ES2432644T3 - Inhibición mediante iARN de la expresión de alfa-ENaC - Google Patents

Inhibición mediante iARN de la expresión de alfa-ENaC Download PDF

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Publication number
ES2432644T3
ES2432644T3 ES10163500T ES10163500T ES2432644T3 ES 2432644 T3 ES2432644 T3 ES 2432644T3 ES 10163500 T ES10163500 T ES 10163500T ES 10163500 T ES10163500 T ES 10163500T ES 2432644 T3 ES2432644 T3 ES 2432644T3
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Prior art keywords
rnai agent
seq
enac
alpha
antisense strand
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ES10163500T
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English (en)
Spanish (es)
Inventor
Gino Van Heeke
Emma Hickman
Henry Luke Danahay
Pamela Tan
Anke Geick
Hans-Peter Vornlocher
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Novartis AG
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Novartis AG
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/713Double-stranded nucleic acids or oligonucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/12Drugs for disorders of the metabolism for electrolyte homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
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    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/14Type of nucleic acid interfering nucleic acids [NA]
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/31Chemical structure of the backbone
    • C12N2310/315Phosphorothioates
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/32Chemical structure of the sugar
    • C12N2310/3212'-O-R Modification
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    • C12N2310/00Structure or type of the nucleic acid
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    • C12N2310/3222'-R Modification
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    • C12N2310/00Structure or type of the nucleic acid
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
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    • C12N2310/3513Protein; Peptide
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    • C12N2310/3515Lipophilic moiety, e.g. cholesterol
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/35Nature of the modification
    • C12N2310/352Nature of the modification linked to the nucleic acid via a carbon atom
    • C12N2310/3521Methyl

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  • Veterinary Medicine (AREA)
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  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • General Chemical & Material Sciences (AREA)
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  • Wood Science & Technology (AREA)
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  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ES10163500T 2007-06-15 2008-06-13 Inhibición mediante iARN de la expresión de alfa-ENaC Active ES2432644T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP07110376 2007-06-15
EP07110376 2007-06-15
EP07114265 2007-08-13
EP07114265 2007-08-13

Publications (1)

Publication Number Publication Date
ES2432644T3 true ES2432644T3 (es) 2013-12-04

Family

ID=40130244

Family Applications (6)

Application Number Title Priority Date Filing Date
ES10163500T Active ES2432644T3 (es) 2007-06-15 2008-06-13 Inhibición mediante iARN de la expresión de alfa-ENaC
ES10163502T Active ES2432532T3 (es) 2007-06-15 2008-06-13 Inhibición de ARNi de la expresión alfa-ENaC
ES10163496T Active ES2432643T3 (es) 2007-06-15 2008-06-13 Inhibición de la expresión de la alfa-ENaC por medio de ARNi
ES10163501T Active ES2432158T3 (es) 2007-06-15 2008-06-13 Inhibición por ARNi de la expresión de alfa-ENaC
ES10163498.8T Active ES2439277T3 (es) 2007-06-15 2008-06-13 Inhibición de la expresión de la alfa-ENaC por medio de ARNi
ES10163499T Active ES2432157T3 (es) 2007-06-15 2008-06-13 Inhibición mediante iARN de la expresión de alfa-ENaC

Family Applications After (5)

Application Number Title Priority Date Filing Date
ES10163502T Active ES2432532T3 (es) 2007-06-15 2008-06-13 Inhibición de ARNi de la expresión alfa-ENaC
ES10163496T Active ES2432643T3 (es) 2007-06-15 2008-06-13 Inhibición de la expresión de la alfa-ENaC por medio de ARNi
ES10163501T Active ES2432158T3 (es) 2007-06-15 2008-06-13 Inhibición por ARNi de la expresión de alfa-ENaC
ES10163498.8T Active ES2439277T3 (es) 2007-06-15 2008-06-13 Inhibición de la expresión de la alfa-ENaC por medio de ARNi
ES10163499T Active ES2432157T3 (es) 2007-06-15 2008-06-13 Inhibición mediante iARN de la expresión de alfa-ENaC

Country Status (26)

