JP2010528021A - キナーゼのインヒビターとして有用なチアゾールおよびピラゾール - Google Patents

キナーゼのインヒビターとして有用なチアゾールおよびピラゾール Download PDF

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Publication number
JP2010528021A
JP2010528021A JP2010509424A JP2010509424A JP2010528021A JP 2010528021 A JP2010528021 A JP 2010528021A JP 2010509424 A JP2010509424 A JP 2010509424A JP 2010509424 A JP2010509424 A JP 2010509424A JP 2010528021 A JP2010528021 A JP 2010528021A
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Japan
Prior art keywords
ring
compound
compound according
aliphatic
cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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JP2010509424A
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English (en)
Japanese (ja)
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JP2010528021A5 (enExample
Inventor
マイケル モーティモア，
ジュリアン ゴレック，
ダニエル ロビンソン，
クリストファー デービス，
ジョン スタッドレイ，
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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Application filed by Vertex Pharmaceuticals Inc filed Critical Vertex Pharmaceuticals Inc
Publication of JP2010528021A publication Critical patent/JP2010528021A/ja
Publication of JP2010528021A5 publication Critical patent/JP2010528021A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2010509424A 2007-05-24 2008-05-02 キナーゼのインヒビターとして有用なチアゾールおよびピラゾール Pending JP2010528021A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93987607P 2007-05-24 2007-05-24
PCT/US2008/062331 WO2008147626A2 (en) 2007-05-24 2008-05-02 Thiazoles and pyrazoles useful as kinase inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014097421A Division JP2014141529A (ja) 2007-05-24 2014-05-09 キナーゼのインヒビターとして有用なチアゾールおよびピラゾール

Publications (2)

Publication Number Publication Date
JP2010528021A true JP2010528021A (ja) 2010-08-19
JP2010528021A5 JP2010528021A5 (enExample) 2012-06-21

Family

ID=39926662

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2010509424A Pending JP2010528021A (ja) 2007-05-24 2008-05-02 キナーゼのインヒビターとして有用なチアゾールおよびピラゾール
JP2014097421A Pending JP2014141529A (ja) 2007-05-24 2014-05-09 キナーゼのインヒビターとして有用なチアゾールおよびピラゾール

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2014097421A Pending JP2014141529A (ja) 2007-05-24 2014-05-09 キナーゼのインヒビターとして有用なチアゾールおよびピラゾール

Country Status (8)

