JP2010529212A5 - - Google Patents
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- Publication number
- JP2010529212A5 JP2010529212A5 JP2009551999A JP2009551999A JP2010529212A5 JP 2010529212 A5 JP2010529212 A5 JP 2010529212A5 JP 2009551999 A JP2009551999 A JP 2009551999A JP 2009551999 A JP2009551999 A JP 2009551999A JP 2010529212 A5 JP2010529212 A5 JP 2010529212A5
- Authority
- JP
- Japan
- Prior art keywords
- poz
- compound
- group
- functional group
- active functional
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 18
- 229920000765 poly(2-oxazolines) Polymers 0.000 claims 18
- 125000000524 functional group Chemical group 0.000 claims 16
- 125000003342 alkenyl group Chemical group 0.000 claims 7
- 125000000547 substituted alkyl group Chemical group 0.000 claims 7
- 125000003710 aryl alkyl group Chemical group 0.000 claims 6
- 229920000642 polymer Polymers 0.000 claims 5
- 238000000034 method Methods 0.000 claims 4
- -1 n- propyl Chemical group 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 3
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 125000005647 linker group Chemical group 0.000 claims 3
- PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 239000012038 nucleophile Substances 0.000 claims 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- ZMZDMBWJUHKJPS-UHFFFAOYSA-M Thiocyanate anion Chemical compound [S-]C#N ZMZDMBWJUHKJPS-UHFFFAOYSA-M 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 150000001345 alkine derivatives Chemical class 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 150000001540 azides Chemical class 0.000 claims 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 claims 1
- PFKFTWBEEFSNDU-UHFFFAOYSA-N carbonyldiimidazole Chemical class C1=CN=CN1C(=O)N1C=CN=C1 PFKFTWBEEFSNDU-UHFFFAOYSA-N 0.000 claims 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 1
- 150000001768 cations Chemical class 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- HAGNOTPFDLDDCR-UHFFFAOYSA-N cyanic acid;isothiocyanic acid Chemical compound N=C=S.OC#N HAGNOTPFDLDDCR-UHFFFAOYSA-N 0.000 claims 1
- AFOSIXZFDONLBT-UHFFFAOYSA-N divinyl sulfone Chemical compound C=CS(=O)(=O)C=C AFOSIXZFDONLBT-UHFFFAOYSA-N 0.000 claims 1
- 150000002118 epoxides Chemical class 0.000 claims 1
- ZMZDMBWJUHKJPS-UHFFFAOYSA-N hydrogen thiocyanate Natural products SC#N ZMZDMBWJUHKJPS-UHFFFAOYSA-N 0.000 claims 1
- PGLTVOMIXTUURA-UHFFFAOYSA-N iodoacetamide Chemical compound NC(=O)CI PGLTVOMIXTUURA-UHFFFAOYSA-N 0.000 claims 1
- 239000012948 isocyanate Substances 0.000 claims 1
- 150000002513 isocyanates Chemical class 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 229910052751 metal Inorganic materials 0.000 claims 1
- 150000002825 nitriles Chemical class 0.000 claims 1
- 238000006116 polymerization reaction Methods 0.000 claims 1
- 230000002194 synthesizing effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89221207P | 2007-02-28 | 2007-02-28 | |
| US60/892,212 | 2007-02-28 | ||
| PCT/US2008/002626 WO2008106186A2 (en) | 2007-02-28 | 2008-02-28 | Activated polyoxazolines and compositions comprising the same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010529212A JP2010529212A (ja) | 2010-08-26 |
| JP2010529212A5 true JP2010529212A5 (enExample) | 2011-04-07 |
