JP5580192B2 - 運動障害の処置のためのｐｄｅ７インヒビターの使用 - Google Patents

運動障害の処置のためのｐｄｅ７インヒビターの使用 Download PDF

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Publication number
JP5580192B2
JP5580192B2 JP2010501232A JP2010501232A JP5580192B2 JP 5580192 B2 JP5580192 B2 JP 5580192B2 JP 2010501232 A JP2010501232 A JP 2010501232A JP 2010501232 A JP2010501232 A JP 2010501232A JP 5580192 B2 JP5580192 B2 JP 5580192B2
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alkyl
carbon atoms
substituted
group
aryl
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JP2010522768A5 (enExample
JP2010522768A (ja
Inventor
ジョン イー． バーグマン，
ニール エス． カットサル，
グレゴリー エー． デモプーロス，
ビンセント エー． フローリオ，
ジョージ ゲイタナリス，
パトリック グレイ，
ジョン ホフマン，
レネ オンラスト，
ホンクイ ツェン，
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オメロス コーポレーション
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/527—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim spiro-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Psychology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2010501232A 2007-03-27 2008-03-27 運動障害の処置のためのｐｄｅ７インヒビターの使用 Active JP5580192B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US92049607P 2007-03-27 2007-03-27
US60/920,496 2007-03-27
PCT/US2008/058530 WO2008119057A2 (en) 2007-03-27 2008-03-27 The use of pde7 inhibitors for the treatment of movement disorders

Related Child Applications (1)

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JP2014109910A Division JP5943964B2 (ja) 2007-03-27 2014-05-28 運動障害の処置のためのｐｄｅ７インヒビターの使用

Publications (3)

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JP2010522768A JP2010522768A (ja) 2010-07-08
JP2010522768A5 JP2010522768A5 (enExample) 2011-03-31
JP5580192B2 true JP5580192B2 (ja) 2014-08-27

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JP2010501232A Active JP5580192B2 (ja) 2007-03-27 2008-03-27 運動障害の処置のためのｐｄｅ７インヒビターの使用
JP2014109910A Active JP5943964B2 (ja) 2007-03-27 2014-05-28 運動障害の処置のためのｐｄｅ７インヒビターの使用

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Country Link
US (3) US20080260643A1 (enExample)
EP (1) EP2139475B1 (enExample)
JP (2) JP5580192B2 (enExample)
CN (2) CN104758291B (enExample)
AU (1) AU2008230710B2 (enExample)
CA (1) CA2681650C (enExample)
ES (1) ES2533206T3 (enExample)
MX (1) MX2009010450A (enExample)
NZ (1) NZ580413A (enExample)
RU (1) RU2449790C2 (enExample)
WO (1) WO2008119057A2 (enExample)

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US8637528B2 (en) 2007-03-27 2014-01-28 Omeros Corporation Use of PDE7 inhibitors for the treatment of movement disorders
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FR2943673B1 (fr) * 2009-03-27 2013-03-29 Sanofi Aventis Applications therapeutiques de derives de quinazolinedione
FR2944206B1 (fr) 2009-04-09 2012-12-28 Sanofi Aventis Applications therapeutiques dans le domaine cardiovasculaire de derives de quinazolinedione
FR2944282B1 (fr) 2009-04-09 2013-05-03 Sanofi Aventis Derives de quinazolinedione, leur preparation et leurs diverses applications therapeutiques
AU2013202493B2 (en) * 2009-05-04 2016-03-10 Omeros Corporation Use of PDE7 inhibitors for the treatment of movement disorders
ES2353093B1 (es) 2009-05-20 2012-01-03 Consejo Superior De Investigaciones Científicas (Csic) Uso de derivados de quinazolinas y sus composiciones farmacéuticas en enfermedades neurodegenerativas.
ES2360783B1 (es) 2009-10-02 2012-07-04 Consejo Superior De Investigaciones Científicas (Csic) 1,2,4-tiadiazoles-5-imino sustituidos utiles en el tratamiento de enfermedades neurodegenerativas
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RU2665134C2 (ru) * 2012-05-07 2018-08-28 Омерос Корпорейшн Лечение зависимости и расстройств побуждений с применением ингибиторов фдэ7
KR20190040054A (ko) * 2016-08-26 2019-04-16 미쓰비시 타나베 파마 코퍼레이션 이환식 함질소 헤테로환 화합물
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Also Published As

Publication number Publication date
BRPI0809244A2 (pt) 2014-09-23
WO2008119057A3 (en) 2008-11-20
CN104758291A (zh) 2015-07-08
WO2008119057A2 (en) 2008-10-02
US20190183824A1 (en) 2019-06-20
CA2681650C (en) 2016-11-22
US20080260643A1 (en) 2008-10-23
JP5943964B2 (ja) 2016-07-05
EP2139475B1 (en) 2014-12-17
NZ580413A (en) 2012-11-30
EP2139475A4 (en) 2012-03-07
JP2014198718A (ja) 2014-10-23
ES2533206T3 (es) 2015-04-08
CN104758291B (zh) 2020-03-03
AU2008230710B2 (en) 2014-04-10
CA2681650A1 (en) 2008-10-02
CN101917992A (zh) 2010-12-15
MX2009010450A (es) 2009-11-23
RU2449790C2 (ru) 2012-05-10
HK1139861A1 (en) 2010-09-30
EP2139475A2 (en) 2010-01-06
AU2008230710A1 (en) 2008-10-02
RU2009138966A (ru) 2011-05-10
US20110091388A1 (en) 2011-04-21
JP2010522768A (ja) 2010-07-08

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