JP2010521147A5 - - Google Patents
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- Publication number
- JP2010521147A5 JP2010521147A5 JP2009553239A JP2009553239A JP2010521147A5 JP 2010521147 A5 JP2010521147 A5 JP 2010521147A5 JP 2009553239 A JP2009553239 A JP 2009553239A JP 2009553239 A JP2009553239 A JP 2009553239A JP 2010521147 A5 JP2010521147 A5 JP 2010521147A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- antigen
- binding fragment
- seq
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000427 antigen Substances 0.000 claims 21
- 102000036639 antigens Human genes 0.000 claims 21
- 108091007433 antigens Proteins 0.000 claims 21
- 239000012634 fragment Substances 0.000 claims 21
- 125000003275 alpha amino acid group Chemical group 0.000 claims 14
- 241001473385 H5N1 subtype Species 0.000 claims 11
- 208000015181 infectious disease Diseases 0.000 claims 5
- 241000712461 unidentified influenza virus Species 0.000 claims 5
- 230000003472 neutralizing effect Effects 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 101710154606 Hemagglutinin Proteins 0.000 claims 1
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims 1
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims 1
- 101710176177 Protein A56 Proteins 0.000 claims 1
- 108010029566 avian influenza A virus hemagglutinin Proteins 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000000185 hemagglutinin Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89461207P | 2007-03-13 | 2007-03-13 | |
| US60/894,612 | 2007-03-13 | ||
| PCT/IB2008/001527 WO2008110937A2 (en) | 2007-03-13 | 2008-03-13 | Antibodies against h5n1 strains of influenza a virus |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010521147A JP2010521147A (ja) | 2010-06-24 |
| JP2010521147A5 true JP2010521147A5 (cg-RX-API-DMAC7.html) | 2011-05-06 |
| JP5346820B2 JP5346820B2 (ja) | 2013-11-20 |
Family
ID=39760169
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009553239A Expired - Fee Related JP5346820B2 (ja) | 2007-03-13 | 2008-03-13 | H5n1亜型a型インフルエンザウィルスに対する抗体 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US8124092B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2125886A2 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5346820B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN102046654A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2008110937A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2427641T3 (es) | 2003-05-22 | 2013-10-31 | Ibio, Inc. | Molécula vehículo recombinante para la expresión, el suministro y la purificación de polipéptidos diana |
| KR101446025B1 (ko) | 2005-08-03 | 2014-10-01 | 아이바이오, 인크. | 면역글로불린의 생산을 위한 조성물 및 방법 |
| EP2125886A2 (en) * | 2007-03-13 | 2009-12-02 | Humabs LLC | Antibodies against h5n1 strains of influenza a virus |
| WO2009009759A2 (en) | 2007-07-11 | 2009-01-15 | Fraunhofer Usa, Inc. | Yersinia pestis antigens, vaccine compositions, and related methods |
| RU2553325C2 (ru) * | 2008-07-25 | 2015-06-10 | Институт Фо Ресёч Ин Биомедицин | Нейтрализующие антитела против вируса гриппа а и их использование |
| US8871207B2 (en) | 2008-07-25 | 2014-10-28 | Humabs, LLC | Neutralizing anti-influenza A virus antibodies and uses thereof |
| WO2010037046A1 (en) | 2008-09-28 | 2010-04-01 | Fraunhofer Usa, Inc. | Humanized neuraminidase antibody and methods of use thereof |
| GB0818356D0 (en) * | 2008-10-07 | 2008-11-12 | Istituto Superiore Di Sanito | Antibodies |
