JP2010523684A5 - - Google Patents
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- JP2010523684A5 JP2010523684A5 JP2010503091A JP2010503091A JP2010523684A5 JP 2010523684 A5 JP2010523684 A5 JP 2010523684A5 JP 2010503091 A JP2010503091 A JP 2010503091A JP 2010503091 A JP2010503091 A JP 2010503091A JP 2010523684 A5 JP2010523684 A5 JP 2010523684A5
- Authority
- JP
- Japan
- Prior art keywords
- item
- alkyl
- aryl
- carbonyl
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims description 398
- 125000000217 alkyl group Chemical group 0.000 claims description 300
- 125000003118 aryl group Chemical group 0.000 claims description 224
- -1 tetracycline compound Chemical class 0.000 claims description 223
- 125000000623 heterocyclic group Chemical group 0.000 claims description 215
- 229910052739 hydrogen Inorganic materials 0.000 claims description 212
- 239000001257 hydrogen Substances 0.000 claims description 212
- 125000003545 alkoxy group Chemical group 0.000 claims description 171
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 167
- 125000003342 alkenyl group Chemical group 0.000 claims description 165
- 125000002252 acyl group Chemical group 0.000 claims description 163
- 229910052736 halogen Inorganic materials 0.000 claims description 162
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 161
- 150000002367 halogens Chemical class 0.000 claims description 161
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 160
- 125000000304 alkynyl group Chemical group 0.000 claims description 159
- 150000002431 hydrogen Chemical class 0.000 claims description 159
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 claims description 159
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims description 159
- 150000003568 thioethers Chemical class 0.000 claims description 159
- 150000001875 compounds Chemical class 0.000 claims description 58
- 239000004098 Tetracycline Substances 0.000 claims description 57
- 229960002180 tetracycline Drugs 0.000 claims description 57
- 229930101283 tetracycline Natural products 0.000 claims description 57
- 235000019364 tetracycline Nutrition 0.000 claims description 57
- 125000001931 aliphatic group Chemical group 0.000 claims description 48
- 229910052760 oxygen Inorganic materials 0.000 claims description 30
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 22
- 102100021947 Survival motor neuron protein Human genes 0.000 claims description 16
- 101000617738 Homo sapiens Survival motor neuron protein Proteins 0.000 claims description 14
- 108020004999 messenger RNA Proteins 0.000 claims description 11
- 239000000651 prodrug Chemical group 0.000 claims description 8
- 229940002612 prodrug Drugs 0.000 claims description 8
- 150000003839 salts Chemical class 0.000 claims description 6
- 208000002320 spinal muscular atrophy Diseases 0.000 claims description 6
- 229910052717 sulfur Inorganic materials 0.000 claims description 6
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 150000002148 esters Chemical class 0.000 claims description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 2
- 210000005228 liver tissue Anatomy 0.000 claims description 2
- 210000005084 renal tissue Anatomy 0.000 claims description 2
- 150000003522 tetracyclines Chemical class 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 3
- 108700024394 Exon Proteins 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 description 58
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 51
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 35
- 125000004193 piperazinyl group Chemical group 0.000 description 13
- 125000003386 piperidinyl group Chemical group 0.000 description 8
- 229910052799 carbon Inorganic materials 0.000 description 7
- 125000004183 alkoxy alkyl group Chemical group 0.000 description 4
- 125000004103 aminoalkyl group Chemical group 0.000 description 4
- 125000004663 dialkyl amino group Chemical group 0.000 description 4
