JP2010531811A5 - - Google Patents
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- Publication number
- JP2010531811A5 JP2010531811A5 JP2010513583A JP2010513583A JP2010531811A5 JP 2010531811 A5 JP2010531811 A5 JP 2010531811A5 JP 2010513583 A JP2010513583 A JP 2010513583A JP 2010513583 A JP2010513583 A JP 2010513583A JP 2010531811 A5 JP2010531811 A5 JP 2010531811A5
- Authority
- JP
- Japan
- Prior art keywords
- hydroxy
- alkyl
- compound according
- aryl
- arylalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 150000001875 compounds Chemical class 0.000 claims 28
- 239000001257 hydrogen Substances 0.000 claims 19
- 229910052739 hydrogen Inorganic materials 0.000 claims 19
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 19
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 18
- 125000000217 alkyl group Chemical group 0.000 claims 16
- 125000003118 aryl group Chemical group 0.000 claims 13
- 125000003710 aryl alkyl group Chemical group 0.000 claims 11
- 125000005843 halogen group Chemical group 0.000 claims 11
- 125000004093 cyano group Chemical group *C#N 0.000 claims 8
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 8
- 125000000753 cycloalkyl group Chemical group 0.000 claims 7
- 239000003814 drug Substances 0.000 claims 7
- PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 5
- 125000004414 alkyl thio group Chemical group 0.000 claims 4
- 208000027866 inflammatory disease Diseases 0.000 claims 4
- -1 n- butyl Chemical group 0.000 claims 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims 4
- 125000003396 thiol group Chemical class [H]S* 0.000 claims 4
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 claims 4
- 239000003963 antioxidant agent Substances 0.000 claims 3
- 230000003078 antioxidant effect Effects 0.000 claims 3
- 125000001188 haloalkyl group Chemical group 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- UQACRQOXQZWPRQ-UHFFFAOYSA-N 2-(4-hydroxyphenyl)-2H-chromen-7-ol Chemical compound OC1=CC=C(C=C1)C1OC2=C(C=C1)C=CC(=C2)O UQACRQOXQZWPRQ-UHFFFAOYSA-N 0.000 claims 2
- 125000004423 acyloxy group Chemical group 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000002877 alkyl aryl group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 125000004103 aminoalkyl group Chemical group 0.000 claims 2
- 125000001691 aryl alkyl amino group Chemical group 0.000 claims 2
- LHHCSNFAOIFYRV-DOVBMPENSA-N boceprevir Chemical compound O=C([C@@H]1[C@@H]2[C@@H](C2(C)C)CN1C(=O)[C@@H](NC(=O)NC(C)(C)C)C(C)(C)C)NC(C(=O)C(N)=O)CC1CCC1 LHHCSNFAOIFYRV-DOVBMPENSA-N 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000003373 pyrazinyl group Chemical group 0.000 claims 2
- 125000002098 pyridazinyl group Chemical group 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 125000004469 siloxy group Chemical group [SiH3]O* 0.000 claims 2
- 125000001425 triazolyl group Chemical group 0.000 claims 2
- JYEUMXHLPRZUAT-UHFFFAOYSA-N 1,2,3-triazine Chemical compound C1=CN=NN=C1 JYEUMXHLPRZUAT-UHFFFAOYSA-N 0.000 claims 1
- IZPZSLYHQNABBJ-UHFFFAOYSA-N 2,3-bis(4-hydroxyphenyl)-2h-chromen-7-ol Chemical compound C1=CC(O)=CC=C1C1C(C=2C=CC(O)=CC=2)=CC2=CC=C(O)C=C2O1 IZPZSLYHQNABBJ-UHFFFAOYSA-N 0.000 claims 1
- WYTFJXIXGZKHDL-UHFFFAOYSA-N 2-(4-fluorophenyl)-3-(4-hydroxyphenyl)-2h-chromen-7-ol Chemical compound C1=CC(O)=CC=C1C1=CC2=CC=C(O)C=C2OC1C1=CC=C(F)C=C1 WYTFJXIXGZKHDL-UHFFFAOYSA-N 0.000 claims 1
