JP2010528047A5 - - Google Patents
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- Publication number
- JP2010528047A5 JP2010528047A5 JP2010509554A JP2010509554A JP2010528047A5 JP 2010528047 A5 JP2010528047 A5 JP 2010528047A5 JP 2010509554 A JP2010509554 A JP 2010509554A JP 2010509554 A JP2010509554 A JP 2010509554A JP 2010528047 A5 JP2010528047 A5 JP 2010528047A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- antibody
- factor
- antagonist
- amd
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000005557 antagonist Substances 0.000 claims description 15
- 230000000295 complement effect Effects 0.000 claims description 15
- 206010064930 age-related macular degeneration Diseases 0.000 claims description 14
- 208000002780 macular degeneration Diseases 0.000 claims description 14
- 208000005590 Choroidal Neovascularization Diseases 0.000 claims description 10
- 206010060823 Choroidal neovascularisation Diseases 0.000 claims description 10
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 8
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 8
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 8
- 201000005667 central retinal vein occlusion Diseases 0.000 claims description 8
- 208000004644 retinal vein occlusion Diseases 0.000 claims description 8
- 239000012634 fragment Substances 0.000 claims description 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 6
- 206010055665 Corneal neovascularisation Diseases 0.000 claims description 4
- 206010012688 Diabetic retinal oedema Diseases 0.000 claims description 4
- 201000002563 Histoplasmosis Diseases 0.000 claims description 4
- 208000007135 Retinal Neovascularization Diseases 0.000 claims description 4
- 208000017442 Retinal disease Diseases 0.000 claims description 4
- 206010038923 Retinopathy Diseases 0.000 claims description 4
- 206010046851 Uveitis Diseases 0.000 claims description 4
- 201000000159 corneal neovascularization Diseases 0.000 claims description 4
- 208000001309 degenerative myopia Diseases 0.000 claims description 4
- 230000004340 degenerative myopia Effects 0.000 claims description 4
- 206010012601 diabetes mellitus Diseases 0.000 claims description 4
- 201000011190 diabetic macular edema Diseases 0.000 claims description 4
- 208000028867 ischemia Diseases 0.000 claims description 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 4
- 208000006542 von Hippel-Lindau disease Diseases 0.000 claims description 4
- 241000124008 Mammalia Species 0.000 claims description 2
- 208000000208 Wet Macular Degeneration Diseases 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 208000011325 dry age related macular degeneration Diseases 0.000 claims description 2
- 229920001184 polypeptide Polymers 0.000 claims description 2
- 150000003384 small molecules Chemical class 0.000 claims description 2
- 230000002265 prevention Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 17
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93979107P | 2007-05-23 | 2007-05-23 | |
| US60/939,791 | 2007-05-23 | ||
| PCT/US2008/064526 WO2008147883A1 (en) | 2007-05-23 | 2008-05-22 | Prevention and treatment of complement-associated eye conditions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013236445A Division JP2014087346A (ja) | 2007-05-23 | 2013-11-15 | 補体が関係している眼の状態の予防および治療 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010528047A JP2010528047A (ja) | 2010-08-19 |
| JP2010528047A5 true JP2010528047A5 (show.php) | 2012-05-10 |
