JP2010530369A5 - - Google Patents
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- JP2010530369A5 JP2010530369A5 JP2010511658A JP2010511658A JP2010530369A5 JP 2010530369 A5 JP2010530369 A5 JP 2010530369A5 JP 2010511658 A JP2010511658 A JP 2010511658A JP 2010511658 A JP2010511658 A JP 2010511658A JP 2010530369 A5 JP2010530369 A5 JP 2010530369A5
- Authority
- JP
- Japan
- Prior art keywords
- acid
- interferon
- cell
- irna agents
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07110376 | 2007-06-15 | ||
| EP07110376.6 | 2007-06-15 | ||
| EP07114265 | 2007-08-13 | ||
| EP07114265.7 | 2007-08-13 | ||
| PCT/EP2008/057476 WO2008152131A2 (en) | 2007-06-15 | 2008-06-13 | Rnai inhibition of alpha-enac expression |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014029519A Division JP5719047B2 (ja) | 2007-06-15 | 2014-02-19 | α−ENaC発現のRNAi阻害 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010530369A JP2010530369A (ja) | 2010-09-09 |
| JP2010530369A5 true JP2010530369A5 (enExample) | 2011-07-28 |
| JP5485146B2 JP5485146B2 (ja) | 2014-05-07 |
Family
ID=40130244
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010511658A Expired - Fee Related JP5485146B2 (ja) | 2007-06-15 | 2008-06-13 | α−ENaC発現のRNAi阻害 |
| JP2014029519A Expired - Fee Related JP5719047B2 (ja) | 2007-06-15 | 2014-02-19 | α−ENaC発現のRNAi阻害 |
| JP2015055783A Expired - Fee Related JP6193906B2 (ja) | 2007-06-15 | 2015-03-19 | α−ENaC発現のRNAi阻害 |
| JP2017149211A Expired - Fee Related JP6680728B2 (ja) | 2007-06-15 | 2017-08-01 | α−ENaC発現のRNAi阻害 |
| JP2020046007A Active JP7157775B2 (ja) | 2007-06-15 | 2020-03-17 | α-ENaC発現のRNAi阻害 |
| JP2022162309A Pending JP2022188234A (ja) | 2007-06-15 | 2022-10-07 | α-ENaC発現のRNAi阻害 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014029519A Expired - Fee Related JP5719047B2 (ja) | 2007-06-15 | 2014-02-19 | α−ENaC発現のRNAi阻害 |
| JP2015055783A Expired - Fee Related JP6193906B2 (ja) | 2007-06-15 | 2015-03-19 | α−ENaC発現のRNAi阻害 |
| JP2017149211A Expired - Fee Related JP6680728B2 (ja) | 2007-06-15 | 2017-08-01 | α−ENaC発現のRNAi阻害 |
| JP2020046007A Active JP7157775B2 (ja) | 2007-06-15 | 2020-03-17 | α-ENaC発現のRNAi阻害 |
| JP2022162309A Pending JP2022188234A (ja) | 2007-06-15 | 2022-10-07 | α-ENaC発現のRNAi阻害 |
Country Status (26)
| Country | Link |
|---|---|
| US (12) | US7718632B2 (enExample) |
| EP (7) | EP2224005B1 (enExample) |
| JP (6) | JP5485146B2 (enExample) |
| KR (2) | KR101821081B1 (enExample) |
| CN (1) | CN101778941B (enExample) |
| AR (1) | AR066984A1 (enExample) |
| AU (1) | AU2008263876B2 (enExample) |
| BR (1) | BRPI0813680A8 (enExample) |
| CA (1) | CA2690674C (enExample) |
| CL (1) | CL2008001756A1 (enExample) |
| CO (1) | CO6251331A2 (enExample) |
| CR (1) | CR11136A (enExample) |
| CU (1) | CU23774A3 (enExample) |
| EA (1) | EA200901653A1 (enExample) |
| EC (1) | ECSP099794A (enExample) |
| ES (6) | ES2432644T3 (enExample) |
| GT (1) | GT200900315A (enExample) |
| IL (1) | IL202366A0 (enExample) |
| MA (1) | MA31564B1 (enExample) |
| MX (1) | MX2009013609A (enExample) |
| PE (1) | PE20090942A1 (enExample) |
| SG (3) | SG169988A1 (enExample) |
| SV (1) | SV2009003434A (enExample) |
| TN (1) | TN2009000521A1 (enExample) |
| TW (3) | TWI552753B (enExample) |
| WO (1) | WO2008152131A2 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2322145T3 (es) * | 2002-07-26 | 2009-06-17 | Novartis Vaccines And Diagnostics, Inc. | Moleculas pequeñas modificadas de adn inerferente y procedimiento de uso. |
| KR100473148B1 (ko) * | 2002-11-27 | 2005-03-10 | (주)텔리언 | 버스트모드 패킷 전달을 위한 정합장치 및 방법 |
| US8765704B1 (en) | 2008-02-28 | 2014-07-01 | Novartis Ag | Modified small interfering RNA molecules and methods of use |
| JP2008514242A (ja) * | 2004-10-01 | 2008-05-08 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス, インコーポレイテッド | 改変型の小さい干渉rna分子および使用方法 |
