JP2010529212A5 - - Google Patents
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- Publication number
- JP2010529212A5 JP2010529212A5 JP2009551999A JP2009551999A JP2010529212A5 JP 2010529212 A5 JP2010529212 A5 JP 2010529212A5 JP 2009551999 A JP2009551999 A JP 2009551999A JP 2009551999 A JP2009551999 A JP 2009551999A JP 2010529212 A5 JP2010529212 A5 JP 2010529212A5
- Authority
- JP
- Japan
- Prior art keywords
- poz
- compound
- group
- functional group
- active functional
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 18
- 229920000765 poly(2-oxazolines) Polymers 0.000 claims 18
- 125000000524 functional group Chemical group 0.000 claims 16
- 125000003342 alkenyl group Chemical group 0.000 claims 7
- 125000000547 substituted alkyl group Chemical group 0.000 claims 7
- 125000003710 aryl alkyl group Chemical group 0.000 claims 6
- 229920000642 polymer Polymers 0.000 claims 5
- 238000000034 method Methods 0.000 claims 4
- -1 n- propyl Chemical group 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 3
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 125000005647 linker group Chemical group 0.000 claims 3
- PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 239000012038 nucleophile Substances 0.000 claims 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- ZMZDMBWJUHKJPS-UHFFFAOYSA-M Thiocyanate anion Chemical compound [S-]C#N ZMZDMBWJUHKJPS-UHFFFAOYSA-M 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 150000001345 alkine derivatives Chemical class 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 150000001540 azides Chemical class 0.000 claims 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 claims 1
- PFKFTWBEEFSNDU-UHFFFAOYSA-N carbonyldiimidazole Chemical class C1=CN=CN1C(=O)N1C=CN=C1 PFKFTWBEEFSNDU-UHFFFAOYSA-N 0.000 claims 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 1
- 150000001768 cations Chemical class 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- HAGNOTPFDLDDCR-UHFFFAOYSA-N cyanic acid;isothiocyanic acid Chemical compound N=C=S.OC#N HAGNOTPFDLDDCR-UHFFFAOYSA-N 0.000 claims 1
- AFOSIXZFDONLBT-UHFFFAOYSA-N divinyl sulfone Chemical compound C=CS(=O)(=O)C=C AFOSIXZFDONLBT-UHFFFAOYSA-N 0.000 claims 1
- 150000002118 epoxides Chemical class 0.000 claims 1
- ZMZDMBWJUHKJPS-UHFFFAOYSA-N hydrogen thiocyanate Natural products SC#N ZMZDMBWJUHKJPS-UHFFFAOYSA-N 0.000 claims 1
- PGLTVOMIXTUURA-UHFFFAOYSA-N iodoacetamide Chemical compound NC(=O)CI PGLTVOMIXTUURA-UHFFFAOYSA-N 0.000 claims 1
- 239000012948 isocyanate Substances 0.000 claims 1
- 150000002513 isocyanates Chemical class 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 229910052751 metal Inorganic materials 0.000 claims 1
- 150000002825 nitriles Chemical class 0.000 claims 1
- 238000006116 polymerization reaction Methods 0.000 claims 1
- 230000002194 synthesizing effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89221207P | 2007-02-28 | 2007-02-28 | |
| US60/892,212 | 2007-02-28 | ||
| PCT/US2008/002626 WO2008106186A2 (en) | 2007-02-28 | 2008-02-28 | Activated polyoxazolines and compositions comprising the same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010529212A JP2010529212A (ja) | 2010-08-26 |
| JP2010529212A5 true JP2010529212A5 (https=) | 2011-04-07 |