| JP5416695B2 JP5416695B2 (ja) | 2014-02-12 |
Family
ID=39638868
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010509554A Expired - Fee Related JP5416695B2 (ja) | 2007-05-23 | 2008-05-22 | 補体が関係している眼の状態の予防および治療 |
| JP2013236445A Withdrawn JP2014087346A (ja) | 2007-05-23 | 2013-11-15 | 補体が関係している眼の状態の予防および治療 |
| JP2016015288A Withdrawn JP2016145205A (ja) | 2007-05-23 | 2016-01-29 | 補体が関係している眼の状態の予防および治療 |
| JP2017146477A Pending JP2017197577A (ja) | 2007-05-23 | 2017-07-28 | 補体が関係している眼の状態の予防および治療 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013236445A Withdrawn JP2014087346A (ja) | 2007-05-23 | 2013-11-15 | 補体が関係している眼の状態の予防および治療 |
| JP2016015288A Withdrawn JP2016145205A (ja) | 2007-05-23 | 2016-01-29 | 補体が関係している眼の状態の予防および治療 |
| JP2017146477A Pending JP2017197577A (ja) | 2007-05-23 | 2017-07-28 | 補体が関係している眼の状態の予防および治療 |
Country Status (28)
| Country | Link |
|---|---|
| US (6) | US8007791B2 (show.php) |
| EP (1) | EP2152755B1 (show.php) |
| JP (4) | JP5416695B2 (show.php) |
| KR (1) | KR101540126B1 (show.php) |
| CN (3) | CN101754980B (show.php) |
| AR (1) | AR066660A1 (show.php) |
| AU (1) | AU2008256835B2 (show.php) |
| BR (1) | BRPI0811142A8 (show.php) |
| CA (1) | CA2683498A1 (show.php) |
| CL (1) | CL2008001498A1 (show.php) |
| CY (1) | CY1116062T1 (show.php) |
| DK (1) | DK2152755T3 (show.php) |
| ES (1) | ES2533242T3 (show.php) |
| HK (1) | HK1207327A1 (show.php) |
| HR (1) | HRP20150281T1 (show.php) |
| IL (2) | IL201476A (show.php) |
| MX (1) | MX2009012422A (show.php) |
| PE (1) | PE20090294A1 (show.php) |
| PH (1) | PH12013500992B1 (show.php) |
| PL (1) | PL2152755T3 (show.php) |
| PT (1) | PT2152755E (show.php) |
| RS (1) | RS53901B1 (show.php) |
| RU (2) | RU2522976C2 (show.php) |
| SG (1) | SG10201401404RA (show.php) |
| SI (1) | SI2152755T1 (show.php) |
| TW (2) | TW201417829A (show.php) |
| WO (1) | WO2008147883A1 (show.php) |
| ZA (1) | ZA200907028B (show.php) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4764590B2 (ja) * | 2000-04-29 | 2011-09-07 | ユニバーシティー オブ アイオワ リサーチ ファウンデーション | 黄班変性関連疾患の診断および治療 |
| KR20130137716A (ko) | 2005-11-04 | 2013-12-17 | 제넨테크, 인크. | 안질환 치료를 위한 보체 경로 억제제의 용도 |
| MY157948A (en) | 2006-11-02 | 2016-08-30 | Genentech Inc | Humanized anti-factor d antibodies |
| AR066660A1 (es) * | 2007-05-23 | 2009-09-02 | Genentech Inc | Prevencion y tratamiento de condiciones del ojo asociadas con su complemento |
| CR20170001A (es) | 2008-04-28 | 2017-08-10 | Genentech Inc | Anticuerpos anti factor d humanizados |
| KR20110058866A (ko) * | 2008-09-02 | 2011-06-01 | 노파르티스 아게 | 비시클릭 키나제 억제제 |
| SG2014007389A (en) | 2009-01-29 | 2014-04-28 | Forsight Vision4 Inc | Posterior segment drug delivery |
| US8623395B2 (en) | 2010-01-29 | 2014-01-07 | Forsight Vision4, Inc. | Implantable therapeutic device |
| US9309325B2 (en) | 2009-05-07 | 2016-04-12 | The Regents Of The University Of California | Antibodies and methods of use thereof |
| US20110165648A1 (en) * | 2009-11-04 | 2011-07-07 | Menno Van Lookeren Campagne | Co-crystal structure of factor D and anti-factor D antibody |
| HRP20211909T1 (hr) * | 2010-08-05 | 2022-03-18 | Forsight Vision4, Inc. | Uređaj za liječenja oka |
| EP2635704B1 (en) | 2010-11-01 | 2017-04-19 | F. Hoffmann-La Roche AG | Predicting progression to advanced age-related macular degeneration using a polygenic score |
| CN103402996B (zh) | 2011-01-04 | 2015-02-11 | 诺瓦提斯公司 | 可用于治疗年龄相关性黄斑变性(amd)的吲哚化合物或其类似物 |