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 3
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 3
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 3
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 3
- 125000004070 6 membered heterocyclic group Chemical group 0.000 description 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 description 2
- 125000005036 alkoxyphenyl group Chemical class 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 description 2
- 229910052731 fluorine Inorganic materials 0.000 description 2
- 239000011737 fluorine Substances 0.000 description 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 description 2
- 125000002757 morpholinyl group Chemical group 0.000 description 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 125000004076 pyridyl group Chemical group 0.000 description 2
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 description 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 description 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
- 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 description 1
- 125000002541 furyl group Chemical group 0.000 description 1
- 125000005928 isopropyloxycarbonyl group Chemical group [H]C([H])([H])C([H])(OC(*)=O)C([H])([H])[H] 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 description 1
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 description 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92303107P | 2007-04-12 | 2007-04-12 | |
| US93088307P | 2007-05-18 | 2007-05-18 | |
| US94611007P | 2007-06-25 | 2007-06-25 | |
| US99416307P | 2007-09-18 | 2007-09-18 | |
| US98619207P | 2007-11-07 | 2007-11-07 | |
| PCT/US2008/004827 WO2008127722A1 (en) | 2007-04-12 | 2008-04-14 | Methods for treating spinal muscular atrophy using tetracycline compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010523684A JP2010523684A (ja) | 2010-07-15 |
| JP2010523684A5 true JP2010523684A5 (https=) | 2011-06-02 |
Family
ID=39682763
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010503091A Pending JP2010523684A (ja) | 2007-04-12 | 2008-04-14 | テトラサイクリン化合物を用いる、脊髄筋委縮症を治療するための方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7935687B2 (https=) |
| EP (1) | EP2144614A1 (https=) |
| JP (1) | JP2010523684A (https=) |
| AU (1) | AU2008239606A1 (https=) |
| CA (1) | CA2688725A1 (https=) |
| WO (1) | WO2008127722A1 (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6756365B2 (en) * | 1991-11-06 | 2004-06-29 | Trustees Of Tufts College | Reducing tetracycline resistance in living cells |
| WO1999037306A1 (en) * | 1998-01-23 | 1999-07-29 | Trustees Of Tufts College | Pharmaceutically active compounds and methods of use thereof |
| US20040224927A1 (en) * | 2000-06-16 | 2004-11-11 | Trustees Of Tufts College | 7-N-substituted phenyl tetracycline compounds |
| US20020132798A1 (en) * | 2000-06-16 | 2002-09-19 | Nelson Mark L. | 7-phenyl-substituted tetracycline compounds |
| IL153672A0 (en) * | 2000-07-07 | 2003-07-06 | Tufts College | 7-substituted tetracycline compounds |
| US7094806B2 (en) * | 2000-07-07 | 2006-08-22 | Trustees Of Tufts College | 7, 8 and 9-substituted tetracycline compounds |
| US8088820B2 (en) * | 2001-04-24 | 2012-01-03 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for the treatment of malaria |
| CA2503446C (en) | 2002-10-24 | 2012-12-18 | Paratek Pharmaceuticals, Inc. | Methods of using substituted tetracycline compounds to modulate rna |
| US20050143352A1 (en) | 2003-07-09 | 2005-06-30 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| US20060287283A1 (en) * | 2003-07-09 | 2006-12-21 | Paratek Pharmaceuticals, Inc. | Prodrugs of 9-aminomethyl tetracycline compounds |
| EP2033950A1 (en) * | 2004-10-25 | 2009-03-11 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| CA2597212A1 (en) | 2005-02-04 | 2006-08-10 | Paratek Pharmaceuticals, Inc. | 11a, 12-derivatives of tetracycline compounds |
