JP2010523684A - テトラサイクリン化合物を用いる、脊髄筋委縮症を治療するための方法 - Google Patents
テトラサイクリン化合物を用いる、脊髄筋委縮症を治療するための方法 Download PDFInfo
- Publication number
- JP2010523684A JP2010523684A JP2010503091A JP2010503091A JP2010523684A JP 2010523684 A JP2010523684 A JP 2010523684A JP 2010503091 A JP2010503091 A JP 2010503091A JP 2010503091 A JP2010503091 A JP 2010503091A JP 2010523684 A JP2010523684 A JP 2010523684A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aryl
- hydrogen
- carbonyl
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92303107P | 2007-04-12 | 2007-04-12 | |
| US93088307P | 2007-05-18 | 2007-05-18 | |
| US94611007P | 2007-06-25 | 2007-06-25 | |
| US99416307P | 2007-09-18 | 2007-09-18 | |
| US98619207P | 2007-11-07 | 2007-11-07 | |
| PCT/US2008/004827 WO2008127722A1 (en) | 2007-04-12 | 2008-04-14 | Methods for treating spinal muscular atrophy using tetracycline compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010523684A true JP2010523684A (ja) | 2010-07-15 |
| JP2010523684A5 JP2010523684A5 (enExample) | 2011-06-02 |
Family
ID=39682763
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010503091A Pending JP2010523684A (ja) | 2007-04-12 | 2008-04-14 | テトラサイクリン化合物を用いる、脊髄筋委縮症を治療するための方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7935687B2 (enExample) |
| EP (1) | EP2144614A1 (enExample) |
| JP (1) | JP2010523684A (enExample) |
| AU (1) | AU2008239606A1 (enExample) |
| CA (1) | CA2688725A1 (enExample) |
| WO (1) | WO2008127722A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015519369A (ja) * | 2012-05-30 | 2015-07-09 | パラテック ファーマシューティカルズ インコーポレイテッド | 7−二置換フェニルテトラサイクリン誘導体 |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6756365B2 (en) * | 1991-11-06 | 2004-06-29 | Trustees Of Tufts College | Reducing tetracycline resistance in living cells |
| JP2002501026A (ja) * | 1998-01-23 | 2002-01-15 | トルスティーズ オブ トゥフツ カレッジ | 薬学的に活性の化合物及びその利用法 |
| US20040224927A1 (en) * | 2000-06-16 | 2004-11-11 | Trustees Of Tufts College | 7-N-substituted phenyl tetracycline compounds |
| US20020132798A1 (en) * | 2000-06-16 | 2002-09-19 | Nelson Mark L. | 7-phenyl-substituted tetracycline compounds |
| US7094806B2 (en) | 2000-07-07 | 2006-08-22 | Trustees Of Tufts College | 7, 8 and 9-substituted tetracycline compounds |
| IL153672A0 (en) * | 2000-07-07 | 2003-07-06 | Tufts College | 7-substituted tetracycline compounds |
| US8088820B2 (en) * | 2001-04-24 | 2012-01-03 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for the treatment of malaria |
| CA2503446C (en) * | 2002-10-24 | 2012-12-18 | Paratek Pharmaceuticals, Inc. | Methods of using substituted tetracycline compounds to modulate rna |
| EP1648859B1 (en) | 2003-07-09 | 2013-02-27 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| US20060287283A1 (en) * | 2003-07-09 | 2006-12-21 | Paratek Pharmaceuticals, Inc. | Prodrugs of 9-aminomethyl tetracycline compounds |
| EP2269991A3 (en) * | 2004-10-25 | 2011-09-21 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| WO2006084265A1 (en) * | 2005-02-04 | 2006-08-10 | Paratek Pharmaceuticals, Inc. | 11a, 12-DERIVATIVES OF TETRACYCLINE COMPOUNDS |
| JP2009502809A (ja) * | 2005-07-21 | 2009-01-29 | パラテック ファーマシューティカルズ インコーポレイテッド | 10−置換テトラサイクリンおよびその使用方法 |
| CA2652347A1 (en) * | 2006-05-15 | 2007-11-22 | Paratek Pharmaceuticals, Inc. | Methods of regulating expression of genes or of gene products using substituted tetracycline compounds |
| EP2450347B1 (en) * | 2006-12-21 | 2015-06-24 | Paratek Pharmaceuticals, Inc. | Tetracycline derivatives for the treatment of bacterial, viral and parasitic infections |
