JP2010524939A5 - - Google Patents
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- Publication number
- JP2010524939A5 JP2010524939A5 JP2010504079A JP2010504079A JP2010524939A5 JP 2010524939 A5 JP2010524939 A5 JP 2010524939A5 JP 2010504079 A JP2010504079 A JP 2010504079A JP 2010504079 A JP2010504079 A JP 2010504079A JP 2010524939 A5 JP2010524939 A5 JP 2010524939A5
- Authority
- JP
- Japan
- Prior art keywords
- carbons
- nuclear receptor
- alkyl
- receptor binding
- binding agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/785,251 | 2007-04-16 | ||
| US11/785,251 US8158828B2 (en) | 2005-11-28 | 2007-04-16 | Nuclear receptor binding agents |
| PCT/US2008/004908 WO2008130571A1 (en) | 2007-04-16 | 2008-04-16 | Nuclear receptor binding agents |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014033091A Division JP5913400B2 (ja) | 2007-04-16 | 2014-02-24 | 核内受容体結合剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010524939A JP2010524939A (ja) | 2010-07-22 |
| JP2010524939A5 true JP2010524939A5 (https=) | 2011-06-02 |
| JP5815237B2 JP5815237B2 (ja) | 2015-11-17 |
Family
ID=39876311
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010504079A Expired - Fee Related JP5815237B2 (ja) | 2007-04-16 | 2008-04-16 | 核内受容体結合剤 |
| JP2014033091A Expired - Fee Related JP5913400B2 (ja) | 2007-04-16 | 2014-02-24 | 核内受容体結合剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014033091A Expired - Fee Related JP5913400B2 (ja) | 2007-04-16 | 2014-02-24 | 核内受容体結合剤 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US8158828B2 (https=) |
| JP (2) | JP5815237B2 (https=) |
| KR (2) | KR101563609B1 (https=) |
| WO (1) | WO2008130571A1 (https=) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8637706B2 (en) | 2005-11-28 | 2014-01-28 | Gtx, Inc. | Nuclear receptor binding agents |
| US9409856B2 (en) | 2005-11-28 | 2016-08-09 | Gtx, Inc. | Estrogen receptor ligands and methods of use thereof |
| US8546451B2 (en) * | 2005-11-28 | 2013-10-01 | Gtx, Inc. | Estrogen receptor ligands and methods of use thereof |
| EA201500845A1 (ru) * | 2005-11-28 | 2016-04-29 | Джи Ти Икс, ИНК. | Агенты, связывающиеся с ядерными рецепторами |
| US8158828B2 (en) | 2005-11-28 | 2012-04-17 | Gtx, Inc. | Nuclear receptor binding agents |
| EP3345607B1 (en) * | 2006-12-29 | 2022-10-26 | Ossifi-Mab LLC | Methods of altering bone growth by administration of sost or wise antagonist or agonist |
| US20090130232A1 (en) * | 2007-11-20 | 2009-05-21 | Mohammed Zahra | Composition and method for treatment of oral inflammation an ulceration |
| WO2009076548A1 (en) * | 2007-12-13 | 2009-06-18 | Cytori Therapeutics, Inc. | Methods of inhibiting tumor development using adipose-derived regenerative cells |
| US8871751B2 (en) * | 2008-01-18 | 2014-10-28 | The Board Of Trustees Of The University Of Illinois | Compositions and methods relating to nuclear hormone and steroid hormone receptors including inhibitors of estrogen receptor alpha-mediated gene expression and inhibition of breast cancer |
| WO2010056979A1 (en) * | 2008-11-14 | 2010-05-20 | Immune Control, Inc. | Phenothiazine derivatives for treatment of asthma |