| JP5615558B2 JP5615558B2 (ja) | 2014-10-29 |
Family
ID=39721806
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009551999A Active JP5615558B2 (ja) | 2007-02-28 | 2008-02-28 | 活性ポリオキサゾリンおよびそれを含む組成物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7943141B2 (enExample) |
| EP (1) | EP2134181A4 (enExample) |
| JP (1) | JP5615558B2 (enExample) |
| KR (2) | KR101508617B1 (enExample) |
| CN (2) | CN106046370A (enExample) |
| WO (1) | WO2008106186A2 (enExample) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009043027A2 (en) * | 2007-09-27 | 2009-04-02 | Serina Therapeutics, Inc. | Multi-armed forms of activated polyoxazoline and methods of synthesis thereof |
| US8101706B2 (en) | 2008-01-11 | 2012-01-24 | Serina Therapeutics, Inc. | Multifunctional forms of polyoxazoline copolymers and drug compositions comprising the same |
| JP5514736B2 (ja) | 2008-01-11 | 2014-06-04 | セリナ・セラピユーテイツクス・インコーポレーテツド | ポリオキサゾリン共重合体の多機能形態およびそれを含む薬物組成物 |
| AU2009282413B2 (en) | 2008-08-11 | 2014-07-17 | Nektar Therapeutics | Multi-arm polymeric alkanoate conjugates |
| US20110318322A1 (en) | 2009-01-12 | 2011-12-29 | Nektar Therapeutics | Conjugates of a Lysosomal Enzyme Moiety and a Water Soluble Polymer |
| WO2012065086A1 (en) | 2010-11-12 | 2012-05-18 | Nektar Therapeutics | Conjugates of an il-2 moiety and a polymer |
| WO2012088422A1 (en) | 2010-12-22 | 2012-06-28 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of taxane-based compounds |
| WO2012088445A1 (en) | 2010-12-22 | 2012-06-28 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds |
| US20140088021A1 (en) | 2011-05-27 | 2014-03-27 | Nektar Therapeutics | Water-Soluble Polymer-Linked Binding Moiety and Drug Compounds |
| US20160024252A1 (en) * | 2011-08-03 | 2016-01-28 | Anp Technologies, Inc. | Oxazoline Polymer Compositions and Use Thereof |
| WO2013020079A2 (en) | 2011-08-04 | 2013-02-07 | Nektar Therapeutics | Conjugates of an il-11 moiety and a polymer |
| US8383093B1 (en) | 2011-11-01 | 2013-02-26 | Serina Therapeutics, Inc. | Subcutaneous delivery of poly(oxazoline) conjugates |
| JP6178399B2 (ja) * | 2012-03-16 | 2017-08-09 | ベンデル アナリティカル ホールディング ビー．ブイ．Ｂｅｎｄｅｒ Ａｎａｌｙｔｉｃａｌ Ｈｏｌｄｉｎｇ Ｂ．Ｖ． | 求核的に活性化したポリオキサゾリンに由来する架橋ポリマー及び医療製品 |
| MX366404B (es) | 2012-11-15 | 2019-07-08 | Apellis Pharmaceuticals Inc | Analogos de compstatina de celula reactiva, de acción prolongada u objetivos y composiciones y metodos relacionados. |
| CN103897181B (zh) * | 2012-12-27 | 2017-02-08 | 张昊 | 聚合物、其制备方法和应用 |
| US9624191B2 (en) | 2014-03-24 | 2017-04-18 | International Business Machines Corporation | Cyclic carbonate monomers and ring opened polycarbonates therefrom |
| US9215876B2 (en) | 2014-03-24 | 2015-12-22 | International Business Machines Corporation | 1,3,6-dioxazocan-2-ones and antimicrobial cationic polycarbonates therefrom |
| GB201405391D0 (en) * | 2014-03-26 | 2014-05-07 | Applied Biomimetic As | Novel polymers and process for making membranes |
| MA39711A (fr) | 2014-04-03 | 2015-10-08 | Nektar Therapeutics | Conjugués d'une fraction d'il-15 et d'un polymère |
| EP3204442B1 (en) | 2014-07-18 | 2018-09-12 | Universiteit Gent | Method for the preparation of uniform, high molar mass cyclic imino ether polymers |
| CN106715533B (zh) * | 2014-07-31 | 2020-03-13 | 塞瑞纳治疗公司 | 聚恶唑啉抗体药物结合物 |
