JP2020500528A5 - - Google Patents
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- JP2020500528A5 JP2020500528A5 JP2019529497A JP2019529497A JP2020500528A5 JP 2020500528 A5 JP2020500528 A5 JP 2020500528A5 JP 2019529497 A JP2019529497 A JP 2019529497A JP 2019529497 A JP2019529497 A JP 2019529497A JP 2020500528 A5 JP2020500528 A5 JP 2020500528A5
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- JP
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- Prior art keywords
- nanopore
- sample
- adapter
- strand
- tag
- Prior art date
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1620450.5 | 2016-12-01 | ||
| GBGB1620450.5A GB201620450D0 (en) | 2016-12-01 | 2016-12-01 | Method |
| US201762471338P | 2017-03-14 | 2017-03-14 | |
| US62/471,338 | 2017-03-14 | ||
| PCT/GB2017/053603 WO2018100370A1 (en) | 2016-12-01 | 2017-11-29 | Methods and systems for characterizing analytes using nanopores |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020500528A JP2020500528A (ja) | 2020-01-16 |
| JP2020500528A5 true JP2020500528A5 (https=) | 2021-01-14 |
| JP7055805B2 JP7055805B2 (ja) | 2022-04-18 |
Family
ID=58159754
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019529497A Active JP7055805B2 (ja) | 2016-12-01 | 2017-11-29 | ナノポアを用いて検体を特徴付けるための方法及びシステム |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11466317B2 (https=) |
| EP (2) | EP3548636B1 (https=) |
| JP (1) | JP7055805B2 (https=) |
| CN (3) | CN110168104A (https=) |
| AU (1) | AU2017367238B2 (https=) |
| CA (1) | CA3044351A1 (https=) |
| GB (1) | GB201620450D0 (https=) |
| WO (1) | WO2018100370A1 (https=) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6226869B2 (ja) | 2011-10-21 | 2017-11-08 | オックスフォード ナノポール テクノロジーズ リミテッド | 酵素法 |
| GB201202519D0 (en) | 2012-02-13 | 2012-03-28 | Oxford Nanopore Tech Ltd | Apparatus for supporting an array of layers of amphiphilic molecules and method of forming an array of layers of amphiphilic molecules |
| EP2875128B8 (en) | 2012-07-19 | 2020-06-24 | Oxford Nanopore Technologies Limited | Modified helicases |
| GB201222928D0 (en) | 2012-12-19 | 2013-01-30 | Oxford Nanopore Tech Ltd | Analysis of a polynucleotide |
| CN118256603A (zh) | 2013-10-18 | 2024-06-28 | 牛津纳米孔科技公开有限公司 | 经修饰的酶 |
| GB201417712D0 (en) | 2014-10-07 | 2014-11-19 | Oxford Nanopore Tech Ltd | Method |
| EP3971300B1 (en) | 2014-10-16 | 2024-06-05 | Oxford Nanopore Technologies plc | Sorting of polymers |
| GB201609221D0 (en) | 2016-05-25 | 2016-07-06 | Oxford Nanopore Tech Ltd | Method |
| EP4063521B1 (en) | 2016-05-25 | 2024-02-21 | Oxford Nanopore Technologies PLC | Method of nanopore sequencing |
| GB201620450D0 (en) | 2016-12-01 | 2017-01-18 | Oxford Nanopore Tech Ltd | Method |
| GB201707140D0 (en) | 2017-05-04 | 2017-06-21 | Oxford Nanopore Tech Ltd | Method |
| GB2569630B (en) | 2017-12-21 | 2022-10-12 | Sharp Life Science Eu Ltd | Droplet Interfaces in Electro-wetting Devices |