| AR066984A1 (es) | 2007-06-15 | 2009-09-23 | Novartis Ag | Inhibicion de la expresion de la subunidad alfa del canal epitelial de sodio (enac) por medio de arni (arn de interferencia) |
| KR20110095391A (ko) * | 2008-11-26 | 2011-08-24 | 머크 샤프 앤드 돔 코포레이션 | 짧은 간섭 핵산 (siNA)을 사용한 상피 나트륨 채널 (ENaC) 유전자 발현의 RNA 간섭 매개 억제 |
| EP2756845B1 (en) * | 2009-04-03 | 2017-03-15 | Dicerna Pharmaceuticals, Inc. | Methods and compositions for the specific inhibition of KRAS by asymmetric double-stranded RNA |
| CN103275978B (zh) * | 2009-04-03 | 2014-10-29 | 百奥迈科生物技术有限公司 | 修饰的小干扰核酸及其制备方法 |
| WO2010111891A1 (zh) * | 2009-04-03 | 2010-10-07 | 北京大学 | 修饰的寡聚核酸分子及其制备方法和应用 |
| US20120207818A1 (en) * | 2009-07-14 | 2012-08-16 | Shinohara Fumikazu | Composition for suppressing expression of target gene |
| DK3252068T3 (da) * | 2009-10-12 | 2025-08-25 | Larry J Smith | Metoder og sammensætninger til modulering af genekspression ved anvendelse af oligonukleotidbaserede lægemidler administreret in vivo eller in vitro |
| MX339050B (es) | 2009-12-18 | 2016-05-09 | Novartis Ag | Composiciones organicas para tratar las enfermedades relacionadas con hsf1. |
| EP3061824B1 (en) * | 2010-04-23 | 2018-08-29 | Arrowhead Pharmaceuticals, Inc. | Organic compositions to treat beta-enac-related diseases |
| CN103703141B (zh) * | 2011-04-08 | 2016-08-17 | 伯乐实验室公司 | 具有降低的非特异性活性的pcr反应混合物 |
| EP2699271A4 (en) | 2011-04-20 | 2015-10-07 | Larry J Smith | METHODS AND COMPOSITIONS FOR MODULATING GENE EXPRESSION USING COMPONENTS THAT SELF-ASSEMBLED IN CELLS AND PRODUCE RNAI ACTIVITY |
| EP3693464A3 (en) * | 2011-06-21 | 2020-12-09 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibition of expression of apolipoprotein c-iii (apoc3) genes |
| WO2013030778A2 (en) | 2011-09-02 | 2013-03-07 | Novartis Ag | Organic compositions to treat hsf1-related diseases |
| JP7291624B2 (ja) | 2016-11-01 | 2023-06-15 | アローヘッド ファーマシューティカルズ インコーポレイテッド | アルファ-vベータ-6インテグリンリガンド及びその使用 |
| KR20200024793A (ko) * | 2017-07-06 | 2020-03-09 | 애로우헤드 파마슈티컬스 인코포레이티드 | 알파-ENaC의 발현을 억제하기 위한 RNAi 작용제 및 사용 방법 |
| CA3074739A1 (en) * | 2017-10-31 | 2019-05-09 | Ionis Pharmaceuticals, Inc. | Modulators of enac expression |
| BR112020006901A2 (pt) * | 2017-11-01 | 2020-10-13 | Arrowhead Pharmaceuticals, Inc. | ligantes de integrina e usos dos mesmos |
| CN109364248B (zh) * | 2018-10-16 | 2021-05-18 | 哈尔滨医科大学 | ENaC及其抑制剂在预防、缓解和/或治疗动脉粥样硬化中的应用 |
| EP4021413A4 (en) * | 2019-08-30 | 2023-07-05 | United States Government as Represented by The Department of Veterans Affairs | LIPOSOMAL TROPONOID COMBINATION FORMULATIONS |
| US12415840B2 (en) | 2020-02-21 | 2025-09-16 | Brookhaven Science Associates, Llc | Modified form of oleosin that when expressed in plants leads to increased triacylglycerol (oil) accumulation |
| EP4319765A1 (en) | 2021-04-08 | 2024-02-14 | Arrowhead Pharmaceuticals, Inc. | Rnai agents for inhibiting expression of receptor for advanced glycation end-products, compositions thereof, and methods of use |
| US11957178B2 (en) | 2021-11-15 | 2024-04-16 | Apackaging Group Llc | Aerosol actuator |
Family Cites Families (58)
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|---|---|---|---|---|
| US4426330A (en) * | 1981-07-20 | 1984-01-17 | Lipid Specialties, Inc. | Synthetic phospholipid compounds |
| US4534899A (en) * | 1981-07-20 | 1985-08-13 | Lipid Specialties, Inc. | Synthetic phospholipid compounds |
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US4837026A (en) * | 1985-10-03 | 1989-06-06 | Rajakhyaksha Vithal J | Transdermal and systemic preparation and method |
| DE3604625C2 (de) * | 1986-02-14 | 1994-01-20 | Bmw Rolls Royce Gmbh | Gasturbine |
| US4920016A (en) | 1986-12-24 | 1990-04-24 | Linear Technology, Inc. | Liposomes with enhanced circulation time |
