JP2010521961A5 - - Google Patents

Info

Publication number

JP2010521961A5

JP2010521961A5 JP2009554082A JP2009554082A JP2010521961A5 JP 2010521961 A5 JP2010521961 A5 JP 2010521961A5 JP 2009554082 A JP2009554082 A JP 2009554082A JP 2009554082 A JP2009554082 A JP 2009554082A JP 2010521961 A5 JP2010521961 A5 JP 2010521961A5

Authority

JP

Japan

Prior art keywords

polyethyleneimine

concentration

virus

sugar

number average

Prior art date

2008-03-19

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

• Espacenet
• Global Dossier
• Discuss

• 229920002873 Polyethylenimine Polymers 0.000 claims 17
• 241000700605 Viruses Species 0.000 claims 14
• 238000000034 method Methods 0.000 claims 14
• 235000000346 sugar Nutrition 0.000 claims 13
• 239000002245 particle Substances 0.000 claims 10
• 150000008163 sugars Chemical class 0.000 claims 4
• 229930006000 Sucrose Natural products 0.000 claims 3
• 239000000546 pharmaceutical excipient Substances 0.000 claims 3
• 239000000243 solution Substances 0.000 claims 3
• 239000005720 sucrose Substances 0.000 claims 3
• MUPFEKGTMRGPLJ-RMMQSMQOSA-N Raffinose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 MUPFEKGTMRGPLJ-RMMQSMQOSA-N 0.000 claims 2
• UQZIYBXSHAGNOE-USOSMYMVSA-N Stachyose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@H](CO[C@@H]2[C@@H](O)[C@@H](O)[C@@H](O)[C@H](CO)O2)O1 UQZIYBXSHAGNOE-USOSMYMVSA-N 0.000 claims 2
• CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 2
• MUPFEKGTMRGPLJ-UHFFFAOYSA-N UNPD196149 Natural products OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(O)C(COC2C(C(O)C(O)C(CO)O2)O)O1 MUPFEKGTMRGPLJ-UHFFFAOYSA-N 0.000 claims 2
• 239000007864 aqueous solution Substances 0.000 claims 2
• 238000001035 drying Methods 0.000 claims 2
• 239000011159 matrix material Substances 0.000 claims 2
• 239000000203 mixture Substances 0.000 claims 2
• 238000004321 preservation Methods 0.000 claims 2
• MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 claims 2
• 239000007787 solid Substances 0.000 claims 2
• UQZIYBXSHAGNOE-XNSRJBNMSA-N stachyose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO[C@@H]3[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O3)O)O2)O)O1 UQZIYBXSHAGNOE-XNSRJBNMSA-N 0.000 claims 2
• 229960005486 vaccine Drugs 0.000 claims 2
• 239000000654 additive Substances 0.000 claims 1
• 230000000996 additive effect Effects 0.000 claims 1
• 239000002671 adjuvant Substances 0.000 claims 1
• 230000002238 attenuated effect Effects 0.000 claims 1
• 230000003115 biocidal effect Effects 0.000 claims 1
• 238000004108 freeze drying Methods 0.000 claims 1
• 239000006166 lysate Substances 0.000 claims 1
• 229940031348 multivalent vaccine Drugs 0.000 claims 1
• 239000000843 powder Substances 0.000 claims 1
• 125000000185 sucrose group Chemical group 0.000 claims 1
• 150000005846 sugar alcohols Chemical class 0.000 claims 1
• 230000003612 virological effect Effects 0.000 claims 1