HRP20180912T1 - Makrociklički polimorfi, pripravci koji sadrže takve polimorfe, postupci proizvodnje i njihova upotreba - Google Patents

Makrociklički polimorfi, pripravci koji sadrže takve polimorfe, postupci proizvodnje i njihova upotreba

Info

Publication number
HRP20180912T1
HRP20180912T1 HRP20180912TT HRP20180912T HRP20180912T1 HR P20180912 T1 HRP20180912 T1 HR P20180912T1 HR P20180912T T HRP20180912T T HR P20180912TT HR P20180912 T HRP20180912 T HR P20180912T HR P20180912 T1 HRP20180912 T1 HR P20180912T1
Authority
HR
Croatia
Prior art keywords
polymorphs
macrocyclic
preparations containing
production procedures
procedures
Prior art date
Application number
HRP20180912TT
Other languages
English (en)
Croatian (hr)
Inventor
Yu-Hung Chiu
Tessie Mary Che
Alex Romero
Yoshi Ichikawa
Youe-Kong Shue
Original Assignee
Merck Sharp & Dohme Corp.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38661942&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20180912(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme Corp. filed Critical Merck Sharp & Dohme Corp.
Publication of HRP20180912T1 publication Critical patent/HRP20180912T1/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
HRP20180912TT 2007-01-22 2008-01-22 Makrociklički polimorfi, pripravci koji sadrže takve polimorfe, postupci proizvodnje i njihova upotreba HRP20180912T1 (hr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US88195007P 2007-01-22 2007-01-22
US11/831,886 US7378508B2 (en) 2007-01-22 2007-07-31 Polymorphic crystalline forms of tiacumicin B
EP08713185.0A EP2125850B1 (en) 2007-01-22 2008-01-22 Macrocyclic polymorphs, compositions comprising such polymorphs, methods of manufacture and use thereof
PCT/US2008/000735 WO2008091554A1 (en) 2007-01-22 2008-01-22 Macrocyclic polymorphs, compositions comprising such polymorphs, and methods of use and manufacture thereof

Publications (1)

Publication Number Publication Date
HRP20180912T1 true HRP20180912T1 (hr) 2018-07-27

Family

ID=38661942

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20180912TT HRP20180912T1 (hr) 2007-01-22 2008-01-22 Makrociklički polimorfi, pripravci koji sadrže takve polimorfe, postupci proizvodnje i njihova upotreba

Country Status (23)