| PT2120963T (pt) | 2006-12-21 | 2018-12-17 | Paratek Pharm Innc | Compostos tetraciclina substituídos para tratamento de distúrbios inflamatórios da pele |
| WO2008127722A1 (en) | 2007-04-12 | 2008-10-23 | Paratek Pharmaceuticals, Inc. | Methods for treating spinal muscular atrophy using tetracycline compounds |
| US20090253660A1 (en) | 2008-03-05 | 2009-10-08 | Paratek Pharmaceuticals, Inc. | Minocycline Compounds and Methods of Use Thereof |
| JP2011517697A (ja) * | 2008-04-14 | 2011-06-16 | パラテック ファーマシューティカルズ インコーポレイテッド | 置換テトラサイクリン化合物 |
| ES2558512T3 (es) | 2008-08-08 | 2016-02-04 | Tetraphase Pharmaceuticals, Inc. | Compuestos de tetraciclina sustituida con C7-fluoro |
| US20100190755A1 (en) * | 2008-09-19 | 2010-07-29 | Paul Abato | Tetracycline compounds for the treatment of rheumatoid arthritis and related methods of treatment |
| WO2010129057A2 (en) | 2009-05-08 | 2010-11-11 | Tetraphase Pharmaceuticals, Inc. | Tetracycline compounds |
| HUE037852T2 (hu) | 2009-08-28 | 2018-09-28 | Tetraphase Pharmaceuticals Inc | Tetraciklin-vegyületek |
| SMT201900096T1 (it) | 2012-08-31 | 2019-02-28 | Tetraphase Pharmaceuticals Inc | Composti di tetracicline |
| KR20210082548A (ko) | 2016-06-13 | 2021-07-05 | 스칼러 락, 인크. | 미오스타틴 억제제의 용도 및 조합 요법 |
| MA46567A (fr) | 2016-10-19 | 2019-08-28 | Tetraphase Pharmaceuticals Inc | Formes cristallines de l'éravacycline |
| SG10201913599RA (en) | 2016-11-01 | 2020-02-27 | Paratek Pharm Innc | 9-aminomethyl minocycline compounds and use thereof in treating community-acquired bacterial pneumonia (cabp) |
| PL4232151T3 (pl) | 2020-10-26 | 2026-02-23 | Scholar Rock, Inc. | Zastosowanie przeciwciała przeciwko pro/latentnej miostatynie w leczeniu rdzeniowego zaniku mięśni |
| CA3251441A1 (en) | 2022-05-04 | 2023-11-09 | Scholar Rock, Inc. | USE OF A MYOSTATIN INHIBITOR FOR THE TREATMENT OF SPINAL MUSCULAR ATROPHY |
| WO2026076383A1 (en) | 2024-10-06 | 2026-04-09 | Scholar Rock, Inc. | Use of myostatin inhibitor for treating spinal muscular atrophy |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004537544A (ja) * | 2001-07-13 | 2004-12-16 | パラテック ファーマシューティカルズ インコーポレイテッド | 標的治療活性を有するテトラサイクリン化合物 |
| JP2006503897A (ja) * | 2002-10-24 | 2006-02-02 | パラテック ファーマシューティカルズ インコーポレイテッド | Rnaを調節するための置換テトラサイクリン化合物の使用方法 |
| WO2006119329A2 (en) * | 2005-05-02 | 2006-11-09 | Combinatorx, Incorporated | Compositions and methods for the treatment of neurodegenerative diseases |
Family Cites Families (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2990331A (en) * | 1956-11-23 | 1961-06-27 | Pfizer & Co C | Stable solutions of salts of tetracyclines for parenteral administration |
| US2980584A (en) * | 1957-10-29 | 1961-04-18 | Pfizer & Co C | Parenteral magnesium oxytetracycline acetic or lactic acid carboxamide vehicle preparation |
| US3062717A (en) * | 1958-12-11 | 1962-11-06 | Pfizer & Co C | Intramuscular calcium tetracycline acetic or lactic acid carboxamide vehicle preparation |
| US3165531A (en) * | 1962-03-08 | 1965-01-12 | Pfizer & Co C | 13-substituted-6-deoxytetracyclines and process utilizing the same |
| US3454697A (en) * | 1965-06-08 | 1969-07-08 | American Cyanamid Co | Tetracycline antibiotic compositions for oral use |
| NL6607516A (enExample) * | 1966-05-31 | 1967-12-01 | ||
| DE1767891C3 (de) * | 1968-06-28 | 1980-10-30 | Pfizer | Verfahren zur Herstellung von wäßrigen arzneilichen Lösungen für die parenterale, perorale und lokale Anwendung mit einem Gehalt an einem Tetracyclinderivat |
| CA999855A (en) | 1972-09-18 | 1976-11-16 | Societa' Farmaceutici Italia S.P.A. | Process for the preparation of tetracyclines derivatives in the 7 position |
