JP2010519959A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010519959A5 JP2010519959A5 JP2009551757A JP2009551757A JP2010519959A5 JP 2010519959 A5 JP2010519959 A5 JP 2010519959A5 JP 2009551757 A JP2009551757 A JP 2009551757A JP 2009551757 A JP2009551757 A JP 2009551757A JP 2010519959 A5 JP2010519959 A5 JP 2010519959A5
- Authority
- JP
- Japan
- Prior art keywords
- bone cement
- bone
- phase
- item
- fluid phase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002639 bone cement Substances 0.000 claims description 109
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims description 34
- 239000000463 material Substances 0.000 claims description 32
- 239000000126 substance Substances 0.000 claims description 32
- 239000000178 monomer Substances 0.000 claims description 29
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 28
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical group COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims description 27
- 210000000988 bone and bone Anatomy 0.000 claims description 27
- 239000012530 fluid Substances 0.000 claims description 24
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims description 24
- 238000000034 method Methods 0.000 claims description 23
- 239000004926 polymethyl methacrylate Substances 0.000 claims description 23
- 238000006116 polymerization reaction Methods 0.000 claims description 20
- 239000000203 mixture Substances 0.000 claims description 19
- 239000001913 cellulose Substances 0.000 claims description 14
- 229920002678 cellulose Polymers 0.000 claims description 14
- 239000000843 powder Substances 0.000 claims description 14
- 239000003795 chemical substances by application Substances 0.000 claims description 7
- 230000001009 osteoporotic effect Effects 0.000 claims description 7
- -1 polyethylene Polymers 0.000 claims description 7
- RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 claims description 6
- 239000004698 Polyethylene Substances 0.000 claims description 6
- 229920000573 polyethylene Polymers 0.000 claims description 6
- 239000012190 activator Substances 0.000 claims description 3
- 239000012985 polymerization agent Substances 0.000 claims description 3
- 230000000379 polymerizing effect Effects 0.000 claims description 3
- 239000003381 stabilizer Substances 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims description 2
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 2
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 2
- 229960001760 dimethyl sulfoxide Drugs 0.000 claims 4
- IAZDPXIOMUYVGZ-WFGJKAKNSA-N Dimethyl sulfoxide Chemical group [2H]C([2H])([2H])S(=O)C([2H])([2H])[2H] IAZDPXIOMUYVGZ-WFGJKAKNSA-N 0.000 claims 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000003999 initiator Substances 0.000 claims 1
- 230000011987 methylation Effects 0.000 claims 1
- 238000007069 methylation reaction Methods 0.000 claims 1
- 239000004568 cement Substances 0.000 description 10
- 239000007788 liquid Substances 0.000 description 7
- 210000001519 tissue Anatomy 0.000 description 5
- 206010028851 Necrosis Diseases 0.000 description 4
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 4
- 230000017074 necrotic cell death Effects 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- 206010017076 Fracture Diseases 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 238000004132 cross linking Methods 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 2
- 208000010392 Bone Fractures Diseases 0.000 description 2
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 description 2
- 230000003190 augmentative effect Effects 0.000 description 2
- 230000006399 behavior Effects 0.000 description 2
- 210000002758 humerus Anatomy 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- GYVGXEWAOAAJEU-UHFFFAOYSA-N n,n,4-trimethylaniline Chemical compound CN(C)C1=CC=C(C)C=C1 GYVGXEWAOAAJEU-UHFFFAOYSA-N 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 210000000689 upper leg Anatomy 0.000 description 2
