JP2010525024A - 置換３−（４−ヒドロキシフェニル）−インドリン−２−オン化合物 - Google Patents

置換３−（４−ヒドロキシフェニル）−インドリン−２−オン化合物 Download PDF

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Publication number
JP2010525024A
JP2010525024A JP2010504685A JP2010504685A JP2010525024A JP 2010525024 A JP2010525024 A JP 2010525024A JP 2010504685 A JP2010504685 A JP 2010504685A JP 2010504685 A JP2010504685 A JP 2010504685A JP 2010525024 A JP2010525024 A JP 2010525024A
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JP
Japan
Prior art keywords
hydroxyphenyl
compound
indoline
optionally substituted
difluoro
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JP2010504685A
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English (en)
Japanese (ja)
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JP2010525024A5 (enExample
Inventor
メッテ・クナック・クリステンセン
フレドリク・ビエールクリング
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Onxeo DK
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Topotarget AS
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Publication of JP2010525024A5 publication Critical patent/JP2010525024A5/ja
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2010504685A 2007-04-24 2008-04-24 置換３−（４−ヒドロキシフェニル）−インドリン−２−オン化合物 Withdrawn JP2010525024A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91362507P 2007-04-24 2007-04-24
PCT/EP2008/054990 WO2008129075A1 (en) 2007-04-24 2008-04-24 Substituted 3-(4-hydroxyphenyl)-indolin-2-one-compounds

Publications (2)

Publication Number Publication Date
JP2010525024A true JP2010525024A (ja) 2010-07-22
JP2010525024A5 JP2010525024A5 (enExample) 2011-06-16

Family

ID=39643405

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010504685A Withdrawn JP2010525024A (ja) 2007-04-24 2008-04-24 置換３−（４−ヒドロキシフェニル）−インドリン−２−オン化合物

Country Status (6)

Country Link
US (1) US20100227863A1 (enExample)
EP (1) EP2139856A1 (enExample)
JP (1) JP2010525024A (enExample)
AU (1) AU2008240599A1 (enExample)
CA (1) CA2684552A1 (enExample)
WO (1) WO2008129075A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023528292A (ja) * 2020-05-20 2023-07-04 カエラス・バイオサイエンス・リミテッド 脆弱Ｘ関連障害の処置のためのｍａｘｉ－Ｋカリウムチャネルオープナー
JP2023546584A (ja) * 2020-10-23 2023-11-06 ザ ボード オブ トラスティーズ オブ ザ ユニバーシテイ オブ イリノイ Ｅｒ陽性がんに選択的な抗がん化合物

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1718611A4 (en) 2004-02-13 2009-09-23 Harvard College 3-3-DI-SUBSTITUTED OXINDOLES AS INHIBITORS OF INITIATION OF TRANSLATION
WO2010109008A1 (en) 2009-03-26 2010-09-30 Topotarget A/S Prodrugs of substituted 3-(4-hydroxyphenyl)-indolin-2-ones
US20160106711A1 (en) * 2012-09-20 2016-04-21 President And Fellows Of Harvard College 3-3-Di-Substituted-Oxindoles as Inhibitors of Translation Initiation
CN105017129B (zh) * 2015-07-02 2017-12-26 广东药科大学 一种吲哚生物碱及其应用
CN110526853B (zh) * 2018-05-23 2021-02-26 浙江大学 3,3-二取代-2-吲哚酮衍生物及其制备方法
CA3103958A1 (en) * 2018-07-03 2020-01-09 The Board Of Trustees Of The University Of Illinois Activators of the unfolded protein response
CN113149888B (zh) * 2021-05-06 2023-03-03 中山大学 一种羟基吲哚酮类衍生物及其制备方法和应用
CN115490673B (zh) * 2022-01-11 2024-10-15 苏州浦合医药科技有限公司 3,3-二取代吲哚酮类化合物及其用途
CN120677152A (zh) * 2023-02-23 2025-09-19 上海济煜医药科技有限公司 双环类化合物及其制备方法和用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1718611A4 (en) * 2004-02-13 2009-09-23 Harvard College 3-3-DI-SUBSTITUTED OXINDOLES AS INHIBITORS OF INITIATION OF TRANSLATION
US20070299102A1 (en) * 2004-04-08 2007-12-27 Topo Target A/S Diphenyl Ox-Indol-2-One Compounds and Their Use in the Treatment of Cancer

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023528292A (ja) * 2020-05-20 2023-07-04 カエラス・バイオサイエンス・リミテッド 脆弱Ｘ関連障害の処置のためのｍａｘｉ－Ｋカリウムチャネルオープナー
JP2023546584A (ja) * 2020-10-23 2023-11-06 ザ ボード オブ トラスティーズ オブ ザ ユニバーシテイ オブ イリノイ Ｅｒ陽性がんに選択的な抗がん化合物

Also Published As

Publication number Publication date
EP2139856A1 (en) 2010-01-06
CA2684552A1 (en) 2008-10-30
AU2008240599A1 (en) 2008-10-30
WO2008129075A1 (en) 2008-10-30
US20100227863A1 (en) 2010-09-09

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