JP2010514787A5 - - Google Patents
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- JP2010514787A5 JP2010514787A5 JP2009544230A JP2009544230A JP2010514787A5 JP 2010514787 A5 JP2010514787 A5 JP 2010514787A5 JP 2009544230 A JP2009544230 A JP 2009544230A JP 2009544230 A JP2009544230 A JP 2009544230A JP 2010514787 A5 JP2010514787 A5 JP 2010514787A5
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- cancer
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- 239000000203 mixture Substances 0.000 claims description 31
- 238000009472 formulation Methods 0.000 claims description 8
- 206010028980 Neoplasm Diseases 0.000 claims description 6
- 201000011510 cancer Diseases 0.000 claims description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 4
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims description 4
- 229960003668 docetaxel Drugs 0.000 claims description 4
- UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 claims description 4
- 229960004768 irinotecan Drugs 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- 206010060862 Prostate cancer Diseases 0.000 claims description 3
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 3
- 208000037819 metastatic cancer Diseases 0.000 claims description 3
- 208000011575 metastatic malignant neoplasm Diseases 0.000 claims description 3
- 206010006187 Breast cancer Diseases 0.000 claims description 2
- 208000026310 Breast neoplasm Diseases 0.000 claims description 2
- 206010009944 Colon cancer Diseases 0.000 claims description 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims description 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 2
- 206010033128 Ovarian cancer Diseases 0.000 claims description 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 2
- 229930012538 Paclitaxel Natural products 0.000 claims description 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 2
- 229930006000 Sucrose Natural products 0.000 claims description 2
- 239000002246 antineoplastic agent Substances 0.000 claims description 2
- VSRXQHXAPYXROS-UHFFFAOYSA-N azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+) Chemical compound [NH2-].[NH2-].[Pt+2].OC(=O)C1(C(O)=O)CCC1 VSRXQHXAPYXROS-UHFFFAOYSA-N 0.000 claims description 2
- 201000006491 bone marrow cancer Diseases 0.000 claims description 2
- 229960004562 carboplatin Drugs 0.000 claims description 2
- 229960004316 cisplatin Drugs 0.000 claims description 2
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims description 2
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 claims description 2
- 229960005277 gemcitabine Drugs 0.000 claims description 2
- 201000007270 liver cancer Diseases 0.000 claims description 2
- 208000014018 liver neoplasm Diseases 0.000 claims description 2
- 201000005202 lung cancer Diseases 0.000 claims description 2
- 208000020816 lung neoplasm Diseases 0.000 claims description 2
- 201000010453 lymph node cancer Diseases 0.000 claims description 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 2
- 229960001592 paclitaxel Drugs 0.000 claims description 2
- 201000002528 pancreatic cancer Diseases 0.000 claims description 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 2
- 238000001959 radiotherapy Methods 0.000 claims description 2
- 239000005720 sucrose Substances 0.000 claims description 2
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims description 2
- 238000000034 method Methods 0.000 description 18
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87186506P | 2006-12-26 | 2006-12-26 | |
| US60/871,865 | 2006-12-26 | ||