- KKIXBOSXUXODLR-UHFFFAOYSA-N 2-[3-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3,4-dihydro-2h-chromen-2-yl]benzene-1,3,5-triol Chemical compound OC1=CC(O)=CC(O)=C1C1C(C=2C=C(O)C(O)=CC=2)CC2=C(O)C=C(O)C=C2O1 KKIXBOSXUXODLR-UHFFFAOYSA-N 0.000 claims 1
- IXTFFZAHEIKMCM-UHFFFAOYSA-N 2-ethenyl-3-(4-hydroxyphenyl)-2h-chromen-7-ol Chemical compound C1=CC(O)=CC=C1C1=CC2=CC=C(O)C=C2OC1C=C IXTFFZAHEIKMCM-UHFFFAOYSA-N 0.000 claims 1
- VZNANJWLISKXOY-UHFFFAOYSA-N 2-ethyl-3-(4-hydroxyphenyl)-2h-chromen-7-ol Chemical compound CCC1OC2=CC(O)=CC=C2C=C1C1=CC=C(O)C=C1 VZNANJWLISKXOY-UHFFFAOYSA-N 0.000 claims 1
- GFXHSESASIXPFM-UHFFFAOYSA-N 2-methyl-3-phenyl-3,4-dihydro-2h-chromen-7-ol Chemical compound CC1OC2=CC(O)=CC=C2CC1C1=CC=CC=C1 GFXHSESASIXPFM-UHFFFAOYSA-N 0.000 claims 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 1
- VKBVRFAROZZBSA-UHFFFAOYSA-N 3-(4-hydroxyphenyl)-2-[(4-methoxyphenyl)methyl]-2H-chromen-7-ol Chemical compound C(C1=CC=C(C=C1)OC)C1OC2=CC(=CC=C2C=C1C1=CC=C(C=C1)O)O VKBVRFAROZZBSA-UHFFFAOYSA-N 0.000 claims 1
- PNXKXCBNXPPSTM-UHFFFAOYSA-N 3-(4-hydroxyphenyl)-2-methyl-2h-chromen-7-ol Chemical compound CC1OC2=CC(O)=CC=C2C=C1C1=CC=C(O)C=C1 PNXKXCBNXPPSTM-UHFFFAOYSA-N 0.000 claims 1
- MPZQEKHNTVQTSZ-UHFFFAOYSA-N 3-(4-hydroxyphenyl)-2-naphthalen-2-yl-2H-chromen-7-ol Chemical compound C1=C(C=CC2=CC=CC=C12)C1OC2=CC(=CC=C2C=C1C1=CC=C(C=C1)O)O MPZQEKHNTVQTSZ-UHFFFAOYSA-N 0.000 claims 1
- RIAREMUPLJUNSS-UHFFFAOYSA-N 3-(4-hydroxyphenyl)-2-phenyl-2h-chromen-7-ol Chemical compound C1=CC(O)=CC=C1C1=CC2=CC=C(O)C=C2OC1C1=CC=CC=C1 RIAREMUPLJUNSS-UHFFFAOYSA-N 0.000 claims 1
- LOWVNTMZFIZRCP-UHFFFAOYSA-N 3-(4-hydroxyphenyl)-2-propan-2-yl-2h-chromen-7-ol Chemical compound CC(C)C1OC2=CC(O)=CC=C2C=C1C1=CC=C(O)C=C1 LOWVNTMZFIZRCP-UHFFFAOYSA-N 0.000 claims 1
- NEDBWJDDHIGNOM-UHFFFAOYSA-N 3-(4-hydroxyphenyl)-2-thiophen-2-yl-2h-chromen-7-ol Chemical compound C1=CC(O)=CC=C1C1=CC2=CC=C(O)C=C2OC1C1=CC=CS1 NEDBWJDDHIGNOM-UHFFFAOYSA-N 0.000 claims 1
- CVDBKEOTQXCRRX-UHFFFAOYSA-N 3-(4-hydroxyphenyl)-3,4-dihydro-2h-chromene-2,7-diol Chemical compound OC1OC2=CC(O)=CC=C2CC1C1=CC=C(O)C=C1 CVDBKEOTQXCRRX-UHFFFAOYSA-N 0.000 claims 1
- HPKHLLZWPBHUOX-UHFFFAOYSA-N 4-(7-methoxy-3-phenyl-2h-chromen-2-yl)phenol Chemical compound O1C2=CC(OC)=CC=C2C=C(C=2C=CC=CC=2)C1C1=CC=C(O)C=C1 HPKHLLZWPBHUOX-UHFFFAOYSA-N 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 206010006895 Cachexia Diseases 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 206010018364 Glomerulonephritis Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- ZAHXYMFVNNUHCP-UHFFFAOYSA-N Naphazoline nitrate Chemical group O[N+]([O-])=O.C=1C=CC2=CC=CC=C2C=1CC1=NCCN1 ZAHXYMFVNNUHCP-UHFFFAOYSA-N 0.000 claims 1
- 206010035664 Pneumonia Diseases 0.000 claims 1
- 206010036774 Proctitis Diseases 0.000 claims 1
- 206010036783 Proctitis ulcerative Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 claims 1
- 125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 206010009887 colitis Diseases 0.000 claims 1
