JP2010516681A5 - - Google Patents
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- Publication number
- JP2010516681A5 JP2010516681A5 JP2009546439A JP2009546439A JP2010516681A5 JP 2010516681 A5 JP2010516681 A5 JP 2010516681A5 JP 2009546439 A JP2009546439 A JP 2009546439A JP 2009546439 A JP2009546439 A JP 2009546439A JP 2010516681 A5 JP2010516681 A5 JP 2010516681A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- polymorph
- dosage form
- solid dosage
- total weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims description 9
- 238000000634 powder X-ray diffraction Methods 0.000 claims description 6
- 239000007909 solid dosage form Substances 0.000 claims 16
- 239000012453 solvate Substances 0.000 claims 2
- 239000013078 crystal Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 238000002441 X-ray diffraction Methods 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 238000001938 differential scanning calorimetry curve Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 0 CC[C@]([C@](C(C)=CC(C)=CC[C@]([C@@](C)O)OC(C(CO[C@@]([C@@]1OC)O[C@](C)[C@@](*C(c(c(CC)c(c(O)c2Cl)Cl)c2O)=O)[C@@]1O)=CC=CC1)=O)O[C@@]([C@]([C@]2O)O)OC(C)(C)[C@]2OC(C(C)C)=O)C=C(C)[C@]1O Chemical compound CC[C@]([C@](C(C)=CC(C)=CC[C@]([C@@](C)O)OC(C(CO[C@@]([C@@]1OC)O[C@](C)[C@@](*C(c(c(CC)c(c(O)c2Cl)Cl)c2O)=O)[C@@]1O)=CC=CC1)=O)O[C@@]([C@]([C@]2O)O)OC(C)(C)[C@]2OC(C(C)C)=O)C=C(C)[C@]1O 0.000 description 1
- 239000002178 crystalline material Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000000113 differential scanning calorimetry Methods 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88195007P | 2007-01-22 | 2007-01-22 | |
| US60/881,950 | 2007-01-22 | ||
| US11/831,886 | 2007-07-31 | ||
| US11/831,886 US7378508B2 (en) | 2007-01-22 | 2007-07-31 | Polymorphic crystalline forms of tiacumicin B |
| PCT/US2008/000735 WO2008091554A1 (en) | 2007-01-22 | 2008-01-22 | Macrocyclic polymorphs, compositions comprising such polymorphs, and methods of use and manufacture thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013151860A Division JP5764168B2 (ja) | 2007-01-22 | 2013-07-22 | 大環状多形、そのような多形を含む組成物、ならびにその使用方法および製造方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010516681A JP2010516681A (ja) | 2010-05-20 |
| JP2010516681A5 true JP2010516681A5 (Direct) | 2011-03-10 |
| JP5468388B2 JP5468388B2 (ja) | 2014-04-09 |
Family
ID=38661942
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009546439A Active JP5468388B2 (ja) | 2007-01-22 | 2008-01-22 | 大環状多形、そのような多形を含む組成物、ならびにその使用方法および製造方法 |
| JP2013151860A Active JP5764168B2 (ja) | 2007-01-22 | 2013-07-22 | 大環状多形、そのような多形を含む組成物、ならびにその使用方法および製造方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013151860A Active JP5764168B2 (ja) | 2007-01-22 | 2013-07-22 | 大環状多形、そのような多形を含む組成物、ならびにその使用方法および製造方法 |
Country Status (23)
| Country | Link |
|---|---|
| US (5) | US7378508B2 (Direct) |
| EP (3) | EP2468761A1 (Direct) |
| JP (2) | JP5468388B2 (Direct) |
| KR (2) | KR20090117924A (Direct) |
| CN (2) | CN102746353A (Direct) |
| BR (1) | BRPI0806878A2 (Direct) |
