JP2010522700A5 - - Google Patents
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- Publication number
- JP2010522700A5 JP2010522700A5 JP2010500048A JP2010500048A JP2010522700A5 JP 2010522700 A5 JP2010522700 A5 JP 2010522700A5 JP 2010500048 A JP2010500048 A JP 2010500048A JP 2010500048 A JP2010500048 A JP 2010500048A JP 2010522700 A5 JP2010522700 A5 JP 2010522700A5
- Authority
- JP
- Japan
- Prior art keywords
- acid
- methyl
- methylspiro
- cyclopropyl
- heptane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 2,2,6-trimethylcyclohexyl Chemical group 0.000 claims 6
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 6
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims 6
- 230000000903 blocking effect Effects 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 3
- VTCRWXGVGZLALO-UHFFFAOYSA-N 1-methyl-2-[(1,2,2-trimethyl-3-bicyclo[3.1.0]hexanyl)methyl]cyclopropane-1-carboxylic acid Chemical compound OC(=O)C1(C)CC1CC1C(C)(C)C2(C)CC2C1 VTCRWXGVGZLALO-UHFFFAOYSA-N 0.000 claims 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- RERQSUBOVZBXHE-VOTSOKGWSA-N (e)-3-[1-(2,2,3-trimethylcyclopent-3-en-1-yl)cyclopropyl]prop-2-enoic acid Chemical compound CC1(C)C(C)=CCC1C1(\C=C\C(O)=O)CC1 RERQSUBOVZBXHE-VOTSOKGWSA-N 0.000 claims 1
- VCCJRCPLNWXPON-NSCUHMNNSA-N (e)-4-(1-methyl-2-bicyclo[3.1.0]hexanyl)but-3-enoic acid Chemical compound C1CC(\C=C\CC(O)=O)C2(C)C1C2 VCCJRCPLNWXPON-NSCUHMNNSA-N 0.000 claims 1
- JDSGMYDTHXDPSJ-GQCTYLIASA-N (e)-4-(2,2,3-trimethylcyclopentyl)but-2-enoic acid Chemical compound CC1CCC(C\C=C\C(O)=O)C1(C)C JDSGMYDTHXDPSJ-GQCTYLIASA-N 0.000 claims 1
- UBOAGQFOYPWMRQ-SNAWJCMRSA-N (e)-4-(2,2,3-trimethylcyclopentyl)but-3-enoic acid Chemical compound CC1CCC(\C=C\CC(O)=O)C1(C)C UBOAGQFOYPWMRQ-SNAWJCMRSA-N 0.000 claims 1
- FSYYIWKNWSLCDN-DUXPYHPUSA-N (e)-4-(4-methylspiro[2.4]heptan-7-yl)but-2-enoic acid Chemical compound CC1CCC(C\C=C\C(O)=O)C11CC1 FSYYIWKNWSLCDN-DUXPYHPUSA-N 0.000 claims 1
- RNTNQSXSWNVYGY-NSCUHMNNSA-N (e)-4-(4-methylspiro[2.4]heptan-7-yl)but-3-enoic acid Chemical compound CC1CCC(\C=C\CC(O)=O)C11CC1 RNTNQSXSWNVYGY-NSCUHMNNSA-N 0.000 claims 1
- SPCQQNDKLJFBNA-DUXPYHPUSA-N (e)-4-(7-methylspiro[2.4]hept-6-en-4-yl)but-2-enoic acid Chemical compound CC1=CCC(C\C=C\C(O)=O)C11CC1 SPCQQNDKLJFBNA-DUXPYHPUSA-N 0.000 claims 1
- DXSRHFVZAUTTBE-XVNBXDOJSA-N (e)-4-(8-methylspiro[2.5]oct-7-en-4-yl)but-2-enoic acid Chemical compound CC1=CCCC(C\C=C\C(O)=O)C11CC1 DXSRHFVZAUTTBE-XVNBXDOJSA-N 0.000 claims 1
- HZLWXBYPIARCGW-SNAWJCMRSA-N 1-[(e)-2-(1-methyl-2-bicyclo[3.1.0]hexanyl)ethenyl]cyclopropane-1-carboxylic acid Chemical compound CC12CC1CCC2\C=C\C1(C(O)=O)CC1 HZLWXBYPIARCGW-SNAWJCMRSA-N 0.000 claims 1
