JP2010520989A5 - - Google Patents
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- JP2010520989A5 JP2010520989A5 JP2009537355A JP2009537355A JP2010520989A5 JP 2010520989 A5 JP2010520989 A5 JP 2010520989A5 JP 2009537355 A JP2009537355 A JP 2009537355A JP 2009537355 A JP2009537355 A JP 2009537355A JP 2010520989 A5 JP2010520989 A5 JP 2010520989A5
- Authority
- JP
- Japan
- Prior art keywords
- sample
- signal generator
- fluorescent signal
- enzyme
- targets
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000523 sample Substances 0.000 claims 22
- 238000000034 method Methods 0.000 claims 11
- 102000004190 Enzymes Human genes 0.000 claims 9
- 108090000790 Enzymes Proteins 0.000 claims 9
- 229940088598 enzyme Drugs 0.000 claims 9
- 102000003992 Peroxidases Human genes 0.000 claims 8
- 108040007629 peroxidase activity proteins Proteins 0.000 claims 8
- 239000000758 substrate Substances 0.000 claims 6
- 239000011230 binding agent Substances 0.000 claims 5
- 239000012472 biological sample Substances 0.000 claims 3
- 239000007800 oxidant agent Substances 0.000 claims 3
- 239000000243 solution Substances 0.000 claims 3
- 102000002260 Alkaline Phosphatase Human genes 0.000 claims 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 claims 1
- 108010015776 Glucose oxidase Proteins 0.000 claims 1
- 239000004366 Glucose oxidase Substances 0.000 claims 1
- 239000003637 basic solution Substances 0.000 claims 1
- 102000005936 beta-Galactosidase Human genes 0.000 claims 1
- 108010005774 beta-Galactosidase Proteins 0.000 claims 1
- 229940116332 glucose oxidase Drugs 0.000 claims 1
- 235000019420 glucose oxidase Nutrition 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
- 230000001590 oxidative effect Effects 0.000 claims 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- ANRHNWWPFJCPAZ-UHFFFAOYSA-M thionine Chemical compound [Cl-].C1=CC(N)=CC2=[S+]C3=CC(N)=CC=C3N=C21 ANRHNWWPFJCPAZ-UHFFFAOYSA-M 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/560,599 US7629125B2 (en) | 2006-11-16 | 2006-11-16 | Sequential analysis of biological samples |
| US11/560,599 | 2006-11-16 | ||
| US11/864,098 | 2007-09-28 | ||
| US11/864,098 US8305579B2 (en) | 2006-11-16 | 2007-09-28 | Sequential analysis of biological samples |
| PCT/US2007/084786 WO2008133728A2 (en) | 2006-11-16 | 2007-11-15 | Sequential analysis of biological samples with intermediate bleaching of fluorescence detector |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010520989A JP2010520989A (ja) | 2010-06-17 |
| JP2010520989A5 true JP2010520989A5 (https=) | 2011-01-06 |
| JP5335686B2 JP5335686B2 (ja) | 2013-11-06 |
Family
ID=39766807
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009537355A Active JP5335686B2 (ja) | 2006-11-16 | 2007-11-15 | 生体試料の連続分析 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8305579B2 (https=) |
| EP (1) | EP2082238B1 (https=) |
| JP (1) | JP5335686B2 (https=) |
| AT (1) | ATE541215T1 (https=) |
| DK (1) | DK2082238T3 (https=) |
| ES (1) | ES2378411T3 (https=) |
| PL (1) | PL2082238T3 (https=) |
| PT (1) | PT2082238E (https=) |
