JP2010532347A5 - - Google Patents
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- Publication number
- JP2010532347A5 JP2010532347A5 JP2010514670A JP2010514670A JP2010532347A5 JP 2010532347 A5 JP2010532347 A5 JP 2010532347A5 JP 2010514670 A JP2010514670 A JP 2010514670A JP 2010514670 A JP2010514670 A JP 2010514670A JP 2010532347 A5 JP2010532347 A5 JP 2010532347A5
- Authority
- JP
- Japan
- Prior art keywords
- bacteria
- ureolytic
- ketoglutarate
- undesirable
- symptoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000894006 Bacteria Species 0.000 claims 27
- 230000003604 ureolytic Effects 0.000 claims 22
- 238000002360 preparation method Methods 0.000 claims 12
- 239000000203 mixture Substances 0.000 claims 9
- KPGXRSRHYNQIFN-UHFFFAOYSA-L 2-oxoglutarate(2-) Chemical compound [O-]C(=O)CCC(=O)C([O-])=O KPGXRSRHYNQIFN-UHFFFAOYSA-L 0.000 claims 8
- 230000015572 biosynthetic process Effects 0.000 claims 8
- 238000005755 formation reaction Methods 0.000 claims 8
- 241000251468 Actinopterygii Species 0.000 claims 7
- 235000019688 fish Nutrition 0.000 claims 7
- 230000001225 therapeutic Effects 0.000 claims 7
- 241000202898 Ureaplasma Species 0.000 claims 6
- 201000009910 diseases by infectious agent Diseases 0.000 claims 6
- 238000011065 in-situ storage Methods 0.000 claims 6
- 230000002265 prevention Effects 0.000 claims 6
- 230000000069 prophylaxis Effects 0.000 claims 6
- 230000000699 topical Effects 0.000 claims 6
- 241000196324 Embryophyta Species 0.000 claims 5
- 230000000694 effects Effects 0.000 claims 5
- 238000009472 formulation Methods 0.000 claims 5
- 108090000790 Enzymes Proteins 0.000 claims 4
- 102000004190 Enzymes Human genes 0.000 claims 4
- 241001465754 Metazoa Species 0.000 claims 4
- 241000204031 Mycoplasma Species 0.000 claims 4
- 108010046334 Urease Proteins 0.000 claims 4
- 230000032770 biofilm formation Effects 0.000 claims 4
- 230000002458 infectious Effects 0.000 claims 4
- 230000000968 intestinal Effects 0.000 claims 4
- 210000001519 tissues Anatomy 0.000 claims 4
- XSQUKJJJFZCRTK-UHFFFAOYSA-N urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 4
- 241000269328 Amphibia Species 0.000 claims 3
- 241000238421 Arthropoda Species 0.000 claims 3
- 241000271566 Aves Species 0.000 claims 3
- 208000002925 Dental Caries Diseases 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 3
- 241000237852 Mollusca Species 0.000 claims 3
- 230000002401 inhibitory effect Effects 0.000 claims 3
- 244000005706 microflora Species 0.000 claims 3
- 208000004300 Atrophic Gastritis Diseases 0.000 claims 2
- 241000193830 Bacillus <bacterium> Species 0.000 claims 2
- 241000589562 Brucella Species 0.000 claims 2
- 206010006895 Cachexia Diseases 0.000 claims 2
- 229940112822 Chewing Gum Drugs 0.000 claims 2
- 241000186216 Corynebacterium Species 0.000 claims 2
- 208000000718 Duodenal Ulcer Diseases 0.000 claims 2
- 241000233866 Fungi Species 0.000 claims 2
- 206010017758 Gastric cancer Diseases 0.000 claims 2
- 206010017860 Gastritis atrophic Diseases 0.000 claims 2
- 210000001035 Gastrointestinal Tract Anatomy 0.000 claims 2
- 210000004392 Genitalia Anatomy 0.000 claims 2
- 210000002816 Gills Anatomy 0.000 claims 2
- 206010018280 Gingival disease Diseases 0.000 claims 2
- 241000590002 Helicobacter pylori Species 0.000 claims 2
- 229940037467 Helicobacter pylori Drugs 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 2
- 241000588748 Klebsiella Species 0.000 claims 2
- 241000736262 Microbiota Species 0.000 claims 2
- 206010065764 Mucosal infection Diseases 0.000 claims 2
- 241000204048 Mycoplasma hominis Species 0.000 claims 2
- 206010025310 Other lymphomas Diseases 0.000 claims 2
- 208000008469 Peptic Ulcer Diseases 0.000 claims 2
- 241000588769 Proteus <enterobacteria> Species 0.000 claims 2
- 241000588770 Proteus mirabilis Species 0.000 claims 2
- 241000588768 Providencia Species 0.000 claims 2
- 241000589516 Pseudomonas Species 0.000 claims 2
- 241000191940 Staphylococcus Species 0.000 claims 2
- 210000002784 Stomach Anatomy 0.000 claims 2
