BR112022024031A2 - Agregados de células duplas de epitélio pigmentado da retina e fotorreceptor, e métodos de uso dos mesmos - Google Patents

Agregados de células duplas de epitélio pigmentado da retina e fotorreceptor, e métodos de uso dos mesmos

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Publication number
BR112022024031A2
BR112022024031A2 BR112022024031A BR112022024031A BR112022024031A2 BR 112022024031 A2 BR112022024031 A2 BR 112022024031A2 BR 112022024031 A BR112022024031 A BR 112022024031A BR 112022024031 A BR112022024031 A BR 112022024031A BR 112022024031 A2 BR112022024031 A2 BR 112022024031A2
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BR
Brazil
Prior art keywords
photoreceptor
dual cell
methods
cell aggregates
pigmented epithelium
Prior art date
Application number
BR112022024031A
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English (en)
Inventor
Dias Andrew
Berndt Erich
Chase Lucas
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Fujifilm Cellular Dynamics Inc
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Publication date
Application filed by Fujifilm Cellular Dynamics Inc filed Critical Fujifilm Cellular Dynamics Inc
Publication of BR112022024031A2 publication Critical patent/BR112022024031A2/pt

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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5058—Neurological cells
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    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/32—Amino acids
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/38—Hormones with nuclear receptors
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
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    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/08—Coculture with; Conditioned medium produced by cells of the nervous system
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    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/08—Coculture with; Conditioned medium produced by cells of the nervous system
    • C12N2502/085—Coculture with; Conditioned medium produced by cells of the nervous system eye cells

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Immunology (AREA)
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  • Urology & Nephrology (AREA)
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  • Ophthalmology & Optometry (AREA)
  • Neurosurgery (AREA)
  • Physics & Mathematics (AREA)
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Abstract

AGREGADOS DE CÉLULAS DUPLAS DE EPITÉLIO PIGMENTADO DA RETINA E FOTORRECEPTOR, E MÉTODOS DE USO DOS MESMOS. A presente invenção refere-se a uma cultura de agregado de células duplas de células epiteliais da retina e fotorreceptores para uso como uma ferramenta de pesquisa, tal como a triagem de compostos ou modelo para estudo de doenças da retina, bem como uma terapêutica para o tratamento de doenças oculares.
BR112022024031A 2020-05-29 2021-05-28 Agregados de células duplas de epitélio pigmentado da retina e fotorreceptor, e métodos de uso dos mesmos BR112022024031A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063032368P 2020-05-29 2020-05-29
PCT/US2021/034930 WO2021243256A1 (en) 2020-05-29 2021-05-28 Retinal pigmented epithelium and photoreceptor dual cell aggregates and methods of use thereof

Publications (1)

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BR112022024031A2 true BR112022024031A2 (pt) 2023-01-31

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US (1) US20230201267A1 (pt)
EP (1) EP4157294A1 (pt)
JP (1) JP2023528377A (pt)
KR (1) KR20230019453A (pt)
CN (1) CN116033912A (pt)
AU (1) AU2021280343A1 (pt)
BR (1) BR112022024031A2 (pt)
CA (1) CA3178949A1 (pt)
IL (1) IL298085A (pt)
MX (1) MX2022015012A (pt)
WO (1) WO2021243256A1 (pt)

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MX2022015012A (es) 2023-03-03
AU2021280343A1 (en) 2022-12-08
IL298085A (en) 2023-01-01
KR20230019453A (ko) 2023-02-08
WO2021243256A1 (en) 2021-12-02
US20230201267A1 (en) 2023-06-29
CA3178949A1 (en) 2021-12-02
EP4157294A1 (en) 2023-04-05
CN116033912A (zh) 2023-04-28
JP2023528377A (ja) 2023-07-04

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