JP2010526091A5 - - Google Patents

Info

Publication number

JP2010526091A5

JP2010526091A5 JP2010506622A JP2010506622A JP2010526091A5 JP 2010526091 A5 JP2010526091 A5 JP 2010526091A5 JP 2010506622 A JP2010506622 A JP 2010506622A JP 2010506622 A JP2010506622 A JP 2010506622A JP 2010526091 A5 JP2010526091 A5 JP 2010526091A5

Authority

JP

Japan

Prior art keywords

click

independently

saturated

functionalized

group

Prior art date

2008-04-30

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 108090000765 processed proteins & peptides Proteins 0.000 claims description 122
• 229920006395 saturated elastomer Polymers 0.000 claims description 121
• 229910052757 nitrogen Inorganic materials 0.000 claims description 103
• 230000008685 targeting Effects 0.000 claims description 103
• -1 alemtuzumab Chemical compound 0.000 claims description 90
• NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 89
• 229910052717 sulfur Inorganic materials 0.000 claims description 89
• 239000011593 sulfur Substances 0.000 claims description 89
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 88
• 229910052760 oxygen Inorganic materials 0.000 claims description 88
• 239000001301 oxygen Substances 0.000 claims description 88
• 150000001875 compounds Chemical class 0.000 claims description 87
• 125000005842 heteroatom Chemical group 0.000 claims description 87
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• 229920000642 polymer Polymers 0.000 claims description 62
• 125000003118 aryl group Chemical group 0.000 claims description 56
• 239000000693 micelle Substances 0.000 claims description 53
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• 238000000034 method Methods 0.000 claims description 34
• 150000001345 alkine derivatives Chemical group 0.000 claims description 31
• 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims description 31
• 125000001183 hydrocarbyl group Chemical group 0.000 claims description 30
• 125000001931 aliphatic group Chemical group 0.000 claims description 26
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• 239000005411 L01XE02 - Gefitinib Substances 0.000 claims description 6
• NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 claims description 6
• ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims description 6
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• DBEPLOCGEIEOCV-WSBQPABSSA-N finasteride Chemical compound N([C@@H]1CC2)C(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](C(=O)NC(C)(C)C)[C@@]2(C)CC1 DBEPLOCGEIEOCV-WSBQPABSSA-N 0.000 claims description 6
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• YLMAHDNUQAMNNX-UHFFFAOYSA-N imatinib methanesulfonate Chemical compound CS(O)(=O)=O.C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 YLMAHDNUQAMNNX-UHFFFAOYSA-N 0.000 claims description 6
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