CN101686687A - 活化的聚噁唑啉及包含该聚噁唑啉的组合物 - Google Patents

活化的聚噁唑啉及包含该聚噁唑啉的组合物 Download PDF

Info

Publication number
CN101686687A
CN101686687A CN200880013983A CN200880013983A CN101686687A CN 101686687 A CN101686687 A CN 101686687A CN 200880013983 A CN200880013983 A CN 200880013983A CN 200880013983 A CN200880013983 A CN 200880013983A CN 101686687 A CN101686687 A CN 101686687A
Authority
CN
China
Prior art keywords
poz
compound
group
unsubstituted
target molecule
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN200880013983A
Other languages
English (en)
Chinese (zh)
Inventor
J.·米尔顿·哈里斯
迈克尔·大卫·本特利
尹君尚
方志浩
弗朗西斯科·玛丽亚·委罗内塞
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Serina Therapeutics Inc
Original Assignee
Serina Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Serina Therapeutics Inc filed Critical Serina Therapeutics Inc
Priority to CN201610344386.7A priority Critical patent/CN106046370A/zh
Publication of CN101686687A publication Critical patent/CN101686687A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/06—Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromolecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A61K31/787—Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
    • C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
    • C07D207/448—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide
    • C07D207/452—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide with hydrocarbon radicals, substituted by hetero atoms, directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/0233—Polyamines derived from (poly)oxazolines, (poly)oxazines or having pendant acyl groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/16—Nitrogen-containing compounds
    • C08K5/34—Heterocyclic compounds having nitrogen in the ring
    • C08K5/3412—Heterocyclic compounds having nitrogen in the ring having one nitrogen atom in the ring
    • C08K5/3415—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L79/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing nitrogen with or without oxygen or carbon only, not provided for in groups C08L61/00 - C08L77/00
    • C08L79/02—Polyamines
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L79/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing nitrogen with or without oxygen or carbon only, not provided for in groups C08L61/00 - C08L77/00
    • C08L79/04—Polycondensates having nitrogen-containing heterocyclic rings in the main chain; Polyhydrazides; Polyamide acids or similar polyimide precursors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Pyrrole Compounds (AREA)
  • Polyethers (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
CN200880013983A 2007-02-28 2008-02-28 活化的聚噁唑啉及包含该聚噁唑啉的组合物 Pending CN101686687A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610344386.7A CN106046370A (zh) 2007-02-28 2008-02-28 聚噁唑啉poz化合物、合成其的方法、以及靶分子‑poz偶联物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US89221207P 2007-02-28 2007-02-28
US60/892,212 2007-02-28
PCT/US2008/002626 WO2008106186A2 (en) 2007-02-28 2008-02-28 Activated polyoxazolines and compositions comprising the same

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201610344386.7A Division CN106046370A (zh) 2007-02-28 2008-02-28 聚噁唑啉poz化合物、合成其的方法、以及靶分子‑poz偶联物

Publications (1)

Publication Number Publication Date
CN101686687A true CN101686687A (zh) 2010-03-31

Family

ID=39721806

Family Applications (2)

Application Number Title Priority Date Filing Date
CN200880013983A Pending CN101686687A (zh) 2007-02-28 2008-02-28 活化的聚噁唑啉及包含该聚噁唑啉的组合物
CN201610344386.7A Pending CN106046370A (zh) 2007-02-28 2008-02-28 聚噁唑啉poz化合物、合成其的方法、以及靶分子‑poz偶联物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201610344386.7A Pending CN106046370A (zh) 2007-02-28 2008-02-28 聚噁唑啉poz化合物、合成其的方法、以及靶分子‑poz偶联物

Country Status (6)

Country Link
US (1) US7943141B2 (enExample)
EP (1) EP2134181A4 (enExample)
JP (1) JP5615558B2 (enExample)
KR (2) KR101508621B1 (enExample)
CN (2) CN101686687A (enExample)
WO (1) WO2008106186A2 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103897181A (zh) * 2012-12-27 2014-07-02 张昊 聚合物、其制备方法和应用
CN107075115A (zh) * 2014-07-18 2017-08-18 根特大学 一种用于制备均匀的高摩尔质量环亚氨醚聚合物的方法
CN107106719A (zh) * 2014-10-06 2017-08-29 加特技术公司 组织粘合性多孔止血产品