| WO2012103165A2 (en) * | 2011-01-26 | 2012-08-02 | Kolltan Pharmaceuticals, Inc. | Anti-kit antibodies and uses thereof |
| EP2867227B1 (en) | 2012-06-28 | 2018-11-21 | Novartis AG | Complement pathway modulators and uses thereof |
| ES2644700T3 (es) | 2012-06-28 | 2017-11-30 | Novartis Ag | Derivados de pirrolidina y su uso como moduladores de la ruta del complemento |
| EP2867225B1 (en) | 2012-06-28 | 2017-08-09 | Novartis AG | Pyrrolidine derivatives and their use as complement pathway modulators |
| CN105121429B (zh) | 2012-06-28 | 2017-12-12 | 诺华股份有限公司 | 补体途径调节剂和其用途 |
| ES2648962T3 (es) | 2012-06-28 | 2018-01-09 | Novartis Ag | Derivados de pirrolidina y su uso como moduladores de la vía del complemento |
| BR112015000578A2 (pt) | 2012-07-12 | 2017-06-27 | Novartis Ag | moduladores da via do complemento e usos dos mesmos |
| US9334332B2 (en) | 2012-07-25 | 2016-05-10 | Kolltan Pharmaceuticals, Inc. | Anti-kit antibodies |
| WO2014120555A1 (en) | 2013-01-31 | 2014-08-07 | The Regents Of The University Of California | Antibodies specific for urokinase-type plasminogen activator and methods of use thereof |
| WO2014160884A1 (en) | 2013-03-28 | 2014-10-02 | Forsight Vision4, Inc. | Ophthalmic implant for delivering therapeutic substances |
| AU2014306867B2 (en) | 2013-08-12 | 2017-10-26 | Genentech, Inc. | Compositions and method for treating complement-associated conditions |
| CA2926812A1 (en) * | 2013-10-07 | 2015-04-16 | Massachusetts Eye And Ear Infirmary | Methods of preventing or reducing photoreceptor cell death |
| JP2016539098A (ja) * | 2013-10-25 | 2016-12-15 | チルドレンズ メディカル センター コーポレーション | 網膜の血管障害を治療又は予防する方法 |
| US10179821B2 (en) * | 2014-05-01 | 2019-01-15 | Genentech, Inc. | Anti-factor D antibodies |
| US10239943B2 (en) | 2014-05-23 | 2019-03-26 | Celldex Therapeutics, Inc. | Treatment of eosinophil or mast cell related disorders |
| MX391052B (es) * | 2015-09-23 | 2025-03-21 | Sangamo Therapeutics Inc | Represores de htt y usos de estos. |
| TW201730211A (zh) | 2015-10-30 | 2017-09-01 | 建南德克公司 | 抗因子d抗體及結合物 |
| KR102162324B1 (ko) | 2015-10-30 | 2020-10-07 | 제넨테크, 인크. | 항-HtrA1 항체 및 이의 사용 방법 |
| AU2016344146A1 (en) | 2015-10-30 | 2018-05-10 | Genentech, Inc. | Methods of measuring Factor D activity and potency of Factor D inhibitors |
| US10654932B2 (en) | 2015-10-30 | 2020-05-19 | Genentech, Inc. | Anti-factor D antibody variant conjugates and uses thereof |
| HRP20211608T1 (hr) * | 2015-12-23 | 2022-01-21 | eleva GmbH | Polipeptidi za inhibiranje aktivacije komplementa |
| EP3405577B8 (en) | 2016-01-20 | 2023-02-15 | 396419 B.C. Ltd. | Compositions and methods for inhibiting factor d |
| WO2018136827A1 (en) | 2017-01-20 | 2018-07-26 | Vitrisa Therapeutics, Inc. | Stem-loop compositions and methods for inhibiting factor d |
| CN110461879B (zh) * | 2017-02-10 | 2024-03-29 | 宾夕法尼亚大学理事会 | 抗因子d抗体及其用途 |
| CN109632924B (zh) * | 2018-12-17 | 2022-02-08 | 上海市第一人民医院 | 人黄斑新生血管性疾病的血浆脂质标记物及其应用 |
| WO2021009778A2 (en) * | 2019-07-18 | 2021-01-21 | Pandorum Technologies Private Limited | Methods for culturing mesenchymal stem cells, products thereof, and applications thereof |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6620915B2 (en) * | 1993-12-23 | 2003-09-16 | Icos Corporation | Monoclonal antibodies specific for integrin α-d subunit |
| WO1999046281A2 (en) | 1998-03-10 | 1999-09-16 | Genentech, Inc. | Novel polypeptides and nucleic acids encoding the same |
| US20050197285A1 (en) * | 1997-03-07 | 2005-09-08 | Rosen Craig A. | Human secreted proteins |
