JP2010522146A5 - - Google Patents
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- Publication number
- JP2010522146A5 JP2010522146A5 JP2009554063A JP2009554063A JP2010522146A5 JP 2010522146 A5 JP2010522146 A5 JP 2010522146A5 JP 2009554063 A JP2009554063 A JP 2009554063A JP 2009554063 A JP2009554063 A JP 2009554063A JP 2010522146 A5 JP2010522146 A5 JP 2010522146A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- treatment
- intended
- citrulline
- nutrition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 23
- RHGKLRLOHDJJDR-BYPYZUCNSA-N L-citrulline Chemical compound NC(=O)NCCC[C@H]([NH3+])C([O-])=O RHGKLRLOHDJJDR-BYPYZUCNSA-N 0.000 claims 11
- 150000003839 salts Chemical class 0.000 claims 8
- 229960002173 citrulline Drugs 0.000 claims 7
- 235000016709 nutrition Nutrition 0.000 claims 5
- 206010006895 Cachexia Diseases 0.000 claims 4
- 230000003902 lesion Effects 0.000 claims 4
- KPGXRSRHYNQIFN-UHFFFAOYSA-N 2-oxoglutaric acid Chemical compound OC(=O)CCC(=O)C(O)=O KPGXRSRHYNQIFN-UHFFFAOYSA-N 0.000 claims 3
- BKAJNAXTPSGJCU-UHFFFAOYSA-N 4-methyl-2-oxopentanoic acid Chemical compound CC(C)CC(=O)C(O)=O BKAJNAXTPSGJCU-UHFFFAOYSA-N 0.000 claims 3
- 239000004475 Arginine Substances 0.000 claims 3
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 claims 3
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 3
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims 3
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 3
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 3
- 208000002720 Malnutrition Diseases 0.000 claims 3
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 claims 3
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 claims 3
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 3
- 230000001071 malnutrition Effects 0.000 claims 3
- 235000000824 malnutrition Nutrition 0.000 claims 3
- 208000015380 nutritional deficiency disease Diseases 0.000 claims 3
- 229960003104 ornithine Drugs 0.000 claims 3
- 235000016236 parenteral nutrition Nutrition 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 230000006315 carbonylation Effects 0.000 claims 2
- 238000005810 carbonylation reaction Methods 0.000 claims 2
- 239000002537 cosmetic Substances 0.000 claims 2
- 235000015872 dietary supplement Nutrition 0.000 claims 2
- 230000035764 nutrition Effects 0.000 claims 2
- 235000021542 oral nutrition Nutrition 0.000 claims 2
- 235000018102 proteins Nutrition 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 230000000699 topical effect Effects 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 201000006474 Brain Ischemia Diseases 0.000 claims 1
- 208000002177 Cataract Diseases 0.000 claims 1
- 206010008120 Cerebral ischaemia Diseases 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 208000021642 Muscular disease Diseases 0.000 claims 1
- 201000009623 Myopathy Diseases 0.000 claims 1
- RHGKLRLOHDJJDR-UHFFFAOYSA-N Ndelta-carbamoyl-DL-ornithine Natural products OC(=O)C(N)CCCNC(N)=O RHGKLRLOHDJJDR-UHFFFAOYSA-N 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 206010036030 Polyarthritis Diseases 0.000 claims 1
- 208000017442 Retinal disease Diseases 0.000 claims 1
- 206010038923 Retinopathy Diseases 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- 230000032683 aging Effects 0.000 claims 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 206010008118 cerebral infarction Diseases 0.000 claims 1