| US8870876B2 (en) | 2009-02-13 | 2014-10-28 | Tarsus Medical Inc. | Methods and devices for treating hallux valgus |
| US20140057946A1 (en) * | 2012-08-23 | 2014-02-27 | Gtx | Estrogen receptor ligands and methods of use thereof |
| WO2013043304A1 (en) * | 2009-02-23 | 2013-03-28 | Gtx, Inc. | Estrogen receptor ligands and methods of use thereof |
| JP5611991B2 (ja) * | 2009-02-23 | 2014-10-22 | ジーティーエックス・インコーポレイテッド | Adtのための医薬の製造におけるエストロゲン受容体リガンドの使用方法 |
| US9624161B2 (en) | 2009-02-23 | 2017-04-18 | Gtx, Inc. | Estrogen receptor ligands and methods of use thereof |
| US9427418B2 (en) | 2009-02-23 | 2016-08-30 | Gtx, Inc. | Estrogen receptor ligands and methods of use thereof |
| US8277459B2 (en) | 2009-09-25 | 2012-10-02 | Tarsus Medical Inc. | Methods and devices for treating a structural bone and joint deformity |
| US10640457B2 (en) | 2009-12-10 | 2020-05-05 | The Trustees Of Columbia University In The City Of New York | Histone acetyltransferase activators and uses thereof |
| ES2907862T3 (es) * | 2009-12-10 | 2022-04-26 | Univ Columbia | Activadores de histona acetiltransferasa y usos de los mismos |
| US8652141B2 (en) | 2010-01-21 | 2014-02-18 | Tarsus Medical Inc. | Methods and devices for treating hallux valgus |
| US8696719B2 (en) | 2010-06-03 | 2014-04-15 | Tarsus Medical Inc. | Methods and devices for treating hallux valgus |
| EP2654428B1 (en) | 2010-12-22 | 2018-02-14 | The Trustees of Columbia University in the City of New York | Histone acetyltransferase modulators and usese thereof |
| US9809532B2 (en) | 2011-06-10 | 2017-11-07 | The Trustees Of Columbia University In The City Of New York | Uses of histone acetyltransferase activators |
| EP2747562A4 (en) * | 2011-08-23 | 2015-05-06 | Gtx Inc | ESTROGEN RECEPTOR LIGANDS AND METHOD FOR THEIR USE |
| EP2773721B1 (de) * | 2011-11-01 | 2015-11-25 | Merck Patent GmbH | Organische elektrolumineszenzvorrichtung |
| US10314807B2 (en) | 2012-07-13 | 2019-06-11 | Gtx, Inc. | Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS) |
| US9744149B2 (en) | 2012-07-13 | 2017-08-29 | Gtx, Inc. | Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs) |
| US9969683B2 (en) | 2012-07-13 | 2018-05-15 | Gtx, Inc. | Method of treating estrogen receptor (ER)-positive breast cancers with selective androgen receptor modulator (SARMS) |
| US10258596B2 (en) | 2012-07-13 | 2019-04-16 | Gtx, Inc. | Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS) |
| LT2872482T (lt) | 2012-07-13 | 2020-12-28 | Oncternal Therapeutics, Inc. | Krūties vėžių gydymo būdas selektyviu androgeno receptoriaus moduliatoriumi |
| US9622992B2 (en) | 2012-07-13 | 2017-04-18 | Gtx, Inc. | Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs) |
| US10987334B2 (en) | 2012-07-13 | 2021-04-27 | University Of Tennessee Research Foundation | Method of treating ER mutant expressing breast cancers with selective androgen receptor modulators (SARMs) |
| US9535071B2 (en) | 2012-09-07 | 2017-01-03 | The Governors Of The University Of Alberta | Methods and compositions for diagnosis of inflammatory liver disease |