Country Link
US (5) US7378508B2 (Direct)
EP (3) EP2468761A1 (Direct)
JP (2) JP5468388B2 (Direct)
KR (2) KR20090117924A (Direct)
CN (2) CN102746353A (Direct)
BR (1) BRPI0806878A2 (Direct)
CA (2) CA2676061C (Direct)
CY (1) CY1120358T1 (Direct)
DK (1) DK2125850T3 (Direct)
ES (2) ES2676308T3 (Direct)
HR (1) HRP20180912T1 (Direct)
HU (2) HUE039395T2 (Direct)
IL (2) IL199984A0 (Direct)
LT (1) LT2125850T (Direct)
MX (2) MX2009007730A (Direct)
NZ (2) NZ578697A (Direct)
PL (2) PL2125850T3 (Direct)
PT (2) PT2125850T (Direct)
RU (1) RU2478643C2 (Direct)
SI (1) SI2125850T1 (Direct)
TR (1) TR201810589T4 (Direct)
TW (2) TWI425942B (Direct)
WO (1) WO2008091554A1 (Direct)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5113978B2 (ja) * 2003-11-21 2013-01-09 味の素株式会社 グルタミン酸誘導体の有機アミン塩及びその利用
DK2305245T3 (en) * 2004-05-14 2019-03-25 Merck Sharp & Dohme TREATMENT OF DISEASES RELATED TO THE USE OF ANTIBIOTICS
US7906489B2 (en) 2004-05-14 2011-03-15 Optimer Pharmaceuticals, Inc. 18-membered macrocycles and analogs thereof
US7935377B2 (en) * 2004-06-04 2011-05-03 Ajinomoto Co., Inc. Crystals of free (2R, 4R)-monatin and use thereof
US7378508B2 (en) * 2007-01-22 2008-05-27 Optimer Pharmaceuticals, Inc. Polymorphic crystalline forms of tiacumicin B
CA2692977A1 (en) * 2007-07-12 2009-01-15 Tragara Pharmaceuticals, Inc. Methods and compositions for the treatment of cancer, tumors, and tumor-related disorders
TWI523654B (zh) * 2007-11-27 2016-03-01 默沙東藥廠 抗生素巨環化合物以及其製造及使用之方法
EP2531197B1 (en) * 2010-02-05 2017-05-17 Tragara Pharmaceuticals, Inc. Solid state forms of macrocyclic kinase inhibitors
CA2799531A1 (en) * 2010-05-18 2011-11-24 Optimer Pharmaceuticals, Inc. Treating recurring clostridium difficile infection using fidaxomicin
MX2013009033A (es) * 2011-02-04 2013-09-06 Optimer Pharmaceuticals Inc Tratamiento de infecciones bacterianas.
WO2013138748A1 (en) * 2012-03-16 2013-09-19 Optimer Pharmaceuticals, Inc. Prevention of clostridium difficile infection in high risk patients
WO2013170142A1 (en) 2012-05-10 2013-11-14 Teva Pharmaceutical Works Ltd. Solid state forms of fidaxomycin and processes for preparation thereof
US8722863B2 (en) 2012-05-10 2014-05-13 Teva Pharmaceutical Works Ltd. Solid state forms of fidaxomycin and processes for preparation thereof
JO3464B1 (ar) * 2013-01-15 2020-07-05 Astellas Pharma Europe Ltd التركيبات الخاصة بمركبات التياكوميسين
CN105142612A (zh) 2013-03-08 2015-12-09 奇普拉股份有限公司 用于直肠给药的药物组合物
CN103275152B (zh) * 2013-05-29 2015-11-18 华北制药集团新药研究开发有限责任公司 一种高纯度非达霉素的制备方法
CN103275153B (zh) * 2013-06-27 2016-03-23 华北制药集团新药研究开发有限责任公司 一种非达霉素晶体的制备方法
CN104560766B (zh) 2013-10-16 2017-07-28 浙江海正药业股份有限公司 一种游动放线菌菌株及其应用
US20150141356A1 (en) * 2013-11-15 2015-05-21 Optimer Pharmaceuticals, Inc. Treatment of Clostridium Difficile Infection in High Risk Patients
WO2015127955A1 (en) 2014-02-25 2015-09-03 Olon S.P.A. A new polymorph of tiacumicin b and process for preparation thereof
EP3110826A1 (en) 2014-02-25 2017-01-04 OLON S.p.A. Process for preparing novel forms of tiacumicin b
CA2940902C (en) 2014-03-18 2022-10-25 Xellia Pharmaceuticals Aps Polymorphs and solid states of tiacumicin b
EA031756B1 (ru) 2014-05-09 2019-02-28 Астеллас Фарма Юэроп Лтд Схема лечения тиакумициновым соединением
US20150329582A1 (en) * 2014-05-13 2015-11-19 Jef DeBrabander Small molecule compounds selective against gram-negative bacterial infections
CN104098637B (zh) 2014-07-09 2017-01-04 浙江海正药业股份有限公司 一种纯化非达霉素的方法
MA41689A (fr) * 2014-10-15 2017-08-22 Bioxcel Corp Prévention ou traitement de troubles du sommeil au moyen d'une formulation de dexmédétomidine
MA42309A (fr) 2015-07-03 2021-03-24 Astellas Pharma Europe Ltd Nouveau composé de tiacumicine pour régime posologique
CN112190589A (zh) * 2020-11-17 2021-01-08 首都医科大学附属北京胸科医院 非达霉素在制备抑制鸟分枝杆菌活性的产品中的应用

Family Cites Families (21)