| CA2963057C (en) | 2014-10-06 | 2023-08-01 | Gatt Technologies B.V. | Tissue-adhesive porous haemostatic product |
| US11903994B2 (en) | 2015-10-07 | 2024-02-20 | Apellis Pharmaceuticals, Inc. | Dosing regimens |
| WO2017062832A1 (en) | 2015-10-08 | 2017-04-13 | Nektar Therapeutics | Combination of an il-2rbeta-selective agonist and a long-acting il-15 agonist |
| IL269844B2 (en) | 2017-04-07 | 2025-01-01 | Apellis Pharmaceuticals Inc | Dosage regimens and related compositions and methods |
| IL270634B2 (en) | 2017-05-15 | 2025-06-01 | Nektar Therapeutics | Long-acting interleukin-15 receptor agonists and related immunotherapeutic compositions and methods |
| JP7325341B2 (ja) | 2017-07-11 | 2023-08-14 | シンソークス，インク． | 非天然ヌクレオチドの組み込み及びその方法 |
| KR20240141853A (ko) | 2017-08-03 | 2024-09-27 | 신톡스, 인크. | 자가면역 질환의 치료를 위한 사이토카인 접합체 |
| EP3502217B1 (en) * | 2017-11-29 | 2020-05-27 | Infineum International Limited | Lubricating oil compositions |
| US10822569B2 (en) | 2018-02-15 | 2020-11-03 | Afton Chemical Corporation | Grafted polymer with soot handling properties |
| CN112004547A (zh) | 2018-02-26 | 2020-11-27 | 新索思股份有限公司 | Il-15缀合物及其用途 |
| US10851324B2 (en) | 2018-02-27 | 2020-12-01 | Afton Chemical Corporation | Grafted polymer with soot handling properties |
| CN110865055B (zh) * | 2018-08-27 | 2022-10-25 | 香港科技大学 | 无金属偶联方法、偶联物及其应用 |
| US10899989B2 (en) | 2018-10-15 | 2021-01-26 | Afton Chemical Corporation | Amino acid grafted polymer with soot handling properties |
| SG11202102930YA (en) | 2018-11-08 | 2021-04-29 | Synthorx Inc | Interleukin 10 conjugates and uses thereof |
| US11046908B2 (en) | 2019-01-11 | 2021-06-29 | Afton Chemical Corporation | Oxazoline modified dispersants |
| EP3923974A4 (en) | 2019-02-06 | 2023-02-08 | Synthorx, Inc. | IL-2 CONJUGATES AND METHODS OF USE THEREOF |
| US12485181B2 (en) | 2019-06-28 | 2025-12-02 | Serina Therapeutics (Al), Inc. | Polyoxazoline-drug conjugates with novel pharmacokinetic properties |
| EP4004085B1 (en) * | 2019-07-30 | 2025-07-30 | Cilag GmbH International | Polyoxazoline copolymer comprising calcium binding groups |
| US12234271B2 (en) | 2019-09-10 | 2025-02-25 | Synthorx, Inc. | Il-2 conjugates and methods of use to treat autoimmune diseases |
| CA3153644A1 (en) | 2019-09-30 | 2021-04-08 | Beijing Xuanyi Pharmasciences Co., Ltd. | Protein-macromolecule conjugates and methods of use thereof |
| PE20231648A1 (es) | 2020-04-22 | 2023-10-17 | Merck Sharp And Dohme Llc | CONJUGADOS DE INTERLEUCINA 2 HUMANA SESGADOS AL DIMERO DEL RECEPTOR DE INTERLEUCINA 2 byc Y CONJUGADOS CON UN POLIMERO HIDROSOLUBLE NO PEPTIDICO |
| US12233132B2 (en) | 2021-02-09 | 2025-02-25 | Serina Therapeutics, Inc. | Polyoxazoline-lipid conjugates and lipid nanoparticles and pharmaceutical compositions including same |
| US20240398933A1 (en) | 2021-09-03 | 2024-12-05 | CureVac SE | Novel lipid nanoparticles for delivery of nucleic acids comprising phosphatidylserine |
| US20240398940A1 (en) | 2021-09-03 | 2024-12-05 | CureVac SE | Novel lipid nanoparticles for delivery of nucleic acids |
| EP4422698A1 (en) | 2021-10-29 | 2024-09-04 | CureVac SE | Improved circular rna for expressing therapeutic proteins |