| US20070093455A1 (en) * | 2005-07-21 | 2007-04-26 | Paul Abato | 10-substituted tetracyclines and methods of use thereof |
| EP2431469A3 (en) * | 2006-05-15 | 2012-05-30 | Paratek Pharmaceuticals, Inc. | Methods of regulating expression of genes or of gene products using substituted tetracycline compounds |
| WO2008079339A2 (en) | 2006-12-21 | 2008-07-03 | Paratek Pharmaceuticals, Inc. | Tetracycline derivatives for the treatment of bacterial, viral and parasitic infections |
| CA2892739A1 (en) | 2006-12-21 | 2008-07-03 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for treatment of inflammatory skin disorders |
| AU2008239606A1 (en) | 2007-04-12 | 2008-10-23 | Paratek Pharmaceuticals, Inc. | Methods for treating spinal muscular atrophy using tetracycline compounds |
| CA2717703A1 (en) * | 2008-03-05 | 2009-09-11 | Paratek Pharmaceuticals, Inc. | Minocycline compounds and methods of use thereof |
| WO2009128913A1 (en) * | 2008-04-14 | 2009-10-22 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| KR101746795B1 (ko) | 2008-08-08 | 2017-06-13 | 테트라페이즈 파마슈티컬스, 인코포레이티드 | Ｃ７-플루오로 치환된 테트라시클린 화합물 |
| US20100190755A1 (en) * | 2008-09-19 | 2010-07-29 | Paul Abato | Tetracycline compounds for the treatment of rheumatoid arthritis and related methods of treatment |
| WO2010129057A2 (en) | 2009-05-08 | 2010-11-11 | Tetraphase Pharmaceuticals, Inc. | Tetracycline compounds |
| NO2470500T3 (https=) | 2009-08-28 | 2018-03-03 | ||
| CA2874640A1 (en) * | 2012-05-30 | 2013-12-05 | Paratek Pharmaceuticals, Inc. | 7-disubstituted-phenyl tetracycline derivatives |
| CA2883238C (en) | 2012-08-31 | 2021-11-23 | Tetraphase Pharmaceuticals, Inc. | Tetracycline compounds |
| AU2017283546C1 (en) | 2016-06-13 | 2020-11-19 | Scholar Rock, Inc. | Use of myostatin inhibitors and combination therapies |
| HUE066360T2 (hu) | 2016-10-19 | 2024-07-28 | Tetraphase Pharmaceuticals Inc | Eravaciklin kristályformái |
| BR112019008897A2 (pt) | 2016-11-01 | 2019-08-13 | Paratek Pharm Innc | método para tratar pneumonia bacteriana adquirida na comunidade. |
| WO2022093724A1 (en) | 2020-10-26 | 2022-05-05 | Scholar Rock, Inc. | Use of anti-pro/latent myostatin antibody for treating spinal muscular atrophy |
| DK4518970T3 (da) | 2022-05-04 | 2026-04-07 | Scholar Rock Inc | Anvendelse af myostatinhæmmer til behandling af spinal muskelatrofi |
| WO2026076383A1 (en) | 2024-10-06 | 2026-04-09 | Scholar Rock, Inc. | Use of myostatin inhibitor for treating spinal muscular atrophy |
Family Cites Families (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2990331A (en) * | 1956-11-23 | 1961-06-27 | Pfizer & Co C | Stable solutions of salts of tetracyclines for parenteral administration |
| US2980584A (en) * | 1957-10-29 | 1961-04-18 | Pfizer & Co C | Parenteral magnesium oxytetracycline acetic or lactic acid carboxamide vehicle preparation |
| US3062717A (en) * | 1958-12-11 | 1962-11-06 | Pfizer & Co C | Intramuscular calcium tetracycline acetic or lactic acid carboxamide vehicle preparation |
| US3165531A (en) * | 1962-03-08 | 1965-01-12 | Pfizer & Co C | 13-substituted-6-deoxytetracyclines and process utilizing the same |
| US3454697A (en) * | 1965-06-08 | 1969-07-08 | American Cyanamid Co | Tetracycline antibiotic compositions for oral use |
| NL6607516A (https=) * | 1966-05-31 | 1967-12-01 | ||
| DE1767891C3 (de) * | 1968-06-28 | 1980-10-30 | Pfizer | Verfahren zur Herstellung von wäßrigen arzneilichen Lösungen für die parenterale, perorale und lokale Anwendung mit einem Gehalt an einem Tetracyclinderivat |
| NL158172B (nl) | 1972-09-18 | 1978-10-16 | Farmaceutici Italia | Werkwijze voor het bereiden van tetracyclinederivaten met een substituent op de 7-plaats. |
| US3957980A (en) * | 1972-10-26 | 1976-05-18 | Pfizer Inc. | Doxycycline parenteral compositions |
| DE2442829A1 (de) * | 1974-09-06 | 1976-03-18 | Merck Patent Gmbh | Tetracyclische verbindungen und verfahren zu ihrer herstellung |
| US4018889A (en) * | 1976-01-02 | 1977-04-19 | Pfizer Inc. | Oxytetracycline compositions |