| PL2350128T3 (pl) | 2008-10-22 | 2015-03-31 | Inst Res Biomedicine | Sposoby wytwarzania przeciwciał z komórek plazmatycznych |
| CN102448986B (zh) * | 2009-05-11 | 2015-11-25 | 克鲁塞尔荷兰公司 | 能中和流感病毒h3n2的人结合分子及其应用 |
| US8784819B2 (en) * | 2009-09-29 | 2014-07-22 | Ibio Inc. | Influenza hemagglutinin antibodies, compositions and related methods |
| US8900590B2 (en) * | 2010-08-12 | 2014-12-02 | Theraclone Sciences, Inc. | Anti-hemagglutinin antibody compositions and methods of use thereof |
| CN102775469B (zh) * | 2011-05-12 | 2018-02-09 | 厦门大学 | 甲型流感病毒核衣壳蛋白的抗原表位及其用途 |
| ES2841899T3 (es) | 2011-07-18 | 2021-07-12 | Inst Res Biomedicine | Anticuerpos neutralizantes del virus de la influenza A y usos de los mismos |
| JP2013087069A (ja) * | 2011-10-17 | 2013-05-13 | Toyobo Co Ltd | H5亜型インフルエンザウイルスを特異的に認識するモノクローナル抗体 |
| US10654915B2 (en) | 2011-12-05 | 2020-05-19 | Trellis Bioscience, Llc | Antibodies useful in passive influenza immunization |
| US9233152B2 (en) | 2012-01-12 | 2016-01-12 | Temasek Life Sciences Laboratory Limited | Monoclonal antibodies targeting neutralizing epitopes on H5 influenza virus of clade 2.3 |
| US9969794B2 (en) | 2012-05-10 | 2018-05-15 | Visterra, Inc. | HA binding agents |
| JP6386465B2 (ja) | 2012-11-13 | 2018-09-05 | ジェネンテック, インコーポレイテッド | 抗ヘマグルチニン抗体及び使用方法 |
| BR112015022623A2 (pt) | 2013-03-14 | 2017-07-18 | Contrafect Corp | composição e métodos baseados em anticorpos neutralizantes, administrados por via intranasal para eficácia terapêutica melhorada |
| DK3052192T3 (da) | 2013-10-02 | 2020-09-28 | Medimmune Llc | Neutraliserende anti-influenza a-antistoffer og anvendelser deraf |
| US10639370B2 (en) | 2014-02-04 | 2020-05-05 | Contrafect Corporation | Antibodies useful in passive influenza immunization, and compositions, combinations and methods for use thereof |
| CN106795216B (zh) | 2014-02-04 | 2021-04-20 | 抗非特公司 | 可用于被动流感免疫的抗体及其组合物、组合和使用方法 |
| KR101628331B1 (ko) * | 2014-03-28 | 2016-06-08 | 주식회사 녹십자엠에스 | 인플루엔자 a 바이러스 특이적 단클론 항체 및 이를 이용한 인플루엔자 감염 치료 및 진단 방법 |
| JP6614523B2 (ja) * | 2014-03-28 | 2019-12-04 | 地方独立行政法人神奈川県立産業技術総合研究所 | インフルエンザウイルスのrna依存性rnaポリメラーゼのpb2サブユニットに対するモノクローナル抗体 |
| CA2954780A1 (en) | 2014-07-15 | 2016-01-21 | Medimmune, Llc | Neutralizing anti-influenza b antibodies and uses thereof |
| TWI701258B (zh) | 2014-12-19 | 2020-08-11 | 美商再生元醫藥公司 | 流行性感冒病毒血球凝集素之人類抗體 |
| EP3307310A2 (en) | 2015-05-13 | 2018-04-18 | The Trustees Of The University Of Pennsylvania | Aav-mediated expression of anti-influenza antibodies and methods of use thereof |
| SMT202100591T1 (it) | 2015-06-01 | 2021-11-12 | Medimmune Llc | Molecole di legame anti-influenza neutralizzanti e loro usi |
| EP3374390A1 (en) | 2015-11-13 | 2018-09-19 | Visterra, Inc. | Compositions and methods for treating and preventing influenza |
| AU2017207330C1 (en) | 2016-01-13 | 2022-06-09 | Medimmune, Llc | Method of treating influenza A |
| AU2017222564A1 (en) | 2016-02-24 | 2018-09-06 | Visterra, Inc. | Formulations of antibody molecules to influenza virus |
| PL238020B1 (pl) * | 2016-09-12 | 2021-06-28 | Inst Biotechnologii I Antybiotykow | Kompozycja przeciwciał monoklonalnych przeciwko hemaglutyninie wirusów grypy serotypu H5 i jej zastosowanie, hybrydomy produkujące rzeczone przeciwciała, sposób diagnozowania infekcji wirusami grypy serotypu H5 oraz zestawy diagnostyczne |
