JP2010524457A5 - - Google Patents
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- JP2010524457A5 JP2010524457A5 JP2010503665A JP2010503665A JP2010524457A5 JP 2010524457 A5 JP2010524457 A5 JP 2010524457A5 JP 2010503665 A JP2010503665 A JP 2010503665A JP 2010503665 A JP2010503665 A JP 2010503665A JP 2010524457 A5 JP2010524457 A5 JP 2010524457A5
- Authority
- JP
- Japan
- Prior art keywords
- rpe
- cell
- pluripotent stem
- human pluripotent
- culture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000003583 retinal pigment epithelium Anatomy 0.000 claims 11
- 210000004027 cell Anatomy 0.000 claims 9
- 238000000034 method Methods 0.000 claims 9
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims 8
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 6
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 6
- 210000001778 pluripotent stem cell Anatomy 0.000 claims 6
- 238000012258 culturing Methods 0.000 claims 4
- 229960003966 nicotinamide Drugs 0.000 claims 4
- 235000005152 nicotinamide Nutrition 0.000 claims 4
- 239000011570 nicotinamide Substances 0.000 claims 4
- 239000007640 basal medium Substances 0.000 claims 3
- 230000004069 differentiation Effects 0.000 claims 3
- 239000003550 marker Substances 0.000 claims 3
- 208000017442 Retinal disease Diseases 0.000 claims 2
- 238000004113 cell culture Methods 0.000 claims 2
- 102000012304 Bestrophin Human genes 0.000 claims 1
- 108050002823 Bestrophin Proteins 0.000 claims 1
- 101000729271 Homo sapiens Retinoid isomerohydrolase Proteins 0.000 claims 1
- 102100031176 Retinoid isomerohydrolase Human genes 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 108010023082 activin A Proteins 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 230000004064 dysfunction Effects 0.000 claims 1
- 210000001671 embryonic stem cell Anatomy 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 239000002356 single layer Substances 0.000 claims 1
- 230000002269 spontaneous effect Effects 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90781807P | 2007-04-18 | 2007-04-18 | |
| US60/907,818 | 2007-04-18 | ||
| PCT/IL2008/000556 WO2008129554A1 (en) | 2007-04-18 | 2008-04-27 | Stem cell-derived retinal pigment epithelial cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010524457A JP2010524457A (ja) | 2010-07-22 |
| JP2010524457A5 true JP2010524457A5 (enExample) | 2011-05-26 |
| JP5395058B2 JP5395058B2 (ja) | 2014-01-22 |
Family
ID=39666210
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010503665A Active JP5395058B2 (ja) | 2007-04-18 | 2008-04-27 | 幹細胞に由来する網膜色素上皮細胞 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US8956866B2 (enExample) |
| EP (4) | EP3640326A1 (enExample) |
| JP (1) | JP5395058B2 (enExample) |
| CN (2) | CN101688178B (enExample) |
| AU (1) | AU2008242106B2 (enExample) |
| CA (1) | CA2684460C (enExample) |
| ES (2) | ES2527444T5 (enExample) |
| IL (2) | IL225163B (enExample) |
| WO (1) | WO2008129554A1 (enExample) |
Families Citing this family (80)
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|---|---|---|---|---|
| US7794704B2 (en) | 2004-01-23 | 2010-09-14 | Advanced Cell Technology, Inc. | Methods for producing enriched populations of human retinal pigment epithelium cells for treatment of retinal degeneration |
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| US8597947B2 (en) | 2004-12-29 | 2013-12-03 | Hadasit Medical Research Services & Development Limited | Undifferentiated stem cell culture systems |
| EP2410043A3 (en) * | 2004-12-29 | 2013-01-23 | Hadasit Medical Research Services And Development Ltd. | Stem cells culture systems |
| CN101688178B (zh) | 2007-04-18 | 2013-12-04 | 哈达锡特医学研究服务及发展有限公司 | 干细胞衍生的视网膜色素上皮细胞 |
| DK2209888T3 (da) * | 2007-10-12 | 2020-01-20 | Astellas Inst For Regenerative Medicine | Forbedrede fremgangsmåder til fremstilling af rpe-celler og sammensætninger af rpe-celler |
| US9534205B2 (en) | 2008-03-17 | 2017-01-03 | The Scripps Research Institute | Combined chemical and genetic approaches for generation of induced pluripotent stem cells |
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| CN101580816B (zh) * | 2009-04-23 | 2012-02-29 | 中国科学院广州生物医药与健康研究院 | 诱导多能性干细胞快速高效产生的新型无血清培养基以及使用其的方法 |
| CA3066806C (en) * | 2009-08-24 | 2023-03-07 | David M. Gamm | Substantially pure human retinal progenitor, forebrain progenitor, and retinal pigment epithelium cell cultures and methods of making the same |
| JP5885255B2 (ja) | 2009-08-28 | 2016-03-15 | セルラー ダイナミクス インターナショナル， インコーポレイテッド | 罹患組織における遺伝的変異の同定 |
| RU2409663C1 (ru) * | 2009-10-14 | 2011-01-20 | Российская Федерация, от имени которой выступает Федеральное Агентство по науке и инновациям | Способ получения дедифференцированных клеток ретинального пигментного эпителия глаза взрослого человека |
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| AU2013216382B2 (en) * | 2012-01-31 | 2018-08-02 | Hadasit Medical Research Services And Development Ltd. | Methods of selecting retinal pigmented epithelial cells |
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2008
- 2008-04-27 CN CN2008800207480A patent/CN101688178B/zh active Active
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- 2008-04-27 CA CA2684460A patent/CA2684460C/en active Active
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- 2008-04-27 WO PCT/IL2008/000556 patent/WO2008129554A1/en not_active Ceased
- 2008-04-27 EP EP19191405.0A patent/EP3640326A1/en not_active Withdrawn
- 2008-04-27 EP EP08738258.6A patent/EP2147094B2/en active Active
- 2008-04-27 JP JP2010503665A patent/JP5395058B2/ja active Active
- 2008-04-27 CN CN201310484803.4A patent/CN103555654B/zh active Active
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2013
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2014
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2017
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