| WO (1) | WO2008133728A2 (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8060348B2 (en) | 2006-08-07 | 2011-11-15 | General Electric Company | Systems for analyzing tissue samples |
| US8131476B2 (en) | 2006-08-07 | 2012-03-06 | General Electric Company | System and method for co-registering multi-channel images of a tissue micro array |
| US9201063B2 (en) | 2006-11-16 | 2015-12-01 | General Electric Company | Sequential analysis of biological samples |
| US8305579B2 (en) | 2006-11-16 | 2012-11-06 | Thomas Pirrie Treynor | Sequential analysis of biological samples |
| US7629125B2 (en) | 2006-11-16 | 2009-12-08 | General Electric Company | Sequential analysis of biological samples |
| US7741045B2 (en) * | 2006-11-16 | 2010-06-22 | General Electric Company | Sequential analysis of biological samples |
| US9677125B2 (en) * | 2009-10-21 | 2017-06-13 | General Electric Company | Detection of plurality of targets in biological samples |
| EP2633080B1 (en) | 2010-10-29 | 2018-12-05 | President and Fellows of Harvard College | Method of detecting targets using fluorescently labelled nucleic acid nanotube probes |
| EP2831587B1 (en) | 2012-03-27 | 2018-05-16 | Ventana Medical Systems, Inc. | Signaling conjugates and methods of use |
| MX2015007432A (es) * | 2012-12-11 | 2016-05-10 | Univ Toronto | Sistema inalambrico de deteccion basado en un dispositivo de comunicacion. |
| HK1213296A1 (zh) * | 2013-06-04 | 2016-06-30 | 豪夫迈‧罗氏有限公司 | 用於fret的新化合物及与其相关的方法 |
| EP4245859A3 (en) | 2014-03-11 | 2023-11-08 | President and Fellows of Harvard College | High-throughput and highly multiplexed imaging with programmable nucleic acid probes |
| US9909167B2 (en) | 2014-06-23 | 2018-03-06 | The Board Of Trustees Of The Leland Stanford Junior University | On-slide staining by primer extension |
| WO2016140726A2 (en) * | 2014-12-16 | 2016-09-09 | President And Fellows Of Harvard College | Triggered assembly of metafluorophores |
| CN108369235B (zh) | 2015-12-18 | 2021-11-26 | 丹麦科达有限公司 | 生色过氧化物酶底物 |
| KR102478639B1 (ko) | 2016-02-23 | 2022-12-19 | 노을 주식회사 | 표지 물질을 저장하는 패치, 이를 이용하는 조직 진단 방법 및 장치 |
| US10371610B2 (en) | 2016-02-23 | 2019-08-06 | Noul Co., Ltd. | Contact-type patch, staining method using the same, and manufacturing method thereof |
| KR20170099738A (ko) | 2016-02-23 | 2017-09-01 | 노을 주식회사 | 접촉식 염색 패치 및 그 제조 방법 |
| CN109789228B (zh) | 2016-07-27 | 2022-10-21 | 斯坦福大学托管董事会 | 高度复用荧光成像 |
| JP2020504600A (ja) | 2016-12-09 | 2020-02-13 | アルティヴュー， インク． | 標識化核酸イメージング剤を使用した多重イメージングのための改善された方法 |
| CN106680257B (zh) * | 2017-01-09 | 2019-05-14 | 中国科学院理化技术研究所 | 基于硅纳米线的β-半乳糖苷酶荧光传感器及其制备方法和应用 |
| ES3030268T3 (en) * | 2017-06-08 | 2025-06-27 | Lumito Ab | A method of analysing a sample for at least one analyte |
| US10871485B2 (en) | 2018-04-13 | 2020-12-22 | Rarecyte, Inc. | Kits for labeling of biomarkers and methods of using the same |
| JP2020071152A (ja) * | 2018-10-31 | 2020-05-07 | ソニー株式会社 | 免疫染色方法、免疫染色システム、および免疫染色キット |
| US20210116377A1 (en) | 2019-10-17 | 2021-04-22 | C2Sense, Inc. | White light emissive species and related methods |