- JKSQXNOUOSUVNZ-SNAWJCMRSA-N 1-[(e)-2-(4-methylspiro[2.4]heptan-7-yl)ethenyl]cyclopropane-1-carboxylic acid Chemical compound C1CC11C(C)CCC1\C=C\C1(C(O)=O)CC1 JKSQXNOUOSUVNZ-SNAWJCMRSA-N 0.000 claims 1
- MMEKRTLZYPFBNP-UHFFFAOYSA-N 1-[2-(4-methylspiro[2.4]heptan-7-yl)ethyl]cyclopropane-1-carboxylic acid Chemical compound C1CC11C(C)CCC1CCC1(C(O)=O)CC1 MMEKRTLZYPFBNP-UHFFFAOYSA-N 0.000 claims 1
- VQBSGHGICMYQGM-UHFFFAOYSA-N 2,2-dimethyl-4-(2,2,3-trimethylcyclopentyl)butanoic acid Chemical compound CC1CCC(CCC(C)(C)C(O)=O)C1(C)C VQBSGHGICMYQGM-UHFFFAOYSA-N 0.000 claims 1
- NDLNYVBNKQVKIM-UHFFFAOYSA-N 2-(3,4-dimethylcyclohexyl)acetic acid Chemical compound CC1CCC(CC(O)=O)CC1C NDLNYVBNKQVKIM-UHFFFAOYSA-N 0.000 claims 1
- MLHVLSFCLWASNP-UHFFFAOYSA-N 2-[(1,4-dimethyl-2-bicyclo[3.1.0]hexanyl)methyl]-1-methylcyclopropane-1-carboxylic acid Chemical compound CC12CC1C(C)CC2CC1CC1(C)C(O)=O MLHVLSFCLWASNP-UHFFFAOYSA-N 0.000 claims 1
- DNSDREPILBQXKN-UHFFFAOYSA-N 2-[(4,5-dimethylspiro[2.4]heptan-7-yl)methyl]-1-methylcyclopropane-1-carboxylic acid Chemical compound C1CC21C(C)C(C)CC2CC1CC1(C)C(O)=O DNSDREPILBQXKN-UHFFFAOYSA-N 0.000 claims 1
- VRFZBVPLWNHCKL-UHFFFAOYSA-N 2-[1-[(1,4-dimethyl-2-bicyclo[3.1.0]hexanyl)methyl]cyclopropyl]propanoic acid Chemical compound C1C(C)C2CC2(C)C1CC1(C(C(O)=O)C)CC1 VRFZBVPLWNHCKL-UHFFFAOYSA-N 0.000 claims 1
- RZFCTOIYOWTBPT-UHFFFAOYSA-N 2-[1-[(1-methyl-2-bicyclo[3.1.0]hexanyl)methyl]cyclopropyl]acetic acid Chemical compound CC12CC1CCC2CC1(CC(O)=O)CC1 RZFCTOIYOWTBPT-UHFFFAOYSA-N 0.000 claims 1
- CXYZORLHNHLYAH-UHFFFAOYSA-N 3,3-dimethyl-4-(2,2,3-trimethylcyclopentyl)butanoic acid Chemical compound CC1CCC(CC(C)(C)CC(O)=O)C1(C)C CXYZORLHNHLYAH-UHFFFAOYSA-N 0.000 claims 1
- QTALZWUULKHVTK-UHFFFAOYSA-N 3-(2,2,6-trimethylcyclohexyl)propanoic acid Chemical compound CC1CCCC(C)(C)C1CCC(O)=O QTALZWUULKHVTK-UHFFFAOYSA-N 0.000 claims 1
- IZZFEHBOGAIUMT-UHFFFAOYSA-N 4-(1-methyl-2-bicyclo[3.1.0]hexanyl)butanoic acid Chemical compound C1CC(CCCC(O)=O)C2(C)C1C2 IZZFEHBOGAIUMT-UHFFFAOYSA-N 0.000 claims 1
- YRIPPWABYROTJJ-UHFFFAOYSA-N 4-(2,2,3-trimethylcyclopent-3-en-1-yl)but-2-enoic acid Chemical compound CC1=CCC(CC=CC(O)=O)C1(C)C YRIPPWABYROTJJ-UHFFFAOYSA-N 0.000 claims 1
- LYFXCRCUENNESS-UHFFFAOYSA-N 4-(2,2,3-trimethylcyclopentyl)butanoic acid Chemical compound CC1CCC(CCCC(O)=O)C1(C)C LYFXCRCUENNESS-UHFFFAOYSA-N 0.000 claims 1
- 239000001274 FEMA 4529 Substances 0.000 claims 1
- LDHQCZJRKDOVOX-NSCUHMNNSA-N crotonic acid Chemical compound C\C=C\C(O)=O LDHQCZJRKDOVOX-NSCUHMNNSA-N 0.000 claims 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims 1
- DUWWHGPELOTTOE-UHFFFAOYSA-N n-(5-chloro-2,4-dimethoxyphenyl)-3-oxobutanamide Chemical compound COC1=CC(OC)=C(NC(=O)CC(C)=O)C=C1Cl DUWWHGPELOTTOE-UHFFFAOYSA-N 0.000 claims 1
- 239000002304 perfume Substances 0.000 claims 1