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000014793 distal colitis Diseases 0.000 claims 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000008024 pharmaceutical diluent Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- JUJWROOIHBZHMG-UHFFFAOYSA-O pyridinium Chemical compound C1=CC=[NH+]C=C1 JUJWROOIHBZHMG-UHFFFAOYSA-O 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 125000000168 pyrrolyl group Chemical group 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 125000005247 tetrazinyl group Chemical group N1=NN=NC(=C1)* 0.000 claims 1
- 125000003831 tetrazolyl group Chemical group 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2007903531A AU2007903531A0 (en) | 2007-06-29 | 2-substituted isoflavonoid compounds, medicaments and uses | |
| PCT/AU2008/000960 WO2009003229A1 (en) | 2007-06-29 | 2008-06-30 | 2-substituted isoflavonoid compounds, medicaments and uses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010531811A JP2010531811A (ja) | 2010-09-30 |
| JP2010531811A5 true JP2010531811A5 (enExample) | 2011-09-29 |
Family
ID=40225642
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010513583A Pending JP2010531811A (ja) | 2007-06-29 | 2008-06-30 | ２−置換イソフラボノイド化合物、医薬及び使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20110166142A1 (enExample) |
| EP (1) | EP2160385A4 (enExample) |
| JP (1) | JP2010531811A (enExample) |
| AU (1) | AU2008271914A1 (enExample) |
| CA (1) | CA2691201A1 (enExample) |
| WO (1) | WO2009003229A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5735967B2 (ja) * | 2009-08-19 | 2015-06-17 | ユニバーシティー オブ ザ フリーステートＵｎｉｖｅｒｓｉｔｙ Ｏｆ Ｔｈｅ Ｆｒｅｅ Ｓｔａｔｅ | Ｃ環３位連結ビフラボノイド及びｃ環３位連結ビフラボノイドアナログの合成 |
| WO2011066606A1 (en) * | 2009-12-01 | 2011-06-09 | Novogen Research Pty Ltd | Pyranoindole compounds and uses thereof |
| GB201017315D0 (en) * | 2010-10-13 | 2010-11-24 | Antoxis Ltd | Compound |
| KR101363472B1 (ko) | 2011-03-30 | 2014-02-17 | 한국화학연구원 | 신규한 크로멘 유도체, 이의 약학적으로 허용가능한 염 또는 이의 이성질체, 이의 제조방법 및 이를 포함하는 ｐａｒ-1 관련 질환의 예방 또는 치료용 약학적 조성물 |
| KR101320945B1 (ko) * | 2012-07-03 | 2013-10-23 | 주식회사파마킹 | 에스-알릴-엘-시스테인을 유효성분으로 포함하는 대장염 예방 또는 치료용 조성물 및 이를 포함하는 의약제제 |
| EP3439644B1 (en) * | 2016-04-06 | 2022-01-12 | Noxopharm Limited | Isoflavonoid composition with improved pharmacokinetics |
| AU2017247006B2 (en) | 2016-04-06 | 2022-05-12 | Noxopharm Limited | Radiotherapy improvements |
| CN109475522A (zh) * | 2016-04-06 | 2019-03-15 | 讷克斯药物有限公司 | 改善癌症治疗 |
| JP2019513827A (ja) * | 2016-04-06 | 2019-05-30 | ノクソファーム リミティド | 標的化薬物送達 |
| CN110128384B (zh) * | 2019-06-19 | 2020-12-25 | 中国科学技术大学 | 一种多功能性的一氧化氮给体分子、聚合物及其制备方法和应用 |
| CN111039910A (zh) * | 2019-12-31 | 2020-04-21 | 云南大学 | 一种光引发的合成3-芳基黄酮或香豆素类化合物的方法及应用 |
| EP4125870A1 (en) | 2020-03-30 | 2023-02-08 | Noxopharm Limited | Methods for the treatment of inflammation associated with infection |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5395842A (en) * | 1988-10-31 | 1995-03-07 | Endorecherche Inc. | Anti-estrogenic compounds and compositions |
| AUPQ266199A0 (en) * | 1999-09-06 | 1999-09-30 | Novogen Research Pty Ltd | Compositions and therapeutic methods involving isoflavones and analogues thereof |
-
2008
- 2008-06-30 WO PCT/AU2008/000960 patent/WO2009003229A1/en not_active Ceased
- 2008-06-30 AU AU2008271914A patent/AU2008271914A1/en not_active Abandoned
- 2008-06-30 CA CA2691201A patent/CA2691201A1/en not_active Abandoned
- 2008-06-30 JP JP2010513583A patent/JP2010531811A/ja active Pending
- 2008-06-30 EP EP08772602A patent/EP2160385A4/en not_active Withdrawn
- 2008-06-30 US US12/666,657 patent/US20110166142A1/en not_active Abandoned