JP2010514798A5 - - Google Patents
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- JP2010514798A5 JP2010514798A5 JP2009544280A JP2009544280A JP2010514798A5 JP 2010514798 A5 JP2010514798 A5 JP 2010514798A5 JP 2009544280 A JP2009544280 A JP 2009544280A JP 2009544280 A JP2009544280 A JP 2009544280A JP 2010514798 A5 JP2010514798 A5 JP 2010514798A5
- Authority
- JP
- Japan
- Prior art keywords
- groups
- npl
- polar
- substituted
- nonpolar
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- -1 hydroxy ethoxymethyl Chemical group 0.000 claims 67
- 239000000203 mixture Substances 0.000 claims 66
- 125000000217 alkyl group Chemical group 0.000 claims 58
- 229910052739 hydrogen Inorganic materials 0.000 claims 58
- 239000001257 hydrogen Substances 0.000 claims 58
- 229910052717 sulfur Inorganic materials 0.000 claims 52
- 229910052760 oxygen Inorganic materials 0.000 claims 43
- 150000002431 hydrogen Chemical class 0.000 claims 41
- 125000005843 halogen group Chemical group 0.000 claims 35
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 32
- 125000003118 aryl group Chemical group 0.000 claims 30
- IAYJZWFYUSNIPN-UHFFFAOYSA-N 2-[4,5-dihydroxy-2-(hydroxymethyl)-6-(4-nitrophenoxy)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound OC1C(O)C(O)C(CO)OC1OC1C(CO)OC(OC=2C=CC(=CC=2)[N+]([O-])=O)C(O)C1O IAYJZWFYUSNIPN-UHFFFAOYSA-N 0.000 claims 29
- 125000001072 heteroaryl group Chemical group 0.000 claims 26
- 125000003545 alkoxy group Chemical group 0.000 claims 25
- 150000003839 salts Chemical class 0.000 claims 23
- 239000012453 solvate Substances 0.000 claims 21
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 18
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 16
- 208000015181 infectious disease Diseases 0.000 claims 12
- 125000005549 heteroarylene group Chemical group 0.000 claims 11
- 125000004442 acylamino group Chemical group 0.000 claims 10
- 125000002431 aminoalkoxy group Chemical group 0.000 claims 10
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 10
- 230000000845 anti-microbial effect Effects 0.000 claims 10
- 125000000732 arylene group Chemical group 0.000 claims 10
- 125000003282 alkyl amino group Chemical group 0.000 claims 9
- 125000004414 alkyl thio group Chemical group 0.000 claims 9
- 125000000753 cycloalkyl group Chemical group 0.000 claims 9
- 125000004663 dialkyl amino group Chemical group 0.000 claims 9
- 125000005391 diazamino group Chemical group 0.000 claims 9
- 125000000623 heterocyclic group Chemical group 0.000 claims 9
- 239000000546 pharmaceutical excipient Substances 0.000 claims 9
- 241001465754 Metazoa Species 0.000 claims 8
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 8
- 125000003342 alkenyl group Chemical group 0.000 claims 8
- 125000000304 alkynyl group Chemical group 0.000 claims 8
- 239000004599 antimicrobial Substances 0.000 claims 8
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 claims 8
- 125000004093 cyano group Chemical group *C#N 0.000 claims 8
- 125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 claims 8
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 claims 8
- 150000007659 semicarbazones Chemical class 0.000 claims 8
- 125000001989 1,3-phenylene group Chemical group [H]C1=C([H])C([*:1])=C([H])C([*:2])=C1[H] 0.000 claims 7
- 125000002947 alkylene group Chemical group 0.000 claims 7
- 230000000813 microbial effect Effects 0.000 claims 6
- 230000002265 prevention Effects 0.000 claims 6
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 5
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 claims 5
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 4
- 239000008177 pharmaceutical agent Substances 0.000 claims 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 3
- 125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 claims 3
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 3
- 229920001577 copolymer Polymers 0.000 claims 3
- 239000000178 monomer Substances 0.000 claims 3
- 125000005576 pyrimidinylene group Chemical group 0.000 claims 3
- 239000002294 steroidal antiinflammatory agent Substances 0.000 claims 3
