0.000 claims 1
- 102000003814 Interleukin-10 Human genes 0.000 claims 1
- 108090000174 Interleukin-10 Proteins 0.000 claims 1
- 241000194035 Lactococcus lactis Species 0.000 claims 1
- 235000014897 Streptococcus lactis Nutrition 0.000 claims 1
- 230000002950 deficient Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Claims (10)
- 欠陥チミジル酸合成酵素遺伝子を含むラクトコッカス種（Lactococcus sp.）の単離株。
- 該遺伝子が、遺伝子破壊によって不活化されている請求項１記載のラクトコッカス種（Lactococcus sp.）の単離株。
- 該ラクトコッカス種（Lactococcus sp.）がラクトコッカス・ラクティス（Lactococcus lactis.）である請求項１又は２記載のラクトコッカス種（Lactococcus sp.）の単離株。
- 完全なチミジル酸合成酵素遺伝子を含まない形質転換プラスミドによる形質転換のための宿主株としての請求項１−３のいずれか1項記載のラクトコッカス種（Lactococcus sp.）株の使用。
- 完全なチミジル酸合成酵素遺伝子を含まない形質転換プラスミドを含む請求項１−３のいずれか１項記載のラクトコッカス種（Lactococcus sp.）の形質転換株。
- 予防用及び／又は治療用分子をコードする遺伝子を含む請求項１−４のいずれか１項記載のラクトコッカス種（Lactococcus sp.）の形質転換株。
- 該予防用及び／又は治療用分子がインターロイキン１０である、請求項６記載のラクトコッカス種（Lactococcus sp.）の形質転換株。
- 予防用及び／又は治療的用分子の配送のための請求項５−７のいずれか１項記載のラクトコッカス種（Lactococcus sp.）の形質転換株の使用。
- 請求項５−７のいずれか１項記載のラクトコッカス種（Lactococcus sp.）の形質転換株を含む医薬組成物。
- 炎症性腸疾患治療用医薬の調製のための請求項６−７のいずれか１項記載のラクトコッカス種（Lactococcus sp.）の形質転換株の使用。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01201631 | 2001-05-03 | ||
| EP01204785 | 2001-12-07 | ||
| PCT/EP2002/004942 WO2002090551A2 (en) | 2001-05-03 | 2002-05-03 | Self-containing lactococcus strain |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008260591A Division JP2009060913A (ja) | 2001-05-03 | 2008-10-07 | 自己自制ラクトコッカス（Ｌｏｃｔｏｃｏｃｃｕｓ）株 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004533246A JP2004533246A (ja) | 2004-11-04 |
| JP2004533246A5 true JP2004533246A5 (ja) | 2005-12-22 |
| JP4347575B2 JP4347575B2 (ja) | 2009-10-21 |
Family
ID=26076897
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002587611A Expired - Fee Related JP4347575B2 (ja) | 2001-05-03 | 2002-05-03 | 自己自制ラクトコッカス（Ｌｏｃｔｏｃｏｃｃｕｓ）株 |
| JP2008260591A Withdrawn JP2009060913A (ja) | 2001-05-03 | 2008-10-07 | 自己自制ラクトコッカス（Ｌｏｃｔｏｃｏｃｃｕｓ）株 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008260591A Withdrawn JP2009060913A (ja) | 2001-05-03 | 2008-10-07 | 自己自制ラクトコッカス（Ｌｏｃｔｏｃｏｃｃｕｓ）株 |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1383897B1 (ja) |
| JP (2) | JP4347575B2 (ja) |
| AT (1) | ATE331789T1 (ja) |
| AU (1) | AU2002314040B2 (ja) |
| CA (1) | CA2446776C (ja) |
| DE (1) | DE60212825T2 (ja) |
| DK (1) | DK1383897T3 (ja) |
| ES (1) | ES2266515T3 (ja) |
| WO (1) | WO2002090551A2 (ja) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7780961B2 (en) | 2001-05-03 | 2010-08-24 | Actogenix N.V. | Self-containing Lactococcus strain |
| JP2005529622A (ja) | 2002-06-19 | 2005-10-06 | ヴェーイーベー・ヴェーゼットウェー | 腸吸収を促進するための方法および手段 |
| AU2003303222A1 (en) * | 2002-12-19 | 2004-07-14 | Universiteit Gent | Mutant proteins showing increased secretion |
| JP4589618B2 (ja) * | 2003-11-28 | 2010-12-01 | 独立行政法人農業生物資源研究所 | 免疫調節性機能を誘導する乳酸菌類とその成分 |
| EP1789529B1 (en) | 2004-08-20 | 2013-10-02 | Actogenix N.V. | Method to improve lactococcus preservation |
| DK2119450T3 (da) * | 2005-11-29 | 2013-05-06 | Actogenix Nv | Induktion af mucosal tolerance over for pankreatisk ø-beta-celle-autoantigener |
| JP2010513245A (ja) * | 2006-12-14 | 2010-04-30 | アクトジェニックス・エヌブイ | 免疫調節を誘起するための結合分子の送達 |
| ES2595729T3 (es) | 2007-01-12 | 2017-01-03 | Intrexon Actobiotics Nv | Promotores de Lactococcus y usos de los mismos |