| PCT/US2007/088645 WO2008083101A1 (en) | 2006-12-26 | 2007-12-21 | Phosphoramidate alkylator prodrugs for the treatment of cancer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010514787A JP2010514787A (ja) | 2010-05-06 |
| JP2010514787A5 true JP2010514787A5 (Direct) | 2012-02-02 |
| JP5357049B2 JP5357049B2 (ja) | 2013-12-04 |
Family
ID=39588979
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009544230A Expired - Fee Related JP5357049B2 (ja) | 2006-12-26 | 2007-12-21 | 癌の治療のためのフォスフォルアミデートアルキル化剤プロドラッグ |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8552048B2 (Direct) |
| EP (1) | EP2114157B1 (Direct) |
| JP (1) | JP5357049B2 (Direct) |
| ES (1) | ES2884044T3 (Direct) |
| WO (1) | WO2008083101A1 (Direct) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA200507752B (en) | 2003-03-28 | 2007-01-31 | Threshold Pharmaceuticals Inc | Compositions and methods for treating cancer |
| CN102746336B (zh) | 2005-06-29 | 2015-08-19 | 施瑞修德制药公司 | 氨基磷酸酯烷化剂前体药物 |
| EP2114157B1 (en) | 2006-12-26 | 2021-05-26 | ImmunoGenesis, Inc. | Phosphoramidate alkylator prodrug for the treatment of cancer |
| JP5765634B2 (ja) * | 2008-10-21 | 2015-08-19 | スレッシュホールド ファーマシューティカルズ， インコーポレイテッド | 低酸素活性化型プロドラッグを用いるがんの処置 |
| RU2013102398A (ru) * | 2010-06-28 | 2014-08-10 | Тресхолд Фармасьютикалз, Инк. | Лечение рака крови |
| KR20130045341A (ko) | 2010-07-12 | 2013-05-03 | 쓰레솔드 파마슈티컬스, 인코포레이티드 | 암 치료를 위한 저산소증 활성 프로드러그와 항혈관형성제의 투여 |
| JP2014509658A (ja) * | 2011-04-01 | 2014-04-21 | スレッショルド ファーマシューティカルズ、インク． | ガン処置方法 |
| KR20140045931A (ko) * | 2011-04-15 | 2014-04-17 | 쓰레솔드 파마슈티컬스, 인코포레이티드 | 경구 투여를 위한 단위투여량 형태 |
| EP2793882A4 (en) * | 2011-12-22 | 2015-04-29 | Threshold Pharmaceuticals Inc | ADMINISTRATION OF HYPOXIA-ACTIVATED PRODRUGS IN COMBINATION WITH CHK1 INHIBITORS FOR THE TREATMENT OF CANCER |
| WO2013126539A1 (en) * | 2012-02-21 | 2013-08-29 | Threshold Pharmaceuticals Inc. | Treatment of cancer |
| US9278124B2 (en) | 2012-10-16 | 2016-03-08 | Halozyme, Inc. | Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods |
| WO2014069063A1 (ja) | 2012-10-29 | 2014-05-08 | 京セラ株式会社 | 弾性表面波センサ |
| WO2015013448A1 (en) | 2013-07-26 | 2015-01-29 | Threshold Pharmaceuticals, Inc. | Treatment of pancreatic cancer with a combination of a hypoxia-acti vated prodrug and a taxane |
| US10071109B2 (en) | 2013-11-06 | 2018-09-11 | Molecular Templates, Inc. | Predictive biomarker for hypoxia-activated prodrug therapy |
| US10131683B2 (en) | 2014-07-17 | 2018-11-20 | Molecular Templates, Inc. | TH-302 solid forms and methods related thereto |
| ES2828026T3 (es) | 2015-03-10 | 2021-05-25 | Obi Pharma Inc | Agentes alquilantes del ADN |
| MY198613A (en) | 2015-04-02 | 2023-09-11 | Ascenta Pharmaceuticals Ltd | Nitrobenzyl derivatives of anti-cancer agents |
| PL412787A1 (pl) | 2015-06-22 | 2017-01-02 | Magdalena Król | Oparty na makrofagach celowany system dostarczania związków związanych z ferrytyną |
| US20180169064A1 (en) | 2015-06-24 | 2018-06-21 | Threshold Pharmaceuticals, Inc. | Aziridine containing dna alkylating agents |
| JP2019527236A (ja) | 2016-08-01 | 2019-09-26 | モレキュラー テンプレーツ，インコーポレイティド | 癌を治療するための免疫調節剤と組み合わせた低酸素活性化型プロドラッグの投与 |
| WO2019238886A1 (en) | 2018-06-13 | 2019-12-19 | University Of Dundee | Bifunctional molecules for targeting usp14 |
| EP3807272A1 (en) | 2018-06-13 | 2021-04-21 | Amphista Therapeutics Ltd | Bifunctional molecules for targeting rpn11 |
| EP3807263A1 (en) | 2018-06-13 | 2021-04-21 | Amphista Therapeutics Ltd | Bifunctional molecules for targeting uchl5 |
