JP2010527368A5 - - Google Patents
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- JP2010527368A5 JP2010527368A5 JP2010508521A JP2010508521A JP2010527368A5 JP 2010527368 A5 JP2010527368 A5 JP 2010527368A5 JP 2010508521 A JP2010508521 A JP 2010508521A JP 2010508521 A JP2010508521 A JP 2010508521A JP 2010527368 A5 JP2010527368 A5 JP 2010527368A5
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- JP
- Japan
- Prior art keywords
- alkyl
- halo
- compound
- alkoxy
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 52
- 229910052739 hydrogen Inorganic materials 0.000 claims 42
- 239000001257 hydrogen Substances 0.000 claims 28
- 229910052794 bromium Inorganic materials 0.000 claims 27
- 229910052736 halogen Inorganic materials 0.000 claims 27
- 150000002367 halogens Chemical class 0.000 claims 27
- 150000002431 hydrogen Chemical class 0.000 claims 27
- 229910052801 chlorine Inorganic materials 0.000 claims 26
- 125000001475 halogen functional group Chemical group 0.000 claims 21
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 21
- 125000000217 alkyl group Chemical group 0.000 claims 19
- 125000004093 cyano group Chemical group *C#N 0.000 claims 19
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 19
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 18
- 125000005110 aryl thio group Chemical group 0.000 claims 17
- 125000001424 substituent group Chemical group 0.000 claims 15
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims 13
- -1 C 1 -C 6 -alkoxy Chemical group 0.000 claims 13
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 13
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 12
- 208000015181 infectious disease Diseases 0.000 claims 12
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims 11
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims 11
- 125000004738 (C1-C6) alkyl sulfinyl group Chemical group 0.000 claims 10
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 10
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 9
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 9
- 238000000034 method Methods 0.000 claims 9
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 9
- 125000001188 haloalkyl group Chemical group 0.000 claims 8
- 244000000013 helminth Species 0.000 claims 8
- 125000003545 alkoxy group Chemical group 0.000 claims 7
- 125000004414 alkyl thio group Chemical group 0.000 claims 7
- 125000004438 haloalkoxy group Chemical group 0.000 claims 7
- 125000004692 haloalkylcarbonyl group Chemical group 0.000 claims 7
- 125000004440 haloalkylsulfinyl group Chemical group 0.000 claims 7
- 125000004995 haloalkylthio group Chemical group 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 108010034145 Helminth Proteins Proteins 0.000 claims 6
- 125000003282 alkyl amino group Chemical group 0.000 claims 6
- 125000004644 alkyl sulfinyl group Chemical group 0.000 claims 6
- 244000078703 ectoparasite Species 0.000 claims 6
- 229910052731 fluorine Inorganic materials 0.000 claims 6
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 5
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 5
- 241000238876 Acari Species 0.000 claims 4
- 241000255925 Diptera Species 0.000 claims 4
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 3
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 3
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims 3