- 235000019260 propionic acid Nutrition 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90914307P | 2007-03-30 | 2007-03-30 | |
| US60/909,143 | 2007-03-30 | ||
| US96251507P | 2007-07-30 | 2007-07-30 | |
| US60/962,515 | 2007-07-30 | ||
| PCT/CH2008/000135 WO2008119196A1 (en) | 2007-03-30 | 2008-03-27 | Off-note blocking sensory organic compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010522700A JP2010522700A (ja) | 2010-07-08 |
| JP2010522700A5 true JP2010522700A5 (enExample) | 2011-05-12 |
| JP5442595B2 JP5442595B2 (ja) | 2014-03-12 |
Family
ID=39580609
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010500048A Active JP5442595B2 (ja) | 2007-03-30 | 2008-03-27 | オフノ−トを遮断する官能有機化合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US8409649B2 (enExample) |
| EP (1) | EP2139841B1 (enExample) |
| JP (1) | JP5442595B2 (enExample) |
| AT (1) | ATE555670T1 (enExample) |
| BR (1) | BRPI0809856B1 (enExample) |
| WO (1) | WO2008119196A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009149577A1 (en) | 2008-06-13 | 2009-12-17 | Givaudan Sa | Methods of identifying modulators of the bitter taste receptor tas2r44 |
| US8603762B2 (en) | 2008-08-07 | 2013-12-10 | Givaudan Sa | Methods to identify modulators of the interaction between dextromethorphan and the bitter taste receptor TAS2R46 |
| US8329239B2 (en) | 2009-03-03 | 2012-12-11 | Givandan S.A. | Off-taste masking |
| NZ602977A (en) | 2010-04-15 | 2016-02-26 | Chromocell Corp | Compounds, compositions, and methods for reducing or eliminating bitter taste |
| WO2012123475A1 (en) | 2011-03-14 | 2012-09-20 | Givaudan Sa | Off-note masking |
| JP5883599B2 (ja) * | 2011-09-20 | 2016-03-15 | 花王株式会社 | カテキン類の苦味抑制剤の評価又は選択方法 |
| KR20140076629A (ko) | 2011-10-20 | 2014-06-20 | 크로모셀 코포레이션 | 쓴맛을 감소시키거나 또는 제거하기 위한 화합물, 조성물 및 방법 |
| US9347934B2 (en) | 2011-10-20 | 2016-05-24 | Chromocell Corporation | Assays for identifying compounds that modulate bitter taste |
| WO2013072332A1 (en) | 2011-11-14 | 2013-05-23 | Givaudan Sa | Methods of using antagonists of bitter taste receptors |
| WO2014150967A1 (en) | 2013-03-15 | 2014-09-25 | Altria Client Services Inc. | Oral energy products including encapsulated caffeine |
| US10798961B2 (en) * | 2013-03-15 | 2020-10-13 | Altria Client Services Llc | Functional food and beverage compositions with improved taste through the use of sensates |
| WO2014176336A1 (en) | 2013-04-24 | 2014-10-30 | Chromocell Corporation | Assays for identifying compounds that modulate bitter taste |
| US10407378B2 (en) * | 2014-04-21 | 2019-09-10 | Takasago International Corporation | Compound, and flavor and/or fragrance composition containing said compound |
| CN105801636A (zh) * | 2016-03-24 | 2016-07-27 | 济南诚汇双达化工有限公司 | 一种柚皮苷二氢查尔酮的合成方法 |
| WO2021214008A1 (en) | 2020-04-20 | 2021-10-28 | Givaudan Sa | Compositions |