| US20250099614A1 (en) | 2022-01-28 | 2025-03-27 | CureVac SE | Nucleic acid encoded transcription factor inhibitors |
| CN118900701A (zh) | 2022-01-31 | 2024-11-05 | 盖纳万科学有限公司 | 聚(烷基噁唑啉)-脂质缀合物及含有聚(烷基噁唑啉)-脂质缀合物的脂质颗粒 |
| CN114685784B (zh) * | 2022-04-26 | 2023-09-15 | 北京清科胜因生物科技有限公司 | 一种用于核酸递送的聚(2-噁唑啉)脂质与脂质纳米颗粒及应用 |
| CN114940756B (zh) * | 2022-06-02 | 2023-11-07 | 北京清科胜因生物科技有限公司 | 一种聚（2-噁唑啉）脂质与脂质纳米颗粒及应用 |
| WO2024098023A2 (en) | 2022-11-04 | 2024-05-10 | Sutro Biopharma, Inc. | Interferon alpha polypeptides and conjugates |
| WO2024184500A1 (en) | 2023-03-08 | 2024-09-12 | CureVac SE | Novel lipid nanoparticle formulations for delivery of nucleic acids |
| WO2024230934A1 (en) | 2023-05-11 | 2024-11-14 | CureVac SE | Therapeutic nucleic acid for the treatment of ophthalmic diseases |
| WO2025158385A1 (en) | 2024-01-25 | 2025-07-31 | Genzyme Corporation | Pegylated il-2 for suppressing adaptive immune response to gene therapy |
| CN118459756A (zh) * | 2024-05-07 | 2024-08-09 | 南京师范大学 | 一种温敏性材料和糖缀合物及其合成方法和在糖固相合成中的应用 |
| EP4656669A1 (en) | 2024-05-28 | 2025-12-03 | Arkema France | Fluorinated copolymers based on an oligo(2-oxazoline) macromonomer |
| WO2026055280A1 (en) | 2024-09-04 | 2026-03-12 | Sanofi | Interleukin 2 (il-2) and cd123 nk cell engager combination therapy |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2643403B2 (ja) * | 1989-01-10 | 1997-08-20 | 花王株式会社 | ポリ（ｎ―アシルアルキレンイミン）系共重合体及びその用途 |
| US5635571A (en) * | 1995-06-30 | 1997-06-03 | Cornell Research Foundation, Inc. | Polymerizable macromonomers and polymers prepared therefrom |
| US5672662A (en) * | 1995-07-07 | 1997-09-30 | Shearwater Polymers, Inc. | Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications |
| CZ20033182A3 (cs) * | 2001-05-21 | 2004-09-15 | Nektar Therapeutics | Inzulínový prostředek a způsob podávání inzulínu |
| US6908963B2 (en) * | 2001-10-09 | 2005-06-21 | Nektar Therapeutics Al, Corporation | Thioester polymer derivatives and method of modifying the N-terminus of a polypeptide therewith |
| ES2654819T3 (es) * | 2001-10-18 | 2018-02-15 | Nektar Therapeutics | Conjugados poliméricos de antagonistas de opioides |
| WO2003066069A1 (en) * | 2002-02-01 | 2003-08-14 | Intradigm Corporation | Polymers for delivering peptides and small molecules in vivo |
| KR101276422B1 (ko) * | 2004-03-15 | 2013-06-19 | 넥타르 테라퓨틱스 | Ｈｉｖ 유입 억제제의 중합체-기재 조성물 및 콘쥬게이트 |
| US8057821B2 (en) * | 2004-11-03 | 2011-11-15 | Egen, Inc. | Biodegradable cross-linked cationic multi-block copolymers for gene delivery and methods of making thereof |
| EP1930361B1 (en) * | 2005-09-01 | 2014-04-16 | Japan Science and Technology Agency | Random copolymer of oxazoline |
-
2008
- 2008-02-28 EP EP08726203A patent/EP2134181A4/en not_active Withdrawn
- 2008-02-28 CN CN201610344386.7A patent/CN106046370A/zh active Pending
- 2008-02-28 KR KR20097020124A patent/KR101508617B1/ko active Active
- 2008-02-28 WO PCT/US2008/002626 patent/WO2008106186A2/en not_active Ceased
- 2008-02-28 JP JP2009551999A patent/JP5615558B2/ja active Active
- 2008-02-28 US US12/529,001 patent/US7943141B2/en active Active
- 2008-02-28 CN CN200880013983A patent/CN101686687A/zh active Pending
- 2008-02-28 KR KR20137028233A patent/KR101508621B1/ko active Active
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