CA2688725A1 - Methods for treating spinal muscular atrophy using tetracycline compounds - Google Patents

Methods for treating spinal muscular atrophy using tetracycline compounds Download PDF

Info

Publication number
CA2688725A1
CA2688725A1 CA2688725A CA2688725A CA2688725A1 CA 2688725 A1 CA2688725 A1 CA 2688725A1 CA 2688725 A CA2688725 A CA 2688725A CA 2688725 A CA2688725 A CA 2688725A CA 2688725 A1 CA2688725 A1 CA 2688725A1
Authority
CA
Canada
Prior art keywords
alkyl
heterocyclic
aryl
hydrogen
carbonyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2688725A
Other languages
English (en)
Inventor
Joel Berniac
Todd Bowser
Michael Draper
Stuart B. Levy
Mark L. Nelson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Paratek Pharmaceuticals Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2688725A1 publication Critical patent/CA2688725A1/en
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA2688725A 2007-04-12 2008-04-14 Methods for treating spinal muscular atrophy using tetracycline compounds Abandoned CA2688725A1 (en)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US92303107P 2007-04-12 2007-04-12
US60/923,031 2007-04-12
US93088307P 2007-05-18 2007-05-18
US60/930,883 2007-05-18
US94611007P 2007-06-25 2007-06-25
US60/946,110 2007-06-25
US99416307P 2007-09-18 2007-09-18
US60/994,163 2007-09-18
US98619207P 2007-11-07 2007-11-07
US60/986,192 2007-11-07
PCT/US2008/004827 WO2008127722A1 (en) 2007-04-12 2008-04-14 Methods for treating spinal muscular atrophy using tetracycline compounds

Publications (1)

Publication Number Publication Date
CA2688725A1 true CA2688725A1 (en) 2008-10-23

Family

ID=39682763

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2688725A Abandoned CA2688725A1 (en) 2007-04-12 2008-04-14 Methods for treating spinal muscular atrophy using tetracycline compounds

Country Status (6)

Country Link
US (2) US7935687B2 (enExample)
EP (1) EP2144614A1 (enExample)
JP (1) JP2010523684A (enExample)
AU (1) AU2008239606A1 (enExample)
CA (1) CA2688725A1 (enExample)
WO (1) WO2008127722A1 (enExample)

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US20040224927A1 (en) 2000-06-16 2004-11-11 Trustees Of Tufts College 7-N-substituted phenyl tetracycline compounds
US20020132798A1 (en) * 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
US7094806B2 (en) 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
KR101027625B1 (ko) * 2000-07-07 2011-04-06 파라테크 파마슈티컬스, 인크. 7-치환 테트라사이클린 화합물
US8088820B2 (en) * 2001-04-24 2012-01-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
EP1562608A4 (en) 2002-10-24 2010-09-01 Paratek Pharm Innc METHOD OF USE OF SUBSTITUTED TETRACYCLINE COMPOUNDS FOR MODULATING THE RNA
KR101228706B1 (ko) 2003-07-09 2013-02-01 파라테크 파마슈티컬스, 인크. 치환된 테트라시클린 화합물
US20060287283A1 (en) * 2003-07-09 2006-12-21 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
EP2269978A3 (en) * 2004-10-25 2011-09-21 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
AU2006210406C1 (en) 2005-02-04 2013-03-07 Paratek Pharmaceuticals, Inc. 11a, 12-derivatives of tetracycline compounds
CA2616224A1 (en) * 2005-07-21 2007-02-01 Paratek Pharmaceuticals, Inc. 10-substituted tetracyclines and methods of use thereof
EP2537934A3 (en) * 2006-05-15 2013-04-10 Paratek Pharmaceuticals, Inc. Methods of regulating expression of genes or of gene products using substituted tetracycline compounds
EP3045449A1 (en) * 2006-12-21 2016-07-20 Paratek Pharmaceuticals, Inc. Tetracycline derivatives for the treatment of bacterial, viral and parasitic infections
CA2673486C (en) 2006-12-21 2015-09-08 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of inflammatory skin disorders
WO2008127722A1 (en) 2007-04-12 2008-10-23 Paratek Pharmaceuticals, Inc. Methods for treating spinal muscular atrophy using tetracycline compounds
BRPI0908951A2 (pt) 2008-03-05 2017-01-17 Paratek Pharm Innc compostos de minociclina e método de uso dos mesmos
EP2276342A4 (en) * 2008-04-14 2012-02-22 Paratek Pharm Innc SUBSTITUTED TETRACYCLIN COMPOUNDS
PL3000805T3 (pl) 2008-08-08 2018-04-30 Tetraphase Pharmaceuticals, Inc. C7-fluoro podstawione związki tetracyklinowe
WO2010033939A1 (en) * 2008-09-19 2010-03-25 Paratek Pharmaceuticals, Inc. Tetracycline compounds for the treatment of rheumatoid arthritis and related methods of treatment
ES2627772T3 (es) 2009-05-08 2017-07-31 Tetraphase Pharmaceuticals, Inc. Compuestos de tetraciclina
WO2011025982A2 (en) 2009-08-28 2011-03-03 Tetraphase Pharmaceuticals, Inc. Tetracycline compounds
JP6522498B2 (ja) * 2012-05-30 2019-05-29 パラテック ファーマシューティカルズ インコーポレイテッド ７−二置換フェニルテトラサイクリン誘導体
AU2013308504B2 (en) 2012-08-31 2016-11-10 Tetraphase Pharmaceuticals, Inc. Tetracycline compounds
LT3368069T (lt) 2016-06-13 2020-12-10 Scholar Rock, Inc. Miostatino inhibitorių naudojimas, ir kombinuotas gydymas
KR102880712B1 (ko) 2016-10-19 2025-11-03 테트라페이즈 파마슈티컬스, 인코포레이티드 에라바사이클린의 결정질 형태
WO2018085216A1 (en) 2016-11-01 2018-05-11 Paratek Pharmaceuticals, Inc. 9-aminomethyl minocycline compounds and use thereof in treating community-acquire bacterial pneumonia (cabp)
CA3193909A1 (en) 2020-10-26 2022-05-05 George NOMIKOS Use of anti-pro/latent myostatin antibody for treating spinal muscular atrophy
WO2023215384A2 (en) 2022-05-04 2023-11-09 Scholar Rock, Inc. Use of myostatin inhibitor for treating spinal muscular atrophy

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Also Published As

Publication number Publication date
US20110207706A1 (en) 2011-08-25
US7935687B2 (en) 2011-05-03
AU2008239606A1 (en) 2008-10-23
US8399437B2 (en) 2013-03-19
US20090118269A1 (en) 2009-05-07
EP2144614A1 (en) 2010-01-20
JP2010523684A (ja) 2010-07-15
WO2008127722A1 (en) 2008-10-23

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Effective date: 20140415