JP2010529004A5 - - Google Patents

Info

Publication number

JP2010529004A5

JP2010529004A5 JP2010509835A JP2010509835A JP2010529004A5 JP 2010529004 A5 JP2010529004 A5 JP 2010529004A5 JP 2010509835 A JP2010509835 A JP 2010509835A JP 2010509835 A JP2010509835 A JP 2010509835A JP 2010529004 A5 JP2010529004 A5 JP 2010529004A5

Authority

JP

Japan

Prior art keywords

pharmaceutical composition

composition according

insulinotropic peptide

organic solvent

dehydrated

Prior art date

2008-05-30

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 239000000203 mixture Substances 0.000 claims description 3
• 239000008194 pharmaceutical composition Substances 0.000 claims 9
• 108090000765 processed proteins & peptides Proteins 0.000 claims 7
• 230000002473 insulinotropic effect Effects 0.000 claims 6
• 239000003960 organic solvent Substances 0.000 claims 4
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 3
• DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 3
• DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical group C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 claims 2
• 201000001320 Atherosclerosis Diseases 0.000 claims 1
• 108010067722 Dipeptidyl Peptidase 4 Proteins 0.000 claims 1
• 102100025012 Dipeptidyl peptidase 4 Human genes 0.000 claims 1
• 208000032928 Dyslipidaemia Diseases 0.000 claims 1
• 208000018522 Gastrointestinal disease Diseases 0.000 claims 1
• 102400000322 Glucagon-like peptide 1 Human genes 0.000 claims 1
• 208000002705 Glucose Intolerance Diseases 0.000 claims 1
• 206010020772 Hypertension Diseases 0.000 claims 1
• 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
• 208000017170 Lipid metabolism disease Diseases 0.000 claims 1
• 208000008589 Obesity Diseases 0.000 claims 1
• 208000007107 Stomach Ulcer Diseases 0.000 claims 1
• 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
• 239000007864 aqueous solution Substances 0.000 claims 1
• 208000010877 cognitive disease Diseases 0.000 claims 1
• 208000029078 coronary artery disease Diseases 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 208000035475 disorder Diseases 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 201000001421 hyperglycemia Diseases 0.000 claims 1
• 208000010125 myocardial infarction Diseases 0.000 claims 1
• 235000020824 obesity Nutrition 0.000 claims 1
• 229920005862 polyol Polymers 0.000 claims 1
• 150000003077 polyols Chemical class 0.000 claims 1
• 201000009104 prediabetes syndrome Diseases 0.000 claims 1
• 230000002265 prevention Effects 0.000 claims 1
• 230000001681 protective effect Effects 0.000 claims 1
• 208000011580 syndromic disease Diseases 0.000 claims 1
• 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
• 238000009472 formulation Methods 0.000 description 2
• 239000000443 aerosol Substances 0.000 description 1
• 239000011521 glass Substances 0.000 description 1
• 239000002245 particle Substances 0.000 description 1
• 238000001556 precipitation Methods 0.000 description 1
• 238000001179 sorption measurement Methods 0.000 description 1
• 239000007921 spray Substances 0.000 description 1