JP2010516287A5 - - Google Patents

Info

Publication number

JP2010516287A5

JP2010516287A5 JP2009547667A JP2009547667A JP2010516287A5 JP 2010516287 A5 JP2010516287 A5 JP 2010516287A5 JP 2009547667 A JP2009547667 A JP 2009547667A JP 2009547667 A JP2009547667 A JP 2009547667A JP 2010516287 A5 JP2010516287 A5 JP 2010516287A5

Authority

JP

Japan

Prior art keywords

hpv

polypeptide

nucleic acid

acid molecule

vector

Prior art date

2008-01-29

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 229920001184 polypeptide Polymers 0.000 claims 86
• 102000004196 processed proteins & peptides Human genes 0.000 claims 86
• 108090000765 processed proteins & peptides Proteins 0.000 claims 86
• 108020004707 nucleic acids Proteins 0.000 claims 73
• 102000039446 nucleic acids Human genes 0.000 claims 73
• 150000007523 nucleic acids Chemical class 0.000 claims 73
• 239000013598 vector Substances 0.000 claims 45
• 241001631646 Papillomaviridae Species 0.000 claims 23
• 208000015181 infectious disease Diseases 0.000 claims 15
• 101000622322 Human papillomavirus type 16 Regulatory protein E2 Proteins 0.000 claims 13
• 230000002458 infectious effect Effects 0.000 claims 13
• 125000003275 alpha amino acid group Chemical group 0.000 claims 12
• 239000002245 particle Substances 0.000 claims 12
• 230000003612 virological effect Effects 0.000 claims 11
• 101000622327 Human papillomavirus type 18 Regulatory protein E2 Proteins 0.000 claims 9
• 239000002773 nucleotide Substances 0.000 claims 8
• 125000003729 nucleotide group Chemical group 0.000 claims 8
• 239000000203 mixture Substances 0.000 claims 7
• 241000341655 Human papillomavirus type 16 Species 0.000 claims 6
• 101000954454 Human papillomavirus type 16 Replication protein E1 Proteins 0.000 claims 6
• 241001465754 Metazoa Species 0.000 claims 4
• 239000012528 membrane Substances 0.000 claims 4
• 101000954493 Human papillomavirus type 16 Protein E6 Proteins 0.000 claims 3
• 101000775744 Human papillomavirus type 18 Replication protein E1 Proteins 0.000 claims 3
• 208000009608 Papillomavirus Infections Diseases 0.000 claims 3
• 241000700618 Vaccinia virus Species 0.000 claims 3
• 230000002085 persistent effect Effects 0.000 claims 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• 102000044209 Tumor Suppressor Genes Human genes 0.000 claims 2
• 108700025716 Tumor Suppressor Genes Proteins 0.000 claims 2
• 238000004873 anchoring Methods 0.000 claims 2
• 230000001413 cellular effect Effects 0.000 claims 2
• 230000005860 defense response to virus Effects 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 230000001747 exhibiting effect Effects 0.000 claims 2
• 230000028993 immune response Effects 0.000 claims 2
• 238000002347 injection Methods 0.000 claims 2
• 239000007924 injection Substances 0.000 claims 2
• 231100001223 noncarcinogenic Toxicity 0.000 claims 2
• 239000013603 viral vector Substances 0.000 claims 2
• 108010068327 4-hydroxyphenylpyruvate dioxygenase Proteins 0.000 claims 1
• 241000178270 Canarypox virus Species 0.000 claims 1
• 241000700662 Fowlpox virus Species 0.000 claims 1
• 108090000288 Glycoproteins Proteins 0.000 claims 1
• 102000003886 Glycoproteins Human genes 0.000 claims 1
• 241000725303 Human immunodeficiency virus Species 0.000 claims 1
• 101000954519 Human papillomavirus type 18 Protein E6 Proteins 0.000 claims 1
• 101000767629 Human papillomavirus type 18 Protein E7 Proteins 0.000 claims 1
• 241000712079 Measles morbillivirus Species 0.000 claims 1
• 208000037581 Persistent Infection Diseases 0.000 claims 1
• 206010037742 Rabies Diseases 0.000 claims 1
• 102100021696 Syncytin-1 Human genes 0.000 claims 1
• 108020004440 Thymidine kinase Proteins 0.000 claims 1
• 206010046865 Vaccinia virus infection Diseases 0.000 claims 1
• 108010003533 Viral Envelope Proteins Proteins 0.000 claims 1
• 241000700605 Viruses Species 0.000 claims 1
• 230000003213 activating effect Effects 0.000 claims 1
• 150000001413 amino acids Chemical class 0.000 claims 1
• 238000012217 deletion Methods 0.000 claims 1
• 230000037430 deletion Effects 0.000 claims 1
• 238000001514 detection method Methods 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
• 230000000694 effects Effects 0.000 claims 1
• 230000004927 fusion Effects 0.000 claims 1
• 230000001939 inductive effect Effects 0.000 claims 1
• 238000007918 intramuscular administration Methods 0.000 claims 1
• 230000003902 lesion Effects 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 238000012986 modification Methods 0.000 claims 1
• 230000004048 modification Effects 0.000 claims 1
• 230000029279 positive regulation of transcription, DNA-dependent Effects 0.000 claims 1
• 230000010076 replication Effects 0.000 claims 1
• 230000003248 secreting effect Effects 0.000 claims 1
• 230000028327 secretion Effects 0.000 claims 1
• 230000004936 stimulating effect Effects 0.000 claims 1
• 238000007920 subcutaneous administration Methods 0.000 claims 1
• 208000007089 vaccinia Diseases 0.000 claims 1
• 230000029812 viral genome replication Effects 0.000 claims 1
• 230000003442 weekly effect Effects 0.000 claims 1