BRPI0808383A2 - Cemento ósseo, e, método para formar o mesmo. - Google Patents
Cemento ósseo, e, método para formar o mesmo. Download PDFInfo
- Publication number
- BRPI0808383A2 BRPI0808383A2 BRPI0808383-5A2A BRPI0808383A BRPI0808383A2 BR PI0808383 A2 BRPI0808383 A2 BR PI0808383A2 BR PI0808383 A BRPI0808383 A BR PI0808383A BR PI0808383 A2 BRPI0808383 A2 BR PI0808383A2
- Authority
- BR
- Brazil
- Prior art keywords
- bone cement
- substance
- bone
- fluid phase
- modify
- Prior art date
Links
- 239000002639 bone cement Substances 0.000 title claims description 58
- 238000000034 method Methods 0.000 title claims description 12
- 239000000126 substance Substances 0.000 claims description 33
- 210000000988 bone and bone Anatomy 0.000 claims description 24
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical group CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims description 23
- 239000000178 monomer Substances 0.000 claims description 23
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims description 22
- 239000004926 polymethyl methacrylate Substances 0.000 claims description 22
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical group COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims description 20
- 238000006116 polymerization reaction Methods 0.000 claims description 20
- 239000012530 fluid Substances 0.000 claims description 18
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N dimethyl sulfoxide Natural products CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 15
- 239000000203 mixture Substances 0.000 claims description 13
- 239000001913 cellulose Substances 0.000 claims description 8
- 229920002678 cellulose Polymers 0.000 claims description 8
- 239000000843 powder Substances 0.000 claims description 8
- 239000003795 chemical substances by application Substances 0.000 claims description 5
- 230000001009 osteoporotic effect Effects 0.000 claims description 5
- -1 polyethylene Polymers 0.000 claims description 4
- RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 claims description 3
- 239000004698 Polyethylene Substances 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 3
- 229920000573 polyethylene Polymers 0.000 claims description 3
- 210000002758 humerus Anatomy 0.000 claims description 2
- 210000000689 upper leg Anatomy 0.000 claims description 2
- 230000000379 polymerizing effect Effects 0.000 claims 3
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims 1
- 239000000463 material Substances 0.000 description 8
- 238000004132 cross linking Methods 0.000 description 5
- 206010017076 Fracture Diseases 0.000 description 4
- 206010028851 Necrosis Diseases 0.000 description 4
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 4
- 239000004568 cement Substances 0.000 description 4
- 230000017074 necrotic cell death Effects 0.000 description 4
- 229920000642 polymer Polymers 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- 230000006399 behavior Effects 0.000 description 3
- 208000010392 Bone Fractures Diseases 0.000 description 2
- 239000012190 activator Substances 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 239000003381 stabilizer Substances 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 150000005208 1,4-dihydroxybenzenes Chemical class 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 1
- 101500021165 Aplysia californica Myomodulin-A Proteins 0.000 description 1
- 239000004342 Benzoyl peroxide Substances 0.000 description 1
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 description 1
- 206010031264 Osteonecrosis Diseases 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 206010041541 Spinal compression fracture Diseases 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 239000003522 acrylic cement Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000003416 augmentation Effects 0.000 description 1
- 235000019400 benzoyl peroxide Nutrition 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 238000012669 compression test Methods 0.000 description 1