- 239000004342 Benzoyl peroxide Substances 0.000 description 1
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 description 1
- 206010010214 Compression fracture Diseases 0.000 description 1
- 206010031264 Osteonecrosis Diseases 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- 239000003522 acrylic cement Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000003416 augmentation Effects 0.000 description 1
- 235000019400 benzoyl peroxide Nutrition 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000012669 compression test Methods 0.000 description 1
- 239000002872 contrast media Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 210000001951 dura mater Anatomy 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 230000020169 heat generation Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 238000000518 rheometry Methods 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 125000003011 styrenyl group Chemical group [H]\C(*)=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90467307P | 2007-03-02 | 2007-03-02 | |
| US60/904,673 | 2007-03-02 | ||
| US96705207P | 2007-08-31 | 2007-08-31 | |
| US60/967,052 | 2007-08-31 | ||
| PCT/US2008/002811 WO2008109045A2 (en) | 2007-03-02 | 2008-02-29 | Bone cement with adapted mechanical properties |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013096455A Division JP2013146592A (ja) | 2007-03-02 | 2013-05-01 | 適合した力学的性質を有する骨セメント |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010519959A JP2010519959A (ja) | 2010-06-10 |
| JP2010519959A5 true JP2010519959A5 (https=) | 2013-06-20 |
| JP5646180B2 JP5646180B2 (ja) | 2014-12-24 |
Family
ID=39738977
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009551757A Expired - Fee Related JP5646180B2 (ja) | 2007-03-02 | 2008-02-29 | 適合した力学的性質を有する骨セメント |
| JP2013096455A Abandoned JP2013146592A (ja) | 2007-03-02 | 2013-05-01 | 適合した力学的性質を有する骨セメント |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013096455A Abandoned JP2013146592A (ja) | 2007-03-02 | 2013-05-01 | 適合した力学的性質を有する骨セメント |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US8618188B2 (https=) |
| EP (1) | EP2131877B1 (https=) |
| JP (2) | JP5646180B2 (https=) |
| KR (1) | KR20090125141A (https=) |
| CN (1) | CN101720238B (https=) |
| AU (1) | AU2008223503A1 (https=) |
| BR (1) | BRPI0808383A2 (https=) |
| CA (1) | CA2679552A1 (https=) |
| CO (1) | CO6231005A2 (https=) |
| WO (1) | WO2008109045A2 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9649404B2 (en) | 2009-03-05 | 2017-05-16 | Teknimed | Bone filling cement |
| FR2942723B1 (fr) * | 2009-03-05 | 2011-06-10 | Teknimes | Ciment pour comblement osseux |
| US20110150762A1 (en) * | 2009-09-01 | 2011-06-23 | Andreas Boger | Bone cement containing bone marrow |
| JP5847097B2 (ja) * | 2010-03-05 | 2016-01-20 | ジンテス ゲゼルシャフト ミット ベシュレンクテル ハフツング | 骨造成のための骨セメント系 |
| DE102012001637A1 (de) * | 2012-01-30 | 2013-08-01 | Heraeus Medical Gmbh | Pastenförmiger Knochenzement |
| KR101615622B1 (ko) | 2014-02-25 | 2016-04-26 | 주식회사 마루치 | 단일 페이스트형 치과용 수경성 충전재 조성물 |
| WO2015130079A1 (ko) * | 2014-02-25 | 2015-09-03 | 주식회사 마루치 | 단일 페이스트형 치과용 수경성 충전재 조성물 |
| CN104147639B (zh) * | 2014-08-06 | 2016-01-06 | 山东明德生物医学工程有限公司 | 含锶可注射骨水泥及制备方法 |
| CN104174070B (zh) * | 2014-09-11 | 2016-03-23 | 山东明德生物医学工程有限公司 | 锶钙复合骨水泥及制备方法 |
| CN104945547A (zh) * | 2015-06-30 | 2015-09-30 | 苏州佑君环境科技有限公司 | 一种骨水泥用复合材料的制备方法 |
| KR102628554B1 (ko) * | 2019-03-21 | 2024-01-25 | (주)비티엔 | 주입형 폴리 메틸 메타크릴레이트계 골시멘트 및 이의 제조방법 |
| CN110025823B (zh) * | 2019-03-29 | 2021-06-29 | 太原理工大学 | 一种骨水泥材料及其制备方法 |
| US11381464B2 (en) | 2019-11-28 | 2022-07-05 | Keysight Technologies, Inc. | Methods, systems, and computer readable media for implementing a generalized model for defining application state machines |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH611150A5 (https=) * | 1975-04-18 | 1979-05-31 | Sulzer Ag | |