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 2
- 125000002030 1,2-phenylene group Chemical group [H]C1=C([H])C([*:1])=C([*:2])C([H])=C1[H] 0.000 claims 2
- 125000001140 1,4-phenylene group Chemical group [H]C1=C([H])C([*:2])=C([H])C([H])=C1[*:1] 0.000 claims 2
- WRMNZCZEMHIOCP-UHFFFAOYSA-N 2-phenylethanol Chemical compound OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 claims 2
- CFKMVGJGLGKFKI-UHFFFAOYSA-N 4-chloro-m-cresol Chemical compound CC1=CC(O)=CC=C1Cl CFKMVGJGLGKFKI-UHFFFAOYSA-N 0.000 claims 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 2
- 125000003277 amino group Chemical group 0.000 claims 2
- 239000003963 antioxidant agent Substances 0.000 claims 2
- 235000006708 antioxidants Nutrition 0.000 claims 2
- 125000003710 aryl alkyl group Chemical group 0.000 claims 2
- 239000002738 chelating agent Substances 0.000 claims 2
- OSASVXMJTNOKOY-UHFFFAOYSA-N chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 claims 2
- OSVXSBDYLRYLIG-UHFFFAOYSA-N dioxidochlorine(.) Chemical compound O=Cl=O OSVXSBDYLRYLIG-UHFFFAOYSA-N 0.000 claims 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 claims 2
- UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical compound [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 claims 2
- 238000006116 polymerization reaction Methods 0.000 claims 2
- 239000003755 preservative agent Substances 0.000 claims 2
- 239000003381 stabilizer Substances 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 1
- VVFYQBFGXTYSMW-UHFFFAOYSA-N 1-chloro-1-phenoxyethanol Chemical compound CC(O)(Cl)OC1=CC=CC=C1 VVFYQBFGXTYSMW-UHFFFAOYSA-N 0.000 claims 1
- OAAZUWWNSYWWHG-UHFFFAOYSA-N 1-phenoxypropan-1-ol Chemical compound CCC(O)OC1=CC=CC=C1 OAAZUWWNSYWWHG-UHFFFAOYSA-N 0.000 claims 1
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims 1
- LXAHHHIGZXPRKQ-UHFFFAOYSA-N 5-fluoro-2-methylpyridine Chemical group CC1=CC=C(F)C=N1 LXAHHHIGZXPRKQ-UHFFFAOYSA-N 0.000 claims 1
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 1
- 125000005865 C2-C10alkynyl group Chemical group 0.000 claims 1
- 239000004155 Chlorine dioxide Substances 0.000 claims 1
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims 1
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 claims 1
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 1
- DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 claims 1
- 229960004308 acetylcysteine Drugs 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000004103 aminoalkyl group Chemical group 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 239000000043 antiallergic agent Substances 0.000 claims 1
- 239000003429 antifungal agent Substances 0.000 claims 1
- 229940121375 antifungal agent Drugs 0.000 claims 1
- 230000003078 antioxidant effect Effects 0.000 claims 1
- 239000003443 antiviral agent Substances 0.000 claims 1
- 235000010323 ascorbic acid Nutrition 0.000 claims 1
- 229960005070 ascorbic acid Drugs 0.000 claims 1
- 239000011668 ascorbic acid Substances 0.000 claims 1
- 239000000872 buffer Substances 0.000 claims 1
- 239000012986 chain transfer agent Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 235000019398 chlorine dioxide Nutrition 0.000 claims 1
- 229960004926 chlorobutanol Drugs 0.000 claims 1
- 229960002242 chlorocresol Drugs 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 229960003957 dexamethasone Drugs 0.000 claims 1
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940124274 edetate disodium Drugs 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 239000003623 enhancer Substances 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims 1
- 229960001048 fluorometholone Drugs 0.000 claims 1
- FAOZLTXFLGPHNG-KNAQIMQKSA-N fluorometholone Chemical compound C([C@@]12C)=CC(=O)C=C1[C@@H](C)C[C@@H]1[C@]2(F)[C@@H](O)C[C@]2(C)[C@@](O)(C(C)=O)CC[C@H]21 FAOZLTXFLGPHNG-KNAQIMQKSA-N 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 239000003193 general anesthetic agent Substances 0.000 claims 1
- 239000003862 glucocorticoid Substances 0.000 claims 1
- 229960000890 hydrocortisone Drugs 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 1