| US9433608B2 (en) | 2013-05-08 | 2016-09-06 | Howard University | Compositions and method for treatment of ischemic neuronal reperfusion injury |
| CN107072969B (zh) * | 2014-07-24 | 2020-04-21 | 艾森潘帕克制药股份有限公司 | 使用顺式氯米芬治疗雄激素剥夺疗法诱导的热潮红和骨丢失 |
| US20220054429A1 (en) * | 2015-10-27 | 2022-02-24 | Jay Pharma, Inc. | Compositions comprising cannabidiol and second therapeutic agents for the treatment of cancer |
| WO2018208633A1 (en) * | 2017-05-07 | 2018-11-15 | China Medical University | Methods and compositions for treating withdrawal syndrome |
| WO2022006470A1 (en) | 2020-07-01 | 2022-01-06 | Vanderbilt University | Methods of treatment for a kidney disease |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE269213C (https=) | ||||
| US3413339A (en) * | 1964-06-18 | 1968-11-26 | Parke Davis & Co | Amine compounds and methods for their production |
| FR1536400A (fr) | 1967-07-05 | 1968-08-16 | Salicylanilides | |
| US3960886A (en) * | 1968-07-03 | 1976-06-01 | Sterling Drug Inc. | Substituted N-arylanilines |
| US3625972A (en) * | 1968-07-03 | 1971-12-07 | Sterling Drug Inc | N-phenylbenzanilides |
| FR2140645A1 (en) | 1971-06-11 | 1973-01-19 | Grace W R Ltd | Oxidation stabilised ester lubricants - contg mixed tert aromatic amines |
| US3838131A (en) * | 1972-04-03 | 1974-09-24 | Pfizer | Di(dialkylamino alkoxy)phenanthridines as antiviral agents |
| US3838134A (en) * | 1972-04-03 | 1974-09-24 | G Gauthier | Phenanthridinones as antiviral agents |
| US4373017A (en) * | 1980-03-05 | 1983-02-08 | Konishiroku Photo Industry Co., Ltd. | Photosensitive compound and photosensitive material containing it |
| US5491173A (en) * | 1982-06-25 | 1996-02-13 | Orion-Yhtyma Oy | Tri-phenyl alkene derivatives and their preparation and use |
| ATE148098T1 (de) | 1991-02-21 | 1997-02-15 | Sankyo Co | Benzolderivate zum fördern der produktion des nervenwachstumsfaktors |
| GB9418067D0 (en) | 1994-09-07 | 1994-10-26 | Orion Yhtymae Oy | Triphenylethylenes for the prevention and treatment of osteoporosis |
| EP0783303B1 (en) * | 1994-09-16 | 2002-11-27 | President And Fellows Of Harvard College | Use of aromatic halides for treating mammalian cell proliferation |
| AU732881C (en) * | 1994-09-16 | 2002-11-07 | Children's Medical Center Corporation | Triaryl and diaryl compounds, their analogues and uses thereof |
| GB9518994D0 (en) | 1995-09-16 | 1995-11-15 | Agrevo Uk Ltd | Fungicides |
| WO1997030047A1 (en) | 1996-02-17 | 1997-08-21 | Agrevo Uk Limited | Fungicidal 1,2,4-oxadiazoles and analogues |
| US20020156301A1 (en) * | 1997-06-17 | 2002-10-24 | Sumitomo Chemical Co., Ltd. | Triphenylmethane derivatives and use thereof |
| JPH1171332A (ja) * | 1997-06-17 | 1999-03-16 | Sumitomo Chem Co Ltd | トリフェニルメタン誘導体およびその用途 |
| US6632447B1 (en) * | 1998-05-07 | 2003-10-14 | The University Of Tennessee Research Corporation | Method for chemoprevention of prostate cancer |
| US6166013A (en) * | 1998-07-30 | 2000-12-26 | Abbott Laboratories | Glucocortiocoid-selective agents |
