CA2688725A1 - Methods for treating spinal muscular atrophy using tetracycline compounds - Google Patents

Methods for treating spinal muscular atrophy using tetracycline compounds Download PDF

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Publication number
CA2688725A1
CA2688725A1 CA2688725A CA2688725A CA2688725A1 CA 2688725 A1 CA2688725 A1 CA 2688725A1 CA 2688725 A CA2688725 A CA 2688725A CA 2688725 A CA2688725 A CA 2688725A CA 2688725 A1 CA2688725 A1 CA 2688725A1
Authority
CA
Canada
Prior art keywords
alkyl
heterocyclic
aryl
hydrogen
carbonyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2688725A
Other languages
English (en)
Inventor
Joel Berniac
Todd Bowser
Michael Draper
Stuart B. Levy
Mark L. Nelson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Paratek Pharmaceuticals Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2688725A1 publication Critical patent/CA2688725A1/en
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA2688725A 2007-04-12 2008-04-14 Methods for treating spinal muscular atrophy using tetracycline compounds Abandoned CA2688725A1 (en)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US92303107P 2007-04-12 2007-04-12
US60/923,031 2007-04-12
US93088307P 2007-05-18 2007-05-18
US60/930,883 2007-05-18
US94611007P 2007-06-25 2007-06-25
US60/946,110 2007-06-25
US99416307P 2007-09-18 2007-09-18
US60/994,163 2007-09-18
US98619207P 2007-11-07 2007-11-07
US60/986,192 2007-11-07
PCT/US2008/004827 WO2008127722A1 (en) 2007-04-12 2008-04-14 Methods for treating spinal muscular atrophy using tetracycline compounds

Publications (1)

Publication Number Publication Date
CA2688725A1 true CA2688725A1 (en) 2008-10-23

Family

ID=39682763

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2688725A Abandoned CA2688725A1 (en) 2007-04-12 2008-04-14 Methods for treating spinal muscular atrophy using tetracycline compounds

Country Status (6)

Country Link
US (2) US7935687B2 (https=)
EP (1) EP2144614A1 (https=)
JP (1) JP2010523684A (https=)
AU (1) AU2008239606A1 (https=)
CA (1) CA2688725A1 (https=)
WO (1) WO2008127722A1 (https=)

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CA2318580A1 (en) * 1998-01-23 1999-07-29 Mark L. Nelson Pharmaceutically active compounds and methods of use thereof
US20040224927A1 (en) 2000-06-16 2004-11-11 Trustees Of Tufts College 7-N-substituted phenyl tetracycline compounds
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US7094806B2 (en) * 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
CN1450989A (zh) * 2000-07-07 2003-10-22 塔夫茨大学信托人 7－取代的四环素化合物
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CA2503446C (en) * 2002-10-24 2012-12-18 Paratek Pharmaceuticals, Inc. Methods of using substituted tetracycline compounds to modulate rna
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CA2531728A1 (en) 2003-07-09 2005-02-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
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JP2009502809A (ja) * 2005-07-21 2009-01-29 パラテック ファーマシューティカルズ インコーポレイテッド １０−置換テトラサイクリンおよびその使用方法
AU2007249695A1 (en) * 2006-05-15 2007-11-22 Paratek Pharmaceuticals, Inc. Methods of regulating expression of genes or of gene products using substituted tetracycline compounds
PT2120963T (pt) 2006-12-21 2018-12-17 Paratek Pharm Innc Compostos tetraciclina substituídos para tratamento de distúrbios inflamatórios da pele
PL2109602T3 (pl) * 2006-12-21 2014-09-30 Paratek Pharm Innc Pochodne tetracyliny do leczenia zakażeń bakteryjnych, wirusowych i pasożytniczych
JP2010523684A (ja) 2007-04-12 2010-07-15 パラテック ファーマシューティカルズ インコーポレイテッド テトラサイクリン化合物を用いる、脊髄筋委縮症を治療するための方法
CA2717703A1 (en) 2008-03-05 2009-09-11 Paratek Pharmaceuticals, Inc. Minocycline compounds and methods of use thereof
JP2011517697A (ja) * 2008-04-14 2011-06-16 パラテック ファーマシューティカルズ インコーポレイテッド 置換テトラサイクリン化合物
PT2323972E (pt) 2008-08-08 2013-10-09 Tetraphase Pharmaceuticals Inc Compostos de tetraciclina substituídos com c7-flúor
EP2341771A4 (en) * 2008-09-19 2012-08-15 Paratek Pharm Innc TETRACYCLINE COMPOUNDS FOR THE TREATMENT OF RHEUMATOID ARTHRITIS AND RELATED THERAPEUTIC METHODS
EP2427425B1 (en) 2009-05-08 2017-03-08 Tetraphase Pharmaceuticals, Inc. Tetracycline compounds
IN2012DN02502A (https=) 2009-08-28 2015-08-28 Tetraphase Pharmaceuticals Inc
CA2874640A1 (en) * 2012-05-30 2013-12-05 Paratek Pharmaceuticals, Inc. 7-disubstituted-phenyl tetracycline derivatives
BR112015004523B1 (pt) 2012-08-31 2020-08-04 Tetraphase Pharmaceuticals, Inc Compostos de tetraciclina, composições farmacêuticas e seus usos
NZ789269A (en) 2016-06-13 2026-01-30 Scholar Rock Inc Use of myostatin inhibitors and combination therapies
CN110582486B (zh) 2016-10-19 2024-01-12 四相制药公司 艾若威四环素的结晶形式
BR112019008897A2 (pt) 2016-11-01 2019-08-13 Paratek Pharm Innc método para tratar pneumonia bacteriana adquirida na comunidade.
AU2021369471A1 (en) 2020-10-26 2023-06-15 Scholar Rock, Inc. Use of anti-pro/latent myostatin antibody for treating spinal muscular atrophy
DK4518970T3 (da) 2022-05-04 2026-04-07 Scholar Rock Inc Anvendelse af myostatinhæmmer til behandling af spinal muskelatrofi
WO2026076383A1 (en) 2024-10-06 2026-04-09 Scholar Rock, Inc. Use of myostatin inhibitor for treating spinal muscular atrophy

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Also Published As

Publication number Publication date
US20090118269A1 (en) 2009-05-07
AU2008239606A1 (en) 2008-10-23
US8399437B2 (en) 2013-03-19
US7935687B2 (en) 2011-05-03
WO2008127722A1 (en) 2008-10-23
EP2144614A1 (en) 2010-01-20
US20110207706A1 (en) 2011-08-25
JP2010523684A (ja) 2010-07-15

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20140415