- ZCTXEAQXZGPWFG-UHFFFAOYSA-N imidurea Chemical compound O=C1NC(=O)N(CO)C1NC(=O)NCNC(=O)NC1C(=O)NC(=O)N1CO ZCTXEAQXZGPWFG-UHFFFAOYSA-N 0.000 claims 1
- 239000007943 implant Substances 0.000 claims 1
- 239000000314 lubricant Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229920000609 methyl cellulose Polymers 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000001923 methylcellulose Substances 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- 229960005323 phenoxyethanol Drugs 0.000 claims 1
- 229940067107 phenylethyl alcohol Drugs 0.000 claims 1
- DCNLOVYDMCVNRZ-UHFFFAOYSA-N phenylmercury(.) Chemical class [Hg]C1=CC=CC=C1 DCNLOVYDMCVNRZ-UHFFFAOYSA-N 0.000 claims 1
- XYFCBTPGUUZFHI-UHFFFAOYSA-O phosphonium Chemical compound [PH4+] XYFCBTPGUUZFHI-UHFFFAOYSA-O 0.000 claims 1
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 1
- 229960005205 prednisolone Drugs 0.000 claims 1
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 claims 1
- JUJWROOIHBZHMG-UHFFFAOYSA-O pyridinium Chemical compound C1=CC=[NH+]C=C1 JUJWROOIHBZHMG-UHFFFAOYSA-O 0.000 claims 1
- 150000003856 quaternary ammonium compounds Chemical class 0.000 claims 1
- 229920005604 random copolymer Polymers 0.000 claims 1
- 229960001487 rimexolone Drugs 0.000 claims 1
- QTTRZHGPGKRAFB-OOKHYKNYSA-N rimexolone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CC)(C)[C@@]1(C)C[C@@H]2O QTTRZHGPGKRAFB-OOKHYKNYSA-N 0.000 claims 1
- 229940001607 sodium bisulfite Drugs 0.000 claims 1
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 claims 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 claims 1
- 229940001584 sodium metabisulfite Drugs 0.000 claims 1
- 235000010262 sodium metabisulphite Nutrition 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 235000010199 sorbic acid Nutrition 0.000 claims 1
- 239000004334 sorbic acid Substances 0.000 claims 1
- 229940075582 sorbic acid Drugs 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 claims 1
- 229940033663 thimerosal Drugs 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
- GBXQPDCOMJJCMJ-UHFFFAOYSA-M trimethyl-[6-(trimethylazaniumyl)hexyl]azanium;bromide Chemical compound [Br-].C[N+](C)(C)CCCCCC[N+](C)(C)C GBXQPDCOMJJCMJ-UHFFFAOYSA-M 0.000 claims 1
- 0 *c(cc1NC(c2cc(C(N(C3NCC*3)c3cc(*)cc(NC(CCCCNC(N)=N)=*)c3O)=O)ncn2)=O)cc(NC(CCCCNC(N)=N)=O)c1O[C@@]1CNCC1 Chemical compound *c(cc1NC(c2cc(C(N(C3NCC*3)c3cc(*)cc(NC(CCCCNC(N)=N)=*)c3O)=O)ncn2)=O)cc(NC(CCCCNC(N)=N)=O)c1O[C@@]1CNCC1 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88280006P | 2006-12-29 | 2006-12-29 | |
| US60/882,800 | 2006-12-29 | ||
| PCT/US2007/089001 WO2008083256A2 (en) | 2006-12-29 | 2007-12-28 | Ophthalmic and otic compositions of facially amphiphilic polymers and oligomers and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014061503A Division JP5745666B2 (ja) | 2006-12-29 | 2014-03-25 | 面状両親媒性ポリマー及びオリゴマーの眼科用及び耳科用組成物とその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010514798A JP2010514798A (ja) | 2010-05-06 |
| JP2010514798A5 true JP2010514798A5 (enExample) | 2010-09-16 |
| JP5512279B2 JP5512279B2 (ja) | 2014-06-04 |
Family
ID=39589209
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009544280A Expired - Fee Related JP5512279B2 (ja) | 2006-12-29 | 2007-12-28 | 面状両親媒性ポリマー及びオリゴマーの眼科用及び耳科用組成物とその使用 |
| JP2014061503A Expired - Fee Related JP5745666B2 (ja) | 2006-12-29 | 2014-03-25 | 面状両親媒性ポリマー及びオリゴマーの眼科用及び耳科用組成物とその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014061503A Expired - Fee Related JP5745666B2 (ja) | 2006-12-29 | 2014-03-25 | 面状両親媒性ポリマー及びオリゴマーの眼科用及び耳科用組成物とその使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (5) | US20090092574A1 (enExample) |
| EP (1) | EP2114395B1 (enExample) |
| JP (2) | JP5512279B2 (enExample) |
| CN (3) | CN101631543B (enExample) |
| AU (1) | AU2007339790B2 (enExample) |
| CA (1) | CA2674080C (enExample) |
| DK (1) | DK2114395T3 (enExample) |
| ES (1) | ES2538479T3 (enExample) |
| HU (1) | HUE025868T2 (enExample) |
| PL (1) | PL2114395T3 (enExample) |
| PT (1) | PT2114395E (enExample) |
