JP2018522917A - 創傷を治す方法 - Google Patents
創傷を治す方法 Download PDFInfo
- Publication number
- JP2018522917A JP2018522917A JP2018506887A JP2018506887A JP2018522917A JP 2018522917 A JP2018522917 A JP 2018522917A JP 2018506887 A JP2018506887 A JP 2018506887A JP 2018506887 A JP2018506887 A JP 2018506887A JP 2018522917 A JP2018522917 A JP 2018522917A
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- Prior art keywords
- compound
- wound
- pharmaceutically acceptable
- acceptable salt
- formula
- Prior art date
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- FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical compound C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 description 1
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- 229960005055 sodium ascorbate Drugs 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- FZHLWVUAICIIPW-UHFFFAOYSA-M sodium gallate Chemical compound [Na+].OC1=CC(C([O-])=O)=CC(O)=C1O FZHLWVUAICIIPW-UHFFFAOYSA-M 0.000 description 1
- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 description 1
- LROWVYNUWKVTCU-STWYSWDKSA-M sodium sorbate Chemical compound [Na+].C\C=C\C=C\C([O-])=O LROWVYNUWKVTCU-STWYSWDKSA-M 0.000 description 1
- 235000019250 sodium sorbate Nutrition 0.000 description 1
- 229960003010 sodium sulfate Drugs 0.000 description 1
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 description 1
- KSAVQLQVUXSOCR-UHFFFAOYSA-N sodium;2-[dodecanoyl(methyl)amino]acetic acid Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC(O)=O KSAVQLQVUXSOCR-UHFFFAOYSA-N 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 229940031439 squalene Drugs 0.000 description 1
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
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- 208000003265 stomatitis Diseases 0.000 description 1
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- 125000001424 substituent group Chemical group 0.000 description 1
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- 238000013268 sustained release Methods 0.000 description 1
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- 235000012222 talc Nutrition 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 229940104261 taurate Drugs 0.000 description 1
- 239000004250 tert-Butylhydroquinone Substances 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 235000019281 tert-butylhydroquinone Nutrition 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- BSYVTEYKTMYBMK-UHFFFAOYSA-N tetrahydrofurfuryl alcohol Chemical compound OCC1CCCO1 BSYVTEYKTMYBMK-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 230000008467 tissue growth Effects 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