| US11058137B2 (en) | 2018-09-20 | 2021-07-13 | The Better Meat Co. | Enhanced aerobic fermentation methods for producing edible fungal mycelium blended meats and meat analogue compositions |
| US12274283B2 (en) | 2018-09-20 | 2025-04-15 | The Better Meat Co. | Enhanced aerobic fermentation methods for producing edible fungal mycelium blended meats and meat analogue compositions |
| CN109588688A (zh) * | 2019-01-22 | 2019-04-09 | 中国计量大学 | 一种采用山梨酸钾控制酱油中生物胺含量的方法 |
| PL240449B1 (pl) * | 2019-05-06 | 2022-04-04 | Univ Medyczny Im Piastow Slaskich We Wroclawiu | Pochodna terpenoidowa do zastosowania w chemoprewencji i wspomaganiu chemioterapii nowotworów |
| GB202007984D0 (en) | 2020-05-28 | 2020-07-15 | Givaudan Sa | Compositions |
| CN117642079A (zh) * | 2021-06-18 | 2024-03-01 | 嘉吉公司 | 用于蛋白质组合物的感官改性剂 |
| WO2024240572A1 (en) | 2023-05-22 | 2024-11-28 | Givaudan Sa | Dried cocoa pulp composition, consumables and methods |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58500250A (ja) * | 1981-03-13 | 1983-02-17 | エル．ジ−ボ−ダン エ コンパニ− ソシエテ アノニム | 香料組成物 |
| DE3278403D1 (en) | 1981-09-09 | 1988-06-01 | Givaudan & Cie Sa | Perfuming and/or flavouring compositions containing unsaturated acids |
| JPS60109537A (ja) * | 1983-11-18 | 1985-06-15 | T Hasegawa Co Ltd | シクロペンテン誘導体 |
| US20020004092A1 (en) | 2000-02-02 | 2002-01-10 | Riha William E. | Low calorie beverages containing high intensity sweeteners and arabinogalactan |
| US20030035875A1 (en) * | 2001-04-03 | 2003-02-20 | Dulebohn Joel I. | Composition for improving the taste and sweetness profile of beverages having intense sweeteners |
| EP2270155A3 (en) | 2002-09-25 | 2011-08-10 | Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke | Bitter taste receptors |
| US7632531B2 (en) | 2003-04-11 | 2009-12-15 | International Flavors & Fragnances Inc. | Alkyldienamides exhibiting taste and sensory effect in flavor compositions |
| US20060024335A1 (en) * | 2004-07-29 | 2006-02-02 | Roger Stier E | Oral compositions which mask the bitter taste of a bitter-tasting agent |
| US8367137B2 (en) * | 2005-11-23 | 2013-02-05 | The Coca-Cola Company | High-potency sweetener composition with fatty acid and compositions sweetened therewith |
-
2008
- 2008-03-27 EP EP08714785A patent/EP2139841B1/en active Active
- 2008-03-27 AT AT08714785T patent/ATE555670T1/de active
- 2008-03-27 US US12/593,114 patent/US8409649B2/en active Active
- 2008-03-27 BR BRPI0809856A patent/BRPI0809856B1/pt active IP Right Grant
- 2008-03-27 WO PCT/CH2008/000135 patent/WO2008119196A1/en not_active Ceased
- 2008-03-27 JP JP2010500048A patent/JP5442595B2/ja active Active
-
2013
- 2013-03-29 US US13/853,575 patent/US9451784B2/en active Active
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