| CN121472373A (zh) | 2018-05-22 | 2026-02-06 | 安序源有限公司 | 用于核酸测序的方法、系统和组合物 |
| WO2019227013A1 (en) | 2018-05-24 | 2019-11-28 | Oxford Nanopore Technologies Inc. | Droplet interfaces in electro-wetting devices |
| GB201809323D0 (en) | 2018-06-06 | 2018-07-25 | Oxford Nanopore Tech Ltd | Method |
| GB2585816A (en) * | 2018-12-12 | 2021-01-27 | Univ York | Proof-of-work for blockchain applications |
| CN111455031A (zh) * | 2019-01-18 | 2020-07-28 | 中国科学院微生物研究所 | 基于Nanopore测序技术的多组学测序及分析方法 |
| US11789006B2 (en) * | 2019-03-12 | 2023-10-17 | Oxford Nanopore Technologies Plc | Nanopore sensing device, components and method of operation |
| GB201907243D0 (en) | 2019-05-22 | 2019-07-03 | Oxford Nanopore Tech Ltd | Sensing interactions between molecular entities and nanapores |
| CN114364797B (zh) * | 2019-09-18 | 2023-10-20 | 株式会社日立高新技术 | 生物分子分析方法 |
| KR20220148196A (ko) * | 2020-02-10 | 2022-11-04 | 팔로젠 인코포레이티드 | 나노포어 디바이스 및 이를 사용하여 하전된 입자들을 검출하고 분류하는 방법 |
| WO2021184374A1 (en) * | 2020-03-20 | 2021-09-23 | Genesense Technology Inc | High throughput analytical system for molecule detection and sensing |
| US20230295712A1 (en) | 2020-06-18 | 2023-09-21 | Oxford Nanopore Technologies Plc | A method of selectively characterising a polynucleotide using a detector |
| CN113930406B (zh) * | 2021-12-17 | 2022-04-08 | 北京齐碳科技有限公司 | 一种Pif1-like解旋酶及其应用 |
| AU2021306183A1 (en) * | 2020-07-06 | 2023-01-05 | Illumina Cambridge Limited | Separating polynucleotide fragments |
| CN112309503A (zh) * | 2020-10-19 | 2021-02-02 | 深圳市儒翰基因科技有限公司 | 基于纳米孔电信号的碱基判读方法、判读设备及存储介质 |
| US12090477B2 (en) * | 2021-03-05 | 2024-09-17 | Taiwan Semiconductor Manufacturing Company Ltd. | System and method for detecting biomolecules |
| WO2022243692A1 (en) * | 2021-05-19 | 2022-11-24 | Oxford Nanopore Technologies Plc | Methods for complement strand sequencing |
| GB202107192D0 (en) * | 2021-05-19 | 2021-06-30 | Oxford Nanopore Tech Ltd | Method |
| CN113322180B (zh) * | 2021-05-31 | 2022-07-15 | 中国科学院物理研究所 | 基于纳米孔测序的力谱分析方法和分析装置 |
| CN115537413A (zh) * | 2021-06-29 | 2022-12-30 | 中国农业大学 | 一种双链功能核酸纳米花的组装和形貌调控方法及其应用 |
| CN113462764B (zh) * | 2021-09-01 | 2021-12-17 | 北京齐碳科技有限公司 | 用于表征双链靶多核苷酸的类发夹衔接子、构建体和方法 |
| WO2023055752A2 (en) | 2021-09-28 | 2023-04-06 | Axbio Inc. | Methods for processing a nucleic acid sample and compositions thereof |
| CN114134142B (zh) * | 2021-11-23 | 2024-05-28 | 成都齐碳科技有限公司 | 衔接体、复合物、单链分子、试剂盒、方法和应用 |
| WO2023125605A1 (zh) * | 2021-12-30 | 2023-07-06 | 深圳华大生命科学研究院 | 单分子纳米孔测序方法 |
| CN118679255A (zh) * | 2021-12-31 | 2024-09-20 | 深圳华大生命科学研究院 | 能够阻断马达蛋白的核酸分子及其构建方法和用途 |
| EP4519453A1 (en) | 2022-05-06 | 2025-03-12 | 10X Genomics, Inc. | Methods and compositions for in situ analysis of v(d)j sequences |
| AU2023270700A1 (en) | 2022-05-17 | 2024-10-31 | Oxford Nanopore Technologies Plc | Method and adaptors |
