JP2010522768A5 - - Google Patents
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- JP2010522768A5 JP2010522768A5 JP2010501232A JP2010501232A JP2010522768A5 JP 2010522768 A5 JP2010522768 A5 JP 2010522768A5 JP 2010501232 A JP2010501232 A JP 2010501232A JP 2010501232 A JP2010501232 A JP 2010501232A JP 2010522768 A5 JP2010522768 A5 JP 2010522768A5
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- JP
- Japan
- Prior art keywords
- inhibition
- activity
- alkyl
- pde7a
- pde7
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 230000005764 inhibitory process Effects 0.000 claims description 223
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- 239000002606 phosphodiesterase VII inhibitor Substances 0.000 claims description 208
- 238000000034 method Methods 0.000 claims description 206
- 150000001875 compounds Chemical class 0.000 claims description 177
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 claims description 157
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- 101001117267 Homo sapiens High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A Proteins 0.000 claims description 132
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| US8637528B2 (en) | 2007-03-27 | 2014-01-28 | Omeros Corporation | Use of PDE7 inhibitors for the treatment of movement disorders |
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| FR2944206B1 (fr) | 2009-04-09 | 2012-12-28 | Sanofi Aventis | Applications therapeutiques dans le domaine cardiovasculaire de derives de quinazolinedione |
| FR2944282B1 (fr) | 2009-04-09 | 2013-05-03 | Sanofi Aventis | Derives de quinazolinedione, leur preparation et leurs diverses applications therapeutiques |
| AU2013202493B2 (en) * | 2009-05-04 | 2016-03-10 | Omeros Corporation | Use of PDE7 inhibitors for the treatment of movement disorders |
| ES2353093B1 (es) | 2009-05-20 | 2012-01-03 | Consejo Superior De Investigaciones Científicas (Csic) | Uso de derivados de quinazolinas y sus composiciones farmacéuticas en enfermedades neurodegenerativas. |
| ES2360783B1 (es) | 2009-10-02 | 2012-07-04 | Consejo Superior De Investigaciones Científicas (Csic) | 1,2,4-tiadiazoles-5-imino sustituidos utiles en el tratamiento de enfermedades neurodegenerativas |
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| US9220715B2 (en) | 2010-11-08 | 2015-12-29 | Omeros Corporation | Treatment of addiction and impulse-control disorders using PDE7 inhibitors |
| EP2846805B1 (en) * | 2012-05-07 | 2018-11-21 | Omeros Corporation | Treatment of addiction and impulse-control disorders using pde7 inhibitors |
| RU2665134C2 (ru) * | 2012-05-07 | 2018-08-28 | Омерос Корпорейшн | Лечение зависимости и расстройств побуждений с применением ингибиторов фдэ7 |
| KR20190040054A (ko) * | 2016-08-26 | 2019-04-16 | 미쓰비시 타나베 파마 코퍼레이션 | 이환식 함질소 헤테로환 화합물 |
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| WO2024259383A2 (en) * | 2023-06-14 | 2024-12-19 | President And Fellows Of Harvard College | Ion channel binders and uses thereof |
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-
2008
- 2008-03-27 EP EP08744515.1A patent/EP2139475B1/en active Active
- 2008-03-27 US US12/057,368 patent/US20080260643A1/en not_active Abandoned
- 2008-03-27 CN CN201510082785.6A patent/CN104758291B/zh active Active
- 2008-03-27 JP JP2010501232A patent/JP5580192B2/ja active Active
- 2008-03-27 ES ES08744515.1T patent/ES2533206T3/es active Active
- 2008-03-27 MX MX2009010450A patent/MX2009010450A/es active IP Right Grant
- 2008-03-27 NZ NZ580413A patent/NZ580413A/xx unknown
- 2008-03-27 AU AU2008230710A patent/AU2008230710B2/en active Active
- 2008-03-27 RU RU2009138966/15A patent/RU2449790C2/ru active
- 2008-03-27 CN CN200880017058XA patent/CN101917992A/zh active Pending
- 2008-03-27 CA CA2681650A patent/CA2681650C/en active Active
- 2008-03-27 WO PCT/US2008/058530 patent/WO2008119057A2/en not_active Ceased
-
2010
- 2010-12-21 US US12/974,693 patent/US20110091388A1/en not_active Abandoned
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2014
- 2014-05-28 JP JP2014109910A patent/JP5943964B2/ja active Active
-
2018
- 2018-12-06 US US16/212,064 patent/US20190183824A1/en not_active Abandoned
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