| JP2002542187A (ja) * | 1999-04-16 | 2002-12-10 | アストラゼネカ・アクチエボラーグ | エストロゲン−β受容体リガンド |
| JP4320089B2 (ja) | 1999-07-06 | 2009-08-26 | あすか製薬株式会社 | フェニルスルファメート誘導体 |
| DE19961372A1 (de) | 1999-12-17 | 2001-06-21 | Merck Patent Gmbh | Verfahren zur Herstellung kombinatorischer Bibliotheken arylsubstituierter Amine |
| US7001911B2 (en) * | 2000-06-28 | 2006-02-21 | Bristol-Myers Squibb Company | Fused cyclic modulators of nuclear hormone receptor function |
| AU2001292320A1 (en) | 2000-10-02 | 2002-04-15 | Tanabe Seiyaku Co., Ltd. | Benzylamine compound, process for producing the same, and intermediate therefor |
| US20020192310A1 (en) * | 2001-02-02 | 2002-12-19 | Bland Jeffrey S. | Medical composition for managing hormone balance |
| CN1896048A (zh) * | 2001-03-16 | 2007-01-17 | 出光兴产株式会社 | 芳香氨基化合物的生产方法 |
| JP2002322162A (ja) | 2001-04-26 | 2002-11-08 | Kyowa Hakko Kogyo Co Ltd | チアゾリジン誘導体 |
| US20060287282A1 (en) * | 2001-06-25 | 2006-12-21 | Steiner Mitchell S | Compositions comprising a SARM ad GnRH agonist or a GnRH antagonist, and methods of use thereof |
| CN1679956A (zh) * | 2001-11-29 | 2005-10-12 | Gtx公司 | 治疗因雄激素剥夺引起的症状 |
| AU2003256616B2 (en) | 2002-07-19 | 2009-08-27 | Memory Pharmaceuticals Corporation | Phosphodiesterase 4 inhibitors, including N-substituted aniline and diphenylamine analogs |
| WO2004026823A1 (en) | 2002-09-20 | 2004-04-01 | Pfizer Products Inc. | Amide and sulfonamide ligands for the estrogen receptor |
| JP4176076B2 (ja) * | 2002-11-08 | 2008-11-05 | 華為技術有限公司 | 無線lanユーザの在席情報のやりとりを行うための方法、システムおよび端末 |
| JP2004307380A (ja) | 2003-04-04 | 2004-11-04 | Mitsubishi Chemicals Corp | 新規化合物、電荷輸送材料、有機電界発光素子材料および有機電界発光素子 |
| US7601739B2 (en) * | 2003-08-08 | 2009-10-13 | Virgina Commonwealth University | Compounds having antiestrogenic and tissue selective estrogenic properties, and compounds with anti-androgenic properties for treatment of prostate cancer and androgen receptor dependent diseases |
| US8236861B2 (en) * | 2004-02-13 | 2012-08-07 | Hormos Medical Corporation | Method for enhancing the bioavailablity of ospemifene |
| US8158828B2 (en) | 2005-11-28 | 2012-04-17 | Gtx, Inc. | Nuclear receptor binding agents |
| EA201500845A1 (ru) * | 2005-11-28 | 2016-04-29 | Джи Ти Икс, ИНК. | Агенты, связывающиеся с ядерными рецепторами |
| BRPI0713198A2 (pt) * | 2006-07-19 | 2012-10-16 | Osurf Ohio State University Res Foundation | modulares seletivos de receptores de androgênio, seus análogos e derivados, e seus usos |
-
2007
- 2007-04-16 US US11/785,251 patent/US8158828B2/en not_active Expired - Fee Related
-
2008
- 2008-04-16 KR KR1020147032966A patent/KR101563609B1/ko not_active Expired - Fee Related
- 2008-04-16 WO PCT/US2008/004908 patent/WO2008130571A1/en not_active Ceased
- 2008-04-16 KR KR1020097006912A patent/KR101519456B1/ko not_active Expired - Fee Related
- 2008-04-16 JP JP2010504079A patent/JP5815237B2/ja not_active Expired - Fee Related
-
2014
- 2014-02-24 JP JP2014033091A patent/JP5913400B2/ja not_active Expired - Fee Related
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