| CA (2) | CA2676061C (Direct) |
| CY (1) | CY1120358T1 (Direct) |
| DK (1) | DK2125850T3 (Direct) |
| ES (2) | ES2676308T3 (Direct) |
| HR (1) | HRP20180912T1 (Direct) |
| HU (2) | HUE039395T2 (Direct) |
| IL (2) | IL199984A0 (Direct) |
| LT (1) | LT2125850T (Direct) |
| MX (2) | MX2009007730A (Direct) |
| NZ (2) | NZ578697A (Direct) |
| PL (2) | PL2125850T3 (Direct) |
| PT (2) | PT2125850T (Direct) |
| RU (1) | RU2478643C2 (Direct) |
| SI (1) | SI2125850T1 (Direct) |
| TR (1) | TR201810589T4 (Direct) |
| TW (2) | TWI425942B (Direct) |
| WO (1) | WO2008091554A1 (Direct) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5113978B2 (ja) * | 2003-11-21 | 2013-01-09 | 味の素株式会社 | グルタミン酸誘導体の有機アミン塩及びその利用 |
| DK2305245T3 (en) * | 2004-05-14 | 2019-03-25 | Merck Sharp & Dohme | TREATMENT OF DISEASES RELATED TO THE USE OF ANTIBIOTICS |
| US7906489B2 (en) | 2004-05-14 | 2011-03-15 | Optimer Pharmaceuticals, Inc. | 18-membered macrocycles and analogs thereof |
| US7935377B2 (en) * | 2004-06-04 | 2011-05-03 | Ajinomoto Co., Inc. | Crystals of free (2R, 4R)-monatin and use thereof |
| US7378508B2 (en) * | 2007-01-22 | 2008-05-27 | Optimer Pharmaceuticals, Inc. | Polymorphic crystalline forms of tiacumicin B |
| CA2692977A1 (en) * | 2007-07-12 | 2009-01-15 | Tragara Pharmaceuticals, Inc. | Methods and compositions for the treatment of cancer, tumors, and tumor-related disorders |
| TWI523654B (zh) * | 2007-11-27 | 2016-03-01 | 默沙東藥廠 | 抗生素巨環化合物以及其製造及使用之方法 |
| EP2531197B1 (en) * | 2010-02-05 | 2017-05-17 | Tragara Pharmaceuticals, Inc. | Solid state forms of macrocyclic kinase inhibitors |
| CA2799531A1 (en) * | 2010-05-18 | 2011-11-24 | Optimer Pharmaceuticals, Inc. | Treating recurring clostridium difficile infection using fidaxomicin |
| MX2013009033A (es) * | 2011-02-04 | 2013-09-06 | Optimer Pharmaceuticals Inc | Tratamiento de infecciones bacterianas. |
| WO2013138748A1 (en) * | 2012-03-16 | 2013-09-19 | Optimer Pharmaceuticals, Inc. | Prevention of clostridium difficile infection in high risk patients |
| WO2013170142A1 (en) | 2012-05-10 | 2013-11-14 | Teva Pharmaceutical Works Ltd. | Solid state forms of fidaxomycin and processes for preparation thereof |
| US8722863B2 (en) | 2012-05-10 | 2014-05-13 | Teva Pharmaceutical Works Ltd. | Solid state forms of fidaxomycin and processes for preparation thereof |
| JO3464B1 (ar) * | 2013-01-15 | 2020-07-05 | Astellas Pharma Europe Ltd | التركيبات الخاصة بمركبات التياكوميسين |
| CN105142612A (zh) | 2013-03-08 | 2015-12-09 | 奇普拉股份有限公司 | 用于直肠给药的药物组合物 |
| CN103275152B (zh) * | 2013-05-29 | 2015-11-18 | 华北制药集团新药研究开发有限责任公司 | 一种高纯度非达霉素的制备方法 |
| CN103275153B (zh) * | 2013-06-27 | 2016-03-23 | 华北制药集团新药研究开发有限责任公司 | 一种非达霉素晶体的制备方法 |
| CN104560766B (zh) | 2013-10-16 | 2017-07-28 | 浙江海正药业股份有限公司 | 一种游动放线菌菌株及其应用 |
| US20150141356A1 (en) * | 2013-11-15 | 2015-05-21 | Optimer Pharmaceuticals, Inc. | Treatment of Clostridium Difficile Infection in High Risk Patients |
| WO2015127955A1 (en) | 2014-02-25 | 2015-09-03 | Olon S.P.A. | A new polymorph of tiacumicin b and process for preparation thereof |