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- 125000002640 tocopherol group Chemical class 0.000 description 1
- 235000019149 tocopherols Nutrition 0.000 description 1
- ZIBGPFATKBEMQZ-UHFFFAOYSA-N triethylene glycol Chemical compound OCCOCCOCCO ZIBGPFATKBEMQZ-UHFFFAOYSA-N 0.000 description 1
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- 229960004418 trolamine Drugs 0.000 description 1
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- 239000000814 tuberculostatic agent Substances 0.000 description 1
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- 230000025033 vasoconstriction Effects 0.000 description 1
- 239000012178 vegetable wax Substances 0.000 description 1
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- 235000019155 vitamin A Nutrition 0.000 description 1
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- 239000011718 vitamin C Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 235000020681 well water Nutrition 0.000 description 1
- 239000002349 well water Substances 0.000 description 1
- 239000003357 wound healing promoting agent Substances 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
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- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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Abstract
Description
本出願は、2015年8月11日に出願された印国仮特許出願第4178/CHE/2015号の優先権を主張するものであり、前記仮特許出願の内容は、この参照により本明細書に組み込まれると理解されるべきである。
[1]種々の実施形態の製剤は、下記の方法を使用して、容易に入手可能な出発物質を使用する当技術分野で利用可能な技法を利用して、調製することができる。
11β−HSDまたはHSD−11β(11β−ヒドロキシステロイドデヒドロゲナーゼ)
11β−HSD1(11β−ヒドロキシステロイドデヒドロゲナーゼ−タイプ1)
CDCl3(重水素化クロロホルム)
cDNA(相補的DNA)
CHCl3(クロロホルム)
DCM(ジクロロメタン)
DMF(N,N−ジメチルホルムアミド)
DMSO(ジメチルスルホキシド)
EDTA(エチレンジアミン四酢酸)
EGTA(エチレングリコールジアミン四酢酸)
EtOAc(酢酸エチル)
EtOH(エタノール)
g(グラム)
GC(グルココルチコイド)
h(時間)
HCl(塩酸)
HDF(ヒト皮膚線維芽細胞)
HFD(高脂肪食)
Hz(ヘルツ)
K2CO3(炭酸カリウム)
L(リットル)
MeOH(メタノール)
mg(ミリグラム)
MHz(メガヘルツ)
min(分)
mL(ミリリットル)
mM(ミリモル)
mol(モル)
Na2SO4(硫酸ナトリウム)
NSAID(非ステロイド性抗炎症薬)
PBS(リン酸緩衝生理食塩水)
PCR(ポリメラーゼ連鎖反応)
PGA(ポリ(グリコール酸))
PLA(ポリ(乳酸))
PLGA(乳酸−グリコール酸共重合体)
psi(ポンド毎平方インチ)
PTFE(ポリテトラフルオロエチレン)
RM(反応混合物)
RNA(リボ核酸)
RT(室温)
SEM(平均の標準誤差)
THF(テトラヒドロフラン)
TLC(薄膜クロマトグラフィー)
式(I)の化合物を、合成スキーム1および2で概略するように合成した。
合成スキーム2
クリームベース製剤の形態をした組成物の総重量の0.5重量%の式(I)の化合物を、以下に従って調製した。
1)重液パラフィン2.5g
2)モノステアリン酸グリセリル1.85g
3)ステアリン酸2.0g
4)コクムバター2.0g
5)ポリエチレングリコール5.0g
6)グリセリン5.0g
7)セトステアリルアルコール2.5g
8)セチルアルコール2.0g
9)エチレングリコールモノステアラート1.0g
10)フェノキシエタノール0.5g
11)ソルビン酸カリウム0.5g
12)安息香酸ナトリウム0.5g
13)ビタミンE0.5mL
14)精製水73.65mL
99.5gのVersaPro(商標)クリームベース、商業的に利用可能なクリームベースを、0.5gの式(I)の化合物と共に使用した。
結果
in vitroでのスクラッチアッセイ
