JP2010529193A5 - - Google Patents
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- JP2010529193A5 JP2010529193A5 JP2010512173A JP2010512173A JP2010529193A5 JP 2010529193 A5 JP2010529193 A5 JP 2010529193A5 JP 2010512173 A JP2010512173 A JP 2010512173A JP 2010512173 A JP2010512173 A JP 2010512173A JP 2010529193 A5 JP2010529193 A5 JP 2010529193A5
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- Prior art keywords
- cancer
- disease
- compound
- salt
- prodrug
- Prior art date
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93406207P | 2007-06-11 | 2007-06-11 | |
| US99047507P | 2007-11-27 | 2007-11-27 | |
| PCT/US2008/007288 WO2008154026A1 (en) | 2007-06-11 | 2008-06-11 | Substituted pyrazole compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010529193A JP2010529193A (ja) | 2010-08-26 |
| JP2010529193A5 true JP2010529193A5 (enExample) | 2011-03-10 |
Family
ID=40130080
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010512173A Pending JP2010529193A (ja) | 2007-06-11 | 2008-06-11 | 置換ピラゾール化合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20090029992A1 (enExample) |
| EP (1) | EP2166849A4 (enExample) |
| JP (1) | JP2010529193A (enExample) |
| AU (1) | AU2008262291A1 (enExample) |
| CA (1) | CA2683152A1 (enExample) |
| WO (1) | WO2008154026A1 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6067226B2 (ja) | 2009-03-13 | 2017-01-25 | アジオス ファーマシューティカルズ, インコーポレイテッド | 細胞増殖関連疾患のための方法および組成物 |
| AR077292A1 (es) | 2009-06-29 | 2011-08-17 | Agios Pharmaceuticals Inc | Derivados de piperazin - quinolin sulfonamidas y composiciones farmaceuticas |
| EP2483406A2 (en) | 2009-09-30 | 2012-08-08 | President and Fellows of Harvard College | Methods for modulation of autophagy through the modulation of autophagy-inhibiting gene products |
| ES2594402T3 (es) | 2009-10-21 | 2016-12-20 | Agios Pharmaceuticals, Inc. | Métodos y composiciones para trastornos relacionados con la proliferación celular |
| AU2012236834B2 (en) | 2011-03-28 | 2015-12-10 | Mei Pharma, Inc | (alpha- substituted aralkylamino and heteroarylalkylamino) pyrimidinyl and 1,3,5 -triazinyl benzimidazoles, pharmaceutical compositions containing them, and these compounds for use in treating proliferative diseases |
| HUE065700T2 (hu) | 2011-05-03 | 2024-06-28 | Agios Pharmaceuticals Inc | Piruvát-kináz aktivátorok terápiában történõ alkalmazásra |
| CN102827170A (zh) | 2011-06-17 | 2012-12-19 | 安吉奥斯医药品有限公司 | 治疗活性组合物和它们的使用方法 |
| CN102827073A (zh) | 2011-06-17 | 2012-12-19 | 安吉奥斯医药品有限公司 | 治疗活性组合物和它们的使用方法 |
| CA2860623A1 (en) | 2012-01-06 | 2013-07-11 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| US9474779B2 (en) | 2012-01-19 | 2016-10-25 | Agios Pharmaceuticals, Inc. | Therapeutically active compositions and their methods of use |
| US8916555B2 (en) | 2012-03-16 | 2014-12-23 | Axikin Pharmaceuticals, Inc. | 3,5-diaminopyrazole kinase inhibitors |
| JP6385352B2 (ja) | 2012-10-15 | 2018-09-05 | アジオス ファーマシューティカルズ, インコーポレイテッド | 治療化合物および組成物 |
| AU2014287121B2 (en) * | 2013-07-11 | 2018-11-15 | Agios Pharmaceuticals, Inc. | 2,4- or 4,6-diaminopyrimidine compounds as IDH2 mutants inhibitors for the treatment of cancer |
| WO2015003360A2 (en) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| SG11201600058XA (en) | 2013-07-11 | 2016-02-26 | Agios Pharmaceuticals Inc | N,6-bis(aryl or heteroaryl)-1,3,5-triazine-2,4-diamine compounds as idh2 mutants inhibitors for the treatment of cancer |
| WO2015003355A2 (en) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| US9579324B2 (en) | 2013-07-11 | 2017-02-28 | Agios Pharmaceuticals, Inc | Therapeutically active compounds and their methods of use |
| US20150031627A1 (en) | 2013-07-25 | 2015-01-29 | Agios Pharmaceuticals, Inc | Therapeutically active compounds and their methods of use |
| NZ631142A (en) | 2013-09-18 | 2016-03-31 | Axikin Pharmaceuticals Inc | Pharmaceutically acceptable salts of 3,5-diaminopyrazole kinase inhibitors |
