JP2010525813A - 二本鎖rnaによる遺伝子発現の特異的阻害のための、方法及び組成物 - Google Patents
二本鎖rnaによる遺伝子発現の特異的阻害のための、方法及び組成物 Download PDFInfo
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- JP2010525813A JP2010525813A JP2010506206A JP2010506206A JP2010525813A JP 2010525813 A JP2010525813 A JP 2010525813A JP 2010506206 A JP2010506206 A JP 2010506206A JP 2010506206 A JP2010506206 A JP 2010506206A JP 2010525813 A JP2010525813 A JP 2010525813A
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- nucleic acid
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- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/797,216 US20070265220A1 (en) | 2004-03-15 | 2007-05-01 | Methods and compositions for the specific inhibition of gene expression by double-stranded RNA |
| PCT/US2008/004726 WO2008136902A1 (en) | 2007-05-01 | 2008-04-11 | Methods and compositions for the specific inhibition of gene expression by double-stranded rna |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010525813A true JP2010525813A (ja) | 2010-07-29 |
| JP2010525813A5 JP2010525813A5 (enExample) | 2011-11-17 |
Family
ID=39944357
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010506206A Pending JP2010525813A (ja) | 2007-05-01 | 2008-04-11 | 二本鎖rnaによる遺伝子発現の特異的阻害のための、方法及び組成物 |
Country Status (9)
| Country | Link |
|---|---|
| US (11) | US20070265220A1 (enExample) |
| EP (1) | EP2155772A4 (enExample) |
| JP (1) | JP2010525813A (enExample) |
| CN (1) | CN101848923A (enExample) |
| AU (1) | AU2008246307A1 (enExample) |
| BR (1) | BRPI0811475A2 (enExample) |
| CA (1) | CA2685453A1 (enExample) |
| WO (1) | WO2008136902A1 (enExample) |
| ZA (1) | ZA200908342B (enExample) |
Families Citing this family (112)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1527176B2 (en) | 2002-08-05 | 2017-03-22 | Silence Therapeutics GmbH | Further novel forms of interfering rna molecules |
| US7892793B2 (en) * | 2002-11-04 | 2011-02-22 | University Of Massachusetts | Allele-specific RNA interference |
| ES2357116T5 (es) * | 2003-06-02 | 2021-09-03 | Univ Massachusetts | Métodos y composiciones para mejorar la eficacia y especificad de FNAi |
| US7750144B2 (en) | 2003-06-02 | 2010-07-06 | University Of Massachusetts | Methods and compositions for enhancing the efficacy and specificity of RNA silencing |
| DK1633767T3 (en) | 2003-06-02 | 2019-03-25 | Univ Massachusetts | METHODS AND COMPOSITIONS FOR MANAGING THE EFFECT OF RNA SILENCING |
| US8680063B2 (en) | 2003-09-12 | 2014-03-25 | University Of Massachusetts | RNA interference for the treatment of gain-of-function disorders |
| US7947658B2 (en) * | 2003-09-12 | 2011-05-24 | University Of Massachusetts | RNA interference for the treatment of gain-of-function disorders |
| US20060134787A1 (en) | 2004-12-22 | 2006-06-22 | University Of Massachusetts | Methods and compositions for enhancing the efficacy and specificity of single and double blunt-ended siRNA |
| EP1742958B1 (en) * | 2004-03-15 | 2017-05-17 | City of Hope | Methods and compositions for the specific inhibition of gene expression by double-stranded rna |
| US20070265220A1 (en) | 2004-03-15 | 2007-11-15 | City Of Hope | Methods and compositions for the specific inhibition of gene expression by double-stranded RNA |
| AU2006279280A1 (en) | 2005-08-18 | 2007-02-22 | Alnylam Pharmaceuticals, Inc. | Methods and compositions for treating neurological disease |
| LT2056845T (lt) | 2006-08-08 | 2017-11-27 | Rheinische Friedrich-Wilhelms-Universität Bonn | 5` fosfato oligonukleotidų struktūra ir panaudojimas |
| WO2008143774A2 (en) * | 2007-05-01 | 2008-11-27 | University Of Massachusetts | Methods and compositions for locating snp heterozygosity for allele specific diagnosis and therapy |
| WO2009141146A1 (en) | 2008-05-21 | 2009-11-26 | Gunther Hartmann | 5' triphosphate oligonucleotide with blunt end and uses thereof |
| TWI455944B (zh) | 2008-07-01 | 2014-10-11 | Daiichi Sankyo Co Ltd | 雙股多核苷酸 |
| EP2326351B1 (en) | 2008-08-19 | 2017-12-27 | Nektar Therapeutics | Conjugates of small-interfering nucleic acids |
| US8225729B2 (en) * | 2008-12-16 | 2012-07-24 | Kimberly-Clark Worldwide, Inc. | Three-dimensional wiping substrate and method therefor |
| US20100249214A1 (en) | 2009-02-11 | 2010-09-30 | Dicerna Pharmaceuticals | Multiplex dicer substrate rna interference molecules having joining sequences |
| US11408003B2 (en) | 2008-12-18 | 2022-08-09 | Dicerna Pharmaceuticals, Inc. | Extended dicer substrate agents and methods for the specific inhibition of gene expression |
| EP2379083B1 (en) * | 2008-12-18 | 2017-08-16 | Dicerna Pharmaceuticals, Inc. | Extended dicer substrate agents and methods for the specific inhibition of gene expression |
| EP2411019A2 (en) * | 2009-03-27 | 2012-02-01 | Merck Sharp&Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1 (STAT1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| EP4124657A3 (en) | 2009-04-03 | 2023-05-03 | Dicerna Pharmaceuticals, Inc. | Methods and compositions for the specific inhibition of kras by asymmetric double-stranded rna |
| EP2756845B1 (en) * | 2009-04-03 | 2017-03-15 | Dicerna Pharmaceuticals, Inc. | Methods and compositions for the specific inhibition of KRAS by asymmetric double-stranded RNA |
| US20120114710A1 (en) * | 2009-05-18 | 2012-05-10 | Lynn Kirkpatrick | Carbon nanotubes complexed with multiple bioactive agents and methods related thereto |
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| WO2010144058A1 (en) | 2009-06-10 | 2010-12-16 | Temasek Life Sciences Laboratory Limited | Virus induced gene silencing (vigs) for functional analysis of genes in cotton. |
| ES2613498T3 (es) | 2009-07-01 | 2017-05-24 | Protiva Biotherapeutics Inc. | Nuevas formulaciones de lípidos para el suministro de agentes terapéuticos a tumores sólidos |
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| WO2011038160A2 (en) | 2009-09-23 | 2011-03-31 | Protiva Biotherapeutics, Inc. | Compositions and methods for silencing genes expressed in cancer |
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| US20090043085A1 (en) | 2009-02-12 |
| WO2008136902A1 (en) | 2008-11-13 |
| EP2155772A1 (en) | 2010-02-24 |
| US20090029466A1 (en) | 2009-01-29 |
| CA2685453A1 (en) | 2008-11-13 |
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| CN101848923A (zh) | 2010-09-29 |
| US20160376590A1 (en) | 2016-12-29 |
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