| US6472520B2 (en) * | 1997-03-21 | 2002-10-29 | The Trustees Of Columbia University In The City Of New York | Rat PEG-3 promoter |
| US6410708B1 (en) | 1997-11-21 | 2002-06-25 | Genentech, Inc. | Nucleic acids encoding A-33 related antigen polypeptides |
| US7192589B2 (en) * | 1998-09-16 | 2007-03-20 | Genentech, Inc. | Treatment of inflammatory disorders with STIgMA immunoadhesins |
| ES2288649T3 (es) | 1997-11-21 | 2008-01-16 | Genentech, Inc. | Antigenos tipo a-33 y sus utilizaciones farmacologicas. |
| US8007798B2 (en) * | 1997-11-21 | 2011-08-30 | Genentech, Inc. | Treatment of complement-associated disorders |
| US7282565B2 (en) * | 1998-03-20 | 2007-10-16 | Genentech, Inc. | PRO362 polypeptides |
| US8088386B2 (en) * | 1998-03-20 | 2012-01-03 | Genentech, Inc. | Treatment of complement-associated disorders |
| US7419663B2 (en) * | 1998-03-20 | 2008-09-02 | Genentech, Inc. | Treatment of complement-associated disorders |
| EP1053245A4 (en) | 1998-02-09 | 2002-04-17 | Human Genome Sciences Inc | 45 HUMAN SECRETED PROTEINS |
| WO1999042133A1 (en) * | 1998-02-20 | 1999-08-26 | Tanox, Inc. | Inhibitors of complement activation |
| US6956107B2 (en) | 1998-02-20 | 2005-10-18 | Tanox, Inc. | Inhibitors of complement activation |
| CA2340794A1 (en) | 1998-08-27 | 2000-03-09 | Incyte Pharmaceuticals, Inc. | Protein transport-associated molecules |
| KR100468977B1 (ko) | 1998-12-16 | 2005-02-02 | 제넨테크, 인크. | 분비 및 막횡단 폴리펩티드, 및 이를 코딩하는 핵산 |
| AU770332B2 (en) * | 1998-12-21 | 2004-02-19 | Vegenics Limited | Antibodies to truncated VEGF-D and uses thereof |
| EP1141284A2 (en) | 1998-12-22 | 2001-10-10 | Genentech, Inc. | Methods and compositions for inhibiting neoplastic cell growth |
| KR20010103046A (ko) | 1999-03-08 | 2001-11-17 | 제넨테크, 인크. | 면역 관련 질환 치료용 조성물 및 치료 방법 |
| IL145310A0 (en) | 1999-03-11 | 2003-01-12 | Rmf Dictagene Sa | Vascular adhesion molecules and modulation of their function |
| US6642353B1 (en) * | 1999-03-17 | 2003-11-04 | Chugai Seiyaku Kabushiki Kaisha | Peptide ligands for the erythropoietin receptor |
| AU2883900A (en) | 1999-07-07 | 2001-01-30 | Genentech Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| AU1423601A (en) | 1999-11-02 | 2001-05-30 | Uliyanovsky Gosudarstvenny Tekhnichesky Universitet | Method for cleaning liquids of ferromagnetic particles and device for the implementation thereof |
| EP1234030A4 (en) | 1999-11-19 | 2003-05-07 | Human Genome Sciences Inc | 18 HUMAN SECRETED PROTEINS |
| CA2496312A1 (en) | 1999-12-01 | 2001-06-07 | Kevin P. Baker | Colon tumour marker pro4799 polypeptides and nucleic acids encoding the same |
| CA2412211A1 (en) | 2000-06-23 | 2002-01-03 | Genetech, Inc. | Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis |
| JP2004516013A (ja) | 2000-07-20 | 2004-06-03 | ジェネンテック・インコーポレーテッド | 血管形成に関連する障害を診断及び治療するための組成物と方法 |
| AU2003258714A1 (en) * | 2002-09-06 | 2004-03-29 | Cytos Biotechnology Ag | Immune modulatory compounds and methods |
| RU2232991C1 (ru) * | 2003-04-09 | 2004-07-20 | Государственное учреждение "Московский научно-исследовательский институт эпидемиологии и микробиологии им. Г.Н. Габричевского" | Способ определения функциональной активности фактора d комплемента человека |
| WO2006071856A2 (en) | 2004-12-23 | 2006-07-06 | Glycofi, Inc. | Immunoglobulins comprising predominantly a man5glcnac2 glycoform |
| KR20130137716A (ko) * | 2005-11-04 | 2013-12-17 | 제넨테크, 인크. | 안질환 치료를 위한 보체 경로 억제제의 용도 |
