EP2747562A4 - Estrogen receptor ligands and methods of use thereof - Google Patents

Estrogen receptor ligands and methods of use thereof

Info

Publication number
EP2747562A4
EP2747562A4 EP12834287.0A EP12834287A EP2747562A4 EP 2747562 A4 EP2747562 A4 EP 2747562A4 EP 12834287 A EP12834287 A EP 12834287A EP 2747562 A4 EP2747562 A4 EP 2747562A4
Authority
EP
European Patent Office
Prior art keywords
methods
estrogen receptor
receptor ligands
ligands
estrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP12834287.0A
Other languages
German (de)
French (fr)
Other versions
EP2747562A1 (en
Inventor
James Dalton
Mitchell S Steiner
Christopher C Coss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oncternal Therapeutics Inc
Original Assignee
GTx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US13/215,679 external-priority patent/US9427418B2/en
Application filed by GTx Inc filed Critical GTx Inc
Priority claimed from PCT/US2012/052141 external-priority patent/WO2013043304A1/en
Publication of EP2747562A1 publication Critical patent/EP2747562A1/en
Publication of EP2747562A4 publication Critical patent/EP2747562A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
EP12834287.0A 2011-08-23 2012-08-23 Estrogen receptor ligands and methods of use thereof Withdrawn EP2747562A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13/215,679 US9427418B2 (en) 2009-02-23 2011-08-23 Estrogen receptor ligands and methods of use thereof
PCT/US2012/052141 WO2013043304A1 (en) 2009-02-23 2012-08-23 Estrogen receptor ligands and methods of use thereof

Publications (2)

Publication Number Publication Date
EP2747562A1 EP2747562A1 (en) 2014-07-02
EP2747562A4 true EP2747562A4 (en) 2015-05-06

Family

ID=48444651

Family Applications (1)

Application Number Title Priority Date Filing Date
EP12834287.0A Withdrawn EP2747562A4 (en) 2011-08-23 2012-08-23 Estrogen receptor ligands and methods of use thereof

Country Status (10)

Country Link
EP (1) EP2747562A4 (en)
JP (1) JP2014524479A (en)
KR (1) KR20140064906A (en)
CN (1) CN103957706A (en)
AU (1) AU2012312902B2 (en)
CA (1) CA2845890A1 (en)
IL (1) IL231070A0 (en)
IN (1) IN2014DN01959A (en)
MX (1) MX2014002105A (en)
RU (1) RU2014111060A (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111164093A (en) * 2017-09-27 2020-05-15 塔尔格免疫治疗有限公司 Castration resistant prostate cancer
BR112021015160A2 (en) * 2019-02-01 2022-01-18 Fond Per Listituto Oncologico Di Ricerca Ior Treatment methods for castration-resistant prostate cancer

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007062230A2 (en) * 2005-11-28 2007-05-31 Gtx, Inc. Nuclear receptor binding agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8546451B2 (en) * 2005-11-28 2013-10-01 Gtx, Inc. Estrogen receptor ligands and methods of use thereof
US8158828B2 (en) * 2005-11-28 2012-04-17 Gtx, Inc. Nuclear receptor binding agents
KR20150135547A (en) * 2009-02-23 2015-12-02 지티엑스, 인코포레이티드 Estrogen receptor ligands and methods of use thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007062230A2 (en) * 2005-11-28 2007-05-31 Gtx, Inc. Nuclear receptor binding agents

Also Published As

Publication number Publication date
IN2014DN01959A (en) 2015-05-15
CN103957706A (en) 2014-07-30
AU2012312902A1 (en) 2013-05-23
CA2845890A1 (en) 2013-03-28
RU2014111060A (en) 2015-09-27
AU2012312902B2 (en) 2016-03-17
MX2014002105A (en) 2014-09-25
IL231070A0 (en) 2014-03-31
EP2747562A1 (en) 2014-07-02
JP2014524479A (en) 2014-09-22
KR20140064906A (en) 2014-05-28

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20140305

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DAX Request for extension of the european patent (deleted)
RA4 Supplementary search report drawn up and despatched (corrected)

Effective date: 20150408

RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 35/00 20060101ALI20150331BHEP

Ipc: A61K 45/06 20060101ALI20150331BHEP

Ipc: A61K 31/167 20060101AFI20150331BHEP

Ipc: A61K 31/137 20060101ALI20150331BHEP

Ipc: A61K 31/4453 20060101ALI20150331BHEP

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20180301