JP2010528021A - キナーゼのインヒビターとして有用なチアゾールおよびピラゾール - Google Patents

キナーゼのインヒビターとして有用なチアゾールおよびピラゾール Download PDF

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Publication number
JP2010528021A
JP2010528021A JP2010509424A JP2010509424A JP2010528021A JP 2010528021 A JP2010528021 A JP 2010528021A JP 2010509424 A JP2010509424 A JP 2010509424A JP 2010509424 A JP2010509424 A JP 2010509424A JP 2010528021 A JP2010528021 A JP 2010528021A
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Prior art keywords
ring
compound
compound according
aliphatic
cancer
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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JP2010509424A
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Japanese (ja)
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JP2010528021A5 (enExample
Inventor
マイケル モーティモア，
ジュリアン ゴレック，
ダニエル ロビンソン，
クリストファー デービス，
ジョン スタッドレイ，
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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Application filed by Vertex Pharmaceuticals Inc filed Critical Vertex Pharmaceuticals Inc
Publication of JP2010528021A publication Critical patent/JP2010528021A/ja
Publication of JP2010528021A5 publication Critical patent/JP2010528021A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2010509424A 2007-05-24 2008-05-02 キナーゼのインヒビターとして有用なチアゾールおよびピラゾール Pending JP2010528021A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93987607P 2007-05-24 2007-05-24
PCT/US2008/062331 WO2008147626A2 (en) 2007-05-24 2008-05-02 Thiazoles and pyrazoles useful as kinase inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014097421A Division JP2014141529A (ja) 2007-05-24 2014-05-09 キナーゼのインヒビターとして有用なチアゾールおよびピラゾール

Publications (2)

Publication Number Publication Date
JP2010528021A true JP2010528021A (ja) 2010-08-19
JP2010528021A5 JP2010528021A5 (enExample) 2012-06-21

Family

ID=39926662

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2010509424A Pending JP2010528021A (ja) 2007-05-24 2008-05-02 キナーゼのインヒビターとして有用なチアゾールおよびピラゾール
JP2014097421A Pending JP2014141529A (ja) 2007-05-24 2014-05-09 キナーゼのインヒビターとして有用なチアゾールおよびピラゾール

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2014097421A Pending JP2014141529A (ja) 2007-05-24 2014-05-09 キナーゼのインヒビターとして有用なチアゾールおよびピラゾール

Country Status (8)

Country Link
US (1) US20110060013A1 (enExample)
EP (1) EP2164842A2 (enExample)
JP (2) JP2010528021A (enExample)
CN (1) CN101687852A (enExample)
AU (1) AU2008257044A1 (enExample)
CA (1) CA2687966A1 (enExample)
MX (1) MX2009012719A (enExample)
WO (1) WO2008147626A2 (enExample)

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US6660731B2 (en) 2000-09-15 2003-12-09 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
WO2004072029A2 (en) 2003-02-06 2004-08-26 Vertex Pharmaceuticals Incorporated Pyrazolopyridazines useful as inhibitors of protein kinases
TW200734327A (en) 2005-11-03 2007-09-16 Vertex Pharma Aminopyrimidines useful as kinase inhibitors
WO2008057940A1 (en) 2006-11-02 2008-05-15 Vertex Pharmaceuticals Incorporated Aminopyridines and aminopyrimidines useful as inhibitors of protein kinases
WO2008077086A1 (en) 2006-12-19 2008-06-26 Vertex Pharmaceuticals Incorporated Aminopyrimidines useful as inhibitors of protein kinases
WO2008112642A1 (en) 2007-03-09 2008-09-18 Vertex Pharmaceuticals Incorporated Aminopyrimidines useful as inhibitors of protein kinases
EP2134709A1 (en) 2007-03-09 2009-12-23 Vertex Pharmaceuticals, Inc. Aminopyridines useful as inhibitors of protein kinases
EP2137183B1 (en) 2007-03-09 2011-09-28 Vertex Pharmaceuticals Incorporated Aminopyrimidines useful as inhibitors of protein kinases
JP2010523700A (ja) 2007-04-13 2010-07-15 バーテックス ファーマシューティカルズ インコーポレイテッド キナーゼインヒビターとして有用なアミノピリミジン
CN101801959A (zh) 2007-05-02 2010-08-11 沃泰克斯药物股份有限公司 可用作激酶抑制剂的氨基嘧啶类化合物
CN101679378A (zh) 2007-05-02 2010-03-24 沃泰克斯药物股份有限公司 用作激酶抑制剂的噻唑和吡唑
AR067762A1 (es) 2007-07-31 2009-10-21 Vertex Pharma Proceso para preparar 5-fluoro-1h-pirazolo (3,4-b) piridin-3-amina y derivados de la misma
WO2011128388A2 (en) * 2010-04-15 2011-10-20 Novartis Ag Oxazole and thiazole compounds as ksp inhibitors
MX2014002208A (es) 2011-08-25 2014-05-28 Hoffmann La Roche Inhibidores de serina/treonina quinasa.
KR20140103972A (ko) 2011-12-22 2014-08-27 에프. 호프만-라 로슈 아게 세린/트레오닌 키나아제 억제제로서의 2,4-다이아민-피리미딘 유도체
IN2014KN02601A (enExample) 2012-04-24 2015-05-08 Vertex Pharma
WO2017156493A1 (en) 2016-03-11 2017-09-14 Denali Therapeutics Inc. Compounds, compositions, and methods
SMT202100687T1 (it) 2013-03-12 2022-01-10 Vertex Pharma Inibitori della dna-pk
ES2705342T3 (es) 2013-10-17 2019-03-22 Vertex Pharma Co-cristales de (S)-N-metil-8-(1-((2'-metil-[4,5'-bipirimidin]-6-il)amino)propan-2-il)quinolin-4-carboxamida y derivados deuterados de la misma como inhibidores de DNA-PK
HK1252425A1 (zh) 2015-06-05 2019-05-24 Vertex Pharmaceuticals Incorporated 用於治疗脱髓鞘疾病的三唑类药物
US11214565B2 (en) 2015-11-20 2022-01-04 Denali Therapeutics Inc. Compound, compositions, and methods
SI3472153T1 (sl) 2016-06-16 2022-01-31 Denali Therapeutics Inc. Pirimidin-2-ilamino-1H-pirazoli kot zaviralci LRRK2 za uporabo pri zdravljenju nevrodegenerativnih motenj
EP3518931A4 (en) 2016-09-27 2020-05-13 Vertex Pharmaceuticals Incorporated METHOD FOR TREATING CANCER WITH A COMBINATION OF DNA-DAMAGING SUBSTANCES AND DNA-PK INHIBITORS
KR20220140515A (ko) 2020-01-13 2022-10-18 버지 애널리틱스, 인크. 치환된 피라졸로-피리미딘 및 그의 용도

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Also Published As

Publication number Publication date
WO2008147626A3 (en) 2009-03-19
JP2014141529A (ja) 2014-08-07
CA2687966A1 (en) 2008-12-04
AU2008257044A1 (en) 2008-12-04
EP2164842A2 (en) 2010-03-24
CN101687852A (zh) 2010-03-31
MX2009012719A (es) 2010-02-04
US20110060013A1 (en) 2011-03-10
WO2008147626A2 (en) 2008-12-04

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