| GB202207267D0 (en) | 2022-05-18 | 2022-06-29 | Oxford Nanopore Tech Plc | Calibration and profiling of a nanopore array device |
| WO2024077281A2 (en) * | 2022-10-06 | 2024-04-11 | Cornell University | Genotyping and sequencing assays for prrsv |
| GB202215442D0 (en) | 2022-10-19 | 2022-11-30 | Oxford Nanopore Tech Plc | Analysis of a polymer |
| WO2024086745A2 (en) * | 2022-10-21 | 2024-04-25 | Axbio Inc. | Systems and methods for analyzing a target molecule |
| WO2024101988A1 (en) | 2022-11-11 | 2024-05-16 | Umc Utrecht Holding B.V. | Computer-implemented method for identifying a dna modification |
| GB202216905D0 (en) | 2022-11-11 | 2022-12-28 | Oxford Nanopore Tech Plc | Novel pore monomers and pores |
| CN116478983B (zh) * | 2022-11-21 | 2023-10-24 | 北京普译生物科技有限公司 | 一种rna-dna嵌合接头及其应用 |
| WO2024124567A1 (zh) * | 2022-12-16 | 2024-06-20 | 深圳华大生命科学研究院 | 纳米孔测序方法和试剂盒 |
| GB202301095D0 (en) | 2023-01-25 | 2023-03-08 | Oxford Nanopore Tech Plc | Calibration of a nanopore array device |
| GB202304324D0 (en) | 2023-03-24 | 2023-05-10 | Oxford Nanopore Tech Plc | Method and kits |
| GB202305524D0 (en) | 2023-04-14 | 2023-05-31 | Oxford Nanopore Tech Plc | Novel pore monomers and pores |
| GB202307141D0 (en) | 2023-05-12 | 2023-06-28 | Oxford Nanopore Tech Plc | Modified helicases |
| WO2025000432A1 (zh) * | 2023-06-30 | 2025-01-02 | 深圳华大生命科学研究院 | 利用封闭子进行纳米孔测序的方法 |
| WO2025223677A1 (en) * | 2024-04-26 | 2025-10-30 | Helmholtz-Zentrum für Infektionsforschung GmbH | Method for analyzing molecules of interest, method for automatically selecting electrical signals related to a set of known barcode molecules, signal processing unit and computer program for executing the method |
| WO2026057755A1 (en) | 2024-09-13 | 2026-03-19 | Oxford Nanopore Technologies Plc | Adaptors and kits for rna molecules labelling and characterising |
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| US6362002B1 (en) | 1995-03-17 | 2002-03-26 | President And Fellows Of Harvard College | Characterization of individual polymer molecules based on monomer-interface interactions |
| US20120160687A1 (en) | 1995-03-17 | 2012-06-28 | President And Fellows Of Harvard College | Characterization of individual polymer molecules based on monomer-interface interactions |
| US6267872B1 (en) | 1998-11-06 | 2001-07-31 | The Regents Of The University Of California | Miniature support for thin films containing single channels or nanopores and methods for using same |
| WO2000034527A2 (en) | 1998-12-11 | 2000-06-15 | The Regents Of The University Of California | Targeted molecular bar codes |
| WO2001059453A2 (en) * | 2000-02-11 | 2001-08-16 | The Texas A & M University System | Biosensor compositions and methods of use |
| FR2814939B1 (fr) | 2000-10-05 | 2002-12-20 | Sofradim Production | Ensemble de soutenement sous-uretral dans le traitement de l'incontinence urinaire d'effort de la femme |