| US4837028A (en) * | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5451670A (en) * | 1987-12-09 | 1995-09-19 | City Of Hope | Restriction fragment length polymorphism test for haplotyping domesticated fowl |
| GB8824593D0 (en) | 1988-10-20 | 1988-11-23 | Royal Free Hosp School Med | Liposomes |
| US5013566A (en) * | 1988-12-19 | 1991-05-07 | Sampson Michael James | Process for obtaining improved yields from plants used for hay making by using a coating agent |
| US5328470A (en) * | 1989-03-31 | 1994-07-12 | The Regents Of The University Of Michigan | Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor |
| US5356633A (en) * | 1989-10-20 | 1994-10-18 | Liposome Technology, Inc. | Method of treatment of inflamed tissues |
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| US5665710A (en) * | 1990-04-30 | 1997-09-09 | Georgetown University | Method of making liposomal oligodeoxynucleotide compositions |
| JP3220180B2 (ja) * | 1991-05-23 | 2001-10-22 | 三菱化学株式会社 | 薬剤含有タンパク質結合リポソーム |
| JP3351476B2 (ja) * | 1993-01-22 | 2002-11-25 | 三菱化学株式会社 | リン脂質誘導体及びそれを含有するリポソーム |
| RU2123492C1 (ru) * | 1993-02-19 | 1998-12-20 | Ниппон Синяку Ко., Лтд | Производные глицерина, средство для доставки физиологически активного вещества и фармацевтическая композиция |
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| JP3543347B2 (ja) * | 1994-01-24 | 2004-07-14 | 日本油脂株式会社 | 点火薬造粒物の製造方法 |
| US5543152A (en) * | 1994-06-20 | 1996-08-06 | Inex Pharmaceuticals Corporation | Sphingosomes for enhanced drug delivery |
| US5820873A (en) | 1994-09-30 | 1998-10-13 | The University Of British Columbia | Polyethylene glycol modified ceramide lipids and liposome uses thereof |
| US5756122A (en) | 1995-06-07 | 1998-05-26 | Georgetown University | Liposomally encapsulated nucleic acids having high entrapment efficiencies, method of manufacturer and use thereof for transfection of targeted cells |
| DE69629702T2 (de) | 1995-08-01 | 2004-06-17 | Isis Pharmaceuticals, Inc., Carlsbad | Liposomale oligonukleotidzusammensetzungen |
| US5858397A (en) | 1995-10-11 | 1999-01-12 | University Of British Columbia | Liposomal formulations of mitoxantrone |
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| JP4530335B2 (ja) * | 2004-02-03 | 2010-08-25 | 独立行政法人科学技術振興機構 | 膀胱に発現する上皮型ナトリウムチャネルに対する阻害薬 |
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| WO2007070509A2 (en) * | 2005-12-13 | 2007-06-21 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Epithelial sodium channel inhibiting agents and uses therefor |
| KR101133799B1 (ko) | 2006-08-18 | 2012-04-24 | 에프. 호프만-라 로슈 아게 | 폴리뉴클레오타이드의 생체내 전달을 위한 다가접합체 |
| AU2007306542B2 (en) | 2006-10-11 | 2013-08-01 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Influenza targets |
| AR066984A1 (es) * | 2007-06-15 | 2009-09-23 | Novartis Ag | Inhibicion de la expresion de la subunidad alfa del canal epitelial de sodio (enac) por medio de arni (arn de interferencia) |
-
2008
- 2008-06-12 AR ARP080102518A patent/AR066984A1/es not_active Application Discontinuation
- 2008-06-13 ES ES10163500T patent/ES2432644T3/es active Active
- 2008-06-13 TW TW103118914A patent/TWI552753B/zh not_active IP Right Cessation
- 2008-06-13 MX MX2009013609A patent/MX2009013609A/es active IP Right Grant
- 2008-06-13 SG SG201101084-0A patent/SG169988A1/en unknown
- 2008-06-13 TW TW105120348A patent/TWI629063B/zh not_active IP Right Cessation
- 2008-06-13 BR BRPI0813680A patent/BRPI0813680A8/pt not_active IP Right Cessation
- 2008-06-13 ES ES10163502T patent/ES2432532T3/es active Active
- 2008-06-13 AU AU2008263876A patent/AU2008263876B2/en not_active Ceased
- 2008-06-13 ES ES10163496T patent/ES2432643T3/es active Active
- 2008-06-13 CL CL2008001756A patent/CL2008001756A1/es unknown
- 2008-06-13 EP EP10163498.8A patent/EP2224005B1/en active Active
- 2008-06-13 ES ES10163501T patent/ES2432158T3/es active Active