| US20070190057A1 (en) | 2006-01-23 | 2007-08-16 | Jian Wu | Methods for modulating mannose content of recombinant proteins |
| MY157948A (en) * | 2006-11-02 | 2016-08-30 | Genentech Inc | Humanized anti-factor d antibodies |
| AR066660A1 (es) * | 2007-05-23 | 2009-09-02 | Genentech Inc | Prevencion y tratamiento de condiciones del ojo asociadas con su complemento |
| JP4349447B2 (ja) | 2007-07-19 | 2009-10-21 | トヨタ自動車株式会社 | インバータ制御装置および車両 |
-
2008
- 2008-05-21 AR ARP080102150A patent/AR066660A1/es unknown
- 2008-05-22 CA CA002683498A patent/CA2683498A1/en not_active Abandoned
- 2008-05-22 PL PL08756130T patent/PL2152755T3/pl unknown
- 2008-05-22 EP EP08756130.4A patent/EP2152755B1/en active Active
- 2008-05-22 ES ES08756130.4T patent/ES2533242T3/es active Active
- 2008-05-22 PT PT87561304T patent/PT2152755E/pt unknown
- 2008-05-22 CN CN200880100137.7A patent/CN101754980B/zh not_active Expired - Fee Related
- 2008-05-22 WO PCT/US2008/064526 patent/WO2008147883A1/en not_active Ceased
- 2008-05-22 CN CN201610972614.5A patent/CN107096029B/zh not_active Expired - Fee Related
- 2008-05-22 SI SI200831405T patent/SI2152755T1/sl unknown
- 2008-05-22 AU AU2008256835A patent/AU2008256835B2/en not_active Ceased
- 2008-05-22 KR KR1020097026746A patent/KR101540126B1/ko not_active Expired - Fee Related
- 2008-05-22 RS RS20150223A patent/RS53901B1/sr unknown
- 2008-05-22 JP JP2010509554A patent/JP5416695B2/ja not_active Expired - Fee Related
- 2008-05-22 MX MX2009012422A patent/MX2009012422A/es active IP Right Grant
- 2008-05-22 US US12/154,466 patent/US8007791B2/en not_active Expired - Fee Related
- 2008-05-22 DK DK08756130.4T patent/DK2152755T3/en active
- 2008-05-22 CN CN201410486706.3A patent/CN104367999A/zh active Pending
- 2008-05-22 RU RU2009147744/10A patent/RU2522976C2/ru not_active IP Right Cessation
- 2008-05-22 HR HRP20150281AT patent/HRP20150281T1/hr unknown
- 2008-05-22 SG SG10201401404RA patent/SG10201401404RA/en unknown
- 2008-05-22 BR BRPI0811142A patent/BRPI0811142A8/pt not_active Application Discontinuation
- 2008-05-23 CL CL2008001498A patent/CL2008001498A1/es unknown
- 2008-05-23 TW TW102134844A patent/TW201417829A/zh unknown
- 2008-05-23 PE PE2008000887A patent/PE20090294A1/es not_active Application Discontinuation
- 2008-05-23 TW TW097119194A patent/TWI419704B/zh not_active IP Right Cessation
-
2009
- 2009-10-08 ZA ZA2009/07028A patent/ZA200907028B/en unknown
- 2009-10-13 IL IL201476A patent/IL201476A/en active IP Right Grant
-
2011
- 2011-07-22 US US13/189,301 patent/US8268310B2/en not_active Expired - Fee Related
-
2012
- 2012-07-20 US US13/554,787 patent/US8497094B2/en not_active Expired - Fee Related
-
2013
- 2013-05-16 PH PH12013500992A patent/PH12013500992B1/en unknown
- 2013-06-27 US US13/929,167 patent/US20130302333A1/en not_active Abandoned
- 2013-11-15 JP JP2013236445A patent/JP2014087346A/ja not_active Withdrawn
-
2014
- 2014-04-03 RU RU2014113046/10A patent/RU2014113046A/ru not_active Application Discontinuation
-
2015
- 2015-02-27 CY CY20151100205T patent/CY1116062T1/el unknown
- 2015-08-14 HK HK15107851.6A patent/HK1207327A1/xx unknown
-
2016
- 2016-01-29 JP JP2016015288A patent/JP2016145205A/ja not_active Withdrawn
- 2016-02-03 US US15/014,886 patent/US20160272726A1/en not_active Abandoned
- 2016-10-27 IL IL248552A patent/IL248552A0/en unknown
-
2017
- 2017-07-28 JP JP2017146477A patent/JP2017197577A/ja active Pending
- 2017-11-29 US US15/826,016 patent/US20180079826A1/en not_active Abandoned
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