| US3957980A (en) * | 1972-10-26 | 1976-05-18 | Pfizer Inc. | Doxycycline parenteral compositions |
| DE2442829A1 (de) * | 1974-09-06 | 1976-03-18 | Merck Patent Gmbh | Tetracyclische verbindungen und verfahren zu ihrer herstellung |
| US4018889A (en) * | 1976-01-02 | 1977-04-19 | Pfizer Inc. | Oxytetracycline compositions |
| US4126680A (en) * | 1977-04-27 | 1978-11-21 | Pfizer Inc. | Tetracycline antibiotic compositions |
| US5589470A (en) * | 1990-02-26 | 1996-12-31 | Trustees Of Tufts College | Reducing tetracycline resistance in living cells |
| US5064821A (en) * | 1982-11-18 | 1991-11-12 | Trustees Of Tufts College | Method and compositions for overcoming tetracycline resistance within living cells |
| US4806529A (en) * | 1982-11-18 | 1989-02-21 | Trustees Of Tufts College, Tufts University | Tetracycline activity enhancement |
| US4806372A (en) * | 1985-02-15 | 1989-02-21 | Georgia Oil & Gas Co., Inc. | Nitrite-free-curing of bacon and product thereof |
| US6756365B2 (en) * | 1991-11-06 | 2004-06-29 | Trustees Of Tufts College | Reducing tetracycline resistance in living cells |
| JP2002501026A (ja) | 1998-01-23 | 2002-01-15 | トルスティーズ オブ トゥフツ カレッジ | 薬学的に活性の化合物及びその利用法 |
| US6256365B1 (en) * | 1999-08-16 | 2001-07-03 | Analogic Corporation | Apparatus and method for reconstruction of images in a computed tomography system using oblique slices |
| US6849615B2 (en) * | 1999-09-14 | 2005-02-01 | Paratek Pharmaceuticals, Inc. | 13-substituted methacycline compounds |
| PT1240133E (pt) | 1999-09-14 | 2006-07-31 | Tufts College | Processos para preparar tetraciclinas substituidas com quimicas baseadas em metais de transicao |
| US6500812B2 (en) * | 1999-09-14 | 2002-12-31 | Paratek Pharmaceuticals, Inc. | 13-substituted methacycline compounds |
| CA2397863A1 (en) * | 2000-01-24 | 2001-07-26 | Trustees Of Tufts College | Tetracycline compounds for treatment of cryptosporidium parvum related disorders |
| WO2001074761A1 (en) * | 2000-03-31 | 2001-10-11 | Trustees Of Tufts College | 7-and 9-carbamate, urea, thiourea, thiocarbamate, and heteroaryl-amino substituted tetracycline compounds |
| US6642270B2 (en) * | 2000-05-15 | 2003-11-04 | Paratek Pharmaceuticals, Inc. | 7-substituted fused ring tetracycline compounds |
| US20040224927A1 (en) | 2000-06-16 | 2004-11-11 | Trustees Of Tufts College | 7-N-substituted phenyl tetracycline compounds |
| US20020132798A1 (en) * | 2000-06-16 | 2002-09-19 | Nelson Mark L. | 7-phenyl-substituted tetracycline compounds |
| WO2001098236A2 (en) | 2000-06-16 | 2001-12-27 | Trustees Of Tufts College | 7-phenyl-substituted tetracycline compounds |
| IL153672A0 (en) * | 2000-07-07 | 2003-07-06 | Tufts College | 7-substituted tetracycline compounds |
| US7094806B2 (en) * | 2000-07-07 | 2006-08-22 | Trustees Of Tufts College | 7, 8 and 9-substituted tetracycline compounds |
| ATE504562T1 (de) * | 2000-07-07 | 2011-04-15 | Tufts College | 7-, 8- und 9-substitutierte tetracyclinverbindungen |
| SI1301467T1 (sl) | 2000-07-07 | 2007-02-28 | Tufts College | 9-substituirane minociklinske spojine |
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| ES2551708T3 (es) * | 2002-01-08 | 2015-11-23 | Paratek Pharmaceuticals, Inc. | Compuestos de 4-desdimetilamino tetraciclina |
| EP1482926A4 (en) * | 2002-03-08 | 2006-04-12 | Paratek Pharm Innc | AMINO METHYL SUBSTITUTED TETRACYCLINE COMPOUNDS |
| WO2003079984A2 (en) | 2002-03-21 | 2003-10-02 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| EA200900540A1 (ru) | 2002-07-12 | 2009-12-30 | Пэрэтек Фамэсьютикэлс, Инк. | Замещённые соединения тетрациклина, фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния у субъекта |