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 125000004441 haloalkylsulfonyl group Chemical group 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 239000002917 insecticide Substances 0.000 claims 3
- 125000003107 substituted aryl group Chemical group 0.000 claims 3
- 241000244186 Ascaris Species 0.000 claims 2
- 241000244036 Brugia Species 0.000 claims 2
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 241000244160 Echinococcus Species 0.000 claims 2
- 241000498256 Enterobius Species 0.000 claims 2
- 241000315566 Habronema Species 0.000 claims 2
- 235000019687 Lamb Nutrition 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 241001137882 Nematodirus Species 0.000 claims 2
- 241000243795 Ostertagia Species 0.000 claims 2
- 241001674048 Phthiraptera Species 0.000 claims 2
- 241000545593 Scolytinae Species 0.000 claims 2
- 241000256103 Simuliidae Species 0.000 claims 2
- 241000258242 Siphonaptera Species 0.000 claims 2
- 241000607216 Toxascaris Species 0.000 claims 2
- 241000244031 Toxocara Species 0.000 claims 2
- 241000243774 Trichinella Species 0.000 claims 2
- 241000223259 Trichoderma Species 0.000 claims 2
- 125000000278 alkyl amino alkyl group Chemical group 0.000 claims 2
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 claims 2
- 125000006350 alkyl thio alkyl group Chemical group 0.000 claims 2
- 125000004691 alkyl thio carbonyl group Chemical group 0.000 claims 2
- GOPDFXUMARJJEA-UHFFFAOYSA-N amino(nitro)azanide Chemical compound N[N-][N+]([O-])=O GOPDFXUMARJJEA-UHFFFAOYSA-N 0.000 claims 2
- 125000004103 aminoalkyl group Chemical group 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- 150000001728 carbonyl compounds Chemical class 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 244000079386 endoparasite Species 0.000 claims 2
- 210000002816 gill Anatomy 0.000 claims 2
- 125000001624 naphthyl group Chemical group 0.000 claims 2
- 125000005493 quinolyl group Chemical group 0.000 claims 2
- 210000002784 stomach Anatomy 0.000 claims 2
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 claims 2
- 125000006727 (C1-C6) alkenyl group Chemical group 0.000 claims 1
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims 1
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000005083 alkoxyalkoxy group Chemical group 0.000 claims 1
- 125000003418 alkyl amino alkoxy group Chemical group 0.000 claims 1
- 125000004687 alkyl sulfinyl alkyl group Chemical group 0.000 claims 1
- 125000004688 alkyl sulfonyl alkyl group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 150000003863 ammonium salts Chemical class 0.000 claims 1
- SCJNCDSAIRBRIA-DOFZRALJSA-N arachidonyl-2'-chloroethylamide Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)NCCCl SCJNCDSAIRBRIA-DOFZRALJSA-N 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 1
- 125000005144 cycloalkylsulfonyl group Chemical group 0.000 claims 1
- 238000010511 deprotection reaction Methods 0.000 claims 1
- 125000004985 dialkyl amino alkyl group Chemical group 0.000 claims 1
- 125000004984 dialkylaminoalkoxy group Chemical group 0.000 claims 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 238000007074 heterocyclization reaction Methods 0.000 claims 1
- QHDRKFYEGYYIIK-UHFFFAOYSA-N isovaleronitrile Chemical compound CC(C)CC#N QHDRKFYEGYYIIK-UHFFFAOYSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001590 oxidative effect Effects 0.000 claims 1
- 238000007248 oxidative elimination reaction Methods 0.000 claims 1