ヒト皮膚線維芽細胞(HDF)細胞を、24ウェルプレート(25000細胞/mL)の1mLの増殖培地(Media−106、Gibco)に播種し、24時間37℃、5%CO2で増殖させた。滅菌したp200ピペットの先でそっと掻破することによりコンフルエントな単層に小さな線スクラッチを作成した(掻破プロセス中に注意を払って、確実に一様なサイズおよび距離を全サンプルで作成した)。細胞をPBSで広範囲にわたってすすいで、細胞破片を取り除いてから、異なる処置溶液(1μMの式(I)のテスト分子を含むまたは含まない400nMのコルチゾン)を有する培地を加えた。24時間後、拡散した細胞の画像を、倒立顕微鏡に接続したデジタルカメラを使用して撮影して、創傷領域の閉鎖を観察した。スクラッチアッセイを4連で行った。結果を図1に示す。
以下の調査は、11β−HSD阻害薬CNX−010−640の、食事誘発性肥満のC57マウス(糖尿病患者のモデルとして)、Swiss albinoマウス(正常患者のモデルとして)、およびdb/dbマウス(II型糖尿病かつ肥満の患者のモデルとして)の切除創および切創の修復に対する影響を評価することを目的とした。
動物収容条件
動物を、22±3℃という温度、50〜70%という相対湿度で、12時間明るく、12時間暗いというサイクルで収容した。動物を、ペレット化した餌とボトルに入れた飲み水のための設備を有する、ステンレス鋼の格子天井がついた標準的なポリプロピレンのケージに、個別に収容した。滅菌したもみ殻を、寝床の材料として使用し、毎日交換した。ペレット化したマウスのエサは、M/s.Provimi India Pvt.Ltd. angalore,Indiaにより製造されたか、または、Research Diet(USA)よる高脂肪食(HFD)(D12492)、60%kcalを提供した。Eureka Forbes Ltd.,Mumbai,Indiaにより製造された、清浄器付きオンラインウォータ水フィルタのAquaguardにおいて活性炭フィルタを通し、紫外線にさらした深井戸水を、任意に提供した。全ての実験プロトコルは、Committee for the Purpose of Control and Supervision on Experiments on Animals(CPCSEA;2008年12月5日付No.1241/bc/CPCSEA),インドにより認められているInstitutional Animal Ethics Committee(IAEC)により承認された。
ケタミンおよびキシラジンを使用してマウスに麻酔をかけ、毛を刈り取り、20mm2サイズの円形切開を、後頸部領域に作った。CNX−010−640クリームを、1日に二度、局所的に適用した。創傷修復の保護度合いを、創傷収縮および上皮形成期間を測定することにより評価した。創傷収縮は、肉の見える創傷領域を、ワックスペーパーにより運んでグラフ用紙に透写することにより、一日おきに測定した。傷の残りおよび上皮形成完了にかかる時間を測定した。結果を図2および3、ならびに表1〜3に示す。最終日に、動物を安楽死させ、創傷を含有する組織サンプルを採取して、(図6〜11に示すように)病死組織学的変化を調べ、遺伝子発現プロファイルを求めた(図12〜17)。
[6]ケタミンおよびキシラジンを使用してマウスに麻酔をかけ、毛を刈り取り、4〜5cmの長さの縦方向の切開を背中に作り、糸で縫合した。CNX−010−640クリームを、1日に二度、局所的に適用した。創傷修復の保護度合いを、治癒した創傷部位の皮膚の張力およびコラーゲン含有量を測定することにより評価した。創傷張力は、処置の14日後に測定した。結果を図4および5に示す。
[7]全ての値を平均±SEMで表し、HFD対照と比較する際の処置群の有意値を定めるため、一元配置分散分析後、ダネットの検定を行った。
Claims (28)
- 創傷の処置を必要とする対象に、治療的に有効な量の式(I)の化合物またはその医薬的に許容される塩を投与するステップを含む、創傷を処置する方法。
- 前記創傷は切開または切除である、請求項1に記載の方法。
- 前記化合物は前記創傷部位に局所的に投与される、請求項1または2に記載の方法。
- 前記化合物は、バーム、クリーム、ゲル、リニメント剤、ローション、軟膏、ペースト、ラブ、または膏薬の形態で投与される、請求項1〜3の何れか一項に記載の方法。
- 対象の創傷の処置のための薬物の製造における、式(I)の化合物またはその医薬的に許容される塩の使用。
- 前記創傷は切開または切除である、請求項5に記載の使用。
- 前記薬物は、前記創傷部位に局所的に投与するように適合される、請求項5または6に記載の使用。
- 前記薬物は、バーム、クリーム、ゲル、リニメント剤、ローション、軟膏、ペースト、ラブ、または膏薬の形態をなす、請求項5〜7の何れか一項に記載の使用。
- 対象の創傷の処置で使用するための、式(I)の化合物またはその医薬的に許容される塩。
- 前記創傷は切開または切除である、請求項9に記載の使用化合物。
- 前記創傷部位に局所的に投与される、請求項9または10に記載の使用化合物。
- バーム、クリーム、ゲル、リニメント剤、ローション、軟膏、ペースト、ラブ、または膏薬の形態で投与される、請求項9〜11の何れか一項に記載の使用化合物。
- 式(I)の化合物またはその医薬的に許容される塩を含む、対象の創傷の処置で使用するための薬剤。
- 前記創傷は切開または切除である、請求項13に記載の薬剤。
- 前記創傷部位に局所的に投与するように適合される、請求項13または14に記載の使用薬剤。
- バーム、クリーム、ゲル、リニメント剤、ローション、軟膏、ペースト、ラブ、または膏薬である、請求項13〜15の何れか一項に記載の使用薬剤。
- 請求項1に記載の式(I)の化合物またはその医薬的に許容される塩と、医薬的に許容される希釈剤、賦形剤、または担体とを含む、対象の創傷の処置で使用するための医薬組成物。
- 0.1〜2%(w/w)の式(I)の化合物またはその医薬的に許容される塩と、99.9〜98%(w/w)の担体とを含む、請求項17に記載の医薬組成物。
- 前記化合物またはその医薬的に許容される塩が、0.1〜1%(w/w)の範囲で存在し、前記担体が99.9〜99%(w/w)の範囲で存在する、請求項18に記載の医薬組成物。