| EP1648859B1 (en) | 2003-07-09 | 2013-02-27 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| US20060287283A1 (en) | 2003-07-09 | 2006-12-21 | Paratek Pharmaceuticals, Inc. | Prodrugs of 9-aminomethyl tetracycline compounds |
| EP1675548A4 (en) | 2003-09-25 | 2008-08-13 | Activbiotics Inc | RIFALAZIL FORMULATIONS |
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| EP2269991A3 (en) | 2004-10-25 | 2011-09-21 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| WO2006047671A2 (en) | 2004-10-25 | 2006-05-04 | Paratek Pharmaceuticals, Inc. | 4-aminotetracyclines and methods of use thereof |
| WO2006084265A1 (en) | 2005-02-04 | 2006-08-10 | Paratek Pharmaceuticals, Inc. | 11a, 12-DERIVATIVES OF TETRACYCLINE COMPOUNDS |
| JP2009502809A (ja) | 2005-07-21 | 2009-01-29 | パラテック ファーマシューティカルズ インコーポレイテッド | 10−置換テトラサイクリンおよびその使用方法 |
| US9078811B2 (en) | 2006-01-24 | 2015-07-14 | Paratek Pharmaceuticals, Inc. | Methods of increasing oral bioavailability of tetracyclines |
| CA2652347A1 (en) | 2006-05-15 | 2007-11-22 | Paratek Pharmaceuticals, Inc. | Methods of regulating expression of genes or of gene products using substituted tetracycline compounds |
| PT2120963T (pt) | 2006-12-21 | 2018-12-17 | Paratek Pharm Innc | Compostos tetraciclina substituídos para tratamento de distúrbios inflamatórios da pele |
| WO2008127722A1 (en) | 2007-04-12 | 2008-10-23 | Paratek Pharmaceuticals, Inc. | Methods for treating spinal muscular atrophy using tetracycline compounds |
| JP2010525069A (ja) | 2007-04-27 | 2010-07-22 | パラテック ファーマシューティカルズ インコーポレイテッド | アミノアルキルテトラサイクリン化合物の合成方法および精製方法 |
| BRPI0813990A2 (pt) | 2007-07-06 | 2011-09-13 | Paratek Pharmaceuticals, Inc. | métodos para sintetizar compostos de minociclina substituìda |
-
2008
- 2008-04-14 WO PCT/US2008/004827 patent/WO2008127722A1/en not_active Ceased
- 2008-04-14 EP EP08742883A patent/EP2144614A1/en not_active Withdrawn
- 2008-04-14 US US12/102,623 patent/US7935687B2/en not_active Expired - Fee Related
- 2008-04-14 CA CA2688725A patent/CA2688725A1/en not_active Abandoned
- 2008-04-14 AU AU2008239606A patent/AU2008239606A1/en not_active Abandoned
- 2008-04-14 JP JP2010503091A patent/JP2010523684A/ja active Pending
-
2011
- 2011-05-03 US US13/099,993 patent/US8399437B2/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004537544A (ja) * | 2001-07-13 | 2004-12-16 | パラテック ファーマシューティカルズ インコーポレイテッド | 標的治療活性を有するテトラサイクリン化合物 |
| JP2006503897A (ja) * | 2002-10-24 | 2006-02-02 | パラテック ファーマシューティカルズ インコーポレイテッド | Rnaを調節するための置換テトラサイクリン化合物の使用方法 |
| WO2006119329A2 (en) * | 2005-05-02 | 2006-11-09 | Combinatorx, Incorporated | Compositions and methods for the treatment of neurodegenerative diseases |
Non-Patent Citations (1)
| Title |
|---|
| JPN6013016497; ANDREASSI,C. et al: 'Aclarubicin treatment restores SMN levels to cells derived from type I spinal muscular atrophy patie' HUMAN MOLECULAR GENETICS Vol.10, No.24, 2001, p.2841-2849 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015519369A (ja) * | 2012-05-30 | 2015-07-09 | パラテック ファーマシューティカルズ インコーポレイテッド | 7−二置換フェニルテトラサイクリン誘導体 |
| JP2018083815A (ja) * | 2012-05-30 | 2018-05-31 | パラテック ファーマシューティカルズ インコーポレイテッド | 7−二置換フェニルテトラサイクリン誘導体 |
Also Published As
| Publication number | Publication date |
|---|---|
| US7935687B2 (en) | 2011-05-03 |
| WO2008127722A1 (en) | 2008-10-23 |
| US20090118269A1 (en) | 2009-05-07 |
| CA2688725A1 (en) | 2008-10-23 |
| US20110207706A1 (en) | 2011-08-25 |
| EP2144614A1 (en) | 2010-01-20 |
| US8399437B2 (en) | 2013-03-19 |
| AU2008239606A1 (en) | 2008-10-23 |
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