AU2008230710B2 - The use of PDE7 inhibitors for the treatment of movement disorders - Google Patents

The use of PDE7 inhibitors for the treatment of movement disorders Download PDF

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Publication number
AU2008230710B2
AU2008230710B2 AU2008230710A AU2008230710A AU2008230710B2 AU 2008230710 B2 AU2008230710 B2 AU 2008230710B2 AU 2008230710 A AU2008230710 A AU 2008230710A AU 2008230710 A AU2008230710 A AU 2008230710A AU 2008230710 B2 AU2008230710 B2 AU 2008230710B2
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AU
Australia
Prior art keywords
pde7
alkyl
activity
inhibiting
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2008230710A
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English (en)
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AU2008230710A1 (en
Inventor
John E. Bergmann
Neil S. Cutshall
Gregory A. Demopulos
Vincent A. Florio
George Gaitanaris
Patrick Gray
John Hohmann
Rene Onrust
Hongkui Zeng
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Omeros Corp
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Omeros Medical Systems Inc
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Publication date
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Publication of AU2008230710A1 publication Critical patent/AU2008230710A1/en
Priority to AU2013202067A priority Critical patent/AU2013202067B2/en
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Publication of AU2008230710B2 publication Critical patent/AU2008230710B2/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/527—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim spiro-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2008230710A 2007-03-27 2008-03-27 The use of PDE7 inhibitors for the treatment of movement disorders Active AU2008230710B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2013202067A AU2013202067B2 (en) 2007-03-27 2013-03-22 The use of PDE7 inhibitors for the treatment of movement disorders

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US92049607P 2007-03-27 2007-03-27
US60/920,496 2007-03-27
PCT/US2008/058530 WO2008119057A2 (en) 2007-03-27 2008-03-27 The use of pde7 inhibitors for the treatment of movement disorders

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2013202067A Division AU2013202067B2 (en) 2007-03-27 2013-03-22 The use of PDE7 inhibitors for the treatment of movement disorders

Publications (2)

Publication Number Publication Date
AU2008230710A1 AU2008230710A1 (en) 2008-10-02
AU2008230710B2 true AU2008230710B2 (en) 2014-04-10

Family

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Family Applications (1)

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AU2008230710A Active AU2008230710B2 (en) 2007-03-27 2008-03-27 The use of PDE7 inhibitors for the treatment of movement disorders

Country Status (11)

Country Link
US (3) US20080260643A1 (enExample)
EP (1) EP2139475B1 (enExample)
JP (2) JP5580192B2 (enExample)
CN (2) CN101917992A (enExample)
AU (1) AU2008230710B2 (enExample)
CA (1) CA2681650C (enExample)
ES (1) ES2533206T3 (enExample)
MX (1) MX2009010450A (enExample)
NZ (1) NZ580413A (enExample)
RU (1) RU2449790C2 (enExample)
WO (1) WO2008119057A2 (enExample)

Families Citing this family (17)

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Publication number Priority date Publication date Assignee Title
US8637528B2 (en) * 2007-03-27 2014-01-28 Omeros Corporation Use of PDE7 inhibitors for the treatment of movement disorders
JP2012521429A (ja) * 2009-03-23 2012-09-13 メルク・シャープ・エンド・ドーム・コーポレイション 疼痛治療用のｐ２ｘ３受容体アンタゴニスト
FR2943673B1 (fr) 2009-03-27 2013-03-29 Sanofi Aventis Applications therapeutiques de derives de quinazolinedione
FR2944206B1 (fr) 2009-04-09 2012-12-28 Sanofi Aventis Applications therapeutiques dans le domaine cardiovasculaire de derives de quinazolinedione
FR2944282B1 (fr) 2009-04-09 2013-05-03 Sanofi Aventis Derives de quinazolinedione, leur preparation et leurs diverses applications therapeutiques
AU2013202493B2 (en) * 2009-05-04 2016-03-10 Omeros Corporation Use of PDE7 inhibitors for the treatment of movement disorders
ES2353093B1 (es) * 2009-05-20 2012-01-03 Consejo Superior De Investigaciones Científicas (Csic) Uso de derivados de quinazolinas y sus composiciones farmacéuticas en enfermedades neurodegenerativas.
ES2360783B1 (es) 2009-10-02 2012-07-04 Consejo Superior De Investigaciones Científicas (Csic) 1,2,4-tiadiazoles-5-imino sustituidos utiles en el tratamiento de enfermedades neurodegenerativas
KR102385359B1 (ko) * 2010-11-08 2022-04-11 오메로스 코포레이션 Pde7 억제제를 사용한 중독 및 충동-조절 장애의 치료
US9220715B2 (en) 2010-11-08 2015-12-29 Omeros Corporation Treatment of addiction and impulse-control disorders using PDE7 inhibitors
AU2013266793B2 (en) * 2012-05-07 2016-08-04 Omeros Corporation Treatment of addiction and impulse-control disorders using PDE7 inhibitors
RU2665134C2 (ru) * 2012-05-07 2018-08-28 Омерос Корпорейшн Лечение зависимости и расстройств побуждений с применением ингибиторов фдэ7
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EP3565631B1 (en) * 2017-01-05 2024-04-24 Noctrix Health, Inc. Restless leg syndrome or overactive nerve treatment
JP2021535180A (ja) * 2018-09-05 2021-12-16 ユニベルシテイト ファン アムステルダム パーキンソン病の処置の為のｐｄｅ１１又はｐｄｅ２阻害剤の使用
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WO2024259383A2 (en) * 2023-06-14 2024-12-19 President And Fellows Of Harvard College Ion channel binders and uses thereof

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Also Published As

Publication number Publication date
CA2681650A1 (en) 2008-10-02
CN101917992A (zh) 2010-12-15
JP2014198718A (ja) 2014-10-23
BRPI0809244A2 (pt) 2014-09-23
US20110091388A1 (en) 2011-04-21
MX2009010450A (es) 2009-11-23
RU2449790C2 (ru) 2012-05-10
AU2008230710A1 (en) 2008-10-02
JP5943964B2 (ja) 2016-07-05
JP2010522768A (ja) 2010-07-08
CA2681650C (en) 2016-11-22
WO2008119057A2 (en) 2008-10-02
ES2533206T3 (es) 2015-04-08
HK1139861A1 (en) 2010-09-30
JP5580192B2 (ja) 2014-08-27
CN104758291B (zh) 2020-03-03
RU2009138966A (ru) 2011-05-10
EP2139475A4 (en) 2012-03-07
US20080260643A1 (en) 2008-10-23
EP2139475B1 (en) 2014-12-17
US20190183824A1 (en) 2019-06-20
CN104758291A (zh) 2015-07-08
EP2139475A2 (en) 2010-01-06
WO2008119057A3 (en) 2008-11-20
NZ580413A (en) 2012-11-30

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