- 125000002572 propoxy group Chemical group [*]OC([H])([H])C(C([H])([H])[H])([H])[H] 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 claims 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 1
- 229920002554 vinyl polymer Polymers 0.000 claims 1
- 0 CC(C(C*C=*)=PN*C(*)=O)=* Chemical compound CC(C(C*C=*)=PN*C(*)=O)=* 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93048507P | 2007-05-15 | 2007-05-15 | |
| US60/930,485 | 2007-05-15 | ||
| PCT/US2008/063417 WO2008144275A1 (en) | 2007-05-15 | 2008-05-12 | Aryloazol-2-yl cyanoethylamino compounds, method of making and method of using thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010527368A JP2010527368A (ja) | 2010-08-12 |
| JP2010527368A5 true JP2010527368A5 (cg-RX-API-DMAC7.html) | 2011-06-30 |
| JP5562840B2 JP5562840B2 (ja) | 2014-07-30 |
Family
ID=38608776
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010508521A Expired - Fee Related JP5562840B2 (ja) | 2007-05-15 | 2008-05-12 | アリーロアゾール−２−イルシアノエチルアミノ化合物、これらの製造方法及び使用方法 |
Country Status (31)
Families Citing this family (50)
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| CA2706448C (en) * | 2007-11-26 | 2016-08-16 | Merial Limited | Solvent systems for pour-on formulations for combating parasites |
| CN102239151B (zh) * | 2008-10-21 | 2014-07-02 | 梅里亚有限公司 | 硫代酰胺化合物，其制备方法和使用方法 |
| LT3050874T (lt) * | 2008-11-14 | 2019-04-10 | Merial Inc. | Enantiomeriškai praturtinti arilazol-2-ilo cianetilamino paraziticidiniai junginiai |
| EP2364147A2 (en) | 2008-11-19 | 2011-09-14 | Merial Limited | Compositions comprising 1-arylpyrazole alone or in combination with formamidine for the treatment of parasitic infection |
| EP2376513B1 (en) | 2008-12-04 | 2015-02-25 | Merial Limited | Dimeric avermectin and milbemycin derivatives |
| DE102009012423A1 (de) * | 2009-03-10 | 2010-09-16 | Bayer Animal Health Gmbh | Zubereitung auf Ölbasis |
| UA108641C2 (uk) | 2010-04-02 | 2015-05-25 | Паразитицидна композиція, яка містить чотири активних агенти, та спосіб її застосування | |
| SG11201400558YA (en) | 2011-09-12 | 2014-04-28 | Merial Ltd | Parasiticidal compositions comprising an isoxazoline active agent, methods and uses thereof |
| AU2012324491A1 (en) | 2011-10-19 | 2014-04-17 | Zoetis Services Llc | Use of aminoacetonitrile derivatives against endoparasites |
| MX368738B (es) | 2011-11-17 | 2019-10-14 | Boehringer Ingelheim Animal Health Usa Inc | Composiciones que comprenden un aril pirazol y un imidazol sustituido, metodos y usos de las mismas. |
| BR122020002199B1 (pt) | 2011-12-02 | 2021-01-19 | Merial, Inc. | formulações de moxidectina injetável de ação prolongada e novas formas de cristal de moxidectina |
| TR201909461T4 (tr) | 2012-02-06 | 2019-07-22 | Boehringer Ingelheim Animal Health Usa Inc | Si̇stemi̇k olarak etki̇ eden akti̇f maddeleri̇ i̇çeren parazi̇ti̇si̇dal oral veteri̇nerli̇ğe ai̇t bi̇leşi̇mler, bunlarin yöntemleri̇ ve kullanimlari |
| JO3626B1 (ar) | 2012-02-23 | 2020-08-27 | Merial Inc | تركيبات موضعية تحتوي على فيبرونيل و بيرميثرين و طرق استخدامها |
| ES2633611T5 (es) | 2012-04-04 | 2023-09-26 | Intervet Int Bv | Composiciones farmacéuticas orales sólidas de compuestos de isoxazolina |
| MX367536B (es) | 2012-04-20 | 2019-08-26 | Boehringer Ingelheim Animal Health Usa Inc | Composiciones parasiticidas que comprenden derivados de benzimidazol, métodos y usos de los mismos. |
| MX356342B (es) * | 2012-08-30 | 2018-05-23 | Univ Tokyo | Agente de control de endoparásitos y método para usarlo. |