- 239000002872 contrast media Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 210000001951 dura mater Anatomy 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 230000020169 heat generation Effects 0.000 description 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- GYVGXEWAOAAJEU-UHFFFAOYSA-N n,n,4-trimethylaniline Chemical compound CN(C)C1=CC=C(C)C=C1 GYVGXEWAOAAJEU-UHFFFAOYSA-N 0.000 description 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 125000003011 styrenyl group Chemical group [H]\C(*)=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/0047—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L24/0073—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix
- A61L24/0084—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix containing fillers of phosphorus-containing inorganic compounds, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0036—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/0047—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L24/0073—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix
- A61L24/0094—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix containing macromolecular fillers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/06—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Surgery (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Composite Materials (AREA)
- Inorganic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90467307P | 2007-03-02 | 2007-03-02 | |
| US60/904673 | 2007-03-02 | ||
| US96705207P | 2007-08-31 | 2007-08-31 | |
| US60/976052 | 2007-08-31 | ||
| PCT/US2008/002811 WO2008109045A2 (en) | 2007-03-02 | 2008-02-29 | Bone cement with adapted mechanical properties |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0808383A2 true BRPI0808383A2 (pt) | 2014-07-01 |
Family
ID=39738977
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0808383-5A2A BRPI0808383A2 (pt) | 2007-03-02 | 2008-02-29 | Cemento ósseo, e, método para formar o mesmo. |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US8618188B2 (https=) |
| EP (1) | EP2131877B1 (https=) |
| JP (2) | JP5646180B2 (https=) |
| KR (1) | KR20090125141A (https=) |
| CN (1) | CN101720238B (https=) |
| AU (1) | AU2008223503A1 (https=) |
| BR (1) | BRPI0808383A2 (https=) |
| CA (1) | CA2679552A1 (https=) |
| CO (1) | CO6231005A2 (https=) |
| WO (1) | WO2008109045A2 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9649404B2 (en) | 2009-03-05 | 2017-05-16 | Teknimed | Bone filling cement |
| FR2942723B1 (fr) * | 2009-03-05 | 2011-06-10 | Teknimes | Ciment pour comblement osseux |
| US20110150762A1 (en) * | 2009-09-01 | 2011-06-23 | Andreas Boger | Bone cement containing bone marrow |
| JP5847097B2 (ja) * | 2010-03-05 | 2016-01-20 | ジンテス ゲゼルシャフト ミット ベシュレンクテル ハフツング | 骨造成のための骨セメント系 |
| DE102012001637A1 (de) * | 2012-01-30 | 2013-08-01 | Heraeus Medical Gmbh | Pastenförmiger Knochenzement |
| KR101615622B1 (ko) | 2014-02-25 | 2016-04-26 | 주식회사 마루치 | 단일 페이스트형 치과용 수경성 충전재 조성물 |
| WO2015130079A1 (ko) * | 2014-02-25 | 2015-09-03 | 주식회사 마루치 | 단일 페이스트형 치과용 수경성 충전재 조성물 |
| CN104147639B (zh) * | 2014-08-06 | 2016-01-06 | 山东明德生物医学工程有限公司 | 含锶可注射骨水泥及制备方法 |
| CN104174070B (zh) * | 2014-09-11 | 2016-03-23 | 山东明德生物医学工程有限公司 | 锶钙复合骨水泥及制备方法 |
| CN104945547A (zh) * | 2015-06-30 | 2015-09-30 | 苏州佑君环境科技有限公司 | 一种骨水泥用复合材料的制备方法 |
| KR102628554B1 (ko) * | 2019-03-21 | 2024-01-25 | (주)비티엔 | 주입형 폴리 메틸 메타크릴레이트계 골시멘트 및 이의 제조방법 |
| CN110025823B (zh) * | 2019-03-29 | 2021-06-29 | 太原理工大学 | 一种骨水泥材料及其制备方法 |
| US11381464B2 (en) | 2019-11-28 | 2022-07-05 | Keysight Technologies, Inc. | Methods, systems, and computer readable media for implementing a generalized model for defining application state machines |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH611150A5 (https=) * | 1975-04-18 | 1979-05-31 | Sulzer Ag | |
| DE3245956A1 (de) * | 1982-12-11 | 1984-06-14 | Beiersdorf Ag, 2000 Hamburg | Chirurgisches material |
| EP0439250B1 (en) * | 1990-01-25 | 1994-11-02 | Howmedica Inc. | Bone cement |
| DE4433201A1 (de) * | 1994-09-17 | 1996-03-21 | Merck Patent Gmbh | Verfahren zur Herstellung von wirkstoffhaltigen Knochenzementen |
| JP4080565B2 (ja) * | 1996-04-26 | 2008-04-23 | 大日本インキ化学工業株式会社 | 多孔質体の製造方法および多孔質体 |