| KR20190135000A (ko) | 2017-02-28 | 2019-12-05 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | Aav 벡터를 기반으로 하는 인플루엔자 백신 |
| CN118956781A (zh) | 2017-02-28 | 2024-11-15 | 宾夕法尼亚州大学信托人 | 腺相关病毒(aav)进化枝f载体及其用途 |
| JOP20190200A1 (ar) | 2017-02-28 | 2019-08-27 | Univ Pennsylvania | تركيبات نافعة في معالجة ضمور العضل النخاعي |
| AU2018275359C1 (en) | 2017-06-02 | 2022-02-03 | Pfizer Inc. | Antibodies specific for FLT3 and their uses |
| US11230593B2 (en) | 2019-03-25 | 2022-01-25 | Visterra, Inc. | Compositions and methods for treating and preventing influenza |
| WO2021142413A1 (en) * | 2020-01-12 | 2021-07-15 | Vanderbilt University | Human antibodies to crimean congo hemorrhagic fever virus |
| WO2021202815A1 (en) * | 2020-03-31 | 2021-10-07 | Northeastern University | Colorimetric and multiplexed isothermal rna-and antibody-based assay for sars-cov-2 and other viral diagnostics and cell analysis |
| CN114181302B (zh) * | 2020-09-14 | 2023-03-24 | 东莞市朋志生物科技有限公司 | 针对甲型流感病毒的抗体、试剂盒和载体 |
| US12319747B2 (en) | 2023-07-03 | 2025-06-03 | Medicovestor, Inc. | Methods of using anti-SP17 immunotherapeutics |
| US12364777B2 (en) | 2023-10-20 | 2025-07-22 | Medicovestor, Inc. | Homodimeric antibodies for use in treating cancers and methods of use |
| US12116410B1 (en) | 2023-12-26 | 2024-10-15 | Medicovestor, Inc. | Methods of manufacturing dimeric antibodies |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2817869B1 (fr) | 2000-12-07 | 2005-01-14 | Technopharm | Anticorps monoclonal humain dirige contre le virus influenza ou un fragment de celui-ci |
| CN1652815A (zh) * | 2002-03-13 | 2005-08-10 | 麒麟麦酒株式会社 | 针对流感病毒m2蛋白的人单克隆抗体其制备和使用方法 |
| JP5525688B2 (ja) | 2005-08-19 | 2014-06-18 | 株式会社ビーエル | インフルエンザウイルスh5亜型の免疫検出法 |
| EP1928914A2 (en) | 2005-09-15 | 2008-06-11 | Crucell Holland B.V. | Method for preparing immunoglobulin libraries |
| GB0522460D0 (en) | 2005-11-03 | 2005-12-14 | Prendergast Patrick T | Composition and method for the treatment of avian influenza |
| JP2009524434A (ja) | 2006-01-26 | 2009-07-02 | エイチエックス・ダイアグノスティックス・インコーポレイテッド | トリインフルエンザウイルス亜型h5ヘマグルチニンに結合するモノクローナル抗体およびそれらの使用 |
| EP2522678A1 (en) | 2006-05-15 | 2012-11-14 | Sea Lane Biotechnologies, LLC | Neutralizing antibodies to influenza viruses |
| CN101541832B (zh) * | 2006-09-07 | 2014-11-12 | 克鲁塞尔荷兰公司 | 能中和流感病毒h5n1的人结合分子及其应用 |
| HRP20130163T1 (hr) | 2006-09-07 | 2013-03-31 | Crucell Holland B.V. | Ljudske molekule za vezanje koje mogu neutralizirati virus influence h5n1 i njihova uporaba |
| WO2008033105A1 (en) | 2006-09-13 | 2008-03-20 | Dso National Laboratories | Hemagglutinin antibody and uses thereof |
| WO2008033159A1 (en) | 2006-09-15 | 2008-03-20 | Fraunhofer Usa, Inc. | Influenza antibodies, compositions, and related methods |
| EP2125886A2 (en) * | 2007-03-13 | 2009-12-02 | Humabs LLC | Antibodies against h5n1 strains of influenza a virus |
-
2008
- 2008-03-13 EP EP08762860A patent/EP2125886A2/en not_active Withdrawn
- 2008-03-13 WO PCT/IB2008/001527 patent/WO2008110937A2/en not_active Ceased
- 2008-03-13 CN CN2008800130493A patent/CN102046654A/zh active Pending
- 2008-03-13 JP JP2009553239A patent/JP5346820B2/ja not_active Expired - Fee Related
- 2008-03-13 US US12/048,040 patent/US8124092B2/en not_active Expired - Fee Related
-
2012
- 2012-01-16 US US13/351,066 patent/US20120114664A1/en not_active Abandoned
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