| WO (1) | WO2008083256A2 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070207211A1 (en) * | 2003-04-10 | 2007-09-06 | Pr Pharmaceuticals, Inc. | Emulsion-based microparticles and methods for the production thereof |
| US20090092574A1 (en) | 2006-12-29 | 2009-04-09 | Scott Richard W | Ophthalmic And Otic Compositions Of Facially Amphiphilic Polymers And Oligomers And Uses Thereof |
| MX2011000971A (es) * | 2008-07-28 | 2011-06-24 | Polymedix Inc | Compuestos antipaludicos. |
| US8278309B2 (en) * | 2008-10-27 | 2012-10-02 | Polymedix, Inc. | Synthetic mimetics of host defense and uses thereof |
| ITTO20090131A1 (it) * | 2009-02-24 | 2010-08-25 | Liofarmaceutici Srl | Composizioni oftalmiche contenenti teicoplanina |
| CN103108632A (zh) * | 2010-07-07 | 2013-05-15 | 波利梅伊公司 | 免疫调节的方法 |
| US20120190653A1 (en) * | 2011-01-20 | 2012-07-26 | Dow Pharmaceutical Sciences, Inc. | Therapeutic eye drop comprising doxycycline and a stabilizer |
| EP2709619B1 (en) * | 2011-05-16 | 2017-10-11 | Cellceutix Corporation | Compounds for use in treatment of mucositis |
| TW202126313A (zh) * | 2011-09-16 | 2021-07-16 | 美商遠景生物製藥股份有限公司 | 安定之普維酮—碘組成物 |
| CA2862170A1 (en) * | 2012-01-18 | 2013-07-25 | Cellceutix Corporation | Compounds and methods for treating candidiasis and aspergillus infections |
| US20150164882A1 (en) | 2013-07-22 | 2015-06-18 | Imprimis Pharmaceuticals, Inc. | Pharmaceutical compositions for intraocular administration and methods for fabricating thereof |
| JP6047203B2 (ja) * | 2015-02-20 | 2016-12-21 | セルセウティックス コーポレイション | 消化管の炎症性疾患の予防および／または治療のための宿主防御タンパク質（ｈｄｐ）模倣薬 |
| KR20180064399A (ko) | 2015-09-03 | 2018-06-14 | 더 어드미니스트레이터 오브 더 튜레인 에듀케이셔널 펀드 | 다목적 소독 및 멸균 용액을 위한 조성물 및 방법 |
| BR112018077281A2 (pt) * | 2016-07-01 | 2019-04-02 | Boulos & Cooper Pharmaceuticals Pty Ltd | novos antibióticos |
| IT201900000561A1 (it) * | 2019-01-14 | 2020-07-14 | Medivis S R L | Formulazioni topiche oftalmiche chimicamente e fisicamente stabili a base di Nepafenac |
| US11771694B2 (en) | 2020-06-05 | 2023-10-03 | Innovation Pharmaceuticals Inc. | Arylamide compounds for treatment and prevention of viral infections |
| JP2024506384A (ja) | 2021-02-10 | 2024-02-13 | イオリクス セラピューティクス，インコーポレーテッド | ロフルミラストの眼科的送達方法 |
| MX2024003580A (es) | 2021-09-22 | 2024-04-05 | Iolyx Therapeutics Inc | Metodos de tratamiento de enfermedades inflamatorias oculares. |
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| SE352811B (enExample) | 1971-06-04 | 1973-01-15 | Pharmacia Ab | |
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-
2007
- 2007-12-27 US US11/965,194 patent/US20090092574A1/en not_active Abandoned
- 2007-12-28 CN CN2007800519191A patent/CN101631543B/zh not_active Expired - Fee Related
- 2007-12-28 PT PT78700119T patent/PT2114395E/pt unknown
- 2007-12-28 EP EP07870011.9A patent/EP2114395B1/en not_active Not-in-force
- 2007-12-28 CN CN201110305158.6A patent/CN102600163B/zh not_active Expired - Fee Related
- 2007-12-28 PL PL07870011T patent/PL2114395T3/pl unknown
- 2007-12-28 CA CA2674080A patent/CA2674080C/en active Active
- 2007-12-28 JP JP2009544280A patent/JP5512279B2/ja not_active Expired - Fee Related
- 2007-12-28 AU AU2007339790A patent/AU2007339790B2/en not_active Ceased
- 2007-12-28 DK DK07870011.9T patent/DK2114395T3/en active
- 2007-12-28 WO PCT/US2007/089001 patent/WO2008083256A2/en not_active Ceased
- 2007-12-28 HU HUE07870011A patent/HUE025868T2/en unknown
- 2007-12-28 ES ES07870011.9T patent/ES2538479T3/es active Active
- 2007-12-28 CN CN2011103047415A patent/CN102342941A/zh active Pending
-
2012
- 2012-10-26 US US13/661,466 patent/US9192623B2/en active Active
-
2014
- 2014-03-25 JP JP2014061503A patent/JP5745666B2/ja not_active Expired - Fee Related
-
2015
- 2015-10-09 US US14/879,257 patent/US10166232B2/en active Active
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2018
- 2018-11-13 US US16/188,904 patent/US20190314370A1/en not_active Abandoned
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2020
- 2020-10-28 US US17/082,666 patent/US20210093636A1/en not_active Abandoned
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