| DE3245956A1 (de) * | 1982-12-11 | 1984-06-14 | Beiersdorf Ag, 2000 Hamburg | Chirurgisches material |
| EP0439250B1 (en) * | 1990-01-25 | 1994-11-02 | Howmedica Inc. | Bone cement |
| DE4433201A1 (de) * | 1994-09-17 | 1996-03-21 | Merck Patent Gmbh | Verfahren zur Herstellung von wirkstoffhaltigen Knochenzementen |
| JP4080565B2 (ja) * | 1996-04-26 | 2008-04-23 | 大日本インキ化学工業株式会社 | 多孔質体の製造方法および多孔質体 |
| DE19641775A1 (de) * | 1996-08-22 | 1998-02-26 | Merck Patent Gmbh | Verfahren zur Herstellung von wirkstoffhaltigen Knochenzementen |
| ATE336270T1 (de) | 2003-02-13 | 2006-09-15 | Synthes Ag | Injizierbare knochenersatzmischung |
| US7093576B2 (en) * | 2004-06-15 | 2006-08-22 | Ford Global Technologies, Llc | System and method to prime an electronic returnless fuel system during an engine start |
| US7651701B2 (en) * | 2005-08-29 | 2010-01-26 | Sanatis Gmbh | Bone cement composition and method of making the same |
-
2008
- 2008-02-29 BR BRPI0808383-5A2A patent/BRPI0808383A2/pt not_active Application Discontinuation
- 2008-02-29 WO PCT/US2008/002811 patent/WO2008109045A2/en not_active Ceased
- 2008-02-29 EP EP08726365.3A patent/EP2131877B1/en not_active Not-in-force
- 2008-02-29 JP JP2009551757A patent/JP5646180B2/ja not_active Expired - Fee Related
- 2008-02-29 CA CA002679552A patent/CA2679552A1/en not_active Abandoned
- 2008-02-29 CN CN200880014552.0A patent/CN101720238B/zh not_active Expired - Fee Related
- 2008-02-29 US US12/529,562 patent/US8618188B2/en active Active
- 2008-02-29 AU AU2008223503A patent/AU2008223503A1/en not_active Abandoned
- 2008-02-29 KR KR1020097020056A patent/KR20090125141A/ko not_active Ceased
-
2009
- 2009-09-30 CO CO09107331A patent/CO6231005A2/es not_active Application Discontinuation
-
2013
- 2013-05-01 JP JP2013096455A patent/JP2013146592A/ja not_active Abandoned
- 2013-12-10 US US14/102,155 patent/US20140100297A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5646180B2 (ja) | 適合した力学的性質を有する骨セメント | |
| JP2010519959A5 (https=) | ||
| Boger et al. | Variation of the mechanical properties of PMMA to suit osteoporotic cancellous bone | |
| AU2008278578B2 (en) | Expandable bone filler materials and methods of using same | |
| US8575274B2 (en) | Multi-solution bone cements and methods of making the same | |
| de Lacerda Schickert et al. | Tough and injectable fiber reinforced calcium phosphate cement as an alternative to polymethylmethacrylate cement for vertebral augmentation: a biomechanical study | |
| EP1494730B1 (en) | Composition for hard tissue augmentation | |
| US20090239970A1 (en) | Multi-solution bone cements and methods of making the same | |
| JP2004236729A (ja) | 骨セメント組成物 | |
| CN104826170A (zh) | 一种显影性骨水泥及制备方法和用途 | |
| Boger et al. | NMP‐modified PMMA bone cement with adapted mechanical and hardening properties for the use in cancellous bone augmentation | |
| JP2009502404A (ja) | 骨セメント及びその使用方法 | |
| JP2013503659A (ja) | 骨髄を含む骨セメント | |
| RU2822874C1 (ru) | Костный цемент | |
| KR20230164271A (ko) | 실리콘 혼합 골 시멘트 및 이의 제조방법 | |
| Dunne | Bone cement fixation: acrylic cements | |
| Bongio et al. | Development of an in vitro confinement test to predict the clinical handling of polymer-based injectable bone substitutes | |
| RU2811210C1 (ru) | Состав костного цемента для ортопедической и вертебрологической хирургии | |
| US20090275671A1 (en) | Two component bone cement composition for vertebroplasty | |
| WO2025127963A1 (ru) | Костный цемент | |
| EA048809B1 (ru) | Костный цемент | |
| KR20250146355A (ko) | 합성골용 조성물의 제조 방법 및 합성골용 제품 | |
| Kühn | Handling Properties of Polymethylmetacrylate Bone Cements | |
| AU2013204295B2 (en) | Bone cement and methods of use thereof | |
| Tai et al. | Research Article Modification of Mechanical Properties, Polymerization Temperature, and Handling Time of Polymethylmethacrylate Cement for Enhancing Applicability in Vertebroplasty |