| US20020197618A1 (en) | 2001-01-20 | 2002-12-26 | Sampson Jeffrey R. | Synthesis and amplification of unstructured nucleic acids for rapid sequencing |
| US8278055B2 (en) * | 2002-05-01 | 2012-10-02 | Intel Corporation | Methods and device for analyte characterization |
| US7238485B2 (en) | 2004-03-23 | 2007-07-03 | President And Fellows Of Harvard College | Methods and apparatus for characterizing polynucleotides |
| WO2005124888A1 (en) | 2004-06-08 | 2005-12-29 | President And Fellows Of Harvard College | Suspended carbon nanotube field effect transistor |
| GB0505971D0 (en) | 2005-03-23 | 2005-04-27 | Isis Innovation | Delivery of molecules to a lipid bilayer |
| WO2008102120A1 (en) | 2007-02-20 | 2008-08-28 | Oxford Nanopore Technologies Limited | Lipid bilayer sensor system |
| US8698481B2 (en) | 2007-09-12 | 2014-04-15 | President And Fellows Of Harvard College | High-resolution molecular sensor |
| GB0724736D0 (en) | 2007-12-19 | 2008-01-30 | Oxford Nanolabs Ltd | Formation of layers of amphiphilic molecules |
| JP2011527191A (ja) | 2008-07-07 | 2011-10-27 | オックスフォード ナノポア テクノロジーズ リミテッド | 塩基検出細孔 |
| WO2010004265A1 (en) | 2008-07-07 | 2010-01-14 | Oxford Nanopore Technologies Limited | Enzyme-pore constructs |
| GB0820927D0 (en) | 2008-11-14 | 2008-12-24 | Isis Innovation | Method |
| US20120100530A1 (en) | 2009-01-30 | 2012-04-26 | Oxford Nanopore Technologies Limited | Enzyme mutant |
| GB0901588D0 (en) | 2009-02-02 | 2009-03-11 | Itis Holdings Plc | Apparatus and methods for providing journey information |
| CN102741430B (zh) | 2009-12-01 | 2016-07-13 | 牛津楠路珀尔科技有限公司 | 生化分析仪器、用于进行生化分析的第一模块以及相关方法 |
| US8586301B2 (en) | 2010-06-30 | 2013-11-19 | Stratos Genomics, Inc. | Multiplexed identification of nucleic acid sequences |
| WO2012042226A2 (en) | 2010-10-01 | 2012-04-05 | Oxford Nanopore Technologies Limited | Biochemical analysis apparatus and rotary valve |
| AU2012215135B9 (en) | 2011-02-11 | 2017-03-09 | Oxford Nanopore Technologies Limited | Mutant pores |
| US9347929B2 (en) | 2011-03-01 | 2016-05-24 | The Regents Of The University Of Michigan | Controlling translocation through nanopores with fluid wall |
| SG10201604316WA (en) * | 2011-05-27 | 2016-07-28 | Oxford Nanopore Tech Ltd | Coupling method |
| AU2012288629B2 (en) | 2011-07-25 | 2017-02-02 | Oxford Nanopore Technologies Limited | Hairpin loop method for double strand polynucleotide sequencing using transmembrane pores |
| EP3663412B1 (en) | 2011-09-23 | 2022-03-09 | Oxford Nanopore Technologies PLC | Analysis of a polymer comprising polymer units by means of translocation through a nanopore |
| JP6226869B2 (ja) | 2011-10-21 | 2017-11-08 | オックスフォード ナノポール テクノロジーズ リミテッド | 酵素法 |
| US9617591B2 (en) | 2011-12-29 | 2017-04-11 | Oxford Nanopore Technologies Ltd. | Method for characterising a polynucleotide by using a XPD helicase |