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| CN103267808A (zh) * | 2013-04-22 | 2013-08-28 | 上海谱尼测试技术有限公司 | 一种电子电气产品中地乐酚含量的测定方法 |
| ES2905848T3 (es) | 2013-11-01 | 2022-04-12 | Boehringer Ingelheim Animal Health Usa Inc | Compuestos de isoxazolina antiparasitarios y plaguicidas |
| NZ726251A (en) | 2014-04-17 | 2017-11-24 | Merial Inc | Use of malononitrile compounds for protecting animals from parasites |
| ES2842592T3 (es) | 2014-05-19 | 2021-07-14 | Boehringer Ingelheim Animal Health Usa Inc | Compuestos antihelmínticos |
| NZ728102A (en) | 2014-06-19 | 2018-04-27 | Merial Inc | Parasiticidal compositions comprising indole derivatives, methods and uses thereof |
| EP3211998B1 (en) | 2014-10-31 | 2021-04-07 | Boehringer Ingelheim Animal Health USA Inc. | Parasiticidal composition comprising fipronil |
| UY36570A (es) | 2015-02-26 | 2016-10-31 | Merial Inc | Formulaciones inyectables de acción prolongada que comprenden un agente activo isoxazolina, métodos y usos de las mismas |
| ES2916216T3 (es) | 2015-05-20 | 2022-06-29 | Boehringer Ingelheim Animal Health Usa Inc | Compuestos de depsipéptidos antihelmínticos |
| UY37137A (es) | 2016-02-24 | 2017-09-29 | Merial Inc | Compuestos antiparasitarios de isoxazolina, formulaciones inyectables de acción prolongada que los comprenden, métodos y usos de los mismos |
| CN106106475A (zh) * | 2016-06-22 | 2016-11-16 | 叶松 | 一种防治梨食芽蛾的组合物及其制备方法 |
| WO2018039508A1 (en) | 2016-08-25 | 2018-03-01 | Merial, Inc. | Method for reducing unwanted effects in parasiticidal treatments |
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| CN106918705B (zh) * | 2017-01-22 | 2023-06-13 | 贵州勤邦食品安全科学技术有限公司 | 检测甲氰菊酯的试纸及其应用 |
| CN111194316A (zh) | 2017-08-14 | 2020-05-22 | 勃林格殷格翰动物保健美国公司 | 农药的和杀寄生物的吡唑-异噁唑啉化合物 |
| CN108033925A (zh) * | 2017-12-27 | 2018-05-15 | 温州大学 | 一种苯并三氮唑化合物及其制备方法 |
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| IL279977B2 (en) | 2018-07-09 | 2024-06-01 | Boehringer Ingelheim Animal Health Usa Inc | Heterocyclic anthelmintic compounds |
| CN108752217B (zh) * | 2018-07-18 | 2021-08-06 | 浙江沙星科技有限公司 | 一种度鲁特韦关键中间体2,4-二氟苄胺的合成方法 |
| US11773066B2 (en) | 2018-11-20 | 2023-10-03 | Boehringer Ingelheim Animal Health USA Inc. | Indazolylcyanoethylamino compound, compositions of same, method of making, and methods of using thereof |
| CN109694472B (zh) * | 2018-12-13 | 2021-06-29 | 万华化学集团股份有限公司 | 功能性聚醚起始剂及其合成和在聚醚合成中的应用 |
| JP2022522200A (ja) | 2019-03-01 | 2022-04-14 | ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド | 注射用クロルスロン組成物、その方法および使用 |
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| CN110470768B (zh) * | 2019-08-27 | 2022-05-24 | 谱尼测试集团吉林有限公司 | 一种测定水质中吡嘧磺隆、三唑磷、丁草胺残留量的方法 |
| CA3183100A1 (en) | 2020-05-29 | 2021-12-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Anthelmintic heterocyclic compounds |
| US12161089B2 (en) | 2020-12-21 | 2024-12-10 | Boehringer Ingelheim Animal Health USA Inc. | Parasiticidal collar comprising isoxazoline compounds |
| WO2023156938A1 (en) | 2022-02-17 | 2023-08-24 | Boehringer Ingelheim Vetmedica Gmbh | Method and system for providing a fluid product mailer |
| CN115888184A (zh) * | 2022-11-10 | 2023-04-04 | 上海市精神卫生中心（上海市心理咨询培训中心） | 一种用于血液镁离子检测的固相萃取装置及其应用 |
| CN115770411B (zh) * | 2022-11-10 | 2025-07-25 | 上海市精神卫生中心（上海市心理咨询培训中心） | 一种键合原卟啉的镁离子固相萃取剂及其应用 |
| CN117143519B (zh) * | 2023-05-05 | 2025-05-02 | 迪力阀门科技有限公司 | 一种耐高温蝶阀及其生产工艺 |
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