JP2010528021A - キナーゼのインヒビターとして有用なチアゾールおよびピラゾール - Google Patents

キナーゼのインヒビターとして有用なチアゾールおよびピラゾール Download PDF

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Publication number
JP2010528021A
JP2010528021A JP2010509424A JP2010509424A JP2010528021A JP 2010528021 A JP2010528021 A JP 2010528021A JP 2010509424 A JP2010509424 A JP 2010509424A JP 2010509424 A JP2010509424 A JP 2010509424A JP 2010528021 A JP2010528021 A JP 2010528021A
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JP
Japan
Prior art keywords
ring
compound
compound according
aliphatic
cancer
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Pending
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JP2010509424A
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English (en)
Japanese (ja)
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JP2010528021A5 (cg-RX-API-DMAC7.html
Inventor
マイケル モーティモア，
ジュリアン ゴレック，
ダニエル ロビンソン，
クリストファー デービス，
ジョン スタッドレイ，
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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Application filed by Vertex Pharmaceuticals Inc filed Critical Vertex Pharmaceuticals Inc
Publication of JP2010528021A publication Critical patent/JP2010528021A/ja
Publication of JP2010528021A5 publication Critical patent/JP2010528021A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2010509424A 2007-05-24 2008-05-02 キナーゼのインヒビターとして有用なチアゾールおよびピラゾール Pending JP2010528021A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93987607P 2007-05-24 2007-05-24
PCT/US2008/062331 WO2008147626A2 (en) 2007-05-24 2008-05-02 Thiazoles and pyrazoles useful as kinase inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014097421A Division JP2014141529A (ja) 2007-05-24 2014-05-09 キナーゼのインヒビターとして有用なチアゾールおよびピラゾール

Publications (2)

Publication Number Publication Date
JP2010528021A true JP2010528021A (ja) 2010-08-19
JP2010528021A5 JP2010528021A5 (cg-RX-API-DMAC7.html) 2012-06-21

Family

ID=39926662

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2010509424A Pending JP2010528021A (ja) 2007-05-24 2008-05-02 キナーゼのインヒビターとして有用なチアゾールおよびピラゾール
JP2014097421A Pending JP2014141529A (ja) 2007-05-24 2014-05-09 キナーゼのインヒビターとして有用なチアゾールおよびピラゾール

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2014097421A Pending JP2014141529A (ja) 2007-05-24 2014-05-09 キナーゼのインヒビターとして有用なチアゾールおよびピラゾール

Country Status (8)

Country Link
US (1) US20110060013A1 (cg-RX-API-DMAC7.html)
EP (1) EP2164842A2 (cg-RX-API-DMAC7.html)
JP (2) JP2010528021A (cg-RX-API-DMAC7.html)
CN (1) CN101687852A (cg-RX-API-DMAC7.html)
AU (1) AU2008257044A1 (cg-RX-API-DMAC7.html)
CA (1) CA2687966A1 (cg-RX-API-DMAC7.html)
MX (1) MX2009012719A (cg-RX-API-DMAC7.html)
WO (1) WO2008147626A2 (cg-RX-API-DMAC7.html)