| BR112014016112B8 (pt) | 2011-12-29 | 2022-12-27 | Oxford Nanopore Tech Ltd | Método e aparelho para caracterizar um polinucleotídeo alvo, kit, e, uso de uma helicase |
| JP6333179B2 (ja) | 2012-01-20 | 2018-05-30 | ジニア テクノロジーズ， インコーポレイテッド | ナノポアベースの分子検出および配列決定 |
| DK2814959T3 (en) | 2012-02-17 | 2018-04-23 | Hutchinson Fred Cancer Res | COMPOSITIONS AND PROCEDURES FOR EXACTLY IDENTIFYING MUTATIONS |
| JP6271505B2 (ja) | 2012-04-10 | 2018-01-31 | オックスフォード ナノポール テクノロジーズ リミテッド | 変異体ライセニンポア |
| AU2013267609C1 (en) | 2012-05-31 | 2019-01-03 | Board Of Regents, The University Of Texas System | Method for accurate sequencing of DNA |
| US9116118B2 (en) * | 2012-06-08 | 2015-08-25 | Pacific Biosciences Of California, Inc. | Modified base detection with nanopore sequencing |
| EP3674412A1 (en) * | 2012-06-20 | 2020-07-01 | The Trustees of Columbia University in the City of New York | Nucleic acid sequencing by nanopore detection of tag molecules |
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| US11155860B2 (en) | 2012-07-19 | 2021-10-26 | Oxford Nanopore Technologies Ltd. | SSB method |
| US9797009B2 (en) | 2012-07-19 | 2017-10-24 | Oxford Nanopore Technologies Limited | Enzyme construct |
| EP2911771B1 (en) | 2012-10-26 | 2017-01-18 | Oxford Nanopore Technologies Limited | Droplet interfaces |
| GB201313121D0 (en) | 2013-07-23 | 2013-09-04 | Oxford Nanopore Tech Ltd | Array of volumes of polar medium |
| EP2917732B1 (en) * | 2012-11-09 | 2016-09-07 | Stratos Genomics Inc. | Concentrating a target molecule for sensing by a nanopore |
| US9605309B2 (en) * | 2012-11-09 | 2017-03-28 | Genia Technologies, Inc. | Nucleic acid sequencing using tags |
| GB201314695D0 (en) | 2013-08-16 | 2013-10-02 | Oxford Nanopore Tech Ltd | Method |
| KR102168813B1 (ko) | 2013-03-08 | 2020-10-22 | 옥스포드 나노포어 테크놀로지즈 리미티드 | 효소 정지 방법 |
| US10732183B2 (en) | 2013-03-15 | 2020-08-04 | The Trustees Of Columbia University In The City Of New York | Method for detecting multiple predetermined compounds in a sample |
| CN203450281U (zh) | 2013-08-01 | 2014-02-26 | 大行科技(深圳)有限公司 | 一种折叠自行车走线结构 |
| GB201406151D0 (en) | 2014-04-04 | 2014-05-21 | Oxford Nanopore Tech Ltd | Method |
| CN118256603A (zh) | 2013-10-18 | 2024-06-28 | 牛津纳米孔科技公开有限公司 | 经修饰的酶 |
| GB201406155D0 (en) | 2014-04-04 | 2014-05-21 | Oxford Nanopore Tech Ltd | Method |
| JP6749243B2 (ja) | 2014-01-22 | 2020-09-02 | オックスフォード ナノポール テクノロジーズ リミテッド | １つまたは複数のポリヌクレオチド結合タンパク質を標的ポリヌクレオチドに付着させる方法 |
| WO2015127387A1 (en) | 2014-02-21 | 2015-08-27 | Northeastern University | Fluorescence-based analysis of biopolymers using nanopores |
| GB201403096D0 (en) | 2014-02-21 | 2014-04-09 | Oxford Nanopore Tech Ltd | Sample preparation method |
| US20170096703A1 (en) | 2014-03-21 | 2017-04-06 | Oxford Nanopore Technologies Ltd. | Analysis of a polymer from multi-dimensional measurements |
| EP3126515B1 (en) | 2014-04-04 | 2018-08-29 | Oxford Nanopore Technologies Limited | Method for characterising a double stranded nucleic acid using a nano-pore and anchor molecules at both ends of said nucleic acid |