| WO2021076919A1 (en) * | 2019-10-17 | 2021-04-22 | C2Sense, Inc. | Luminescence imaging for sensing and/or authentication |
| EP3916393B1 (en) * | 2020-05-27 | 2023-01-25 | Miltenyi Biotec B.V. & Co. KG | Method for detection of cells by repetitive staining and destaining |
| CN113552362B (zh) * | 2021-07-23 | 2024-08-09 | 湖北百奥斯生物科技有限公司 | 一种新型信号放大的免疫荧光试剂盒 |
| US11911170B2 (en) * | 2021-09-13 | 2024-02-27 | Christopher J. Rourk | Deep brain sensing and stimulation probe |
| WO2025230880A1 (en) * | 2024-04-29 | 2025-11-06 | Agilent Technologies, Inc. | Chromogenic peroxidase substrates |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4405720A (en) | 1981-03-04 | 1983-09-20 | The United States Of America As Represented By The Department Of Health And Human Services | Silver stains for protein in gels |
| GB8405437D0 (en) | 1984-03-01 | 1984-04-04 | Amersham Int Plc | Detecting polynucleotide sequences |
| JP3130513B2 (ja) | 1989-04-19 | 2001-01-31 | イビデン株式会社 | 生体活性物質測定用装置 |
| US5843640A (en) | 1992-06-19 | 1998-12-01 | Northwestern University | Method of simultaneously detecting amplified nucleic acid sequences and cellular antigens in cells |
| AU5355594A (en) | 1992-10-09 | 1994-05-09 | Oncor, Inc. | Methods for the detection of chromosome structural abnormalities by (in situ) hybridization to fixed tissue |
| AU7401394A (en) | 1993-07-20 | 1995-02-20 | University Of Massachusetts Medical Center | In vivo nucleic acid hybridization method |
| FR2711671A1 (fr) | 1993-10-22 | 1995-05-05 | Centre Nat Rech Scient | Procédé de détection et de quantification d'une séquence nucléotidique dans une population cellulaire. |
| US5807522A (en) | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
| DE4421891C2 (de) | 1994-06-23 | 1996-05-15 | Helmut Prof Dr Med Feucht | Verfahren zum Nachweis von komplementaktivierenden IgG-Antikörpern gegen HLA-DR-Antigene |
| US5571643A (en) | 1994-07-22 | 1996-11-05 | Martin; Mark T. | Spectrophotometric quantitation of images in X-ray film and electrophoresis gel bands |
| EP0709466B1 (en) | 1994-10-28 | 2006-09-27 | Gen-Probe Incorporated | Compositions and methods for the simultaneous detection and quantification of multiple specific nucleic acid sequences |
| US5830645A (en) | 1994-12-09 | 1998-11-03 | The Regents Of The University Of California | Comparative fluorescence hybridization to nucleic acid arrays |
| US5763152A (en) | 1995-03-31 | 1998-06-09 | Fuji Photo Film Co., Ltd. | Silver halide photographic light-sensitive material |
| EP0801306A1 (en) | 1996-04-10 | 1997-10-15 | Becton, Dickinson and Company | Method for immunohistochemically quantitating co-localized molecules |
| WO1998002577A1 (en) | 1996-07-15 | 1998-01-22 | The Children's Medical Center Corporation | Method to co-detect introduced genes and their products |
| US6735531B2 (en) | 1996-10-07 | 2004-05-11 | Lab Vision Corporation | Method and apparatus for automatic tissue staining |
| AU4976699A (en) | 1998-07-10 | 2000-02-01 | Chromagen, Inc. | Novel fluorogenic substrates for hydrolytic enzymes |
| US6573043B1 (en) | 1998-10-07 | 2003-06-03 | Genentech, Inc. | Tissue analysis and kits therefor |