- 208000007107 Stomach Ulcer Diseases 0.000 claims 2
- 206010046577 Urinary tract infection Diseases 0.000 claims 2
- 241000607734 Yersinia <bacteria> Species 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 230000001580 bacterial Effects 0.000 claims 2
- 230000037396 body weight Effects 0.000 claims 2
- 239000004202 carbamide Substances 0.000 claims 2
- 230000015556 catabolic process Effects 0.000 claims 2
- 235000015218 chewing gum Nutrition 0.000 claims 2
- 230000001684 chronic Effects 0.000 claims 2
- 230000004059 degradation Effects 0.000 claims 2
- 238000006731 degradation reaction Methods 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 235000013305 food Nutrition 0.000 claims 2
- 201000011587 gastric lymphoma Diseases 0.000 claims 2
- 244000005709 gut microbiome Species 0.000 claims 2
- 230000004054 inflammatory process Effects 0.000 claims 2
- 238000001990 intravenous administration Methods 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000001717 pathogenic Effects 0.000 claims 2
- 210000002345 respiratory system Anatomy 0.000 claims 2
- 230000000087 stabilizing Effects 0.000 claims 2
- 201000011549 stomach cancer Diseases 0.000 claims 2
- 230000002485 urinary Effects 0.000 claims 2
- 210000002229 urogenital system Anatomy 0.000 claims 2
- 239000000003 vaginal tablet Substances 0.000 claims 2
- 241000972773 Aulopiformes Species 0.000 claims 1
- 239000002028 Biomass Substances 0.000 claims 1
- 241000251730 Chondrichthyes Species 0.000 claims 1
- 208000006558 Dental Calculus Diseases 0.000 claims 1
- 210000003750 Lower Gastrointestinal Tract Anatomy 0.000 claims 1
- 241000204046 Termitidae Species 0.000 claims 1
- 229940120293 Vaginal Suppository Drugs 0.000 claims 1
- 229940044977 Vaginal Tablet Drugs 0.000 claims 1
- 239000003674 animal food additive Substances 0.000 claims 1
- 239000002551 biofuel Substances 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 235000015872 dietary supplement Nutrition 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 239000002778 food additive Substances 0.000 claims 1
- 201000005917 gastric ulcer Diseases 0.000 claims 1
- JFCQEDHGNNZCLN-UHFFFAOYSA-L glutarate(2-) Chemical compound [O-]C(=O)CCCC([O-])=O JFCQEDHGNNZCLN-UHFFFAOYSA-L 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 230000002262 irrigation Effects 0.000 claims 1
- 238000003973 irrigation Methods 0.000 claims 1
- 229920005610 lignin Polymers 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 230000000051 modifying Effects 0.000 claims 1
- 230000001105 regulatory Effects 0.000 claims 1
- 235000019515 salmon Nutrition 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 239000000829 suppository Substances 0.000 claims 1
- 239000006216 vaginal suppository Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07460015.6 | 2007-07-03 | ||
| EP07460015A EP1917959B1 (en) | 2006-07-03 | 2007-07-03 | New medical use of alfa-ketoglutarate |
| PCT/PL2007/000086 WO2009005379A1 (en) | 2007-07-03 | 2007-12-31 | New medical applications of alpha-ketoglutarate |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014076402A Division JP2014193866A (ja) | 2007-07-03 | 2014-04-02 | α−ケトグルタレートの新規の医学的用途 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010532347A JP2010532347A (ja) | 2010-10-07 |
| JP2010532347A5 true JP2010532347A5 (zh) | 2011-02-24 |
| JP5518702B2 JP5518702B2 (ja) | 2014-06-11 |
Family
ID=39322797
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010514670A Expired - Fee Related JP5518702B2 (ja) | 2007-07-03 | 2007-12-31 | α−ケトグルタレートの新規の医学的用途 |
| JP2014076402A Pending JP2014193866A (ja) | 2007-07-03 | 2014-04-02 | α−ケトグルタレートの新規の医学的用途 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014076402A Pending JP2014193866A (ja) | 2007-07-03 | 2014-04-02 | α−ケトグルタレートの新規の医学的用途 |
Country Status (5)
| Country | Link |
|---|---|
| JP (2) | JP5518702B2 (zh) |
| KR (2) | KR20150003908A (zh) |
| CN (2) | CN104825433A (zh) |
| IL (1) | IL203051A (zh) |