| US4126680A (en) * | 1977-04-27 | 1978-11-21 | Pfizer Inc. | Tetracycline antibiotic compositions |
| US4806529A (en) * | 1982-11-18 | 1989-02-21 | Trustees Of Tufts College, Tufts University | Tetracycline activity enhancement |
| US5064821A (en) * | 1982-11-18 | 1991-11-12 | Trustees Of Tufts College | Method and compositions for overcoming tetracycline resistance within living cells |
| US5589470A (en) * | 1990-02-26 | 1996-12-31 | Trustees Of Tufts College | Reducing tetracycline resistance in living cells |
| US4806372A (en) * | 1985-02-15 | 1989-02-21 | Georgia Oil & Gas Co., Inc. | Nitrite-free-curing of bacon and product thereof |
| US6756365B2 (en) * | 1991-11-06 | 2004-06-29 | Trustees Of Tufts College | Reducing tetracycline resistance in living cells |
| WO1999037306A1 (en) | 1998-01-23 | 1999-07-29 | Trustees Of Tufts College | Pharmaceutically active compounds and methods of use thereof |
| US6256365B1 (en) * | 1999-08-16 | 2001-07-03 | Analogic Corporation | Apparatus and method for reconstruction of images in a computed tomography system using oblique slices |
| US6849615B2 (en) * | 1999-09-14 | 2005-02-01 | Paratek Pharmaceuticals, Inc. | 13-substituted methacycline compounds |
| US6500812B2 (en) * | 1999-09-14 | 2002-12-31 | Paratek Pharmaceuticals, Inc. | 13-substituted methacycline compounds |
| EA016099B1 (ru) * | 1999-09-14 | 2012-02-28 | Трастис Оф Тафтс Коллидж | Замещенный аналог тетрациклина (варианты) и способ получения замещенного аналога тетрациклина |
| AU3105801A (en) * | 2000-01-24 | 2001-07-31 | Trustees Of Tufts College | Tetracycline compounds for treatment of cryptosporidium parvum related disorders |
| EA200201046A1 (ru) | 2000-03-31 | 2003-04-24 | Трастис Оф Тафтс Коллидж | 7- или 9-замещенные соединения тетрациклина, способ их получения (варианты), фармацевтическая композиция, способ лечения состояния, чувствительного к действию тетрациклина, у млекопитающего и реакционноспособное промежуточное производное |
| CA2409063A1 (en) * | 2000-05-15 | 2001-11-22 | Mark L. Nelson | 7-substituted fused ring tetracycline compounds |
| US20040224927A1 (en) | 2000-06-16 | 2004-11-11 | Trustees Of Tufts College | 7-N-substituted phenyl tetracycline compounds |
| US20020132798A1 (en) * | 2000-06-16 | 2002-09-19 | Nelson Mark L. | 7-phenyl-substituted tetracycline compounds |
| AU2001268475A1 (en) | 2000-06-16 | 2002-01-02 | Trustees Of Tufts College | 7-phenyl-substituted tetracycline compounds |
| IL153672A0 (en) * | 2000-07-07 | 2003-07-06 | Tufts College | 7-substituted tetracycline compounds |
| US20050143353A1 (en) | 2000-07-07 | 2005-06-30 | Paratek Pharmaceuticals, Inc. | 13-Substituted methacycline compounds |
| EA009175B1 (ru) * | 2000-07-07 | 2007-12-28 | Трастис Оф Тафтс Коллидж | Замещенные соединения миноциклина, фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния млекопитающего |
| US7094806B2 (en) * | 2000-07-07 | 2006-08-22 | Trustees Of Tufts College | 7, 8 and 9-substituted tetracycline compounds |
| WO2002004404A2 (en) * | 2000-07-07 | 2002-01-17 | Trustees Of Tufts College | 7,8 and 9-substituted tetracycline compounds |
| EA013835B1 (ru) * | 2001-03-13 | 2010-08-30 | Пэрэтек Фамэсьютикэлс, Инк. | Замещенные соединения тетрациклина (варианты), фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния субъекта |
| EP1241160A1 (en) * | 2001-03-13 | 2002-09-18 | Glaxo Group Limited | Tetracycline derivatives and their use as antibiotic agents |
| US7553828B2 (en) * | 2001-03-13 | 2009-06-30 | Paratek Pharmaceuticals, Inc. | 9-aminomethyl substituted minocycline compounds |
| WO2002072506A2 (en) * | 2001-03-13 | 2002-09-19 | Paratek Pharmaceuticals, Inc. | 7-pyrollyl tetracycline compounds and methods of use thereof |
| US6841546B2 (en) | 2001-03-14 | 2005-01-11 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds as antifungal agents |