| JP5615558B2 JP5615558B2 (ja) | 2014-10-29 |
Family
ID=39721806
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009551999A Active JP5615558B2 (ja) | 2007-02-28 | 2008-02-28 | 活性ポリオキサゾリンおよびそれを含む組成物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7943141B2 (https=) |
| EP (1) | EP2134181A4 (https=) |
| JP (1) | JP5615558B2 (https=) |
| KR (2) | KR101508621B1 (https=) |
| CN (2) | CN101686687A (https=) |
| WO (1) | WO2008106186A2 (https=) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8088884B2 (en) * | 2007-09-27 | 2012-01-03 | Serina Therapeutics, Inc. | Multi-armed forms of activated polyoxazoline and methods of synthesis thereof |
| US8110651B2 (en) | 2008-01-11 | 2012-02-07 | Serina Therapeutics, Inc. | Multifunctional forms of polyoxazoline copolymers and drug compositions comprising the same |
| US8101706B2 (en) | 2008-01-11 | 2012-01-24 | Serina Therapeutics, Inc. | Multifunctional forms of polyoxazoline copolymers and drug compositions comprising the same |
| KR101671537B1 (ko) | 2008-08-11 | 2016-11-01 | 넥타르 테라퓨틱스 | 다분지형 중합체 알카노에이트 컨쥬게이트 |
| WO2010080720A2 (en) | 2009-01-12 | 2010-07-15 | Nektar Therapeutics | Conjugates of a lysosomal enzyme moiety and a water soluble polymer |
| ES2866674T3 (es) | 2010-11-12 | 2021-10-19 | Nektar Therapeutics | Conjugados de una fracción de IL-2 y un polímero |
| US10894087B2 (en) | 2010-12-22 | 2021-01-19 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds |
| WO2012088422A1 (en) | 2010-12-22 | 2012-06-28 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of taxane-based compounds |
| US20140088021A1 (en) | 2011-05-27 | 2014-03-27 | Nektar Therapeutics | Water-Soluble Polymer-Linked Binding Moiety and Drug Compounds |
| WO2013020005A2 (en) * | 2011-08-03 | 2013-02-07 | Anp Technologies, Inc. | Oxazoline polymer compositions and use thereof |
| WO2013020079A2 (en) | 2011-08-04 | 2013-02-07 | Nektar Therapeutics | Conjugates of an il-11 moiety and a polymer |
| US8383093B1 (en) * | 2011-11-01 | 2013-02-26 | Serina Therapeutics, Inc. | Subcutaneous delivery of poly(oxazoline) conjugates |
| US9416228B2 (en) * | 2012-03-16 | 2016-08-16 | Bender Analytical Holding B.V. | Cross-linked polymers and medical products derived from nucleophilically activated polyoxazoline |
| ES2879430T3 (es) | 2012-11-15 | 2021-11-22 | Apellis Pharmaceuticals Inc | Análogos de compstatina de acción prolongada y composiciones y métodos relacionados |
| CN103897181B (zh) * | 2012-12-27 | 2017-02-08 | 张昊 | 聚合物、其制备方法和应用 |
| US9624191B2 (en) | 2014-03-24 | 2017-04-18 | International Business Machines Corporation | Cyclic carbonate monomers and ring opened polycarbonates therefrom |
| US9215876B2 (en) | 2014-03-24 | 2015-12-22 | International Business Machines Corporation | 1,3,6-dioxazocan-2-ones and antimicrobial cationic polycarbonates therefrom |
| GB201405391D0 (en) * | 2014-03-26 | 2014-05-07 | Applied Biomimetic As | Novel polymers and process for making membranes |
| MA39711A (fr) | 2014-04-03 | 2015-10-08 | Nektar Therapeutics | Conjugués d'une fraction d'il-15 et d'un polymère |
| CN107075115B (zh) * | 2014-07-18 | 2020-05-29 | 根特大学 | 一种用于制备均匀的高摩尔质量环亚氨醚聚合物的方法 |
| US10071168B2 (en) * | 2014-07-31 | 2018-09-11 | Serina Therapeutics, Inc. | Polyoxazoline antibody drug conjugates |