| WO (1) | WO2009005379A1 (zh) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2771022T3 (da) | 2011-10-11 | 2020-09-28 | Viela Bio Inc | Cd40l-specifikke tn3-afledte skeletter (scaffolds) og fremgangsmåder til anvendelse deraf |
| CN103168972A (zh) * | 2013-04-19 | 2013-06-26 | 中国水产科学研究院黑龙江水产研究所 | 一种提高鲤鱼生长性能和蛋白质沉积的饲料 |
| AU2013408773B2 (en) * | 2013-12-27 | 2017-10-19 | Colgate-Palmolive Company | Prebiotic oral care compositions containing carboxylic acids |
| CN104257643B (zh) * | 2014-09-15 | 2016-09-21 | 华南理工大学 | 基于α-酮戊二酸的泌尿系磷酸盐结石的溶石剂及其制备方法 |
| CN104721176B (zh) * | 2015-02-02 | 2018-07-10 | 中山大学 | α-酮戊二酸在提高细菌对抗生素敏感性方面的应用 |
| ES2839211T3 (es) | 2015-03-12 | 2021-07-05 | Medimmune Llc | Método para purificar proteínas de fusión a albúmina |
| CN105325731A (zh) * | 2015-12-07 | 2016-02-17 | 湖南农业大学 | α-酮戊二酸作为饲料添加剂的用途及相应饲料 |
| CN105475230B (zh) * | 2015-12-17 | 2018-04-20 | 中国农业大学 | 一种提高大龄动物繁殖力的方法 |
| LU100900B1 (de) * | 2018-08-10 | 2020-02-17 | Thomas Melchior Homann | Verbindungen zur modulation von a-ketoglutarsäure (2kg)-abhängigen oxygenasen |
| WO2020073088A1 (en) * | 2018-10-10 | 2020-04-16 | Servatus Ltd | Methods of treatment of inflammatory conditions and associated infections |
| JP7293406B2 (ja) * | 2019-06-14 | 2023-06-19 | シージェイ チェルジェダン コーポレイション | コリネバクテリウム属菌株およびその培養物を含む胃腸疾患予防、治療または改善用組成物 |
| US20230093480A1 (en) * | 2019-12-30 | 2023-03-23 | Devicare SL | Compositions for clinical complications associated to devices implanted in the urinary tract |
| CN111067885A (zh) * | 2020-02-20 | 2020-04-28 | 杨益文 | 一种消除幽门螺旋螺杆菌及治疗胃及十二指肠溃疡的药物 |
| CN111820330A (zh) * | 2020-07-17 | 2020-10-27 | 禹城保立康生物饲料有限公司 | 一种提高哺乳仔猪发育的母猪饲料 |
| CN113337436A (zh) * | 2021-06-09 | 2021-09-03 | 中国科学院新疆生态与地理研究所 | 一种尿素分解菌及其选育方法和应用 |
| CN113995054A (zh) * | 2021-11-02 | 2022-02-01 | 中国科学院亚热带农业生态研究所 | 鸟氨酸-α-酮戊二酸在制备促进保育猪生长饲料中的应用 |
| CN115340313B (zh) * | 2022-01-17 | 2023-04-18 | 浙江理工大学 | 一种物理复合微生物技术强化再生骨料方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4919855B1 (zh) * | 1970-10-06 | 1974-05-21 | ||
| SE9303691D0 (sv) * | 1993-11-09 | 1993-11-09 | Gramineer Ab | New beverage |
| JP2002529545A (ja) * | 1998-11-06 | 2002-09-10 | ユニベルシテ ドゥ モントリオール | バイオフィルムを除去するための改良型の殺菌性及び非殺菌性溶液 |
| JP4533496B2 (ja) * | 2000-03-15 | 2010-09-01 | 三菱重工業株式会社 | バイオマスからの燃料製造方法 |
| EP1184443A1 (en) * | 2000-09-04 | 2002-03-06 | Biofuel B.V. | Process for the production of liquid fuels from biomass |
| FR2822704B1 (fr) * | 2001-03-29 | 2005-02-18 | Chiesi Sa | Sels de cetoacides et d'acides amines gastroresistants et leur utilisation pour la preparation de medicaments |
| SE0200256D0 (sv) * | 2001-12-21 | 2002-01-29 | Gramineer Internat Ab | New composition, methods and use |
| PL368572A1 (en) * | 2004-06-17 | 2005-12-27 | Sgp & Sons Ab | Pharmaceutical compound for prevention and therapy of increased level of cholesterol, ldl and triglycerides as well as application of the pharmaceutical compound as an agent acting against atherosclerosis and used in circulatory system affections |
| EP1778616A1 (en) * | 2004-08-09 | 2007-05-02 | Cancer Research Technology Limited | Alpha-ketoglutarates and their use as therapeutic agents |
| WO2006043336A1 (ja) * | 2004-10-20 | 2006-04-27 | Kotobuki Pharmaceutical Co., Ltd. | 胃粘膜疾患の治療又は予防のための組成物 |
| US7803817B2 (en) * | 2005-05-11 | 2010-09-28 | Vecta, Ltd. | Composition and methods for inhibiting gastric acid secretion |
-
2007
- 2007-12-31 WO PCT/PL2007/000086 patent/WO2009005379A1/en active Application Filing
- 2007-12-31 JP JP2010514670A patent/JP5518702B2/ja not_active Expired - Fee Related
- 2007-12-31 CN CN201510209789.6A patent/CN104825433A/zh active Pending
- 2007-12-31 CN CN2007801004718A patent/CN102014888A/zh active Pending
- 2007-12-31 KR KR1020147033914A patent/KR20150003908A/ko not_active Application Discontinuation
- 2007-12-31 KR KR1020107002525A patent/KR101610791B1/ko not_active IP Right Cessation
-
2009
- 2009-12-30 IL IL203051A patent/IL203051A/en not_active IP Right Cessation
-
2014
- 2014-04-02 JP JP2014076402A patent/JP2014193866A/ja active Pending
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