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009043027A2 (en) * 2007-09-27 2009-04-02 Serina Therapeutics, Inc. Multi-armed forms of activated polyoxazoline and methods of synthesis thereof
US8101706B2 (en) 2008-01-11 2012-01-24 Serina Therapeutics, Inc. Multifunctional forms of polyoxazoline copolymers and drug compositions comprising the same
CN101959934B (zh) 2008-01-11 2012-12-12 塞瑞纳治疗公司 聚噁唑啉共聚物的多官能形式和包含它的药物组合物
KR101671537B1 (ko) 2008-08-11 2016-11-01 넥타르 테라퓨틱스 다분지형 중합체 알카노에이트 컨쥬게이트
US20110318322A1 (en) 2009-01-12 2011-12-29 Nektar Therapeutics Conjugates of a Lysosomal Enzyme Moiety and a Water Soluble Polymer
RS61854B1 (sr) 2010-11-12 2021-06-30 Nektar Therapeutics Konjugati il-2 dela i polimera
WO2012088445A1 (en) 2010-12-22 2012-06-28 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds
WO2012088422A1 (en) 2010-12-22 2012-06-28 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of taxane-based compounds
WO2012166555A1 (en) 2011-05-27 2012-12-06 Nektar Therapeutics Water - soluble polymer - linked binding moiety and drug compounds
US20160024252A1 (en) * 2011-08-03 2016-01-28 Anp Technologies, Inc. Oxazoline Polymer Compositions and Use Thereof
WO2013020079A2 (en) 2011-08-04 2013-02-07 Nektar Therapeutics Conjugates of an il-11 moiety and a polymer
US8383093B1 (en) 2011-11-01 2013-02-26 Serina Therapeutics, Inc. Subcutaneous delivery of poly(oxazoline) conjugates
US9416228B2 (en) * 2012-03-16 2016-08-16 Bender Analytical Holding B.V. Cross-linked polymers and medical products derived from nucleophilically activated polyoxazoline
PT2920201T (pt) 2012-11-15 2020-04-03 Apellis Pharmaceuticals Inc Análogos de compstatina de longa ação e composições e métodos relacionados
US9624191B2 (en) 2014-03-24 2017-04-18 International Business Machines Corporation Cyclic carbonate monomers and ring opened polycarbonates therefrom
US9215876B2 (en) 2014-03-24 2015-12-22 International Business Machines Corporation 1,3,6-dioxazocan-2-ones and antimicrobial cationic polycarbonates therefrom
GB201405391D0 (en) * 2014-03-26 2014-05-07 Applied Biomimetic As Novel polymers and process for making membranes
MA39711A (fr) 2014-04-03 2015-10-08 Nektar Therapeutics Conjugués d'une fraction d'il-15 et d'un polymère
CA2956709A1 (en) * 2014-07-31 2016-02-04 Serina Therapeutics, Inc. Polyoxazoline antibody drug conjugates
MX392574B (es) 2015-10-07 2025-03-24 Apellis Pharmaceuticals Inc Análogos de compstatina de acción prolongada para usarse en el tratamiento de trastornos oculares
US12233104B2 (en) 2015-10-08 2025-02-25 Nektar Therapeutics Combination of an IL-2RBETA-selective agonist and a long-acting IL-15 agonist
KR20190139931A (ko) 2017-04-07 2019-12-18 아펠리스 파마슈티컬스 인코포레이티드 투여 요법 및 관련 조성물 및 방법
US12036283B2 (en) 2017-05-15 2024-07-16 Nektar Therapeutics Long-acting interleukin-15 receptor agonists and related immunotherapeutic compositions and methods
JP7325341B2 (ja) 2017-07-11 2023-08-14 シンソークス，インク． 非天然ヌクレオチドの組み込み及びその方法
BR112020002272A2 (pt) 2017-08-03 2020-07-28 Synthorx, Inc. conjugados de citocina para o tratamento de doenças autoimunes
EP3502217B1 (en) * 2017-11-29 2020-05-27 Infineum International Limited Lubricating oil compositions
US10822569B2 (en) 2018-02-15 2020-11-03 Afton Chemical Corporation Grafted polymer with soot handling properties
KR102812714B1 (ko) 2018-02-26 2025-05-27 신톡스, 인크. Il-15 접합체 및 이의 용도
US10851324B2 (en) 2018-02-27 2020-12-01 Afton Chemical Corporation Grafted polymer with soot handling properties
CN110865055B (zh) * 2018-08-27 2022-10-25 香港科技大学 无金属偶联方法、偶联物及其应用
US10899989B2 (en) 2018-10-15 2021-01-26 Afton Chemical Corporation Amino acid grafted polymer with soot handling properties
JP7636323B2 (ja) 2018-11-08 2025-02-26 シンソークス， インコーポレイテッド インターロイキン１０コンジュゲートおよびその使用
US11046908B2 (en) 2019-01-11 2021-06-29 Afton Chemical Corporation Oxazoline modified dispersants
CN113660946A (zh) 2019-02-06 2021-11-16 新索思股份有限公司 Il-2缀合物及其使用方法
US12485181B2 (en) 2019-06-28 2025-12-02 Serina Therapeutics (Al), Inc. Polyoxazoline-drug conjugates with novel pharmacokinetic properties
EP4004085B1 (en) * 2019-07-30 2025-07-30 Cilag GmbH International Polyoxazoline copolymer comprising calcium binding groups
JP7758662B2 (ja) 2019-09-10 2025-10-22 シンソークス， インコーポレイテッド Ｉｌ－２コンジュゲートおよび自己免疫疾患を治療するための使用方法
TW202203973A (zh) 2020-04-22 2022-02-01 美商默沙東藥廠 對介白素-2受體βγc二聚體具偏性且結合至非肽、水溶性聚合物之人類介白素-2結合物
CA3206128A1 (en) 2021-02-09 2022-08-18 J. Milton Harris Polyoxazoline-lipid conjugates and lipid nanoparticles and pharmaceutical compositions including same
MX2024002725A (es) 2021-09-03 2024-03-15 CureVac SE Nuevas nanoparticulas lipidicas para la administracion de acidos nucleicos que comprenden fosfatidilserina.
WO2023031394A1 (en) 2021-09-03 2023-03-09 CureVac SE Novel lipid nanoparticles for delivery of nucleic acids
EP4422698A1 (en) 2021-10-29 2024-09-04 CureVac SE Improved circular rna for expressing therapeutic proteins
WO2023144330A1 (en) 2022-01-28 2023-08-03 CureVac SE Nucleic acid encoded transcription factor inhibitors
CA3248399A1 (en) 2022-01-31 2023-08-03 Genevant Sciences Gmbh POLY(ALKYLOXAZOLINE)-LIPIDS CONJUGATES AND LIPID PARTICLES CONTAINING THEM
CN114685784B (zh) * 2022-04-26 2023-09-15 北京清科胜因生物科技有限公司 一种用于核酸递送的聚(2-噁唑啉)脂质与脂质纳米颗粒及应用
CN114940756B (zh) * 2022-06-02 2023-11-07 北京清科胜因生物科技有限公司 一种聚（2-噁唑啉）脂质与脂质纳米颗粒及应用
WO2024098023A2 (en) 2022-11-04 2024-05-10 Sutro Biopharma, Inc. Interferon alpha polypeptides and conjugates
AU2024233180A1 (en) 2023-03-08 2025-09-25 CureVac SE Novel lipid nanoparticle formulations for delivery of nucleic acids
WO2024230934A1 (en) 2023-05-11 2024-11-14 CureVac SE Therapeutic nucleic acid for the treatment of ophthalmic diseases
WO2025158385A1 (en) 2024-01-25 2025-07-31 Genzyme Corporation Pegylated il-2 for suppressing adaptive immune response to gene therapy
EP4656669A1 (en) 2024-05-28 2025-12-03 Arkema France Fluorinated copolymers based on an oligo(2-oxazoline) macromonomer

