JP2020534004A5 - - Google Patents
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- Publication number
- JP2020534004A5 JP2020534004A5 JP2020516436A JP2020516436A JP2020534004A5 JP 2020534004 A5 JP2020534004 A5 JP 2020534004A5 JP 2020516436 A JP2020516436 A JP 2020516436A JP 2020516436 A JP2020516436 A JP 2020516436A JP 2020534004 A5 JP2020534004 A5 JP 2020534004A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- thymic
- organoid
- keratin
- vitro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 230000002992 thymic effect Effects 0.000 claims 27
- 238000000034 method Methods 0.000 claims 24
- 210000002220 organoid Anatomy 0.000 claims 18
- 210000004027 cell Anatomy 0.000 claims 15
- 238000000338 in vitro Methods 0.000 claims 9
- 210000001744 T-lymphocyte Anatomy 0.000 claims 8
- 102000005705 Keratin-5 Human genes 0.000 claims 4
- 108010070553 Keratin-5 Proteins 0.000 claims 4
- 102000005712 Keratin-8 Human genes 0.000 claims 4
- 108010070511 Keratin-8 Proteins 0.000 claims 4
- 210000003386 epithelial cell of thymus gland Anatomy 0.000 claims 4
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 4
- 108010049955 Bone Morphogenetic Protein 4 Proteins 0.000 claims 3
- 102100024505 Bone morphogenetic protein 4 Human genes 0.000 claims 3
- 102000004864 Fibroblast growth factor 10 Human genes 0.000 claims 3
- 108090001047 Fibroblast growth factor 10 Proteins 0.000 claims 3
- 102000003972 Fibroblast growth factor 7 Human genes 0.000 claims 3
- 108090000385 Fibroblast growth factor 7 Proteins 0.000 claims 3
- 102000003956 Fibroblast growth factor 8 Human genes 0.000 claims 3
- 108090000368 Fibroblast growth factor 8 Proteins 0.000 claims 3
- 101000599951 Homo sapiens Insulin-like growth factor I Proteins 0.000 claims 3
- 102100037852 Insulin-like growth factor I Human genes 0.000 claims 3
- 238000012258 culturing Methods 0.000 claims 3
- 229940098448 fibroblast growth factor 7 Drugs 0.000 claims 3
- 210000000130 stem cell Anatomy 0.000 claims 3
- QASFUMOKHFSJGL-LAFRSMQTSA-N Cyclopamine Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H](CC2=C3C)[C@@H]1[C@@H]2CC[C@@]13O[C@@H]2C[C@H](C)CN[C@H]2[C@H]1C QASFUMOKHFSJGL-LAFRSMQTSA-N 0.000 claims 2
- 102100021592 Interleukin-7 Human genes 0.000 claims 2
- 108010002586 Interleukin-7 Proteins 0.000 claims 2
- 102000011782 Keratins Human genes 0.000 claims 2
- 108010076876 Keratins Proteins 0.000 claims 2
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 2
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 2
- 230000024245 cell differentiation Effects 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- QASFUMOKHFSJGL-UHFFFAOYSA-N cyclopamine Natural products C1C=C2CC(O)CCC2(C)C(CC2=C3C)C1C2CCC13OC2CC(C)CNC2C1C QASFUMOKHFSJGL-UHFFFAOYSA-N 0.000 claims 2
- 210000004039 endoderm cell Anatomy 0.000 claims 2
- 210000001778 pluripotent stem cell Anatomy 0.000 claims 2
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 102100033553 Delta-like protein 4 Human genes 0.000 claims 1
- 102100023371 Forkhead box protein N1 Human genes 0.000 claims 1
- 101000872077 Homo sapiens Delta-like protein 4 Proteins 0.000 claims 1
- 101000907576 Homo sapiens Forkhead box protein N1 Proteins 0.000 claims 1
- 101001124791 Homo sapiens Proteasome subunit beta type-11 Proteins 0.000 claims 1
- 206010061598 Immunodeficiency Diseases 0.000 claims 1
- 208000029462 Immunodeficiency disease Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 102000004245 Proteasome Endopeptidase Complex Human genes 0.000 claims 1
- 108090000708 Proteasome Endopeptidase Complex Proteins 0.000 claims 1
- 102100029082 Proteasome subunit beta type-11 Human genes 0.000 claims 1
- 108700022368 Whn Proteins 0.000 claims 1
- -1 Wnt3a Proteins 0.000 claims 1
- 230000001363 autoimmune Effects 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 210000001900 endoderm Anatomy 0.000 claims 1
- 230000007813 immunodeficiency Effects 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 229940100994 interleukin-7 Drugs 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 230000001575 pathological effect Effects 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 210000002536 stromal cell Anatomy 0.000 claims 1
- 230000001131 transforming effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762560908P | 2017-09-20 | 2017-09-20 | |
| US62/560,908 | 2017-09-20 | ||
| PCT/US2018/051625 WO2019060336A1 (en) | 2017-09-20 | 2018-09-19 | IN VITRO GENERATION OF THYMIC ORGANOID FROM HUMAN PLURIPOTENT STEM CELLS |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020534004A JP2020534004A (ja) | 2020-11-26 |
| JP2020534004A5 true JP2020534004A5 (enExample) | 2021-11-04 |