| BR112017006943B1 (pt) * | 2014-10-06 | 2020-12-01 | Gatt Technologies B.V | produto hemostático poroso adesivo de tecido |
| EP3359555B1 (en) | 2015-10-07 | 2023-12-20 | Apellis Pharmaceuticals, Inc. | Dosing regimens |
| AU2016335860B2 (en) | 2015-10-08 | 2023-08-10 | Nektar Therapeutics | Combination of an IL-2Rbeta-selective agonist and a long-acting IL-15 agonist |
| JP2020516607A (ja) | 2017-04-07 | 2020-06-11 | アペリス・ファーマシューティカルズ・インコーポレイテッドＡｐｅｌｌｉｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | 投与レジメンならびに関連組成物および方法 |
| US12036283B2 (en) | 2017-05-15 | 2024-07-16 | Nektar Therapeutics | Long-acting interleukin-15 receptor agonists and related immunotherapeutic compositions and methods |
| AU2018300069C1 (en) | 2017-07-11 | 2025-11-20 | Synthorx, Inc. | Incorporation of unnatural nucleotides and methods thereof |
| WO2019028419A1 (en) | 2017-08-03 | 2019-02-07 | Synthorx, Inc. | CYTOKINE CONJUGATES FOR THE TREATMENT OF PROLIFERATIVE AND INFECTIOUS DISEASES |
| EP3502217B1 (en) * | 2017-11-29 | 2020-05-27 | Infineum International Limited | Lubricating oil compositions |
| US10822569B2 (en) | 2018-02-15 | 2020-11-03 | Afton Chemical Corporation | Grafted polymer with soot handling properties |
| CA3091857A1 (en) | 2018-02-26 | 2019-08-29 | Synthorx, Inc. | Il-15 conjugates and uses thereof |
| US10851324B2 (en) | 2018-02-27 | 2020-12-01 | Afton Chemical Corporation | Grafted polymer with soot handling properties |
| CN110865055B (zh) * | 2018-08-27 | 2022-10-25 | 香港科技大学 | 无金属偶联方法、偶联物及其应用 |
| US10899989B2 (en) | 2018-10-15 | 2021-01-26 | Afton Chemical Corporation | Amino acid grafted polymer with soot handling properties |
| ES3059360T3 (en) | 2018-11-08 | 2026-03-19 | Synthorx Inc | Interleukin 10 conjugates and uses thereof |
| US11046908B2 (en) | 2019-01-11 | 2021-06-29 | Afton Chemical Corporation | Oxazoline modified dispersants |
| KR20260039812A (ko) | 2019-02-06 | 2026-03-20 | 신톡스, 인크. | Il-2 콘쥬게이트 및 이의 사용 방법 |
| US12485181B2 (en) | 2019-06-28 | 2025-12-02 | Serina Therapeutics (Al), Inc. | Polyoxazoline-drug conjugates with novel pharmacokinetic properties |
| EP4004085B1 (en) * | 2019-07-30 | 2025-07-30 | Cilag GmbH International | Polyoxazoline copolymer comprising calcium binding groups |
| MX2022002740A (es) | 2019-09-10 | 2022-03-25 | Synthorx Inc | Conjugados de il-2 y metodos de uso para tratar enfermedades autoinmunes. |
| CA3153644A1 (en) | 2019-09-30 | 2021-04-08 | Beijing Xuanyi Pharmasciences Co., Ltd. | Protein-macromolecule conjugates and methods of use thereof |
| AR121891A1 (es) | 2020-04-22 | 2022-07-20 | Merck Sharp & Dohme | CONJUGADOS DE INTERLEUCINA 2 HUMANA SESGADOS AL DÍMERO DEL RECEPTOR DE INTERLEUCINA 2 bgᶜ Y CONJUGADOS CON UN POLÍMERO HIDROSOLUBLE NO PEPTÍDICO |
| CN117098558A (zh) | 2021-02-09 | 2023-11-21 | 塞瑞纳治疗公司 | 聚噁唑啉-脂质缀合物及包含其的脂质纳米颗粒和药物组合物 |
| MX2024002726A (es) | 2021-09-03 | 2024-03-20 | CureVac SE | Nuevas nanoparticulas lipidicas para la administracion de acidos nucleicos. |
| WO2023031392A2 (en) | 2021-09-03 | 2023-03-09 | CureVac SE | Novel lipid nanoparticles for delivery of nucleic acids comprising phosphatidylserine |
| WO2023073228A1 (en) | 2021-10-29 | 2023-05-04 | CureVac SE | Improved circular rna for expressing therapeutic proteins |