- 前記化合物またはその医薬的に許容される塩が約0.5%(w/w)存在し、前記担体が約99.5%(w/w)存在する、請求項19に記載の医薬組成物。
- 0.1〜2%(w/w)の式(I)の組成物またはその医薬的に許容される塩と;約5〜約10%(w/w)の1つまたは複数の皮膚軟化薬と;約10〜約15%(w/w)の1つまたは複数の界面活性剤と;約1〜約10%(w/w)の1つまたは複数の湿潤剤と;約1〜約5%(w/w)の1つまたは複数の防腐剤と;約0.1〜約2%(w/w)の1つまたは複数の抗酸化剤と;100%(w/w)に達するまでの残りを成す溶媒とを含む、請求項18〜20の何れか一項に記載の医薬組成物。
- 前記1つまたは複数の皮膚軟化薬は、重液パラフィン、コクムバター、およびセチルアルコールからなる群から選択される、請求項21に記載の医薬組成物。
- 前記1つまたは複数の界面活性剤は、モノステアリン酸グリセリル、ステアリン酸、ポリエチレングリコール、セトステアリルアルコール、およびモノステアリン酸エチレングリコールからなる群から選択される、請求項21または22に記載の医薬組成物。
- 前記1つまたは複数の湿潤剤はグリセリンである、請求項21〜23の何れか一項に記載の医薬組成物。
- 前記1つまたは複数の防腐剤は、フェノキシエタノール、ソルビン酸カリウム、および安息香酸ナトリウムからなる群から選択される、請求項21〜24の何れか一項に記載の医薬組成物。
- 前記1つまたは複数の抗酸化剤はビタミンEである、請求項21〜25の何れか一項に記載の医薬組成物。
- 前記溶媒は水である、請求項21〜26の何れか一項に記載の医薬組成物。
- 0.5%(w/w)の式(I)の化合物またはその医薬的に許容される塩と;重液パラフィン−2.5%(w/w)と;モノステアリン酸グリセリル−1.85%(w/w)と;ステアリン酸−2.0%(w/w)と;コクムバター−2.0%(w/w)と;ポリエチレングリコール−5.0%(w/w)と;グリセリン−5.0%(w/w)と;セトステアリルアルコール−2.5%(w/w)と;セチルアルコール−2.0%(w/w)と;モノステアリン酸エチレングリコール−1.0%(w/w)と;フェノキシエタノール−0.5%(w/w)と;ソルビン酸カリウム−0.5%(w/w)と;安息香酸ナトリウム−0.5%(w/w)と;ビタミンE−0.5%(w/w)と;精製水−73.65%(w/w)とを含む、請求項17に記載の医薬組成物。
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PCT/IN2016/050270 WO2017025988A1 (en) | 2015-08-11 | 2016-08-11 | Method of wound healing |
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EP3821892A1 (en) | 2019-11-12 | 2021-05-19 | University of Leeds | (s)-2-(1-(5-(cyclohexylcarbamoyl)-6-(propylthio)pyridin-2-yl)piperidin-3-yl) acetic acid for use in treating wounds |
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Non-Patent Citations (4)
Title |
---|
JOURNAL OF ENDOCRINOLOGY, vol. 221, JPN7020001871, 2014, pages 51 - 61, ISSN: 0004461593 * |
PNAS, vol. 102, no. 34, JPN7020001870, 2005, pages 12165 - 12170, ISSN: 0004461592 * |
THE JOURNAL OF CLINICAL INVESTIGATION, vol. 123, no. 7, JPN7020001869, 2013, pages 3051 - 3060, ISSN: 0004461591 * |
WOUND REPAIR AND REGENERATION, vol. 21, no. 5, JPN7020001868, 2013, pages 715 - 722, ISSN: 0004461590 * |
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US20180221356A1 (en) | 2018-08-09 |
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EP3349752B1 (en) | 2021-06-30 |
BR112018002763A2 (pt) | 2018-10-09 |
JP6953396B2 (ja) | 2021-10-27 |
MX2018001684A (es) | 2018-05-17 |
AU2016305746A1 (en) | 2018-03-08 |
DK3349752T3 (da) | 2021-09-27 |
ES2891086T3 (es) | 2022-01-26 |
US10328063B2 (en) | 2019-06-25 |
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HK1254325A1 (zh) | 2019-07-19 |
ZA201800600B (en) | 2018-11-28 |
CA2993922A1 (en) | 2017-02-16 |
WO2017025988A1 (en) | 2017-02-16 |
WO2017025989A1 (en) | 2017-02-16 |
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