- 235000013477 citrulline Nutrition 0.000 claims 1
- 230000001079 digestive effect Effects 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 210000001508 eye Anatomy 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 208000012268 mitochondrial disease Diseases 0.000 claims 1
- 230000004065 mitochondrial dysfunction Effects 0.000 claims 1
- 210000003205 muscle Anatomy 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 238000011903 nutritional therapy Methods 0.000 claims 1
- 208000030428 polyarticular arthritis Diseases 0.000 claims 1
- 239000000047 product Substances 0.000 claims 1
- 239000000523 sample Substances 0.000 claims 1
- 230000009759 skin aging Effects 0.000 claims 1
- 230000009469 supplementation Effects 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 235000000112 undernutrition Nutrition 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0702090A FR2913885B1 (fr) | 2007-03-22 | 2007-03-22 | Utilisation de la citrulline pour le traitement des pathologies liees a une augmentation de la carbonylation des proteines |
| PCT/FR2008/000379 WO2008135661A2 (fr) | 2007-03-22 | 2008-03-20 | Utilisation de la citrulline pour pour le traitement de pathologies liees a une augmentation de la carbonylation des protéines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010522146A JP2010522146A (ja) | 2010-07-01 |
| JP2010522146A5 true JP2010522146A5 (enExample) | 2011-05-06 |
Family
ID=38561836
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009554063A Pending JP2010522146A (ja) | 2007-03-22 | 2008-03-20 | タンパク質のカルボニル化の増加の予防およびそれを原因とする病変の治療のためのシトルリンの使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20100093863A1 (enExample) |
| EP (1) | EP2136777A2 (enExample) |
| JP (1) | JP2010522146A (enExample) |
| CN (1) | CN101686919A (enExample) |
| CA (1) | CA2689608A1 (enExample) |
| FR (1) | FR2913885B1 (enExample) |
| IL (1) | IL200830A0 (enExample) |
| WO (1) | WO2008135661A2 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102600260A (zh) * | 2010-12-24 | 2012-07-25 | 漆又毛 | 一种氨基酸和提取物组合物防治老年性痴呆的药物用途 |
| ES2727043T3 (es) * | 2011-03-18 | 2019-10-11 | Nestle Sa | Composiciones y métodos útiles para mejorar enfermedades relacionadas con la edad |
| BR112013026706A2 (pt) * | 2011-04-18 | 2016-12-27 | Nestec Sa | composições nutricionais compreendendo ácido alfa-hidroxi-isocaproico |
| WO2014125376A2 (en) * | 2013-02-15 | 2014-08-21 | Mediterranean Institute For Life Sciences | Protein damage in aging and age-related diseases |
| CN106137782A (zh) * | 2015-04-22 | 2016-11-23 | 捷通国际有限公司 | 包含青藤碱的局部组合物及用于抑制蛋白羰基化的方法 |
| JP7220838B2 (ja) * | 2015-09-29 | 2023-02-13 | 学校法人北里研究所 | 経口組成物 |
| CN105147684B (zh) * | 2015-09-30 | 2017-12-12 | 暨南大学 | 胡椒碱在制备防治败血症药物中的应用 |
| KR102531118B1 (ko) * | 2023-01-05 | 2023-05-11 | 주식회사 마이크로엑스 | 패혈증의 예방, 개선 또는 치료용 조성물 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5385938B1 (en) * | 1986-12-23 | 1997-07-15 | Tristrata Inc | Method of using glycolic acid for treating wrinkles |
| FR2691359B1 (fr) * | 1992-05-20 | 1995-06-23 | Krempf Michel | Nouvelle application therapeutique du malate de 1-citrulline. |
| DE4341000A1 (de) * | 1993-12-02 | 1995-06-08 | Beiersdorf Ag | Verwendung von L-Arginin, L-Ornithin oder L-Citrullin und topischen Zubereitungen mit diesen Stoffen |