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Publication number Priority date Publication date Assignee Title
GB1458512A (en) * 1973-11-22 1976-12-15 Lepetit Spa Antibiotic substance
US4321361A (en) * 1980-06-12 1982-03-23 Eli Lilly And Company Demycinosyltylosin and process for its production
US4918174A (en) * 1986-09-26 1990-04-17 Abbott Laboratories Tiacumicin compounds
US5698155A (en) 1991-05-31 1997-12-16 Gs Technologies, Inc. Method for the manufacture of pharmaceutical cellulose capsules
US5583115A (en) * 1995-05-09 1996-12-10 Abbott Laboratories Dialkyltiacumicin compounds
US5767096A (en) * 1996-07-12 1998-06-16 Abbott Laboratories Bromotiacumicin compounds
JP2000072760A (ja) 1998-06-19 2000-03-07 Ajinomoto Co Inc 新規シストチアゾール類縁体
JP2000053514A (ja) 1998-08-06 2000-02-22 Aquas Corp レジオネラ属細菌が生産する殺菌性物質、これを用いた殺菌剤、水処理剤、スライム抑制剤、及びこれらの製造方法
JP2000239266A (ja) 1999-02-17 2000-09-05 Ajinomoto Co Inc 新規ポリエン系抗生物質
ATE444368T1 (de) 2000-04-28 2009-10-15 Kosan Biosciences Inc Kristallines epothilon d
AU2001211213A1 (en) 2000-10-20 2002-04-29 Galephar M/F Stable oral formulation containing benzimidazole derivative
DK1539977T3 (en) * 2002-07-29 2014-11-17 Optimer Pharmaceuticals Inc PREPARATION OF TIACUMICIN
US20070105791A1 (en) * 2002-07-29 2007-05-10 Optimer Pharmaceuticals, Inc. Method of treating clostridium difficile-associated diarrhea
US7906489B2 (en) * 2004-05-14 2011-03-15 Optimer Pharmaceuticals, Inc. 18-membered macrocycles and analogs thereof
DK2305245T3 (en) 2004-05-14 2019-03-25 Merck Sharp & Dohme TREATMENT OF DISEASES RELATED TO THE USE OF ANTIBIOTICS
US7378508B2 (en) * 2007-01-22 2008-05-27 Optimer Pharmaceuticals, Inc. Polymorphic crystalline forms of tiacumicin B
EP1848273A4 (en) * 2005-01-31 2010-02-24 Optimer Pharmaceuticals Inc 18-PIECE MACROCYCLES AND ITS ANALOG
CN102503994A (zh) 2005-10-21 2012-06-20 奥普蒂姆药物公司 治疗艰难梭菌相关的腹泻的方法
US20080176927A1 (en) 2007-01-19 2008-07-24 Optimer Pharmaceuticals, Inc. Compositions of stable tiacumicins
ZA200905337B (en) * 2007-01-22 2010-10-27 Optimer Pharmaceuticals Inc Macrocyclic polymorphs, compositions comprising such polymorphs, and methods of use and manufacture thereof
TWI523654B (zh) 2007-11-27 2016-03-01 默沙東藥廠 抗生素巨環化合物以及其製造及使用之方法

Also Published As

Publication number Publication date
TW200840562A (en) 2008-10-16
HUE039395T2 (hu) 2018-12-28
CA2880860A1 (en) 2008-07-31
RU2009131727A (ru) 2011-02-27
CN101663312B (zh) 2013-10-23
PL3412678T3 (pl) 2020-12-14
US20090163428A1 (en) 2009-06-25
DK2125850T3 (en) 2018-07-30
BRPI0806878A2 (pt) 2014-06-24
NZ601347A (en) 2013-11-29
KR20150006082A (ko) 2015-01-15
US8883986B2 (en) 2014-11-11
IL199984A0 (en) 2010-04-15
LT2125850T (lt) 2018-08-10
HUE052444T2 (hu) 2021-05-28
PT2125850T (pt) 2018-07-11
TWI425942B (zh) 2014-02-11
US8859510B2 (en) 2014-10-14
CN101663312A (zh) 2010-03-03
SI2125850T1 (en) 2018-08-31
EP3412678B1 (en) 2020-08-19
EP3412678A1 (en) 2018-12-12
JP2010516681A (ja) 2010-05-20
TW201350114A (zh) 2013-12-16
EP2125850B1 (en) 2018-05-30
WO2008091554A1 (en) 2008-07-31
PL2125850T3 (pl) 2018-08-31
US7863249B2 (en) 2011-01-04
US20080194497A1 (en) 2008-08-14
JP2013241440A (ja) 2013-12-05
JP5468388B2 (ja) 2014-04-09
MX348083B (es) 2017-05-25
RU2478643C2 (ru) 2013-04-10
NZ578697A (en) 2012-08-31
IL220255A0 (en) 2012-07-31
KR20090117924A (ko) 2009-11-16
US7378508B2 (en) 2008-05-27
ES2676308T3 (es) 2018-07-18
CA2676061A1 (en) 2008-07-31
TR201810589T4 (tr) 2018-08-27
CY1120358T1 (el) 2019-07-10
CA2676061C (en) 2016-01-19
US20130252914A1 (en) 2013-09-26
US20070259949A1 (en) 2007-11-08
AU2008209580A1 (en) 2008-07-31
EP2125850A1 (en) 2009-12-02
JP5764168B2 (ja) 2015-08-12
EP2468761A1 (en) 2012-06-27
TWI453015B (zh) 2014-09-21
US20100081800A1 (en) 2010-04-01
MX2009007730A (es) 2009-08-07
ES2821384T3 (es) 2021-04-26
CN102746353A (zh) 2012-10-24
PT3412678T (pt) 2020-09-29

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