| DE19641775A1 (de) * | 1996-08-22 | 1998-02-26 | Merck Patent Gmbh | Verfahren zur Herstellung von wirkstoffhaltigen Knochenzementen |
| ATE336270T1 (de) | 2003-02-13 | 2006-09-15 | Synthes Ag | Injizierbare knochenersatzmischung |
| US7093576B2 (en) * | 2004-06-15 | 2006-08-22 | Ford Global Technologies, Llc | System and method to prime an electronic returnless fuel system during an engine start |
| US7651701B2 (en) * | 2005-08-29 | 2010-01-26 | Sanatis Gmbh | Bone cement composition and method of making the same |
-
2008
- 2008-02-29 BR BRPI0808383-5A2A patent/BRPI0808383A2/pt not_active Application Discontinuation
- 2008-02-29 WO PCT/US2008/002811 patent/WO2008109045A2/en not_active Ceased
- 2008-02-29 EP EP08726365.3A patent/EP2131877B1/en not_active Not-in-force
- 2008-02-29 JP JP2009551757A patent/JP5646180B2/ja not_active Expired - Fee Related
- 2008-02-29 CA CA002679552A patent/CA2679552A1/en not_active Abandoned
- 2008-02-29 CN CN200880014552.0A patent/CN101720238B/zh not_active Expired - Fee Related
- 2008-02-29 US US12/529,562 patent/US8618188B2/en active Active
- 2008-02-29 AU AU2008223503A patent/AU2008223503A1/en not_active Abandoned
- 2008-02-29 KR KR1020097020056A patent/KR20090125141A/ko not_active Ceased
-
2009
- 2009-09-30 CO CO09107331A patent/CO6231005A2/es not_active Application Discontinuation
-
2013
- 2013-05-01 JP JP2013096455A patent/JP2013146592A/ja not_active Abandoned
- 2013-12-10 US US14/102,155 patent/US20140100297A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN101720238A (zh) | 2010-06-02 |
| JP5646180B2 (ja) | 2014-12-24 |
| JP2010519959A (ja) | 2010-06-10 |
| KR20090125141A (ko) | 2009-12-03 |
| EP2131877A2 (en) | 2009-12-16 |
| WO2008109045A2 (en) | 2008-09-12 |
| CN101720238B (zh) | 2014-01-08 |
| AU2008223503A1 (en) | 2008-09-12 |
| US8618188B2 (en) | 2013-12-31 |
| WO2008109045A3 (en) | 2009-07-09 |
| CA2679552A1 (en) | 2008-09-12 |
| EP2131877B1 (en) | 2018-03-28 |
| CO6231005A2 (es) | 2010-12-20 |
| US20100056654A1 (en) | 2010-03-04 |
| JP2013146592A (ja) | 2013-08-01 |
| US20140100297A1 (en) | 2014-04-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BRPI0808383A2 (pt) | Cemento ósseo, e, método para formar o mesmo. | |
| JP2010519959A5 (https=) | ||
| US8524798B2 (en) | Materials and apparatus for in-situ bone repair | |
| Boger et al. | Variation of the mechanical properties of PMMA to suit osteoporotic cancellous bone | |
| EP1931399B1 (en) | Bone cement composition and method of making the same | |
| CA2564687A1 (en) | Bone substitute compositions and method of use | |
| BRPI0712910B1 (pt) | sistema de múltiplos componentes para uma composição de aumento ósseo injetável, e, composição de aumento ósseo injetável | |
| Tang et al. | Fabrication of injectable and expandable PMMA/PAASf bone cements | |
| EP2451492A2 (en) | Compositions for tissue augmentation | |
| BRPI0711900A2 (pt) | sistema de múltiplos componentes para uma composição de enchimento de vazio ósseo injetável, composição injetável de enchimento de vazio ósseo, e, método para preencher um vazio em um osso em um paciente que sofre de um distúrbio ósseo | |
| BR112012021729B1 (pt) | sistema de cimento ósseo para reforçar um osso | |
| BRPI0615994A2 (pt) | material composto injetável adequado para uso como um substituto para osso | |
| BRPI1013668B1 (pt) | cimento ósseo injetável para o preenchimento de ossos e composição para a preparação de um cimento ósseo | |
| US9393346B2 (en) | Polymer cements used for fixing prostheses, for bone repair and for vertebroplasty, and obtained from liquid single-phase formulations | |
| JP2013503659A (ja) | 骨髄を含む骨セメント | |
| Bongio et al. | Development of an in vitro confinement test to predict the clinical handling of polymer-based injectable bone substitutes | |
| RU2822874C1 (ru) | Костный цемент | |
| EP2081610B1 (en) | Materials and apparatus for in-situ bone repair | |
| JP2020500092A (ja) | 光重合性骨充填材材料 | |
| EA048809B1 (ru) | Костный цемент | |
| WO2025127963A1 (ru) | Костный цемент |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07G | Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL. |