| JP7372910B2 JP7372910B2 (ja) | 2023-11-01 |
Family
ID=63794667
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020516436A Active JP7372910B2 (ja) | 2017-09-20 | 2018-09-19 | ヒト多能性幹細胞由来の胸腺オルガノイドのインビトロ生成 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US11898166B2 (enExample) |
| EP (1) | EP3684920A1 (enExample) |
| JP (1) | JP7372910B2 (enExample) |
| WO (1) | WO2019060336A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011140441A2 (en) | 2010-05-06 | 2011-11-10 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
| EP3149156B1 (en) | 2014-05-28 | 2021-02-17 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into gastric tissues through directed differentiation |
| KR102546194B1 (ko) | 2016-11-04 | 2023-06-21 | 칠드런즈 호스피탈 메디칼 센터 | 간 유사 장기 조성물 및 이를 제조 및 사용하는 방법 |
| WO2018191673A1 (en) | 2017-04-14 | 2018-10-18 | Children's Hospital Medical Center | Multi donor stem cell compositions and methods of making same |
| EP3694603A4 (en) | 2017-10-10 | 2021-07-14 | Children's Hospital Medical Center | ESOPHAGUS TISSUE AND / OR ORGANOID COMPOSITIONS AND METHOD FOR MANUFACTURING THEREOF |
| EP3727394A4 (en) | 2017-12-21 | 2021-09-08 | Children's Hospital Medical Center | DIGITALIZED HUMAN ORGANOIDS AND METHOD OF USING THEREOF |
| JP7506657B2 (ja) | 2018-07-26 | 2024-06-26 | チルドレンズ ホスピタル メディカル センター | 肝胆膵組織およびその作製方法 |
| US12428622B2 (en) | 2018-09-12 | 2025-09-30 | Children's Hospital Medical Center | Organoid compositions for the production of hematopoietic stem cells and derivatives thereof |
| EP3947639A4 (en) | 2019-04-01 | 2023-01-25 | The Trustees of Columbia University in the City of New York | METHOD OF PROMOTING THYMICAL PITHELIAL CELL AND THYMAL PITHELIAL CELL PROGENITOR DIFFERENTIATION FROM PLURIPOTENTIC STEM CELLS |
| EP3959304A4 (en) * | 2019-04-26 | 2023-01-25 | The Regents Of The University Of Colorado, A Body Corporate | GENERATION OF FUNCTIONAL AND PATIENT-SPECIFIC THYMUS TISSUE IN VIVO FROM INDUCED PLURIPOTENTS STEM CELLS |
| JP7610533B2 (ja) | 2019-05-31 | 2025-01-08 | チルドレンズ ホスピタル メディカル センター | 造血幹細胞の生成および拡大方法 |
| CN114502721A (zh) * | 2019-08-13 | 2022-05-13 | 儿童医院医学中心 | 用于制备类器官组合物的改进方法 |
| US20230002727A1 (en) * | 2019-11-25 | 2023-01-05 | Allegheny Singer Research Institute | Thymus organoids bioengineered from human pluripotent stem cells |
| KR20230004690A (ko) * | 2020-04-28 | 2023-01-06 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 시험관 내에서 흉선 세포를 생성하는 방법 |
| WO2022076751A1 (en) * | 2020-10-07 | 2022-04-14 | The Regents Of The University Of Colorado, A Body Corporate | Compositions, methods and use for in vitro and in vivo generation of functional thymic tissue |
| GB2601793B (en) * | 2020-12-10 | 2025-07-23 | The Francis Crick Institute Ltd | Thymic constructs and uses thereof |
| KR20240075885A (ko) * | 2021-10-15 | 2024-05-29 | 타이뮨 테라퓨틱스, 인코포레이티드 | 가슴샘 세포 및 제조 방법 |
| US20250332259A1 (en) * | 2022-06-17 | 2025-10-30 | Kyoto University | Thymic epithelial cell production method |
| KR20250109947A (ko) * | 2024-01-11 | 2025-07-18 | 재단법인 아산사회복지재단 | 흉선 세포 또는 흉선 상피세포를 유효성분으로 포함하는 암 예방용 약학적 조성물 |
| CN119614476A (zh) * | 2024-11-13 | 2025-03-14 | 广州市第一人民医院（广州消化疾病中心、广州医科大学附属市一人民医院、华南理工大学附属第二医院） | 胸腺类器官的构建方法和应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2602145T3 (es) | 2002-09-06 | 2017-02-17 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Inmunoterapia con linfocitos específicos de antígeno seleccionados in vitro después de quimioterapia supresora de linfocitos no mieloablativa |
| AU2008247311A1 (en) | 2007-05-03 | 2008-11-13 | Australian Stem Cell Centre Ltd. | Novel thymic cellular populations and uses thereof |
| WO2010143529A1 (ja) * | 2009-06-09 | 2010-12-16 | 国立大学法人名古屋大学 | 多能性幹細胞を胸腺上皮へ分化誘導する方法 |
| US8383099B2 (en) | 2009-08-28 | 2013-02-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Adoptive cell therapy with young T cells |
| US20120244133A1 (en) | 2011-03-22 | 2012-09-27 | The United States of America, as represented by the Secretary, Department of Health and | Methods of growing tumor infiltrating lymphocytes in gas-permeable containers |
| WO2014066649A1 (en) | 2012-10-26 | 2014-05-01 | The Regents Of The University Of California | A strategy for engineering various 3d tissues, organoids and vasculature |
| TW202344686A (zh) | 2015-10-30 | 2023-11-16 | 美國加利福尼亞大學董事會 | 從幹細胞產生t細胞之方法及使用該t細胞之免疫療法 |
-
2018
- 2018-09-19 JP JP2020516436A patent/JP7372910B2/ja active Active
- 2018-09-19 WO PCT/US2018/051625 patent/WO2019060336A1/en not_active Ceased
- 2018-09-19 EP EP18783234.0A patent/EP3684920A1/en active Pending
- 2018-09-19 US US16/648,008 patent/US11898166B2/en active Active
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