| ES2492468T3 (es) | 2007-01-25 | 2014-09-09 | Actogenix N.V. | Tratamiento de enfermedad inmunitaria por administración a través de la mucosa de antígenos usando Lactobacillus genéticamente modificado |
| EP3181682B1 (en) * | 2008-09-29 | 2021-04-21 | Intrexon Actobiotics NV | Reduced colonization of microbes at the mucosa |
| WO2012164083A1 (en) | 2011-06-01 | 2012-12-06 | Actogenix N.V. | Polycistronic expression system for bacteria |
| EP2758512B1 (en) | 2011-09-23 | 2018-05-09 | Intrexon Actobiotics NV | Modified gram positive bacteria and uses thereof |
| CN103917639B (zh) | 2011-09-23 | 2017-09-26 | 英特瑞克斯顿阿克图比奥帝克斯有限公司 | 经修饰的革兰氏阳性细菌及其用途 |
| US9688967B2 (en) | 2014-12-05 | 2017-06-27 | Synlogic, Inc. | Bacteria engineered to treat diseases associated with hyperammonemia |
| US20160206666A1 (en) | 2014-12-22 | 2016-07-21 | Synlogic, Inc. | Bacteria engineered to treat diseases that benefit from reduced gut inflammation and/or tighten gut mucosal barrier |
| BR112017018656B1 (pt) * | 2015-03-02 | 2021-11-30 | Synlogic, Inc | Bactéria geneticamente modificada, composição farmaceuticamente aceitável compreendendo a dita bactéria e uso da dita composição para tratar ou prevenir uma doença ou condição associada à inflamação intestinal e/ou função da barreira intestinal comprometida |
| CN106148254B (zh) * | 2015-03-26 | 2019-11-12 | 南京华贞生物医药科技有限公司 | 一种用于减肥降脂的转化体及其构建方法与应用 |
| US11685925B2 (en) | 2015-10-30 | 2023-06-27 | Synlogic Operating Company, Inc. | Bacteria engineered to treat diseases that benefit from reduced gut inflammation and/or tightened gut mucosal barrier |
| EP4095150A1 (en) | 2015-11-16 | 2022-11-30 | Synlogic Operating Company, Inc. | Bacteria engineered to reduce hyperphenylalaninemia |
| RU2760997C2 (ru) | 2016-01-14 | 2021-12-02 | Интрексон Актобиотикс Н.В. | Композиции и способы для лечения диабета 1 типа |
| RU2768027C2 (ru) | 2016-09-02 | 2022-03-23 | Интрексон Актобиотикс Н.В. | Генетически модифицированные бактерии, стабильно экспрессирующие ил-10 и инсулин |
| KR102469701B1 (ko) | 2016-09-13 | 2022-11-22 | 인트랙슨 액토바이오틱스 엔.브이. | 점막부착성 미생물 |
| EP3864048A1 (en) | 2018-10-11 | 2021-08-18 | Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. | Bacteria expressing single chain antibodies against toll-like receptors |
| US20220340621A1 (en) | 2019-09-27 | 2022-10-27 | Intrexon Actobiotics Nv D/B/A Precigen Actobio | Treatment of celiac disease |
| CN115298308A (zh) | 2020-03-20 | 2022-11-04 | 同生运营公司 | 经工程化以减轻高苯丙氨酸血症的微生物 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4231764A1 (de) * | 1992-09-23 | 1994-03-24 | Inst Pflanzengenetik & Kultur | Verfahren zur chromosomalen Integration eines Produkt-Gens |
-
2002
- 2002-05-03 DE DE60212825T patent/DE60212825T2/de not_active Expired - Lifetime
- 2002-05-03 EP EP02740565A patent/EP1383897B1/en not_active Expired - Lifetime
- 2002-05-03 AU AU2002314040A patent/AU2002314040B2/en not_active Ceased
- 2002-05-03 DK DK02740565T patent/DK1383897T3/da active
- 2002-05-03 WO PCT/EP2002/004942 patent/WO2002090551A2/en active IP Right Grant
- 2002-05-03 AT AT02740565T patent/ATE331789T1/de active
- 2002-05-03 JP JP2002587611A patent/JP4347575B2/ja not_active Expired - Fee Related
- 2002-05-03 ES ES02740565T patent/ES2266515T3/es not_active Expired - Lifetime
- 2002-05-03 CA CA2446776A patent/CA2446776C/en not_active Expired - Fee Related
-
2008
- 2008-10-07 JP JP2008260591A patent/JP2009060913A/ja not_active Withdrawn
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