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2643403B2 (ja) * 1989-01-10 1997-08-20 花王株式会社 ポリ（ｎ―アシルアルキレンイミン）系共重合体及びその用途
US5635571A (en) * 1995-06-30 1997-06-03 Cornell Research Foundation, Inc. Polymerizable macromonomers and polymers prepared therefrom
US5672662A (en) * 1995-07-07 1997-09-30 Shearwater Polymers, Inc. Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
AR033903A1 (es) * 2001-05-21 2004-01-07 Inhale Therapeutic Syst Una composicion de insulina modificada quimicamente para la administracion pulmonar
US6908963B2 (en) * 2001-10-09 2005-06-21 Nektar Therapeutics Al, Corporation Thioester polymer derivatives and method of modifying the N-terminus of a polypeptide therewith
US7056500B2 (en) * 2001-10-18 2006-06-06 Nektar Therapeutics Al, Corporation Polymer conjugates of opioid antagonists
WO2003066069A1 (en) * 2002-02-01 2003-08-14 Intradigm Corporation Polymers for delivering peptides and small molecules in vivo
KR101276422B1 (ko) * 2004-03-15 2013-06-19 넥타르 테라퓨틱스 Ｈｉｖ 유입 억제제의 중합체-기재 조성물 및 콘쥬게이트
US8057821B2 (en) * 2004-11-03 2011-11-15 Egen, Inc. Biodegradable cross-linked cationic multi-block copolymers for gene delivery and methods of making thereof
EP1930361B1 (en) * 2005-09-01 2014-04-16 Japan Science and Technology Agency Random copolymer of oxazoline