| EP1381372A2 (en) | 2001-03-14 | 2004-01-21 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds as synergistic antifungal agents |
| US8088820B2 (en) | 2001-04-24 | 2012-01-03 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for the treatment of malaria |
| EP2327409A1 (en) | 2001-07-13 | 2011-06-01 | Paratek Pharmaceuticals, Inc. | Tetracycline compound having target therapeutic activities |
| US20060194773A1 (en) | 2001-07-13 | 2006-08-31 | Paratek Pharmaceuticals, Inc. | Tetracyline compounds having target therapeutic activities |
| AU2002365120A1 (en) * | 2001-08-02 | 2003-07-15 | Paratek Pharmaceuticals, Inc. | Medicaments |
| AU2002323688A1 (en) | 2001-09-10 | 2003-03-24 | Paratek Pharmaceuticals, Inc. | Computational method for determining oral bioavailability |
| ES2551708T3 (es) * | 2002-01-08 | 2015-11-23 | Paratek Pharmaceuticals, Inc. | Compuestos de 4-desdimetilamino tetraciclina |
| EP2311451A1 (en) | 2002-03-08 | 2011-04-20 | Paratek Pharmaceuticals, Inc. | Amino-methyl substituted tetracycline compounds |
| EP1503981A4 (en) | 2002-03-21 | 2007-08-15 | Paratek Pharm Innc | SUBSTITUTED TETRACYCLINE COMPOUNDS |
| AU2003261161B2 (en) | 2002-07-12 | 2009-09-10 | Paratek Pharmaceuticals, Inc | 3, 10, and 12a substituted tetracycline compounds |
| CA2503446C (en) | 2002-10-24 | 2012-12-18 | Paratek Pharmaceuticals, Inc. | Methods of using substituted tetracycline compounds to modulate rna |
| US20050143352A1 (en) | 2003-07-09 | 2005-06-30 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| US20060287283A1 (en) | 2003-07-09 | 2006-12-21 | Paratek Pharmaceuticals, Inc. | Prodrugs of 9-aminomethyl tetracycline compounds |
| EP1675548A4 (en) | 2003-09-25 | 2008-08-13 | Activbiotics Inc | RIFALAZIL FORMULATIONS |
| JP5010284B2 (ja) | 2004-01-15 | 2012-08-29 | パラテック ファーマシューティカルズ インコーポレイテッド | テトラサイクリン化合物の芳香族ａ環誘導体 |
| EP2033950A1 (en) | 2004-10-25 | 2009-03-11 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| EP1805134B1 (en) | 2004-10-25 | 2012-06-20 | Paratek Pharmaceuticals, Inc. | 4-aminotetracyclines and methods of use thereof |
| CA2597212A1 (en) | 2005-02-04 | 2006-08-10 | Paratek Pharmaceuticals, Inc. | 11a, 12-derivatives of tetracycline compounds |
| WO2006119295A2 (en) * | 2005-05-02 | 2006-11-09 | Combinatorx, Incorporated | Compositions and methods for the treatment of neurodegenerative diseases |
| US20070093455A1 (en) | 2005-07-21 | 2007-04-26 | Paul Abato | 10-substituted tetracyclines and methods of use thereof |
| AU2007208214B2 (en) | 2006-01-24 | 2013-02-14 | Paratek Pharmaceuticals, Inc. | Methods of increasing oral bioavailability of tetracyclines |
| EP2431469A3 (en) | 2006-05-15 | 2012-05-30 | Paratek Pharmaceuticals, Inc. | Methods of regulating expression of genes or of gene products using substituted tetracycline compounds |
| CA2892739A1 (en) | 2006-12-21 | 2008-07-03 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for treatment of inflammatory skin disorders |
| AU2008239606A1 (en) | 2007-04-12 | 2008-10-23 | Paratek Pharmaceuticals, Inc. | Methods for treating spinal muscular atrophy using tetracycline compounds |
| EP2216323A3 (en) | 2007-04-27 | 2010-12-29 | Paratek Pharmaceuticals, Inc. | Methods for synthesizing and purifying aminoalkyl tetracycline compounds |
| EP2176216B1 (en) | 2007-07-06 | 2012-04-25 | Paratek Pharmaceuticals, Inc. | Methods for synthesizing 9-substituted minocycline |
-
2008
- 2008-04-14 AU AU2008239606A patent/AU2008239606A1/en not_active Abandoned
- 2008-04-14 EP EP08742883A patent/EP2144614A1/en not_active Withdrawn
- 2008-04-14 CA CA2688725A patent/CA2688725A1/en not_active Abandoned
- 2008-04-14 JP JP2010503091A patent/JP2010523684A/ja active Pending
- 2008-04-14 US US12/102,623 patent/US7935687B2/en not_active Expired - Fee Related
- 2008-04-14 WO PCT/US2008/004827 patent/WO2008127722A1/en not_active Ceased
-
2011
- 2011-05-03 US US13/099,993 patent/US8399437B2/en not_active Expired - Fee Related
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