ATE541215T1 - Sequenzielle analyse biologischer proben mit zwischenbleichung eines fluoreszenzdetektors - Google Patents

Sequenzielle analyse biologischer proben mit zwischenbleichung eines fluoreszenzdetektors

Info

Publication number
ATE541215T1
ATE541215T1 AT07874283T AT07874283T ATE541215T1 AT E541215 T1 ATE541215 T1 AT E541215T1 AT 07874283 T AT07874283 T AT 07874283T AT 07874283 T AT07874283 T AT 07874283T AT E541215 T1 ATE541215 T1 AT E541215T1
Authority
AT
Austria
Prior art keywords
sample
signal generator
fluorescent signal
enzyme
methods
Prior art date
Application number
AT07874283T
Other languages
English (en)
Inventor
Anup Sood
Michael J Gerdes
Thomas Pirrie Treynor
Zhengyu Pang
Original Assignee
Gen Electric
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/560,599 external-priority patent/US7629125B2/en
Application filed by Gen Electric filed Critical Gen Electric
Application granted granted Critical
Publication of ATE541215T1 publication Critical patent/ATE541215T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/581—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with enzyme label (including co-enzymes, co-factors, enzyme inhibitors or substrates)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Optical Measuring Cells (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
AT07874283T 2006-11-16 2007-11-15 Sequenzielle analyse biologischer proben mit zwischenbleichung eines fluoreszenzdetektors ATE541215T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/560,599 US7629125B2 (en) 2006-11-16 2006-11-16 Sequential analysis of biological samples
US11/864,098 US8305579B2 (en) 2006-11-16 2007-09-28 Sequential analysis of biological samples
PCT/US2007/084786 WO2008133728A2 (en) 2006-11-16 2007-11-15 Sequential analysis of biological samples with intermediate bleaching of fluorescence detector

Publications (1)

Publication Number Publication Date
ATE541215T1 true ATE541215T1 (de) 2012-01-15

Family

ID=39766807

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07874283T ATE541215T1 (de) 2006-11-16 2007-11-15 Sequenzielle analyse biologischer proben mit zwischenbleichung eines fluoreszenzdetektors

Country Status (9)