| EP3110826A1 (en) | 2014-02-25 | 2017-01-04 | OLON S.p.A. | Process for preparing novel forms of tiacumicin b |
| CA2940902C (en) | 2014-03-18 | 2022-10-25 | Xellia Pharmaceuticals Aps | Polymorphs and solid states of tiacumicin b |
| EA031756B1 (ru) | 2014-05-09 | 2019-02-28 | Астеллас Фарма Юэроп Лтд | Схема лечения тиакумициновым соединением |
| US20150329582A1 (en) * | 2014-05-13 | 2015-11-19 | Jef DeBrabander | Small molecule compounds selective against gram-negative bacterial infections |
| CN104098637B (zh) | 2014-07-09 | 2017-01-04 | 浙江海正药业股份有限公司 | 一种纯化非达霉素的方法 |
| MA41689A (fr) * | 2014-10-15 | 2017-08-22 | Bioxcel Corp | Prévention ou traitement de troubles du sommeil au moyen d'une formulation de dexmédétomidine |
| MA42309A (fr) | 2015-07-03 | 2021-03-24 | Astellas Pharma Europe Ltd | Nouveau composé de tiacumicine pour régime posologique |
| CN112190589A (zh) * | 2020-11-17 | 2021-01-08 | 首都医科大学附属北京胸科医院 | 非达霉素在制备抑制鸟分枝杆菌活性的产品中的应用 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1458512A (en) * | 1973-11-22 | 1976-12-15 | Lepetit Spa | Antibiotic substance |
| US4321361A (en) * | 1980-06-12 | 1982-03-23 | Eli Lilly And Company | Demycinosyltylosin and process for its production |
| US4918174A (en) * | 1986-09-26 | 1990-04-17 | Abbott Laboratories | Tiacumicin compounds |
| US5698155A (en) | 1991-05-31 | 1997-12-16 | Gs Technologies, Inc. | Method for the manufacture of pharmaceutical cellulose capsules |
| US5583115A (en) * | 1995-05-09 | 1996-12-10 | Abbott Laboratories | Dialkyltiacumicin compounds |
| US5767096A (en) * | 1996-07-12 | 1998-06-16 | Abbott Laboratories | Bromotiacumicin compounds |
| JP2000072760A (ja) | 1998-06-19 | 2000-03-07 | Ajinomoto Co Inc | 新規シストチアゾール類縁体 |
| JP2000053514A (ja) | 1998-08-06 | 2000-02-22 | Aquas Corp | レジオネラ属細菌が生産する殺菌性物質、これを用いた殺菌剤、水処理剤、スライム抑制剤、及びこれらの製造方法 |
| JP2000239266A (ja) | 1999-02-17 | 2000-09-05 | Ajinomoto Co Inc | 新規ポリエン系抗生物質 |
| ATE444368T1 (de) | 2000-04-28 | 2009-10-15 | Kosan Biosciences Inc | Kristallines epothilon d |
| AU2001211213A1 (en) | 2000-10-20 | 2002-04-29 | Galephar M/F | Stable oral formulation containing benzimidazole derivative |
| DK1539977T3 (en) * | 2002-07-29 | 2014-11-17 | Optimer Pharmaceuticals Inc | PREPARATION OF TIACUMICIN |
| US20070105791A1 (en) * | 2002-07-29 | 2007-05-10 | Optimer Pharmaceuticals, Inc. | Method of treating clostridium difficile-associated diarrhea |
| US7906489B2 (en) * | 2004-05-14 | 2011-03-15 | Optimer Pharmaceuticals, Inc. | 18-membered macrocycles and analogs thereof |
| DK2305245T3 (en) | 2004-05-14 | 2019-03-25 | Merck Sharp & Dohme | TREATMENT OF DISEASES RELATED TO THE USE OF ANTIBIOTICS |
| US7378508B2 (en) * | 2007-01-22 | 2008-05-27 | Optimer Pharmaceuticals, Inc. | Polymorphic crystalline forms of tiacumicin B |
| EP1848273A4 (en) * | 2005-01-31 | 2010-02-24 | Optimer Pharmaceuticals Inc | 18-PIECE MACROCYCLES AND ITS ANALOG |
| CN102503994A (zh) | 2005-10-21 | 2012-06-20 | 奥普蒂姆药物公司 | 治疗艰难梭菌相关的腹泻的方法 |
| US20080176927A1 (en) | 2007-01-19 | 2008-07-24 | Optimer Pharmaceuticals, Inc. | Compositions of stable tiacumicins |
