JP2010523559A5 - - Google Patents
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- Publication number
- JP2010523559A5 JP2010523559A5 JP2010502079A JP2010502079A JP2010523559A5 JP 2010523559 A5 JP2010523559 A5 JP 2010523559A5 JP 2010502079 A JP2010502079 A JP 2010502079A JP 2010502079 A JP2010502079 A JP 2010502079A JP 2010523559 A5 JP2010523559 A5 JP 2010523559A5
- Authority
- JP
- Japan
- Prior art keywords
- phenoxy
- polymorph
- diethylamine
- chloro
- propyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000001069 Raman spectroscopy Methods 0.000 claims 12
- 238000001237 Raman spectrum Methods 0.000 claims 12
- ORILYTVJVMAKLC-UHFFFAOYSA-N adamantane Chemical compound C1C(C2)CC3CC1CC2C3 ORILYTVJVMAKLC-UHFFFAOYSA-N 0.000 claims 12
- KJNNWYBAOPXVJY-UHFFFAOYSA-N 3-[4-[2-butyl-1-[4-(4-chlorophenoxy)phenyl]imidazol-4-yl]phenoxy]-n,n-diethylpropan-1-amine Chemical compound CCCCC1=NC(C=2C=CC(OCCCN(CC)CC)=CC=2)=CN1C(C=C1)=CC=C1OC1=CC=C(Cl)C=C1 KJNNWYBAOPXVJY-UHFFFAOYSA-N 0.000 claims 9
- -1 4-Chloro-phenoxy Chemical group 0.000 claims 9
- 239000007787 solid Substances 0.000 claims 9
- 238000002329 infrared spectrum Methods 0.000 claims 8
- 239000002904 solvent Substances 0.000 claims 8
- 238000001460 carbon-13 nuclear magnetic resonance spectrum Methods 0.000 claims 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- 239000007790 solid phase Substances 0.000 claims 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 238000000634 powder X-ray diffraction Methods 0.000 claims 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 238000001556 precipitation Methods 0.000 claims 2
- 230000005855 radiation Effects 0.000 claims 2
- 230000001476 alcoholic effect Effects 0.000 claims 1
- 125000001664 diethylamino group Chemical group [H]C([H])([H])C([H])([H])N(*)C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000002140 imidazol-4-yl group Chemical group [H]N1C([H])=NC([*])=C1[H] 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000012071 phase Substances 0.000 claims 1
- 239000002244 precipitate Substances 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92196407P | 2007-04-05 | 2007-04-05 | |
| US92578607P | 2007-04-23 | 2007-04-23 | |
| PCT/US2008/003325 WO2008123914A1 (en) | 2007-04-05 | 2008-03-12 | Crystalline forms i and ii of [3-(4-{2-butyl-1-[4-(4-chloro-phenoxy)-phenyl]-1h-imidazol-4-yl}-phenoxy)-propyl]-diethyl-amine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010523559A JP2010523559A (ja) | 2010-07-15 |
| JP2010523559A5 true JP2010523559A5 (enExample) | 2011-03-31 |
Family
ID=39469930
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010502079A Pending JP2010523559A (ja) | 2007-04-05 | 2008-03-12 | ［３−（４−｛２−ブチル−１−［４−（４−クロロ−フェノキシ）−フェニル］−１ｈ−イミダゾール−４−イル｝−フェノキシ）−プロピル］−ジエチルアミンの結晶形態 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US7884219B2 (enExample) |
| EP (1) | EP2144883A1 (enExample) |
| JP (1) | JP2010523559A (enExample) |
| AR (1) | AR065896A1 (enExample) |
| CA (1) | CA2681864A1 (enExample) |
| CL (1) | CL2008000987A1 (enExample) |
| PA (1) | PA8775601A1 (enExample) |