Country Link
US (1) US8305579B2 (de)
EP (1) EP2082238B1 (de)
JP (1) JP5335686B2 (de)
AT (1) ATE541215T1 (de)
DK (1) DK2082238T3 (de)
ES (1) ES2378411T3 (de)
PL (1) PL2082238T3 (de)
PT (1) PT2082238E (de)
WO (1) WO2008133728A2 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8060348B2 (en) 2006-08-07 2011-11-15 General Electric Company Systems for analyzing tissue samples
US8131476B2 (en) 2006-08-07 2012-03-06 General Electric Company System and method for co-registering multi-channel images of a tissue micro array
US7741045B2 (en) * 2006-11-16 2010-06-22 General Electric Company Sequential analysis of biological samples
US7629125B2 (en) * 2006-11-16 2009-12-08 General Electric Company Sequential analysis of biological samples
US8305579B2 (en) 2006-11-16 2012-11-06 Thomas Pirrie Treynor Sequential analysis of biological samples
US9201063B2 (en) 2006-11-16 2015-12-01 General Electric Company Sequential analysis of biological samples
US9677125B2 (en) * 2009-10-21 2017-06-13 General Electric Company Detection of plurality of targets in biological samples
EP2633080B1 (de) 2010-10-29 2018-12-05 President and Fellows of Harvard College Verfahren zur detektion von zielmolekülen durch fluoreszensmarkierte sonden bestehend aus nukleinsäure-nanotuben
ES2678211T3 (es) 2012-03-27 2018-08-09 Ventana Medical Systems, Inc. Conjugados de señalización y procedimientos de uso
MX2015007432A (es) * 2012-12-11 2016-05-10 Univ Toronto Sistema inalambrico de deteccion basado en un dispositivo de comunicacion.
CN105247069A (zh) * 2013-06-04 2016-01-13 豪夫迈·罗氏有限公司 用于fret的新化合物及与其相关的方法
AU2015229406C1 (en) 2014-03-11 2021-01-07 President And Fellows Of Harvard College High-throughput and highly multiplexed imaging with programmable nucleic acid probes
US9909167B2 (en) 2014-06-23 2018-03-06 The Board Of Trustees Of The Leland Stanford Junior University On-slide staining by primer extension
CN108064339A (zh) * 2014-12-16 2018-05-22 哈佛学院院长及董事 元荧光团的触发组装
CA3008353A1 (en) 2015-12-18 2017-06-22 Dako Denmark A/S Chromogenic peroxidase substrates
KR20170099737A (ko) 2016-02-23 2017-09-01 노을 주식회사 접촉식 염색 패치 및 이를 이용하는 염색 방법
US10371610B2 (en) * 2016-02-23 2019-08-06 Noul Co., Ltd. Contact-type patch, staining method using the same, and manufacturing method thereof
CA3031586A1 (en) 2016-07-27 2018-02-01 The Board Of Trustees Of The Leland Stanford Junior University Highly-multiplexed fluorescent imaging
CN110050071A (zh) 2016-12-09 2019-07-23 乌尔蒂维尤股份有限公司 用于使用标记的核酸成像剂进行多路复用成像的改进方法
CN106680257B (zh) * 2017-01-09 2019-05-14 中国科学院理化技术研究所 基于硅纳米线的β-半乳糖苷酶荧光传感器及其制备方法和应用
US12019074B2 (en) * 2017-06-08 2024-06-25 Lumito Ab Method of analysing a sample for at least one analyte
WO2019200326A1 (en) * 2018-04-13 2019-10-17 Rarecyte, Inc. Kits for labeling of biomarkers and methods of using the same
JP2020071152A (ja) * 2018-10-31 2020-05-07 ソニー株式会社 免疫染色方法、免疫染色システム、および免疫染色キット
WO2021076919A1 (en) * 2019-10-17 2021-04-22 C2Sense, Inc. Luminescence imaging for sensing and/or authentication
US11662346B2 (en) 2019-10-17 2023-05-30 C2Sense, Inc. Systems and methods for sensing using consumer electronic devices
CN113552362A (zh) * 2021-07-23 2021-10-26 湖北百奥斯生物科技有限公司 一种新型信号放大的免疫荧光试剂盒
WO2023039283A1 (en) * 2021-09-13 2023-03-16 Rourk Christopher J Deep brain sensing and stimulation probe