| ZA200905337B (en) * | 2007-01-22 | 2010-10-27 | Optimer Pharmaceuticals Inc | Macrocyclic polymorphs, compositions comprising such polymorphs, and methods of use and manufacture thereof |
| TWI523654B (zh) | 2007-11-27 | 2016-03-01 | 默沙東藥廠 | 抗生素巨環化合物以及其製造及使用之方法 |
-
2007
- 2007-07-31 US US11/831,886 patent/US7378508B2/en not_active Expired - Lifetime
-
2008
- 2008-01-22 TR TR2018/10589T patent/TR201810589T4/tr unknown
- 2008-01-22 PL PL08713185T patent/PL2125850T3/pl unknown
- 2008-01-22 PT PT87131850T patent/PT2125850T/pt unknown
- 2008-01-22 EP EP12156793A patent/EP2468761A1/en not_active Withdrawn
- 2008-01-22 RU RU2009131727/04A patent/RU2478643C2/ru active
- 2008-01-22 LT LTEP08713185.0T patent/LT2125850T/lt unknown
- 2008-01-22 MX MX2009007730A patent/MX2009007730A/es active IP Right Grant
- 2008-01-22 PT PT181677303T patent/PT3412678T/pt unknown
- 2008-01-22 HU HUE08713185A patent/HUE039395T2/hu unknown
- 2008-01-22 KR KR1020097017476A patent/KR20090117924A/ko not_active Ceased
- 2008-01-22 KR KR1020147036325A patent/KR20150006082A/ko not_active Ceased
- 2008-01-22 CN CN2012101288303A patent/CN102746353A/zh active Pending
- 2008-01-22 MX MX2013009811A patent/MX348083B/es unknown
- 2008-01-22 CA CA2676061A patent/CA2676061C/en active Active
- 2008-01-22 NZ NZ578697A patent/NZ578697A/xx unknown
- 2008-01-22 TW TW097102320A patent/TWI425942B/zh active
- 2008-01-22 ES ES08713185.0T patent/ES2676308T3/es active Active
- 2008-01-22 PL PL18167730T patent/PL3412678T3/pl unknown
- 2008-01-22 EP EP08713185.0A patent/EP2125850B1/en active Active
- 2008-01-22 US US12/523,790 patent/US8859510B2/en active Active
- 2008-01-22 TW TW102129518A patent/TWI453015B/zh active
- 2008-01-22 BR BRPI0806878-0A2A patent/BRPI0806878A2/pt not_active Application Discontinuation
- 2008-01-22 HU HUE18167730A patent/HUE052444T2/hu unknown
- 2008-01-22 JP JP2009546439A patent/JP5468388B2/ja active Active
- 2008-01-22 EP EP18167730.3A patent/EP3412678B1/en active Active
- 2008-01-22 CN CN2008800091323A patent/CN101663312B/zh not_active Ceased
- 2008-01-22 WO PCT/US2008/000735 patent/WO2008091554A1/en not_active Ceased
- 2008-01-22 HR HRP20180912TT patent/HRP20180912T1/hr unknown
- 2008-01-22 DK DK08713185.0T patent/DK2125850T3/en active
- 2008-01-22 NZ NZ601347A patent/NZ601347A/xx unknown
- 2008-01-22 SI SI200831973T patent/SI2125850T1/en unknown
- 2008-01-22 ES ES18167730T patent/ES2821384T3/es active Active
- 2008-01-22 CA CA2880860A patent/CA2880860A1/en not_active Withdrawn
- 2008-04-11 US US12/101,552 patent/US7863249B2/en active Active
-
2009
- 2009-03-04 US US12/397,686 patent/US8883986B2/en active Active
- 2009-07-21 IL IL199984A patent/IL199984A0/en unknown
-
2012
- 2012-06-07 IL IL220255A patent/IL220255A0/en unknown
-
2013
- 2013-03-15 US US13/839,299 patent/US20130252914A1/en not_active Abandoned
- 2013-07-22 JP JP2013151860A patent/JP5764168B2/ja active Active
-
2018
- 2018-06-27 CY CY20181100659T patent/CY1120358T1/el unknown
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