| PE (1) | PE20090808A1 (enExample) |
| TW (1) | TW200900384A (enExample) |
| UY (1) | UY31004A1 (enExample) |
| WO (1) | WO2008123914A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010523559A (ja) * | 2007-04-05 | 2010-07-15 | トランス テック ファーマ，インコーポレイテッド | ［３−（４−｛２−ブチル−１−［４−（４−クロロ−フェノキシ）−フェニル］−１ｈ−イミダゾール−４−イル｝−フェノキシ）−プロピル］−ジエチルアミンの結晶形態 |
| EP2470510B1 (en) | 2009-09-30 | 2014-05-14 | TransTech Pharma, LLC | Substituted imidazole derivatives for treatment of alzheimers disease. |
| US9717710B2 (en) * | 2012-10-05 | 2017-08-01 | Vtv Therapeutics Llc | Treatment of mild and moderate Alzheimer's disease |
| SG11201502210VA (en) * | 2012-10-05 | 2015-04-29 | Vtvx Holdings I Llc | Treatment of mild and moderate alzheimer's disease |
| CN103726005A (zh) * | 2012-10-16 | 2014-04-16 | 深圳富泰宏精密工业有限公司 | 珐琅涂层的制造方法及其制品 |
| WO2019190822A1 (en) * | 2018-03-28 | 2019-10-03 | Vtv Therapeutics Llc | Crystalline forms of [3-(4- {2-butyl-1-[4-(4-chloro-phenoxy)-phenyl]-1h-imidazol-4-yl} -phenoxy)-propyl]-diethyl-amine |
| WO2019190823A1 (en) | 2018-03-28 | 2019-10-03 | Vtv Therapeutics Llc | Pharmaceutically acceptable salts of [3-(4- {2-butyl-1-[4-(4-chlorophenoxy)-phenyl]-1h-imidazol-4-yl} -phenoxy)-propyl]-diethyl-amine |
| EP3864008A1 (en) | 2018-10-10 | 2021-08-18 | vTv Therapeutics LLC | Metabolites of [3-(4-{2-butyl-l-[4-(4-chloro-phenoxy)-phenyl]-lh-imidazol-4-yl } -phen ox y)-prop yl] -diethyl-amine |
| WO2020086388A1 (en) | 2018-10-22 | 2020-04-30 | Vtv Therapeutics Llc | Glucokinase activator compositions for the treatment of cognitive impairment |
| US11648235B1 (en) | 2022-12-30 | 2023-05-16 | Cantex Pharmaceuticals, Inc. | Treatment of glioblastoma |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101597262A (zh) * | 2002-03-05 | 2009-12-09 | 特兰斯泰克制药公司 | 抑制配体与高级糖化终产物受体相互作用的单和双环吡咯衍生物 |
| MXPA05012350A (es) * | 2003-05-20 | 2006-05-25 | Transtech Pharma Inc | Antagonistas rage como agentes para la amiloidosis inversa y enfermedades asociadas con la misma. |
| JP2010523559A (ja) * | 2007-04-05 | 2010-07-15 | トランス テック ファーマ，インコーポレイテッド | ［３−（４−｛２−ブチル−１−［４−（４−クロロ−フェノキシ）−フェニル］−１ｈ−イミダゾール−４−イル｝−フェノキシ）−プロピル］−ジエチルアミンの結晶形態 |
-
2008
- 2008-03-12 JP JP2010502079A patent/JP2010523559A/ja active Pending
- 2008-03-12 CA CA002681864A patent/CA2681864A1/en not_active Withdrawn
- 2008-03-12 US US12/046,872 patent/US7884219B2/en active Active
- 2008-03-12 EP EP08726789A patent/EP2144883A1/en not_active Withdrawn
- 2008-03-12 WO PCT/US2008/003325 patent/WO2008123914A1/en not_active Ceased
- 2008-03-19 TW TW097109673A patent/TW200900384A/zh unknown
- 2008-03-31 AR ARP080101342A patent/AR065896A1/es unknown
- 2008-04-04 PE PE2008000616A patent/PE20090808A1/es not_active Application Discontinuation
- 2008-04-04 PA PA20088775601A patent/PA8775601A1/es unknown
- 2008-04-04 UY UY31004A patent/UY31004A1/es not_active Application Discontinuation
- 2008-04-04 CL CL200800987A patent/CL2008000987A1/es unknown
-
2010
- 2010-12-30 US US12/982,775 patent/US8372988B2/en active Active
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