| FR2766712B1 (fr) * | 1997-08-01 | 1999-10-22 | Aguettant Lab | Composition de preference solution antioxydante et medicaments en faisant application |
| US20010056068A1 (en) * | 1998-03-04 | 2001-12-27 | Kristof Chwalisz | Method of treatment and prevention of nitric oxide deficiency-related disorders with citrulline and citrulline derivatives |
| US9486429B2 (en) * | 1999-06-01 | 2016-11-08 | Vanderbilt University | Therapeutic methods employing nitric oxide precursors |
| DE19929993C2 (de) * | 1999-06-30 | 2001-07-05 | Sueddeutsche Kalkstickstoff | Kreatin-alpha-ketoglutarate, Verfahren zu ihrer Herstellung und ihre Verwendung |
| NL1014380C2 (nl) * | 2000-02-14 | 2001-08-15 | Friesland Brands Bv | Darmwandversterkend voedingsmiddel. |
| JP3843298B2 (ja) * | 2001-02-05 | 2006-11-08 | 国立大学法人 奈良先端科学技術大学院大学 | シトルリンを含有する活性酸素消去剤 |
| US20040087490A1 (en) * | 2002-09-20 | 2004-05-06 | Troup John P. | Nutritional compositions |
| US20060063827A1 (en) * | 2004-09-23 | 2006-03-23 | Yu Ruey J | Systemic administration of therapeutic amino acids and N-acetylamino acids |
| FR2853210B1 (fr) * | 2003-04-02 | 2006-12-15 | Neolait Sas | Composition activateur de la digestion |
| US20060247207A1 (en) * | 2003-07-01 | 2006-11-02 | Pierzynowski Stefan G | Use of alpha-ketoglutaric acid for the treatment of malnutrition or high plasma glucose condition |
| FR2857262B1 (fr) * | 2003-07-08 | 2007-10-05 | Biocodex Lab | Utilisation de la citrulline dans le cadre de l'insuffisance intestinale |
| JP3878612B2 (ja) * | 2004-03-01 | 2007-02-07 | ピアス株式会社 | 活性酸素抑制用の組成物と、その組成物を配合する皮膚外用剤及び化粧料 |
| FR2869539B1 (fr) * | 2004-04-29 | 2008-08-08 | Univ Paris Descartes | Compositions pharmaceutiques pour la prevention et le traitement de l'atherosclerose |
| WO2005105126A1 (ja) * | 2004-04-30 | 2005-11-10 | National University Corporation NARA Institute of Science and Technology | 野生種スイカ抽出物を含有する活性酸素消去剤ならびに保湿剤 |
| US20060046982A1 (en) * | 2004-08-26 | 2006-03-02 | Waugh William H | Orthomolecular medical use of L-citrulline for capillary endothelial protection and adjacent cell protection in neurodegenerative disease |
| JP4255432B2 (ja) * | 2004-10-28 | 2009-04-15 | 株式会社ファンケル | 異常蛋白質除去用組成物 |
| WO2006131054A1 (en) * | 2005-06-04 | 2006-12-14 | Zichun Li | Chinese pharmaceutical ophthalmological formulations in forms of solutions, ointments and pills for antiaging recovery |
| CN101247801B (zh) * | 2005-08-25 | 2012-08-22 | 协和发酵生化株式会社 | 血中酒精浓度上升抑制用组合物 |
| MX2008012723A (es) * | 2006-04-04 | 2008-10-14 | Nestec Sa | Tratamientos que usan citrulina. |
| FR2907011B1 (fr) * | 2006-10-17 | 2010-05-14 | Univ Paris Descartes | Utilisation de la citrulline pour le traitement des etats de denutrition |
-
2007
- 2007-03-22 FR FR0702090A patent/FR2913885B1/fr not_active Expired - Fee Related
-
2008
- 2008-03-20 EP EP08787826A patent/EP2136777A2/fr not_active Ceased
- 2008-03-20 WO PCT/FR2008/000379 patent/WO2008135661A2/fr not_active Ceased
- 2008-03-20 JP JP2009554063A patent/JP2010522146A/ja active Pending
- 2008-03-20 US US12/532,299 patent/US20100093863A1/en not_active Abandoned
- 2008-03-20 CA CA002689608A patent/CA2689608A1/fr not_active Abandoned
- 2008-03-20 CN CN200880009440A patent/CN101686919A/zh active Pending
-
2009
- 2009-09-09 IL IL200830A patent/IL200830A0/en unknown
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