Country Link
US (12) US7718632B2 (enExample)
EP (7) EP2224005B1 (enExample)
JP (6) JP5485146B2 (enExample)
KR (2) KR101821081B1 (enExample)
CN (1) CN101778941B (enExample)
AR (1) AR066984A1 (enExample)
AU (1) AU2008263876B2 (enExample)
BR (1) BRPI0813680A8 (enExample)
CA (1) CA2690674C (enExample)
CL (1) CL2008001756A1 (enExample)
CO (1) CO6251331A2 (enExample)
CR (1) CR11136A (enExample)
CU (1) CU23774A3 (enExample)
EA (1) EA200901653A1 (enExample)
EC (1) ECSP099794A (enExample)
ES (6) ES2432644T3 (enExample)
GT (1) GT200900315A (enExample)
IL (1) IL202366A0 (enExample)
MA (1) MA31564B1 (enExample)
MX (1) MX2009013609A (enExample)
PE (1) PE20090942A1 (enExample)
SG (3) SG169988A1 (enExample)
SV (1) SV2009003434A (enExample)
TN (1) TN2009000521A1 (enExample)
TW (3) TWI552753B (enExample)
WO (1) WO2008152131A2 (enExample)

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AR066984A1 (es) 2007-06-15 2009-09-23 Novartis Ag Inhibicion de la expresion de la subunidad alfa del canal epitelial de sodio (enac) por medio de arni (arn de interferencia)
KR20110095391A (ko) * 2008-11-26 2011-08-24 머크 샤프 앤드 돔 코포레이션 짧은 간섭 핵산 (siNA)을 사용한 상피 나트륨 채널 (ENaC) 유전자 발현의 RNA 간섭 매개 억제
EP2756845B1 (en) * 2009-04-03 2017-03-15 Dicerna Pharmaceuticals, Inc. Methods and compositions for the specific inhibition of KRAS by asymmetric double-stranded RNA
CN103275978B (zh) * 2009-04-03 2014-10-29 百奥迈科生物技术有限公司 修饰的小干扰核酸及其制备方法
WO2010111891A1 (zh) * 2009-04-03 2010-10-07 北京大学 修饰的寡聚核酸分子及其制备方法和应用
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MX339050B (es) 2009-12-18 2016-05-09 Novartis Ag Composiciones organicas para tratar las enfermedades relacionadas con hsf1.
EP3061824B1 (en) * 2010-04-23 2018-08-29 Arrowhead Pharmaceuticals, Inc. Organic compositions to treat beta-enac-related diseases
CN103703141B (zh) * 2011-04-08 2016-08-17 伯乐实验室公司 具有降低的非特异性活性的pcr反应混合物
EP2699271A4 (en) 2011-04-20 2015-10-07 Larry J Smith METHODS AND COMPOSITIONS FOR MODULATING GENE EXPRESSION USING COMPONENTS THAT SELF-ASSEMBLED IN CELLS AND PRODUCE RNAI ACTIVITY
EP3693464A3 (en) * 2011-06-21 2020-12-09 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibition of expression of apolipoprotein c-iii (apoc3) genes
WO2013030778A2 (en) 2011-09-02 2013-03-07 Novartis Ag Organic compositions to treat hsf1-related diseases
JP7291624B2 (ja) 2016-11-01 2023-06-15 アローヘッド ファーマシューティカルズ インコーポレイテッド アルファ-vベータ-6インテグリンリガンド及びその使用
KR20200024793A (ko) * 2017-07-06 2020-03-09 애로우헤드 파마슈티컬스 인코포레이티드 알파-ENaC의 발현을 억제하기 위한 RNAi 작용제 및 사용 방법
CA3074739A1 (en) * 2017-10-31 2019-05-09 Ionis Pharmaceuticals, Inc. Modulators of enac expression
BR112020006901A2 (pt) * 2017-11-01 2020-10-13 Arrowhead Pharmaceuticals, Inc. ligantes de integrina e usos dos mesmos
CN109364248B (zh) * 2018-10-16 2021-05-18 哈尔滨医科大学 ENaC及其抑制剂在预防、缓解和/或治疗动脉粥样硬化中的应用
EP4021413A4 (en) * 2019-08-30 2023-07-05 United States Government as Represented by The Department of Veterans Affairs LIPOSOMAL TROPONOID COMBINATION FORMULATIONS
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