JP2016511417A5 - - Google Patents
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- JP2016511417A5 JP2016511417A5 JP2016501106A JP2016501106A JP2016511417A5 JP 2016511417 A5 JP2016511417 A5 JP 2016511417A5 JP 2016501106 A JP2016501106 A JP 2016501106A JP 2016501106 A JP2016501106 A JP 2016501106A JP 2016511417 A5 JP2016511417 A5 JP 2016511417A5
- Authority
- JP
- Japan
- Prior art keywords
- binding
- linking agent
- target substance
- reagent
- analyte
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 230000027455 binding Effects 0.000 claims 51
- 239000003795 chemical substances by application Substances 0.000 claims 28
- 239000003153 chemical reaction reagent Substances 0.000 claims 27
- 239000013076 target substance Substances 0.000 claims 24
- 239000012491 analyte Substances 0.000 claims 17
- 238000000034 method Methods 0.000 claims 16
- 230000000295 complement effect Effects 0.000 claims 13
- 239000003431 cross linking reagent Substances 0.000 claims 9
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 6
- 238000001514 detection method Methods 0.000 claims 5
- 108090001008 Avidin Proteins 0.000 claims 3
- 108010090804 Streptavidin Proteins 0.000 claims 3
- 229960002685 biotin Drugs 0.000 claims 3
- 235000020958 biotin Nutrition 0.000 claims 3
- 239000011616 biotin Substances 0.000 claims 3
- 230000003993 interaction Effects 0.000 claims 3
- 230000002788 anti-peptide Effects 0.000 claims 2
- 230000009260 cross reactivity Effects 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 230000009871 nonspecific binding Effects 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 239000004971 Cross linker Substances 0.000 claims 1
- PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 1
- 150000001345 alkine derivatives Chemical class 0.000 claims 1
- 150000001540 azides Chemical class 0.000 claims 1
- 238000012875 competitive assay Methods 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- PGLTVOMIXTUURA-UHFFFAOYSA-N iodoacetamide Chemical group NC(=O)CI PGLTVOMIXTUURA-UHFFFAOYSA-N 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
- 238000000159 protein binding assay Methods 0.000 claims 1
- 238000012493 sandwich binding assay Methods 0.000 claims 1
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361775860P | 2013-03-11 | 2013-03-11 | |
| US61/775,860 | 2013-03-11 | ||
| US201361778727P | 2013-03-13 | 2013-03-13 | |
| US61/778,727 | 2013-03-13 | ||
| PCT/US2014/022948 WO2014164594A1 (en) | 2013-03-11 | 2014-03-11 | Improved methods for conducting multiplexed assays |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016511417A JP2016511417A (ja) | 2016-04-14 |
| JP2016511417A5 true JP2016511417A5 (https=) | 2017-03-09 |
| JP6791750B2 JP6791750B2 (ja) | 2020-11-25 |
Family
ID=51488514
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016501106A Active JP6791750B2 (ja) | 2013-03-11 | 2014-03-11 | 多重化アッセイを行うための改良された方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (13) | US10189023B2 (https=) |
| EP (2) | EP2972353B1 (https=) |
| JP (1) | JP6791750B2 (https=) |
| KR (4) | KR102459433B1 (https=) |
| CN (2) | CN110286215A (https=) |
| AU (3) | AU2014249190C1 (https=) |
| CA (2) | CA3153763A1 (https=) |
| DK (1) | DK2972353T3 (https=) |
| ES (1) | ES2942031T3 (https=) |
| WO (1) | WO2014164594A1 (https=) |
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