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GING-HO HSIUE,ET AL.: "Nonviral Gene Carriers Based on Diblock Copolymers of Poly(2-ethyl-2-oxazoline)", 《BIOCONJUGATE CHEM》 *
MASATOSHI MIYAMOTO ET AL.: "Preparation and Enzymatic Activity of Poly[ (N-acy1imino)ethylenel-Modified Catalase", 《MACROMOLECULES》 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103897181A (zh) * 2012-12-27 2014-07-02 张昊 聚合物、其制备方法和应用
CN103897181B (zh) * 2012-12-27 2017-02-08 张昊 聚合物、其制备方法和应用
CN107075115A (zh) * 2014-07-18 2017-08-18 根特大学 一种用于制备均匀的高摩尔质量环亚氨醚聚合物的方法
CN107075115B (zh) * 2014-07-18 2020-05-29 根特大学 一种用于制备均匀的高摩尔质量环亚氨醚聚合物的方法
CN107106719A (zh) * 2014-10-06 2017-08-29 加特技术公司 组织粘合性多孔止血产品

Also Published As

Publication number Publication date
US20100069579A1 (en) 2010-03-18
KR20090114481A (ko) 2009-11-03
KR101508621B1 (ko) 2015-04-07
JP5615558B2 (ja) 2014-10-29
WO2008106186A2 (en) 2008-09-04
EP2134181A2 (en) 2009-12-23
CN106046370A (zh) 2016-10-26
WO2008106186A3 (en) 2008-10-23
EP2134181A4 (en) 2011-09-28
KR20130125404A (ko) 2013-11-18
JP2010529212A (ja) 2010-08-26
KR101508617B1 (ko) 2015-04-06
US7943141B2 (en) 2011-05-17

Similar Documents

Publication Publication Date Title
CN101686687A (zh) 活化的聚噁唑啉及包含该聚噁唑啉的组合物
CN101959934B (zh) 聚噁唑啉共聚物的多官能形式和包含它的药物组合物
US8088884B2 (en) Multi-armed forms of activated polyoxazoline and methods of synthesis thereof
KR100499655B1 (ko) 헤테로 이작용성 폴리(에틸렌 글리콜) 유도체 및 그의제조 방법
JP4877225B2 (ja) ポリオキシアルキレン誘導体
JP5480257B2 (ja) 実質的に単分散のオリゴマー混合物の合成方法
US20190070301A1 (en) Activated polyoxazolines and conjugates and compositions comprising the same
Li et al. Recent Advances in Post‐polymerization Modifications on Polypeptides: Synthesis and Applications
Li et al. A facile synthesis of branched poly (ethylene glycol) and its heterobifunctional derivatives
Chen et al. High-fidelity propionaldehyde functionalized Poly (ethylene glycol): Synthesis and applications
JP6361083B2 (ja) ヘテロ二官能性ポリエチレングリコール誘導体およびその調製方法
Kuhlmann Sulfur-functional polymers for biomedical applications
JP2018115338A (ja) ヘテロ二官能性ポリエチレングリコール誘導体およびその調製方法
Lin Synthesis of Poly (ethylene glycol) Derivatives for Bioconjugation and Surface Patterning

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C12 Rejection of a patent application after its publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20100331