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JP2004509115A (ja) 2000-09-15 2004-03-25 バーテックス　ファーマシューティカルズ　インコーポレイテッド プロテインキナーゼインヒビターとして有用なピラゾール化合物
US6660731B2 (en) 2000-09-15 2003-12-09 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
WO2004072029A2 (en) 2003-02-06 2004-08-26 Vertex Pharmaceuticals Incorporated Pyrazolopyridazines useful as inhibitors of protein kinases
NZ594385A (en) 2005-11-03 2013-02-22 Vertex Pharma Aminopyrimidines useful as kinase inhibitors
DE602007004750D1 (de) 2006-11-02 2010-03-25 Vertex Pharma Als inhibitoren von proteinkinasen geeignete aminopyridine und aminopyrimidine
AU2007333650A1 (en) 2006-12-19 2008-06-26 Vertex Pharmaceuticals Incorporated Aminopyrimidines useful as inhibitors of protein kinases
AU2008226466B2 (en) 2007-03-09 2013-06-13 Vertex Pharmaceuticals Incorporated Aminopyrimidines useful as inhibitors of protein kinases
WO2008112646A1 (en) 2007-03-09 2008-09-18 Vertex Pharmaceuticals Incorporated Aminopyridines useful as inhibitors of protein kinases
NZ579446A (en) 2007-03-09 2012-02-24 Vertex Pharma Aminopyrimidines useful as inhibitors of protein kinases
WO2008128009A2 (en) 2007-04-13 2008-10-23 Vertex Pharmaceuticals Incorporated Aminopyrimidines useful as kinase inhibitors
EP2152694A2 (en) 2007-05-02 2010-02-17 Vertex Pharmaceuticals Incorporated Thiazoles and pyrazoles useful as kinase inhibitors
CN101801959A (zh) 2007-05-02 2010-08-11 沃泰克斯药物股份有限公司 可用作激酶抑制剂的氨基嘧啶类化合物
NZ582879A (en) 2007-07-31 2012-03-30 Vertex Pharma Process for preparing 5-fluoro-1h-pyrazolo [3, 4-b] pyridin-3-amine and derivatives thereof
EP2558452A2 (en) * 2010-04-15 2013-02-20 Novartis AG Oxazole and thiazole compounds as ksp inhibitors
EP2748159A1 (en) 2011-08-25 2014-07-02 F.Hoffmann-La Roche Ag Serine/threonine pak1 inhibitors
JP2015504876A (ja) 2011-12-22 2015-02-16 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト セリン／トレオニンキナーゼ阻害剤としての２，４−ジアミン−ピリミジン誘導体
LT2841428T (lt) 2012-04-24 2018-12-10 Vertex Pharmaceuticals Incorporated Dnr-pk inhibitoriai
WO2017156493A1 (en) 2016-03-11 2017-09-14 Denali Therapeutics Inc. Compounds, compositions, and methods
CN105246883B (zh) 2013-03-12 2017-07-21 沃泰克斯药物股份有限公司 Dna‑pk抑制剂
KR102411227B1 (ko) 2013-10-17 2022-06-21 버텍스 파마슈티칼스 인코포레이티드 Dna-pk 억제제로서 (s)-n-메틸-8-(1-((2'-메틸-[4,5'-비피리미딘]-6-일)아미노)프로판-2-일)퀴놀린-4-카복스아미드 및 이의 듀테로화된 유도체의 공결정
EP3302465A1 (en) 2015-06-05 2018-04-11 Vertex Pharmaceuticals Incorporated Triazoles for the treatment of demyelinating diseases
WO2017087905A1 (en) 2015-11-20 2017-05-26 Denali Therapeutics Inc. Compound, compositions, and methods
SG10201912632YA (en) 2016-06-16 2020-02-27 Denali Therapeutics Inc Pyrimidin-2-ylamino-1h-pyrazols as lrrk2 inhibitors for use in the treatment of neurodegenerative disorders
TW201815418A (zh) 2016-09-27 2018-05-01 Vertex Pharma 使用dna破壞劑及dna-pk抑制劑之組合治療癌症的方法
EP4090426B1 (en) 2020-01-13 2025-12-31 Verge Analytics, Inc. Substitutes for pyrazolos and pyrimidines and their uses

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Also Published As

Publication number Publication date
CA2687966A1 (en) 2008-12-04
AU2008257044A1 (en) 2008-12-04
JP2014141529A (ja) 2014-08-07
WO2008147626A2 (en) 2008-12-04
EP2164842A2 (en) 2010-03-24
MX2009012719A (es) 2010-02-04
US20110060013A1 (en) 2011-03-10
CN101687852A (zh) 2010-03-31
WO2008147626A3 (en) 2009-03-19

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