| LT3089971T (lt) | 2014-01-01 | 2020-10-12 | Medivation Technologies Llc | Junginiai ir panaudojimo būdai |
| CA2942072C (en) | 2014-03-14 | 2022-07-26 | Agios Pharmaceuticals, Inc. | Pharmaceutical compositions and use of (s)-1-(2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-1-( 4-cyanopyridin-2-yl)-n-( 5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide |
| EP3179992B1 (en) | 2014-08-11 | 2022-05-11 | Acerta Pharma B.V. | Therapeutic combinations of a btk inhibitor, a pd-1 inhibitor and/or a pd-l1 inhibitor |
| US20170231986A1 (en) | 2014-08-11 | 2017-08-17 | Acerta Pharma B.V. | Therapeutic Combinations of a BTK Inhibitor, a PI3K Inhibitor, a JAK-2 Inhibitor, and/or a BCL-2 Inhibitor |
| US20170224819A1 (en) | 2014-08-11 | 2017-08-10 | Acerta Pharma B.V. | Therapeutic Combinations of a BTK Inhibitor, a PI3K Inhibitor, a JAK-2 Inhibitor, and/or a CDK 4/6 Inhibitor |
| JP6450010B2 (ja) | 2014-12-23 | 2019-01-09 | アクシキン ファーマシューティカルズ インコーポレーテッド | 3,5−ジアミノピラゾールキナーゼ阻害剤 |
| PL3307271T3 (pl) | 2015-06-11 | 2024-02-05 | Agios Pharmaceuticals, Inc. | Sposoby stosowania aktywatorów kinazy pirogronianowej |
| RS62829B1 (sr) | 2015-10-15 | 2022-02-28 | Servier Lab | Kombinovana terapija za lečenje maligniteta |
| IL258684B2 (en) | 2015-10-15 | 2023-04-01 | Agios Pharmaceuticals Inc | Combination therapy including an isocitrate dehydrogenase (1idh) inhibitor for use in the treatment of acute myelogenous leukemia (aml) characterized by the presence of a mutant allele of 1idh |
| CA3039026A1 (en) * | 2016-09-07 | 2018-03-15 | The Regents Of The University Of California | Allosteric corticotropin-releasing factor receptor 1 (crfr1) antagonists that decrease p-tau and improve cognition |
| WO2018106641A1 (en) * | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Pyrazoles for the treatment of demyelinating diseases |
| CN117860758A (zh) | 2017-05-23 | 2024-04-12 | 梅制药公司 | 联合疗法 |
| CN110573501B (zh) * | 2017-06-30 | 2023-09-29 | 北京泰德制药股份有限公司 | Rho相关蛋白激酶抑制剂、包含其的药物组合物及其制备方法和用途 |
| MX2020001727A (es) | 2017-08-14 | 2020-03-20 | Mei Pharma Inc | Terapia de combinacion. |
| KR102613433B1 (ko) | 2017-10-11 | 2023-12-13 | 주식회사 대웅제약 | 신규한 페닐피리딘 유도체 및 이를 포함하는 약학 조성물 |
| US10980788B2 (en) | 2018-06-08 | 2021-04-20 | Agios Pharmaceuticals, Inc. | Therapy for treating malignancies |
| CN116514779B (zh) * | 2022-05-06 | 2025-07-01 | 长沙晶易医药科技股份有限公司 | 2,4-二取代-5-氟嘧啶衍生物及其制备方法和应用 |
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| JPS57203072A (en) * | 1981-06-05 | 1982-12-13 | Sankyo Co Ltd | 4-anilinopyrimidine derivative, its preparation, antidepressant comprising it as active ingredient |
| EP1559778A1 (en) * | 1991-08-07 | 2005-08-03 | Albert Einstein College Of Medicine Of Yeshiva University | Proliferation of hepatocyte precursors |
| US5453414A (en) * | 1993-05-20 | 1995-09-26 | Rohm And Haas Company | 2-arylpyrimidines and herbicidal use thereof |
| DE69408750T2 (de) * | 1993-08-26 | 1998-07-23 | Ono Pharmaceutical Co | 4-Aminopyrimidin Derivate |
| JPH10509708A (ja) * | 1994-11-10 | 1998-09-22 | コア セラピューティクス,インコーポレイティド | プロテイン・キナーゼのインヒビターとして有用な医薬ピラゾール組成物 |
| DE19511562A1 (de) * | 1995-03-29 | 1996-10-02 | Hoechst Schering Agrevo Gmbh | Cyclohexylamino- und alkoxy-Stickstoff-Heterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Schädlingsbekämpfungsmittel und Fungizide |
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-
2008
- 2008-06-11 AU AU2008262291A patent/AU2008262291A1/en not_active Abandoned
- 2008-06-11 EP EP08768344A patent/EP2166849A4/en not_active Withdrawn
- 2008-06-11 JP JP2010512173A patent/JP2010529193A/ja active Pending
- 2008-06-11 WO PCT/US2008/007288 patent/WO2008154026A1/en not_active Ceased
- 2008-06-11 US US12/137,355 patent/US20090029992A1/en not_active Abandoned
- 2008-06-11 CA CA002683152A patent/CA2683152A1/en not_active Abandoned
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