| US20250099614A1 (en) | 2022-01-28 | 2025-03-27 | CureVac SE | Nucleic acid encoded transcription factor inhibitors |
| CN118900701A (zh) | 2022-01-31 | 2024-11-05 | 盖纳万科学有限公司 | 聚(烷基噁唑啉)-脂质缀合物及含有聚(烷基噁唑啉)-脂质缀合物的脂质颗粒 |
| CN114685784B (zh) * | 2022-04-26 | 2023-09-15 | 北京清科胜因生物科技有限公司 | 一种用于核酸递送的聚(2-噁唑啉)脂质与脂质纳米颗粒及应用 |
| CN114940756B (zh) * | 2022-06-02 | 2023-11-07 | 北京清科胜因生物科技有限公司 | 一种聚（2-噁唑啉）脂质与脂质纳米颗粒及应用 |
| WO2024098023A2 (en) | 2022-11-04 | 2024-05-10 | Sutro Biopharma, Inc. | Interferon alpha polypeptides and conjugates |
| KR20250153298A (ko) | 2023-03-08 | 2025-10-24 | 큐어백 에스이 | 핵산 전달을 위한 신규의 지질 나노입자 제형 |
| WO2024230934A1 (en) | 2023-05-11 | 2024-11-14 | CureVac SE | Therapeutic nucleic acid for the treatment of ophthalmic diseases |
| WO2025158385A1 (en) | 2024-01-25 | 2025-07-31 | Genzyme Corporation | Pegylated il-2 for suppressing adaptive immune response to gene therapy |
| CN118459756A (zh) * | 2024-05-07 | 2024-08-09 | 南京师范大学 | 一种温敏性材料和糖缀合物及其合成方法和在糖固相合成中的应用 |
| EP4656669A1 (en) | 2024-05-28 | 2025-12-03 | Arkema France | Fluorinated copolymers based on an oligo(2-oxazoline) macromonomer |
| WO2026055280A1 (en) | 2024-09-04 | 2026-03-12 | Sanofi | Interleukin 2 (il-2) and cd123 nk cell engager combination therapy |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2643403B2 (ja) * | 1989-01-10 | 1997-08-20 | 花王株式会社 | ポリ（ｎ―アシルアルキレンイミン）系共重合体及びその用途 |
| US5635571A (en) * | 1995-06-30 | 1997-06-03 | Cornell Research Foundation, Inc. | Polymerizable macromonomers and polymers prepared therefrom |
| US5672662A (en) * | 1995-07-07 | 1997-09-30 | Shearwater Polymers, Inc. | Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications |
| JP2004535401A (ja) * | 2001-05-21 | 2004-11-25 | ネクター セラピューティックス | 化学的に改変されたインスリンの肺投与 |
| US6908963B2 (en) * | 2001-10-09 | 2005-06-21 | Nektar Therapeutics Al, Corporation | Thioester polymer derivatives and method of modifying the N-terminus of a polypeptide therewith |
| ES2654819T3 (es) * | 2001-10-18 | 2018-02-15 | Nektar Therapeutics | Conjugados poliméricos de antagonistas de opioides |
| EP1480657A4 (en) * | 2002-02-01 | 2006-07-05 | Intradigm Corp | POLYMERS FOR ADMINISTERING PEPTIDES AND SMALL MOLECULES IN VIVO / I |
| JP4805911B2 (ja) * | 2004-03-15 | 2011-11-02 | ネクター セラピューティクス | Ｈｉｖ侵入阻害剤のポリマー系組成物及び複合体 |
| US8057821B2 (en) * | 2004-11-03 | 2011-11-15 | Egen, Inc. | Biodegradable cross-linked cationic multi-block copolymers for gene delivery and methods of making thereof |
| WO2007026932A1 (ja) * | 2005-09-01 | 2007-03-08 | Japan Science And Technology Agency | オキサゾリンのランダム共重合体 |
-
2008
- 2008-02-28 KR KR20137028233A patent/KR101508621B1/ko active Active
- 2008-02-28 US US12/529,001 patent/US7943141B2/en active Active
- 2008-02-28 JP JP2009551999A patent/JP5615558B2/ja active Active
- 2008-02-28 CN CN200880013983A patent/CN101686687A/zh active Pending
- 2008-02-28 EP EP08726203A patent/EP2134181A4/en not_active Withdrawn
- 2008-02-28 WO PCT/US2008/002626 patent/WO2008106186A2/en not_active Ceased
- 2008-02-28 KR KR20097020124A patent/KR101508617B1/ko active Active
- 2008-02-28 CN CN201610344386.7A patent/CN106046370A/zh active Pending
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