| GB201417712D0 (en) | 2014-10-07 | 2014-11-19 | Oxford Nanopore Tech Ltd | Method |
| US10443097B2 (en) | 2014-05-02 | 2019-10-15 | Oxford Nanopore Technologies Ltd. | Method of improving the movement of a target polynucleotide with respect to a transmembrane pore |
| WO2015176034A1 (en) | 2014-05-15 | 2015-11-19 | Two Pore Guys, Inc. | Scaffold data storage and target detection in a sample using a nanopore |
| CN106687574B (zh) | 2014-06-03 | 2021-06-29 | 亿明达股份有限公司 | 使用对纳米颗粒或纳米颗粒附近锚定的系链检测事件的组合物，系统和方法 |
| US10400014B2 (en) | 2014-09-01 | 2019-09-03 | Oxford Nanopore Technologies Ltd. | Mutant CsgG pores |
| GB201418159D0 (en) | 2014-10-14 | 2014-11-26 | Oxford Nanopore Tech Ltd | Method |
| EP3971300B1 (en) | 2014-10-16 | 2024-06-05 | Oxford Nanopore Technologies plc | Sorting of polymers |
| KR102457147B1 (ko) * | 2014-10-17 | 2022-10-19 | 옥스포드 나노포어 테크놀로지즈 피엘씨 | 나노 세공 rna 특징 규명을 위한 방법 |
| GB201418469D0 (en) | 2014-10-17 | 2014-12-03 | Oxford Nanopore Tech Ltd | Method |
| US9557294B2 (en) * | 2014-12-19 | 2017-01-31 | Genia Technologies, Inc. | Nanopore-based sequencing with varying voltage stimulus |
| AU2016220404B2 (en) * | 2015-02-17 | 2021-05-27 | Mgi Tech Co., Ltd. | DNA sequencing using controlled strand displacement |
| WO2016161402A1 (en) | 2015-04-03 | 2016-10-06 | Abbott Laboratories | Devices and methods for sample analysis |
| KR102713216B1 (ko) | 2015-06-25 | 2024-10-02 | 로스웰 엠이 아이엔씨. | 바이오분자 센서들 및 방법들 |
| US20200216887A1 (en) | 2016-01-21 | 2020-07-09 | Genia Technologies, Inc. | Nanopore sequencing complexes |
| GB201609221D0 (en) | 2016-05-25 | 2016-07-06 | Oxford Nanopore Tech Ltd | Method |
| GB201620450D0 (en) * | 2016-12-01 | 2017-01-18 | Oxford Nanopore Tech Ltd | Method |
| GB201707140D0 (en) | 2017-05-04 | 2017-06-21 | Oxford Nanopore Tech Ltd | Method |
| GB201809323D0 (en) | 2018-06-06 | 2018-07-25 | Oxford Nanopore Tech Ltd | Method |
-
2016
- 2016-12-01 GB GBGB1620450.5A patent/GB201620450D0/en not_active Ceased
-
2017
- 2017-11-29 EP EP17817029.6A patent/EP3548636B1/en active Active
- 2017-11-29 AU AU2017367238A patent/AU2017367238B2/en active Active
- 2017-11-29 CN CN201780083105.XA patent/CN110168104A/zh active Pending
- 2017-11-29 CA CA3044351A patent/CA3044351A1/en active Pending
- 2017-11-29 CN CN202310379925.0A patent/CN116377044B/zh active Active
- 2017-11-29 US US16/465,987 patent/US11466317B2/en active Active
- 2017-11-29 WO PCT/GB2017/053603 patent/WO2018100370A1/en not_active Ceased
- 2017-11-29 EP EP23182828.6A patent/EP4269617A3/en active Pending
- 2017-11-29 JP JP2019529497A patent/JP7055805B2/ja active Active
- 2017-11-29 CN CN202310379929.9A patent/CN116334200B/zh active Active
-
2022
- 2022-08-03 US US17/817,065 patent/US12509721B2/en active Active
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