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4405720A (en) 1981-03-04 1983-09-20 The United States Of America As Represented By The Department Of Health And Human Services Silver stains for protein in gels
GB8405437D0 (en) 1984-03-01 1984-04-04 Amersham Int Plc Detecting polynucleotide sequences
JP3130513B2 (ja) 1989-04-19 2001-01-31 イビデン株式会社 生体活性物質測定用装置
US5843640A (en) 1992-06-19 1998-12-01 Northwestern University Method of simultaneously detecting amplified nucleic acid sequences and cellular antigens in cells
AU5355594A (en) 1992-10-09 1994-05-09 Oncor, Inc. Methods for the detection of chromosome structural abnormalities by (in situ) hybridization to fixed tissue
CA2167804A1 (en) 1993-07-20 1995-02-02 Robert H. Singer In vivo nucleic acid hybridization method
FR2711671A1 (fr) 1993-10-22 1995-05-05 Centre Nat Rech Scient Procédé de détection et de quantification d'une séquence nucléotidique dans une population cellulaire.
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
DE4421891C2 (de) 1994-06-23 1996-05-15 Helmut Prof Dr Med Feucht Verfahren zum Nachweis von komplementaktivierenden IgG-Antikörpern gegen HLA-DR-Antigene
US5571643A (en) 1994-07-22 1996-11-05 Martin; Mark T. Spectrophotometric quantitation of images in X-ray film and electrophoresis gel bands
ATE340866T1 (de) 1994-10-28 2006-10-15 Gen Probe Inc Zusammensetzungen und verfahren für die gleichzeitige detektion und quantifizierung von einer mehrheit spezifischer nuklein säure sequenzen
US5830645A (en) 1994-12-09 1998-11-03 The Regents Of The University Of California Comparative fluorescence hybridization to nucleic acid arrays
US5763152A (en) 1995-03-31 1998-06-09 Fuji Photo Film Co., Ltd. Silver halide photographic light-sensitive material
EP0801306A1 (de) 1996-04-10 1997-10-15 Becton, Dickinson and Company Methode zur immunohistochemischen Quantifizierung von co-lokalisierten Molekülen
AU3717797A (en) 1996-07-15 1998-02-09 Children's Medical Center Corporation Method to co-detect introduced genes and their products
US6735531B2 (en) 1996-10-07 2004-05-11 Lab Vision Corporation Method and apparatus for automatic tissue staining
JP2002520448A (ja) 1998-07-10 2002-07-09 クロマジェン インコーポレーティッド 加水分解酵素の新規蛍光原基質
US6573043B1 (en) * 1998-10-07 2003-06-03 Genentech, Inc. Tissue analysis and kits therefor
JP4841724B2 (ja) 1998-10-09 2011-12-21 ベジェニクス ピーティーワイ リミテッド 腫瘍イメージングおよび抗腫瘍治療の標的としてのＦｌｔ４（ＶＥＲＧ−３）
WO2000058507A1 (en) 1999-03-30 2000-10-05 Solexa Ltd. Polynucleotide sequencing
US6391649B1 (en) 1999-05-04 2002-05-21 The Rockefeller University Method for the comparative quantitative analysis of proteins and other biological material by isotopic labeling and mass spectroscopy
DE10014685B4 (de) 2000-03-24 2004-07-01 Schubert, Walter, Dr. Verfahren zur Identifizierung von zellspezifischen Zielstrukturen
IL136232A0 (en) 2000-05-18 2001-05-20 Bar Ilan University Res Author Measurements of enzymatic activity in a single, individual cell in population
US20030044353A1 (en) 2001-01-05 2003-03-06 Ralph Weissleder Activatable imaging probes
JP2002323416A (ja) 2001-02-20 2002-11-08 Hitachi Ltd 検査容器
US20050230255A1 (en) 2001-03-30 2005-10-20 Sumner Lloyd W Silver destaining method
JP3899845B2 (ja) 2001-05-23 2007-03-28 日本光電工業株式会社 染色標本の脱色方法および装置
DE10143757A1 (de) 2001-09-06 2003-03-27 Werner M Methode zur Darstellung von Merkmalen in Geweben
US8323903B2 (en) 2001-10-12 2012-12-04 Life Technologies Corporation Antibody complexes and methods for immunolabeling
US7776195B2 (en) 2002-05-28 2010-08-17 Autogenomics, Inc. Integrated sample processing platform
JP2004041121A (ja) 2002-07-12 2004-02-12 Hitachi Ltd アレルギー解析方法及びシステム
US7122319B2 (en) 2002-12-18 2006-10-17 Monogram Biosciences, Inc Multiplexed immunohistochemical assays using molecular tags
US20040241776A1 (en) 2003-05-22 2004-12-02 Agdia, Inc. Multiplex enzyme-linked immunosorbent assay for detecting multiple analytes
JP3936689B2 (ja) 2003-09-09 2007-06-27 日本碍子株式会社 シアニン系有機色素劣化環境の検知方法
JP4538628B2 (ja) 2004-03-16 2010-09-08 学校法人慶應義塾 遺伝子発現検出方法
JP4189495B2 (ja) 2004-08-02 2008-12-03 国立大学法人群馬大学 ゲノムｄｎａのメチル化検出方法
JP2007033159A (ja) 2005-07-25 2007-02-08 Assay Corp 蛍光分子で標識された測定対象物質
JPWO2007055302A1 (ja) 2005-11-10 2009-04-30 国立大学法人富山大学 生体物質と生体物質結合性物質との結合性評価方法
US8305579B2 (en) 2006-11-16 2012-11-06 Thomas Pirrie Treynor Sequential analysis of biological samples
US7629125B2 (en) * 2006-11-16 2009-12-08 General Electric Company Sequential analysis of biological samples

Also Published As

Publication number Publication date
DK2082238T3 (da) 2012-04-02
ES2378411T3 (es) 2012-04-12
US8305579B2 (en) 2012-11-06
PL2082238T3 (pl) 2012-06-29
JP5335686B2 (ja) 2013-11-06
PT2082238E (pt) 2012-02-22
JP2010520989A (ja) 2010-06-17
WO2008133728A3 (en) 2009-01-22
EP2082238B1 (de) 2012-01-11
WO2008133728A2 (en) 2008-11-06
EP2082238A2 (de) 2009-07-29
US20120252685A1 (en) 2012-10-04

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