Country Link
US (1) US20110060013A1 (enExample)
EP (1) EP2164842A2 (enExample)
JP (2) JP2010528021A (enExample)
CN (1) CN101687852A (enExample)
AU (1) AU2008257044A1 (enExample)
CA (1) CA2687966A1 (enExample)
MX (1) MX2009012719A (enExample)
WO (1) WO2008147626A2 (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6660731B2 (en) 2000-09-15 2003-12-09 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
CA2422367C (en) 2000-09-15 2010-05-18 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
US7601718B2 (en) 2003-02-06 2009-10-13 Vertex Pharmaceuticals Incorporated Compositions useful as inhibitors of protein kinases
CA2627808A1 (en) 2005-11-03 2007-05-18 Vertex Pharmaceuticals Incorporated Aminopyrimidines useful as kinase inhibitors
NZ576750A (en) 2006-11-02 2012-01-12 Vertex Pharma Aminopyridines and aminopyrimidines useful as inhibitors of protein kinases
CA2673353A1 (en) 2006-12-19 2008-06-26 Vertex Pharmaceuticals Incorporated Aminopyrimidines useful as inhibitors of protein kinases
CA2679701A1 (en) 2007-03-09 2008-09-18 Vertex Pharmaceuticals Incorporated Aminopyridines useful as inhibitors of protein kinases
JP5520057B2 (ja) 2007-03-09 2014-06-11 バーテックス ファーマシューティカルズ インコーポレイテッド 蛋白キナーゼの阻害剤として有用なアミノピリミジン
NZ579485A (en) 2007-03-09 2012-02-24 Vertex Pharma Aminopyrimidines useful as inhibitors of protein kinases
JP2010523700A (ja) 2007-04-13 2010-07-15 バーテックス ファーマシューティカルズ インコーポレイテッド キナーゼインヒビターとして有用なアミノピリミジン
AU2008247592A1 (en) 2007-05-02 2008-11-13 Vertex Pharmaceuticals Incorporated Thiazoles and pyrazoles useful as kinase inhibitors
CN101801959A (zh) 2007-05-02 2010-08-11 沃泰克斯药物股份有限公司 可用作激酶抑制剂的氨基嘧啶类化合物
NZ582879A (en) 2007-07-31 2012-03-30 Vertex Pharma Process for preparing 5-fluoro-1h-pyrazolo [3, 4-b] pyridin-3-amine and derivatives thereof
US8748626B2 (en) * 2010-04-15 2014-06-10 Novartis Ag Oxazole and thiazole compounds as KSP inhibitors
CN104024248A (zh) 2011-08-25 2014-09-03 霍夫曼-拉罗奇有限公司 丝氨酸/苏氨酸pak1抑制剂
BR112014015549A8 (pt) 2011-12-22 2017-07-04 Hoffmann La Roche composto, método de inibição da atividade pak1, método para o tratamento, processo, composição, utilização de um composto e invenção
SI3459942T1 (sl) 2012-04-24 2021-05-31 Vertex Pharmaceuticals Incorporated Inhibitorji DNA-PK
HRP20211855T1 (hr) 2013-03-12 2022-03-04 Vertex Pharmaceuticals Incorporated Inhibitori dnk-pk
SI3424920T1 (sl) 2013-10-17 2020-08-31 Vertex Pharmaceuticals Incorporated Kokristali (s)-n-metil-8-(1-((2'-metil-(4,5'-bipirimidin)-6-il)amino)propan-2-il) kinolin-4-karboksamida in devterirani derivati le-teh kot inhibitorji dna-pk
HK1252425A1 (zh) 2015-06-05 2019-05-24 Vertex Pharmaceuticals Incorporated 用於治疗脱髓鞘疾病的三唑类药物
US11214565B2 (en) 2015-11-20 2022-01-04 Denali Therapeutics Inc. Compound, compositions, and methods
US11028080B2 (en) 2016-03-11 2021-06-08 Denali Therapeutics Inc. Substituted pyrimidines as LRKK2 inhibitors
JOP20180113B1 (ar) 2016-06-16 2022-03-14 Denali Therapeutics Inc مركبات بيريميدين -2-يل امينو -h1- بيرازول كمثبطات lrrk2 للاستخدام في علاج اضطرابات تنكسية عصبية
MX394860B (es) 2016-09-27 2025-03-24 Vertex Pharma Metodo para tratar cancer usando una combinacion de agentes que dañan adn e inhibidores de proteina cinasa dependiente de adn (adn-pk).
TWI885039B (zh) 2020-01-13 2025-06-01 美商邊際分析公司 經取代吡唑并嘧啶及其用途

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JP2006501176A (ja) * 2002-06-20 2006-01-12 バーテックス ファーマシューティカルズ インコーポレイテッド タンパク質キナーゼの阻害剤としての置換ピリミジンおよびピリミジン誘導体を調製する方法
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Also Published As

Publication number Publication date
US20110060013A1 (en) 2011-03-10
WO2008147626A2 (en) 2008-12-04
MX2009012719A (es) 2010-02-04
AU2008257044A1 (en) 2008-12-04
JP2014141529A (ja) 2014-08-07
EP2164842A2 (en) 2010-03-24
WO2008147626A3 (en) 2009-03-19
CA2687966A1 (en) 2008-12-04
CN101687852A (zh) 2010-03-31

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