- 2008-06-13 JP JP2010511658A patent/JP5485146B2/ja not_active Expired - Fee Related
- 2008-06-13 ES ES10163498.8T patent/ES2439277T3/es active Active
- 2008-06-13 EP EP08761002A patent/EP2171059A2/en not_active Withdrawn
- 2008-06-13 EA EA200901653A patent/EA200901653A1/ru unknown
- 2008-06-13 PE PE2008001013A patent/PE20090942A1/es not_active Application Discontinuation
- 2008-06-13 SG SG10201404955RA patent/SG10201404955RA/en unknown
- 2008-06-13 SG SG10201601846VA patent/SG10201601846VA/en unknown
- 2008-06-13 WO PCT/EP2008/057476 patent/WO2008152131A2/en not_active Ceased
- 2008-06-13 KR KR1020167023121A patent/KR101821081B1/ko not_active Expired - Fee Related
- 2008-06-13 EP EP10163500.1A patent/EP2223693B1/en active Active
- 2008-06-13 ES ES10163499T patent/ES2432157T3/es active Active
- 2008-06-13 EP EP10163502.7A patent/EP2223695B1/en active Active
- 2008-06-13 EP EP10163501.9A patent/EP2223694B1/en active Active
- 2008-06-13 CN CN2008801032623A patent/CN101778941B/zh active Active
- 2008-06-13 KR KR1020107000840A patent/KR101653008B1/ko active Active
- 2008-06-13 EP EP10163496.2A patent/EP2224004B1/en active Active
- 2008-06-13 TW TW097122240A patent/TWI444474B/zh not_active IP Right Cessation
- 2008-06-13 CA CA2690674A patent/CA2690674C/en active Active
- 2008-06-13 EP EP10163499.6A patent/EP2223692B1/en active Active
- 2008-06-16 US US12/140,112 patent/US7718632B2/en active Active
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2009
- 2009-11-26 IL IL202366A patent/IL202366A0/en unknown
- 2009-12-02 CR CR11136A patent/CR11136A/es not_active Application Discontinuation
- 2009-12-11 TN TNP2009000521A patent/TN2009000521A1/fr unknown
- 2009-12-11 GT GT200900315A patent/GT200900315A/es unknown
- 2009-12-11 EC EC2009009794A patent/ECSP099794A/es unknown
- 2009-12-11 CO CO09142201A patent/CO6251331A2/es not_active Application Discontinuation
- 2009-12-14 SV SV2009003434A patent/SV2009003434A/es unknown
- 2009-12-15 CU CU20090215A patent/CU23774A3/es not_active IP Right Cessation
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2010
- 2010-01-06 US US12/683,146 patent/US9074212B2/en active Active
- 2010-01-07 MA MA32484A patent/MA31564B1/fr unknown
- 2010-04-30 US US12/771,518 patent/US7939508B2/en active Active
- 2010-04-30 US US12/771,614 patent/US8168606B2/en not_active Expired - Fee Related
- 2010-04-30 US US12/771,470 patent/US7943592B2/en active Active
- 2010-04-30 US US12/771,566 patent/US8119612B2/en active Active
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2014
- 2014-02-19 JP JP2014029519A patent/JP5719047B2/ja not_active Expired - Fee Related
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2015
- 2015-03-19 JP JP2015055783A patent/JP6193906B2/ja not_active Expired - Fee Related
- 2015-06-03 US US14/729,104 patent/US9476052B2/en active Active
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2016
- 2016-09-09 US US15/260,824 patent/US9914927B2/en active Active
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2017
- 2017-08-01 JP JP2017149211A patent/JP6680728B2/ja not_active Expired - Fee Related
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2018
- 2018-01-18 US US15/874,396 patent/US10544418B2/en active Active
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2020
- 2020-01-24 US US16/752,325 patent/US11208662B2/en active Active
- 2020-03-17 JP JP2020046007A patent/JP7157775B2/ja active Active
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2021
- 2021-12-23 US US17/560,475 patent/US20220112505A1/en not_active Abandoned
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2022
- 2022-04-05 US US17/713,763 patent/US20220235361A1/en not_active Abandoned
- 2022-10-07 JP JP2022162309A patent/JP2022188234A/ja active Pending
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