| KR20210064252A (ko) * | 2018-09-24 | 2021-06-02 | 시에라 온코로지, 인코퍼레이티드 | Cdc7 억제제를 포함하는 암의 치료 방법 |
| EP3650046A1 (en) | 2018-11-08 | 2020-05-13 | Cellis AG | Mesenchymal stem cell based targeted active ingredient delivery system |
| US20230174624A1 (en) | 2020-03-18 | 2023-06-08 | Cellis Ag | Ferritin variants with increased stability, complexation ability and transferrin receptor affinity |
| WO2022195092A1 (en) | 2021-03-18 | 2022-09-22 | Cellis Ag | Ferritin variants with increased stability and complexation ability |
| CN118076359A (zh) * | 2021-08-27 | 2024-05-24 | 深圳艾欣达伟医药科技有限公司 | 使用th-302治疗parp抑制剂耐药的患者 |
| WO2023025291A1 (zh) | 2021-08-27 | 2023-03-02 | 深圳艾欣达伟医药科技有限公司 | 冻干制剂溶液及冻干制剂、方法和用途 |
| EP4494643A4 (en) | 2022-03-15 | 2025-09-10 | Ascentawits Pharmaceuticals Ltd | METHOD OF TREATING A PATIENT WITH BRCA MUTATION CANCER |
| US20250295677A1 (en) | 2022-04-15 | 2025-09-25 | Ascentawits Pharmaceuticals, Ltd. | Method for treating cancer by using th-302 alone or in combination with parp inhibitor |
| EP4529926A1 (en) | 2022-05-23 | 2025-04-02 | Ascentawits Pharmaceuticals, Ltd. | Method for treating cancer by combining alkylating agent prodrug and cell cycle inhibitor |
| AU2023343523A1 (en) | 2022-09-13 | 2025-03-20 | Cellis Ag | Isolated targeted delivery system for the treatment of glioma |
| WO2024061346A1 (zh) | 2022-09-22 | 2024-03-28 | 深圳艾欣达伟医药科技有限公司 | 乏氧激活的化合物在制备治疗癌症患者的药物中的用途 |
| EP4637829A1 (en) | 2022-12-20 | 2025-10-29 | Cellis Sp. z o.o. ([Ltd.] | Isolated targeted delivery system for the treatment of ovarian cancer |
| KR20250160163A (ko) | 2023-02-27 | 2025-11-11 | 아센타위츠 파마슈티컬즈 리미티드 | 용액, 동결건조 제형, 동결건조 제형 단위 패키지, 주사제, 및 주사제 제조 방법 |
| WO2025083276A1 (en) | 2023-10-19 | 2025-04-24 | Cellis Ag | Improved isolated targeted delivery system |
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| US3652579A (en) | 1969-06-26 | 1972-03-28 | Hoffmann La Roche | 1-methyl-2-substituted 5-nitroimidazoles |
| DE2229248C3 (de) | 1971-07-30 | 1980-03-27 | Gruppo Lepetit S.P.A., Mailand (Italien) | 5-Iminomethyl-2-nitroimidazoI-Derivate und Verfahren zu deren Herstellung |
| US4921963A (en) | 1987-04-13 | 1990-05-01 | British Columbia Cancer Foundation | Platinum complexes with one radiosensitizing ligand |
| JPH0819111B2 (ja) | 1987-10-22 | 1996-02-28 | ポーラ化成工業株式会社 | ２―ニトロイミダゾール誘導体及びこれを有効成分とする放射線増感剤 |
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| US5233031A (en) | 1991-09-23 | 1993-08-03 | University Of Rochester | Phosphoramidate analogs of 2'-deoxyuridine |
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| ZA200507752B (en) * | 2003-03-28 | 2007-01-31 | Threshold Pharmaceuticals Inc | Compositions and methods for treating cancer |
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| KR100755435B1 (ko) * | 2005-10-04 | 2007-09-04 | 삼성전자주식회사 | 디지털 방송 제한 수신 단말기 및 그 방법 |
| WO2008011588A2 (en) | 2006-07-20 | 2008-01-24 | Threshold Pharmaceuticals, Inc. | Glycoconjugates of phosphoramidate alkylators for treatment of cancer |
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| EP2114157B1 (en) | 2006-12-26 | 2021-05-26 | ImmunoGenesis, Inc. | Phosphoramidate alkylator prodrug for the treatment of cancer |
-
2007
- 2007-12-21 EP EP07869800.8A patent/EP2114157B1/en active Active
- 2007-12-21 WO PCT/US2007/088645 patent/WO2008083101A1/en not_active Ceased
- 2007-12-21 US US12/521,290 patent/US8552048B2/en active Active
- 2007-12-21 ES ES07869800T patent/ES2884044T3/es active Active
- 2007-12-21 JP JP2009544230A patent/JP5357049B2/ja not_active Expired - Fee Related
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