AU2008230710B2 - The use of PDE7 inhibitors for the treatment of movement disorders - Google Patents

The use of PDE7 inhibitors for the treatment of movement disorders Download PDF

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Publication number
AU2008230710B2
AU2008230710B2 AU2008230710A AU2008230710A AU2008230710B2 AU 2008230710 B2 AU2008230710 B2 AU 2008230710B2 AU 2008230710 A AU2008230710 A AU 2008230710A AU 2008230710 A AU2008230710 A AU 2008230710A AU 2008230710 B2 AU2008230710 B2 AU 2008230710B2
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AU
Australia
Prior art keywords
pde7
alkyl
activity
inhibiting
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2008230710A
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English (en)
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AU2008230710A1 (en
Inventor
John E. Bergmann
Neil S. Cutshall
Gregory A. Demopulos
Vincent A. Florio
George Gaitanaris
Patrick Gray
John Hohmann
Rene Onrust
Hongkui Zeng
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Omeros Corp
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Omeros Medical Systems Inc
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Publication date
Application filed by Omeros Medical Systems Inc filed Critical Omeros Medical Systems Inc
Publication of AU2008230710A1 publication Critical patent/AU2008230710A1/en
Priority to AU2013202067A priority Critical patent/AU2013202067B2/en
Application granted granted Critical
Publication of AU2008230710B2 publication Critical patent/AU2008230710B2/en
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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433Thidiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/527Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim spiro-condensed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Psychology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AU2008230710A 2007-03-27 2008-03-27 The use of PDE7 inhibitors for the treatment of movement disorders Active AU2008230710B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2013202067A AU2013202067B2 (en) 2007-03-27 2013-03-22 The use of PDE7 inhibitors for the treatment of movement disorders

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US92049607P 2007-03-27 2007-03-27
US60/920,496 2007-03-27
PCT/US2008/058530 WO2008119057A2 (en) 2007-03-27 2008-03-27 The use of pde7 inhibitors for the treatment of movement disorders

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2013202067A Division AU2013202067B2 (en) 2007-03-27 2013-03-22 The use of PDE7 inhibitors for the treatment of movement disorders

Publications (2)

Publication Number Publication Date
AU2008230710A1 AU2008230710A1 (en) 2008-10-02
AU2008230710B2 true AU2008230710B2 (en) 2014-04-10

Family

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AU2008230710A Active AU2008230710B2 (en) 2007-03-27 2008-03-27 The use of PDE7 inhibitors for the treatment of movement disorders

Country Status (11)

Country Link
US (3) US20080260643A1 (enExample)
EP (1) EP2139475B1 (enExample)
JP (2) JP5580192B2 (enExample)
CN (2) CN104758291B (enExample)
AU (1) AU2008230710B2 (enExample)
CA (1) CA2681650C (enExample)
ES (1) ES2533206T3 (enExample)
MX (1) MX2009010450A (enExample)
NZ (1) NZ580413A (enExample)
RU (1) RU2449790C2 (enExample)
WO (1) WO2008119057A2 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8637528B2 (en) 2007-03-27 2014-01-28 Omeros Corporation Use of PDE7 inhibitors for the treatment of movement disorders
CA2755768A1 (en) * 2009-03-23 2010-09-30 Merck Sharp & Dohme Corp. P2x3, receptor antagonists for treatment of pain
FR2943673B1 (fr) * 2009-03-27 2013-03-29 Sanofi Aventis Applications therapeutiques de derives de quinazolinedione
FR2944206B1 (fr) 2009-04-09 2012-12-28 Sanofi Aventis Applications therapeutiques dans le domaine cardiovasculaire de derives de quinazolinedione
FR2944282B1 (fr) 2009-04-09 2013-05-03 Sanofi Aventis Derives de quinazolinedione, leur preparation et leurs diverses applications therapeutiques
AU2013202493B2 (en) * 2009-05-04 2016-03-10 Omeros Corporation Use of PDE7 inhibitors for the treatment of movement disorders
ES2353093B1 (es) 2009-05-20 2012-01-03 Consejo Superior De Investigaciones Científicas (Csic) Uso de derivados de quinazolinas y sus composiciones farmacéuticas en enfermedades neurodegenerativas.
ES2360783B1 (es) 2009-10-02 2012-07-04 Consejo Superior De Investigaciones Científicas (Csic) 1,2,4-tiadiazoles-5-imino sustituidos utiles en el tratamiento de enfermedades neurodegenerativas
NZ628055A (en) * 2010-11-08 2016-03-31 Omeros Corp Treatment of addiction and impulse-control disorders using pde7 inhibitors
US9220715B2 (en) 2010-11-08 2015-12-29 Omeros Corporation Treatment of addiction and impulse-control disorders using PDE7 inhibitors
EP2846805B1 (en) * 2012-05-07 2018-11-21 Omeros Corporation Treatment of addiction and impulse-control disorders using pde7 inhibitors
RU2665134C2 (ru) * 2012-05-07 2018-08-28 Омерос Корпорейшн Лечение зависимости и расстройств побуждений с применением ингибиторов фдэ7
KR20190040054A (ko) * 2016-08-26 2019-04-16 미쓰비시 타나베 파마 코퍼레이션 이환식 함질소 헤테로환 화합물
US20210330736A1 (en) * 2018-09-05 2021-10-28 Universiteit Van Amsterdam Use of a pde11 or pde2 inhibitor for the treatment of parkinson's disease
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WO2024259383A2 (en) * 2023-06-14 2024-12-19 President And Fellows Of Harvard College Ion channel binders and uses thereof

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Also Published As

Publication number Publication date
BRPI0809244A2 (pt) 2014-09-23
WO2008119057A3 (en) 2008-11-20
CN104758291A (zh) 2015-07-08
WO2008119057A2 (en) 2008-10-02
US20190183824A1 (en) 2019-06-20
CA2681650C (en) 2016-11-22
US20080260643A1 (en) 2008-10-23
JP5943964B2 (ja) 2016-07-05
EP2139475B1 (en) 2014-12-17
NZ580413A (en) 2012-11-30
EP2139475A4 (en) 2012-03-07
JP5580192B2 (ja) 2014-08-27
JP2014198718A (ja) 2014-10-23
ES2533206T3 (es) 2015-04-08
CN104758291B (zh) 2020-03-03
CA2681650A1 (en) 2008-10-02
CN101917992A (zh) 2010-12-15
MX2009010450A (es) 2009-11-23
RU2449790C2 (ru) 2012-05-10
HK1139861A1 (en) 2010-09-30
EP2139475A2 (en) 2010-01-06
AU2008230710A1 (en) 2008-10-02
RU2009138966A (ru) 2011-05-10
US20110091388A1 (en) 2011-04-21
JP2010522768A (ja) 2010-07-08

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