| AU774266B2 (en) | 1998-10-09 | 2004-06-24 | Vegenics Limited | Flt4 (VEGFR-3) as a target for tumor imaging and anti-tumor therapy |
| WO2000058507A1 (en) | 1999-03-30 | 2000-10-05 | Solexa Ltd. | Polynucleotide sequencing |
| US6391649B1 (en) | 1999-05-04 | 2002-05-21 | The Rockefeller University | Method for the comparative quantitative analysis of proteins and other biological material by isotopic labeling and mass spectroscopy |
| DE10014685B4 (de) | 2000-03-24 | 2004-07-01 | Schubert, Walter, Dr. | Verfahren zur Identifizierung von zellspezifischen Zielstrukturen |
| IL136232A0 (en) | 2000-05-18 | 2001-05-20 | Bar Ilan University Res Author | Measurements of enzymatic activity in a single, individual cell in population |
| US20030044353A1 (en) | 2001-01-05 | 2003-03-06 | Ralph Weissleder | Activatable imaging probes |
| JP2002323416A (ja) | 2001-02-20 | 2002-11-08 | Hitachi Ltd | 検査容器 |
| US20050230255A1 (en) | 2001-03-30 | 2005-10-20 | Sumner Lloyd W | Silver destaining method |
| JP3899845B2 (ja) | 2001-05-23 | 2007-03-28 | 日本光電工業株式会社 | 染色標本の脱色方法および装置 |
| DE10143757A1 (de) | 2001-09-06 | 2003-03-27 | Werner M | Methode zur Darstellung von Merkmalen in Geweben |
| US8323903B2 (en) | 2001-10-12 | 2012-12-04 | Life Technologies Corporation | Antibody complexes and methods for immunolabeling |
| US7776195B2 (en) | 2002-05-28 | 2010-08-17 | Autogenomics, Inc. | Integrated sample processing platform |
| JP2004041121A (ja) | 2002-07-12 | 2004-02-12 | Hitachi Ltd | アレルギー解析方法及びシステム |
| AU2003291249A1 (en) | 2002-12-18 | 2004-07-29 | Aclara Biosciences, Inc. | Multiplexed immunohistochemical assays using molecular tags |
| US20040241776A1 (en) | 2003-05-22 | 2004-12-02 | Agdia, Inc. | Multiplex enzyme-linked immunosorbent assay for detecting multiple analytes |
| JP3936689B2 (ja) | 2003-09-09 | 2007-06-27 | 日本碍子株式会社 | シアニン系有機色素劣化環境の検知方法 |
| JP4538628B2 (ja) | 2004-03-16 | 2010-09-08 | 学校法人慶應義塾 | 遺伝子発現検出方法 |
| JP4189495B2 (ja) | 2004-08-02 | 2008-12-03 | 国立大学法人群馬大学 | ゲノムｄｎａのメチル化検出方法 |
| JP2007033159A (ja) | 2005-07-25 | 2007-02-08 | Assay Corp | 蛍光分子で標識された測定対象物質 |
| JPWO2007055302A1 (ja) | 2005-11-10 | 2009-04-30 | 国立大学法人富山大学 | 生体物質と生体物質結合性物質との結合性評価方法 |
| US8305579B2 (en) | 2006-11-16 | 2012-11-06 | Thomas Pirrie Treynor | Sequential analysis of biological samples |
| US7629125B2 (en) * | 2006-11-16 | 2009-12-08 | General Electric Company | Sequential analysis of biological samples |
-
2007
- 2007-09-28 US US11/864,098 patent/US8305579B2/en not_active Expired - Fee Related
- 2007-11-15 PL PL07874283T patent/PL2082238T3/pl unknown
- 2007-11-15 AT AT07874283T patent/ATE541215T1/de active
- 2007-11-15 JP JP2009537355A patent/JP5335686B2/ja active Active
- 2007-11-15 WO PCT/US2007/084786 patent/WO2008133728A2/en not_active Ceased
- 2007-11-15 ES ES07874283T patent/ES2378411T3/es active Active
- 2007-11-15 DK DK07874283.0T patent/DK2082238T3/da active
- 2007-11-15 PT PT07874283T patent/PT2082238E/pt unknown
- 2007-11-15 EP EP07874283A patent/EP2082238B1/en active Active
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